Abstract: The invention encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more pharmaceutical compositions that are capable of inhibiting TROY to treat the patient with cancer.

Abstract: Compositions, methods, and kits are provided which involve novel fusion protein-based adhesives for use in medical and marine applications. In some aspects, the novel fusion proteins comprise an adhesive domain (e.g., derived from an adhesive protein of a marine organism) and an amyloid domain (e.g., derived from a bacterial amyloid protein). Also provided are copolymers and fibers of the fusion proteins.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted-2/-/-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.) and/or Wnt signalling. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.); to inhibit Wnt signalling; to treat disorders that are ameliorated by the inhibition of PARP (e.g., PARP1, TNKS1, TNKS2, etc.); to treat disorders that are ameliorated by the inhibition of Wnt signalling; to treat proliferative conditions such as cancer, etc.

Abstract: An electrode for use in an input device is formed on a transparent substrate. The electrode has a laminated structure including a first layer, a second layer and a third layer on one surface of the transparent substrate, in this order from the farthest side from the surface. The first layer includes a transparent conductive film. The second layer includes one or more members of a nitride of Mo and a nitride of an Mo alloy. The third layer includes a metal film having a reflectance of 40% or higher and a transmittance of 10% or less.

Abstract: A magnetic resonance imaging (MRI) apparatus and a magnetic resonance spectroscopic method are provided. The MRI apparatus includes a data collector configured to obtain reference data of reference substances, and obtain measurement data of a target region of a subject. The MRI apparatus further includes a processor configured to determine a reference substance of the target region, among the reference substances, and a concentration of the reference substance, using the reference data, the measurement data, and an external factor compensation value compensating an external factor affecting the measurement data.

Abstract: Provided are a semiconductor device and a method of fabricating the same. The semiconductor device includes: an active region provided on a substrate; an inlet channel formed as a single cavity buried in one side of the substrate; an outlet channel formed as a single cavity buried in the other side of the substrate; a micro channel array comprising a plurality of micro channels, wherein the plurality of micro channels are formed as a plurality of cavities buried in the substrate, and one end of the micro channel array is connected to a side of the inlet channel and the other end of the micro channel array is connected to a side of the outlet channel; and a micro heat sink array separating the micro channels from one another.

Abstract: Techniques are generally described for a progressive cavity pump and methods for making and using a progressive cavity pump. In an example, a progressive cavity pump may include a stator, a rotor and/or a bearing. The stator may include a helical shaped interior with a first pitch. The rotor may be inside the stator. The rotor may include a helical shaped exterior with a second pitch. The second pitch may be different from the first pitch. The rotor may be effective to rotate with respect to the stator and effective to move eccentrically within the stator to define at least one cavity inside the stator. At least one bearing may be between the rotor and the stator. The bearing may be sized and shaped so that the rotor is effective to rotate inside the bearing and the bearing is effective to move eccentrically along with the rotor.

Abstract: A cermet coating includes a hard phase and a binder phase that binds the hard phase, wherein the hard phase includes a carbide phase composed of at least one type of WC and CrC; and the binder phase includes at least one type of metal phase selected from Co, Ni, NiCr, and CoCr, has a structure of a metal polycrystalline body, and is bonded directly to a metal substrate.

Abstract: Si/SiO2 core/shell nanostructures with sizes below 30 nm as trapping points in UV curable hybrid organic-inorganic gate dielectrics are presented in order to investigate printable nano floating gate transistors. Not only does the novelty of this invention comes from fabricating high-quality hybrid organic/inorganic gate dielectric layer by Sol-Gel process at low temperature but also incorporating the monolayer of high-density of Si nanoparticles (NPs) without obvious interface defects and keeping the quality of dielectric layers. Fixed-charge trapping defects are successfully removed from hybrid dielectrics by UV curing together with low temperature thermal curing and mobile charges solely related to Si/SiO2 core/shell nanostructures on charge trapping layer clearly demonstrate memory effects on printable device. Thin/uniform SiO2 shell on each Si NP functions as tunneling layer of flash memory devices, significantly simplifying the fabrication of printable nano floating gate memory device.

