Abstract: A method and apparatus are provided to generate tomography images that performs the method. The apparatus and method are configured to determine a basis pattern from modulated phases of incident rays from a spatial light modulator according to a pattern of arranged pixels. The apparatus and method are further configured to perform spatial shift modulation shifting an arrangement of the pixels vertically or horizontally with respect to the basis pattern to obtain shift patterns of the basis pattern. The apparatus and method are configured to generate tomography images for the basis pattern and the shift patterns using spectrum signals of rays obtained from the incident rays passing through the spatial light modulator and entering a subject. The apparatus and method are configured to select a pattern that generates a clearest tomography image of the subject based on the generated tomography images.

Abstract: A network and related methods for transmitting processes in a network secretly and securely is described. The network use keys, through path-key establishment and a key pool bootstrapping, to ensure that packets are transmitted and received properly and secretly in the presence of one or more adversarial nodes.

Abstract: This invention provides methods for treating a subject afflicted with cancer, comprising concurrently administering (i) an HDAC 6-selective inhibitor and (ii) a suitable cytotoxic agent such as SAHA, doxorubicin or etoposide. This invention also provides methods for inducing the death of a transformed cell such as a cancer cell, comprising concurrently contacting the cell with (i) an HDAC 6-selective inhibitor and (ii) a suitable cytotoxic agent such as SAHA, doxorubicin or etoposide.

Abstract: The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

Abstract: The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen Ramalina terebrata, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-?B, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

Abstract: The present disclosure is directed to lenses, devices, methods and/or systems for addressing refractive error. Certain embodiments are directed to changing or controlling the wavefront of the light entering a human eye. The lenses, devices, methods and/or systems can be used for correcting, addressing, mitigating or treating refractive errors and provide excellent vision at distances encompassing far to near without significant ghosting. The refractive error may for example arise from myopia, hyperopia, or presbyopia with or without astigmatism. Certain disclosed embodiments of lenses, devices and/or methods include embodiments that address foveal and/or peripheral vision. Exemplary of lenses in the fields of certain embodiments include contact lenses, corneal onlays, corneal inlays, and lenses for intraocular devices both anterior and posterior chamber, accommodating intraocular lenses, electro-active spectacle lenses and/or refractive surgery.

Abstract: Embodiments of the invention include a method inserting a new face in a polygonal mesh comprising receiving an input corresponding to: a polygonal mesh having a plurality of faces, a selection of a face (fm) of the plurality of faces, a direction vector (d), a modified target plane (pm), and a threshold angle ?. For each edge (e) of the selected face fm, the method further includes determining each adjacent face (fadj) to selected face fm, and inserting a new face at edge e if no adjacent face exists or if fadj is substantially parallel to pm and within threshold ?. In some embodiments, the new face has a normal orthogonal to e and d.

Abstract: The present invention is drawn to compounds of Formula (I) below: and the pharmaceutically acceptable salts thereof, wherein R and R? are defined herein. The compounds are useful inhibitors of histone deacetylases (HDAC).

Abstract: The present invention provides compounds of Formula (I-A), (I-B), and (I-C), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting Myc (e.g., c-Myc) activity. The present invention further provides methods of using the compounds described herein for treating Myc-mediated disorders (e.g., cancer and other proliferative diseases). The present invention also provides assays for identifying Myc inhibitors.

Abstract: A gearset including an internal ring gear; a first pinion gear disposed within the internal ring gear and having teeth meshing with teeth of the internal ring gear; a disc having a central axis collinear with a central axis of the internal ring gear and a slot along a portion of a diameter of a first side thereof; a first pinion shaft having a first end, a second end, and an offset driving lug extending from the second end, the first pinion shaft extending through a hole of the first pinion gear, the offset driving lug of the first pinion shaft engaging with a first end of the slot; a second pinion gear disposed with the internal ring gear and having teeth meshing with teeth of the internal ring gear, the teeth of the second pinion gear not meshing with the teeth of the first pinion gear; a second pinion shaft having a first end, a second end, and an offset driving lug extending from the second end, the second pinion shaft extending through a hole of the second pinion gear, the offset driving lug of the secon

Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.

Abstract: The system for testing stress corrosion cracking (SCC) includes an autoclave having at least one heating element selectively actuated to heat the interior portion of the autoclave, the autoclave being configured for receiving a liquid and/or gas and for forming a corrosive fluid. The system also includes a circulation assembly having a flow line and a test section line. A plurality of test sections is positioned in series along the test section line and configured for receiving the corrosive fluid via the test section line once the required temperature is reached to expose the specimens directly to the corrosive fluid, the fluid flowing through a section of the flow line parallel to the test section line until the required temperature is reached. The circulation assembly includes a circulating pump, a flowmeter positioned along the flow line, and a pressure assembly mounted on the autoclave.

