Patents Assigned to INSTITUTE
  • Hsp90 inhibitors
    Patent number: 9546170
    Abstract: The disclosure relates to Compounds of Formula (1) : and pharmaceutically acceptable salts thereof wherein Z1, Z2, Z3, Xa, Xb, Xc, Y, X2, and X4 are as defined herein, compositions comprising an effective amount of a Compound of Formula (1) or a pharmaceutically acceptable salt thereof, and methods to treat or prevent a condition, such as cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (1) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: January 17, 2017
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Tony Taldone, Gabriela Chiosis
  • RAIL TIE HAVING EMBEDDED AUTOMATIC DIFFERENTIAL SETTLEMENT COMPENSATION APPARATUS USING OIL PRESSURE FOR RAILROAD TRACKS
    Publication number: 20170009405
    Abstract: By supporting a space generated by a settlement of the track bed gravel or asphalt roadbed underneath a concrete rail tie with cylindrical rods, and installing the present invention, one each separately, on the left and right sides of the concrete rail tie, recovery from settlements is automatic, and the response to differential settlements of the left and right rails of the track due to the train load can be easily facilitated, and by installing pressure reducing valves on the upper part of the concrete rail ties, pressure can be reduced while maintaining the track system as is without having to dismantle the concrete rail ties, and accordingly the usability of the concrete rail ties can be improved.
    Type: Application
    Filed: December 4, 2014
    Publication date: January 12, 2017
    Applicant: KOREA RAILROAD RESEARCH INSTITUTE
    Inventors: Seong-Hyeok LEE, Jin-Wook LEE
  • POROUS ACUPUNCTURE NEEDLE AND METHOD FOR MANUFACTURING SAME
    Publication number: 20170007499
    Abstract: The present invention relates to a porous acupuncture needle and a method for manufacturing the same and, more specifically, to a porous acupuncture needle, which has mirco-sized or nano-sized holes formed on the surface thereof to maximize the specific surface thereof, and a method for manufacturing the same.
    Type: Application
    Filed: July 17, 2014
    Publication date: January 12, 2017
    Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Su Il IN, Hye Rim KIM, Abdul RAZZQ
  • IN-SITU HEATED DEPOSITION OF PARYLENE TO ENHANCE PORE PENETRATION INTO SILICONE
    Publication number: 20170009097
    Abstract: A composition of matter is described in which a porous material, such as polydimethylsiloxane (PDMS), is coated with parylene N, C, D, or AF-4 by vapor deposition polymerization while a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.
    Type: Application
    Filed: September 26, 2016
    Publication date: January 12, 2017
    Applicant: California Institute of Technology
    Inventors: Yu-Chong Tai, Dongyang Kang
  • METHOD AND APPARATUS FOR ACOUSTICAL POWER TRANSFER AND COMMUNICATION USING STEEL WEDGES
    Publication number: 20170009573
    Abstract: Systems and methods for transmitting power and information using acoustic energy produced by transducers are provided. The systems have particular application for powering and communication with electronics through drilling and pipe systems. Pairs of acoustic wedges holding transducers are provided for sending energy and information through a substrate which may be a steel pipe. Each wedge has an angled transducer which can be used to produce shear waves. The waves propagate through the substrate and are received by a second acoustic wedge. The shear waves, on reaching the second acoustic wedge, are converted back into electrical signals by a second transducer. Tangential shear waves, high, shallow wave transmission angles, and direct steel-steel bonding between wedges and substrates may be used.
    Type: Application
    Filed: February 24, 2015
    Publication date: January 12, 2017
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Henry A. SCARTON, Gary J. SAULNIER, Kyle R. WILT, R. Benjamin LITMAN
  • SEROTONIN 2C RECEPTOR ANTAGONISTS TO PREVENT AND TREAT STRESS-RELATED TRAUMA DISORDERS
    Publication number: 20170007618
    Abstract: The invention relates to methods for preventing stress-associated disorders. These disorders may be treated with a serotonin 2c receptor (5-HT2CR) antagonist prior to, during, or following a stress-related event. Stress-associated disorders include, for instance, post-traumatic stress disorder (PTSD).