Abstract: A system and process are described for clean separation of biocrudes and water by-products from hydrothermal liquefaction (HTL) product mixtures of organic and biomass-containing feedstocks at elevated temperatures and pressures. Inorganic compound solids are removed prior to separation of biocrude and water by-product fractions to minimize formation of emulsions that impede separation. Separation may be performed at higher temperatures that reduce heat loss and need to cool product mixtures to ambient. The present invention thus achieves separation efficiencies not achieved in conventional HTL processing.

Abstract: A planarization process, the process including performing first sputtering on a material layer, with an area of the material layer which has a relatively low loading condition for sputtering shielded by a first shielding layer, removing the first shielding layer, and performing second sputtering on the material layer to planarize the material layer.

Abstract: Methods for fabricating self-aligned heterostructures and semiconductor arrangements using silicon nanowires are described.

Abstract: Described is a method and apparatus for per-panel photovoltaic energy extraction with integrated converters. Also described are switched-capacitor (SC) converters have been evaluated for many applications because of the possibility for on-chip integration; applications to solar arrays are no exception. Also described is a comprehensive system-level look at solar installations, finding possibilities for optimization at and between all levels of operation in an array. Specifically, novel concepts include new arrangements and options for applying switched-capacitor circuits at 3 levels: for the panel and sub-panel level, as part of the overall control strategy, and for ensuring stable and robust interface to the grid with the possibility of eliminating or reducing the use of electrolytic capacitors.

Abstract: A multi-core apparatus includes cores each including an active cycle counting unit configured to store an active cycle count, and a stall cycle counting unit configured to store a stall cycle count. The multi-core apparatus further includes a job scheduler configured to determine an optimal number of cores in an active state based on state information received from each of the cores, and adjust power to maintain the optimal number of cores.

Abstract: A closed loop type fuel cell system performs a removal function for an oxidant and a reductant, which are unreacted material, including a recirculating component for recirculating the oxidant and the reductant discharged from the main fuel cell back into the main fuel cell; and a regenerating component for removing moisture produced during the operation of the main fuel cell and impurities contained in the recirculated oxidant and reductant.

Abstract: There is provided a control method for radiation beam direction of wireless transmission device in a method for controlling radiation beam for a mobile station considerably moving around in the wireless transmission device comprising: updating and storing movement data of moving position and moving direction of the mobile station every time it moves by receiving sensor data in the mobile station; calculating a moving point to move by using the stored movement data of the mobile station by the wireless transmission device; determining a sector zone of radiation beam emission for the moving point to move; and controlling radiation beam of the mobile station by using the sector zone for the determined radiation beam emission in the wireless transmission device.

Abstract: An antenna device in a wireless communication includes antenna wires of four sides which include three feeding points and have a loop structure and four main switches which are located among the antenna wires of the four sides, wherein the antenna device operates as a loop antenna when the antenna wires of the four sides are connected according to operations of the main switches and wherein the antenna device operates as dipole antennas when the antenna wires of the four sides are disconnected according to operations of the main switches.

Abstract: According to embodiments of the disclosure, a flexible device and a fabrication method thereof are provided. The flexible device has a first area and a second area, and the stiffness of a portion of the first area is greater than the stiffness of the second area. The flexible device may include a flexible substrate and a rigid element. The flexible substrate includes a first surface and a second surface opposite to each other. The second surface has a coarse structure. The surface roughness of the second surface is greater in the first area than in the second area. The rigid element is disposed on the first surface of the flexible substrate and located in the first area. The stiffness of the rigid element is greater than the stiffness of the flexible substrate. A projection area of the coarse structure on the flexible substrate overlaps an area of the rigid element.

Abstract: Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries.

Abstract: The present disclosure provides a method for producing carbon nanoparticles at low cost and with good efficiency. According to the disclosure of the present description, a voltage is applied between a graphite positive electrode and a negative electrode in an aqueous medium to generate arc discharge in a gap. An inert gas is introduced into the gap from a cylinder bottle at a predetermined flow rate. In this manner, carbon nanoparticles can be produced from carbon steam that is generated in the gap as a result of the arc discharge.