Abstract: Provided is an apparatus for real-time non-contact non-destructive thickness measurement using a terahertz wave, and more particularly, an apparatus for real-time non-contact non-destructive thickness measurement using a terahertz wave, which is capable of measuring a thickness of a sample by irradiating a terahertz continuous wave, which is generated from a wavelength-fixed laser and a wavelength-swept laser and of which the frequency is changed at a high speed, to the sample and measuring the terahertz wave transmitting or reflected from the sample.

Abstract: Provided is a method for diagnosing Alzheimer/s disease using a decomposed biomaterial. The method includes: preparing magnetic particles on which primary capture antibodies specifically bound to beta-amyloid are adsorbed; decomposing a biomaterial including beta-amyloid; binding the beta-amyloid to the primary capture antibodies; binding secondary capture antibodies labeled with a fluorescent material to the magnetic particles bound to the beta-amyloid to form a complex; disposing the complex in a channel region of a photo field effect transistor in which a photocurrent is changed according to the amount of incident light; and measuring the photocurrent changed by light excited from the complex to quantify the concentration of the beta-amyloid existing in the biomaterial.

Abstract: Semiconductor devices and methods for manufacturing the same are provided. In one embodiment, the method may include: forming a first shielding layer on a substrate, and forming one of source and drain regions with the first shielding layer as a mask; forming a second shielding layer on the substrate, and forming the other of the source and drain regions with the second shielding layer as a mask; removing a portion of the second shielding layer which is next to the other of the source and drain regions; forming a first gate dielectric layer and floating gate layer; forming a mask layer as a spacer on a sidewall of a remaining portion of the second shielding layer, and patterning the floating gate layer with the mask layer as a mask, and then removing the mask layer; and forming a second gate dielectric layer, and forming a gate conductor as a spacer on the sidewall of the remaining portion of the second shielding layer.

Abstract: Provided is a management device maintaining communication qualities while accommodating a changeable communication environment. Based on correspondence between each geographical position of plural managed devices and available frequencies thereat, pair available frequencies available in common by arbitrary two managed devices are specified for each pair, and notified to the arbitrary two devices. From managed devices, acquiring pair communication qualities obtained when the pair available frequencies is used, defined is a best pair available frequency capable of obtaining a best pair communication quality. Specifying all of candidate paths connecting the each pair, relaying other managed devices, calculated are, based on the best pair communication quality, path communication qualities in the candidate paths connecting the each pair using the best pair available frequency.

Abstract: Disclosed is a vaccine which has a high therapeutic effect on mycoplasma infection and is highly safe. For the purpose of developing effective therapeutic methods for mycoplasma infection, mycoplasma-mimic particles which are effective as a vaccine for mycoplasma infection are provided, and also provided are bacterium-mimic particles including common bacteria. Bacterium-mimic particles such as mycoplasma-mimic particles can be provided by producing liposome particles in which a lipid antigen specific to a pathogenic bacterium such as mycoplasma is contained as a liposome-constituting lipid component. The administration of the mycoplasma-mimic particles enables the induction of a potent immunological activity in living bodies. The mycoplasma-mimic particles can be used as an excellent vaccine for the prevention or treatment of mycoplasma infection.

Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.

Abstract: Provided is a communication method for downlink transmission with a low peak to average power ratio (PAPR) and compatibility with long-term evolution (LTE)-based downlink transmission in an LTE-based mobile communication system in which the performance degradation may occur due to a high PAPR in multi-carrier transmission caused by non-linearity of a power amplifier in a base station including a satellite, to have the effects of supporting a terminal that reuses an existing terrestrial LTE chipset and a terminal that enables downlink reception with a low PAPR with no collision between the terminals, and of implementing an integrated satellite/terrestrial mobile communication system with a minimum change of an existing mobile communication system to ensure economic efficiency.

Abstract: A model-based neuromechanical controller for a robotic limb having at least one joint includes a finite state machine configured to receive feedback data relating to the state of the robotic limb and to determine the state of the robotic limb, a muscle model processor configured to receive state information from the finite state machine and, using muscle geometry and reflex architecture information and a neuromuscular model, to determine at least one desired joint torque or stiffness command to be sent to the robotic limb, and a joint command processor configured to command the biomimetic torques and stiffnesses determined by the muscle model processor at the robotic limb joint. The feedback data is preferably provided by at least one sensor mounted at each joint of the robotic limb. In a preferred embodiment, the robotic limb is a leg and the finite state machine is synchronized to the leg gait cycle.