    Type: Application
    Filed: June 17, 2016
    Publication date: January 12, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Ki Ann Goosens, Edward Stuart Boyden, Michael Vincent Baratta
  • METHOD TO OBTAIN UNBIASED IDENTIFICATION OF INTERACTION OF TEST COMPOUNDS WITH THE PROTEOME
    Publication number: 20170010229
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Application
    Filed: July 5, 2016
    Publication date: January 12, 2017
    Applicant: Institute for Systems Biology
    Inventors: Robert L. MORITZ, Samuel BADER, Ulrike KUSEBAUCH
  • APPARATUS AND METHOD FOR INTERFERENCE CONTROL IN HETEROGENEOUS NETWORK-MULTI CELL MOBILE COMMUNICATION SYSTEM
    Publication number: 20170013505
    Abstract: The present disclosure relates to a pre-5th-generation (5G) or 5G communication system to be provided for supporting rates beyond 4th-generation (4G) communication system such as a long term evolution (LTE). An operating method of a transmitting apparatus in a mobile communication system is provided. The method comprises regenerating a first interference signal for a receiving apparatus that a service is provided by at least one transmitting apparatus different from the transmitting apparatus at second time prior to first time; and transmitting the regenerated first interference signal at the first time.
    Type: Application
    Filed: November 27, 2014
    Publication date: January 12, 2017
    Applicants: Samsung Electronics Co., Ltd., Korea Advanced Institute of Science and Technology
    Inventors: Dae-Kyu Shin, Wan Choi, Hyun-Kyu Yu
  • ELECTRICALLY DRIVEN PUMP AND METHOD FOR MANUFACTURING THE SAME
    Publication number: 20170009778
    Abstract: An electrically driven pump includes a rotor assembly, and the rotor assembly includes a first part and a second part. The first part is integrally formed by injection molding, and includes an upper plate and vanes of an impeller, the upper plate is integrally formed with the vanes by injection molding, and each of the vanes is formed with a first connecting portion. The second part is integrally formed by injection molding, the first part and the second part are fixed by welding the first connecting portion and a second connecting portion, and in this way, the manufacturing cost of the rotor assembly is reduced, also a shaft sleeve integrally formed has a simple forming process.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 12, 2017
    Applicant: HANGZHOU SANHUA RESEARCH INSTITUTE CO., LTD.
    Inventors: Wei YE, Junchao ZHANG, Jun ZHANG, Junfeng BAO
  • Real Time Birefringent Imaging Spectrometer Based on Differential Structure
    Publication number: 20170010159
    Abstract: A real-time birefringent imaging spectrometer based on differential structure is provided. A polarization beam splitter to add an imaging branch is set. Meanwhile, the structure alters the conventional optical structure to the differential structure by setting another polarization beam splitter. Taking the difference between these two interferogram obtained by two branches of differential structure as the final interferogram and performing the required post-processing calculations produces the spectrum at each pixel. Common-mode error is intensively restrained due to the differential structure, and 50% of the optical loss is avoided because of casting off the analyzer; a high spatial resolution, high spectral resolution image is acquired by combining the high spatial resolution, colorful image with the low spatial resolution, high spectral resolution image.
    Type: Application
    Filed: February 11, 2015
    Publication date: January 12, 2017
    Applicant: Harbin Institute of Technology
    Inventors: PENG JIN, SHUAISHUAI ZHU, YU ZHANG, JIE LIN
  • ASSIGNMENT OF COMMUNICATION DEVICES HEURISTICALLY TO GREEN RELAYS IN WIRELESS NETWORK
    Publication number: 20170013509
    Abstract: Technologies are generally described to assignment of communication devices heuristically to green relays in a wireless network. According to some examples, a first device pair that includes a source device and a destination device assigned to a green relay among multiple green relays may be detected. A second device pair that includes another source device and destination device assigned to the green relay may also be detected. Data rates of the first device pair and the second device pair may be compared to select one of the first or second device pairs as a low traffic pair with a minimum data rate. A search among the green relays may then be executed to locate another green relay to assign the low traffic pair. The low traffic pair may be assigned to the other green relay in order to reduce an average traffic load of the original green relay.
    Type: Application
    Filed: December 3, 2013
    Publication date: January 12, 2017
    Applicant: NEW JERSEY INSTITUTE OF TECHNOLOGY
    Inventors: Nirwan Ansari, Tao Han
  • NEAR-ULTRAVIOLET STIMULATED LIGHT-EMITTING COMPOUND AND PRODUCTION METHOD FOR SAME
    Publication number: 20170012218
    Abstract: The present invention relates to a near-ultraviolet stimulated light-emitting compound, and more specifically relates to a fluorescent quinazolinone compound which is stimulated in the near ultraviolet region. The fluorescent quinazolinone compound according to the present invention is colourless in daylight but exhibits a high fluorescent intensity when irradiated with light in the near ultraviolet region. Also, the fluorescent quinazolinone compound can be easily used with printed and plastic moulded products since the compound not only has a high degree of light fastness and thermal stability but also high dispersibility.
    Type: Application
    Filed: January 15, 2015
    Publication date: January 12, 2017
    Applicants: NANO CMS CO., LTD., KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Je Young PARK, In Ja LEE, Shi Surk KIM, Kun JUN, Seung Rim SHIN, Kyoung Lyong AN
  • USER TERMINAL OF MULTI-HOP RELAY SYSTEM AND METHOD FOR APPLYING NON-ORTHOGONAL MULTIPLE ACCESS IN THE SAME
    Publication number: 20170012695
    Abstract: Disclosed is a method for applying non-orthogonal multiple access in a multi-hop relay system constituted by a base station, a relay, a first user terminal, and a second user terminal, including: receiving, by the first user terminal, a first data signal which the first user terminal needs to receive and a second data signal which the second user terminal needs to receive from the base station through a first phase; receiving, by the first user terminal, a third data signal from the base station through a second phase when the second data signal is relayed through the second phase by the relay; and removing an interference signal included in the third data signal received through the second phase by using the second data signal which the first user terminal receives through the first phase.
    Type: Application
    Filed: April 7, 2016
    Publication date: January 12, 2017
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Jung-Bin KIM, Woo Jin BYUN
  • VECTORS AND STRAINS FOR PRODUCING MYRCENE AND METHOD OF PRODUCING MYRCENE USING THE SAME
    Publication number: 20170009240
    Abstract: Disclosed herein are an expression vector capable of expressing myrcene, an Escherichia coli strain transformed with the vector and having improved capability of producing myrcene and a method for producing myrcene and a method for recycling glycerol using the same. In an aspect, the transformed Escherichia coli strain of the present disclosure can produce myrcene with high purity on a large scale using glycerol or glucose as a carbon source. Also, the Escherichia coli strain of the present disclosure is economical and environment-friendly because it can produce high value-added myrcene using waste glycerol as a carbon source. In addition, the strongly volatile myrcene can be produced and isolated at the same time.
    Type: Application
    Filed: November 24, 2015
    Publication date: January 12, 2017
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Han Min WOO, Eun Mi KIM, Youngsoon UM, Gyeongtaek GONG, Sun Mi LEE, Yunje KIM
  • Production of Therapeutic Proteins in Photosynthetic Organisms
    Publication number: 20170009250
    Abstract: The present disclosure relates to methods of expressing therapeutic proteins in photosynthetic organisms and the therapeutic proteins produced by the methods. The therapeutic proteins include high-mobility group box 1 (HMGB1) protein, fibronectin domain (10) (10FN3), fibronectin domain (14) (14FN3), interferon beta (IFN?), proinsulin and vascular endothelial growth factor (VEGF). The photosynthetic organisms include prokaryotes such as cyanobacteria and eukaryotes such as alga and plants. Transformation of eukaryotes is preferably the plastid genome, more preferably the chloroplast genome.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 12, 2017
    Applicants: Sapphire Energy, Inc., The Scripps Research Institute
    Inventors: Beth A. Rasala, Rosa M. F. Cardoso, Machiko Muto, Stephen P. Mayfield, Philip A. Lee, Craig A. Behnke, Michael Mendez
  • METHOD OF MANUFACTURING IMAGE SENSOR INCLUDING NANOSTRUCTURE COLOR FILTER
    Publication number: 20170012078
    Abstract: A method of manufacturing an image senor includes: preparing a sensor substrate including: a sensor layer including a photosensitive cell; and a signal line layer including lines to receive electric signals from the photosensitive cell; forming a first material layer having a first refractive index on the sensor substrate; and forming a nanopattern layer on the first material layer, the nanopattern layer including a material having a second refractive index different from the first refractive index.
    Type: Application
    Filed: June 27, 2016
    Publication date: January 12, 2017
    Applicants: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Seunghoon HAN, Yongsung KIM, Seyedeh Mahsa KAMALI, Amir ARBABI, Yu HORIE, Andrei FARAON, Sungwoo HWANG
  • VIDEO ENCODING METHOD FOR ENCODING DIVISION BLOCK, VIDEO DECODING METHOD FOR DECODING DIVISION BLOCK, AND RECORDING MEDIUM FOR IMPLEMENTING THE SAME
    Publication number: 20170013281
    Abstract: Disclosed are a method of encoding a division block in video encoding and a method of decoding a division block in video decoding. An input picture is divided into encoding unit blocks. The encoding unit blocks are divided into sub-blocks. The sub-blocks are encoded by selectively using at least one of intra prediction encoding and inter prediction encoding. A decoding process is performed through a reverse process of the encoding method. When pixel values of an encoding unit block are encoded in video encoding, the flexibility in selecting an encoding mode is increased and the efficiency of encoding is increased.
    Type: Application
    Filed: September 7, 2016
    Publication date: January 12, 2017
    Applicants: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, KOREAN BROADCASTING SYSTEM
    Inventors: Mun Churl KIM, Bum Shik LEE, Jae Il KIM, Chang Seob PARK, Sang Jin HAHM, In Joon CHO, Keun Sik LEE, Byung Sun KIM
  • METHODS USED TO TREAT CANCER
    Publication number: 20170009231
    Abstract: The invention encompasses methods used in the sensitization and treatment of cancer based upon the expression of SGEF.
    Type: Application
    Filed: July 7, 2016
    Publication date: January 12, 2017
    Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
    Inventor: NHAN TRAN
  • SYNTHESIS OF BORON NITRIDE AND COATING METHOD OF THE SAME
    Publication number: 20170008766
    Abstract: Provided is a method of synthesizing boron nitride, comprising the steps of: preparing a boron compound and a nitrogen compound; mixing the boron compound and the nitrogen compound in a non-aqueous solvent; forming an ester compound by melting the mixture in the non-aqueous solvent; dehydrating the ester compound; and forming boron nitride by nitriding the ester compound in a reductive atmosphere.
    Type: Application
    Filed: July 7, 2016
    Publication date: January 12, 2017
    Applicant: KOREA INSTITUTE OF ENERGY RESEARCH
    Inventors: In Sub HAN, Se Young KIM, Hyun Uk KIM, Young Hoon SEONG, Sang Kuk WOO, Hee Yeon KIM, Doo Won SEO, Min Soo SUH, Seong OK HAN
  • Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
    Patent number: RE46275
    Abstract: Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having average crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density. Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: January 17, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Jackie Y. Ying, Edward S. Ahn, Atsushi Nakahira