Abstract: A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop a method for quantifying remaining liver function to serve as test indicator for judging the liver failure outcome in clinic, particularly for judging the necessity of liver transplantation for patients with liver failure or liver disease. The radioactivity uptake of the test indicator was negatively correlated with the extent of liver reserve. The cutoff value of liver reserve for liver transplantation is also disclosed.
Type:
Grant
Filed:
April 8, 2013
Date of Patent:
August 9, 2016
Assignee:
INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN
Abstract: The present invention relates to generation and high level expression of recombinant non-toxic of epsilon toxin of Clostridium perfringens as a recombinant vaccine against Clostridium perfringens infection and a process for producing the vaccine involving amplifying, cloning, transforming, incubating and purifying the recombinant non-toxic epsilon toxin protein. Thus in this invention, substitution mutation Y71G was executed in recombinant Etx and the recombinant EtxY71G protein was over-expressed in soluble form. Expressed protein was purified near homogeneity by DEAE sepharose anion exchange chromatography with high yield. Potential of rEtxY71G as a vaccine candidate was evaluated and found to be highly specific and immunogenic. The present invention is the first report for high level expression of non toxic rEtxY71G mutant protein of Clostridium perfringens. Upto 100 mg/L of highly immunogenic and homogeneous recombinant EtxY71G protein of 31 kDa was produced.
Type:
Grant
Filed:
July 1, 2011
Date of Patent:
August 9, 2016
Assignee:
National Institute of Immunology
Inventors:
Lalit Chander Garg, Keshav Gopal, Aparna Dixit
Abstract: The present invention relates to an ion trap mass spectrometer using a cold electron source, in a production of a portable mass spectrometer, in which a microchannel plate (MCP) module is used, initial electrons are induced by injecting ultraviolet photons emitted from an ultraviolet diode to a front surface of the MCP module, electron beams amplified from the electrons are amplified using a channeltron electron multiplier (CEM), the amplified electron beams are accurately adjusted and injected into an ion trap, thus increasing the amplification rate, and since a quadrupole field is used as an ion filter which returns the initially injected electrons to the inside of an ion trap mass separator, the ionization rate increases.
Abstract: The present disclosure relates to a polymer-based large-area carbon nanomesh and a method for preparing same. More particularly, the present disclosure provides a method for preparing a carbon nanomesh, including: preparing a polymer nanofilm by coating a solution of a block copolymer or a polymer mixture thereof on a substrate; stabilizing the polymer nanofilm by annealing such that the polymer nanofilm is phase-separated, a pore-forming polymer is removed and, at the same time, a nanomesh-forming polymer forms a stabilized porous polymer nanomesh; and carbonizing the stabilized porous polymer nanomesh by annealing at high temperature to prepare a carbon nanomesh. Using phase separation and cyclization of a polymer, a large-area carbon nanomesh with superior activity can be prepared simply with high reproducibility in large scale.
Type:
Grant
Filed:
April 26, 2013
Date of Patent:
August 9, 2016
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Han-Ik Joh, Su Young Son, Sung Ho Lee, Tae-Wook Kim
Abstract: Compounds having a 1-bora-1-fluoro-2,6,7-trioxabicyclo[2.2.2]octane moiety wherein the fluorine is 18F are described. Also described are reagents for radiolabeling a molecule having Formula I. Method for radiolabeling molecules with the disclosed reagents are also descried, as are radiolabeled molecules prepared thereby.
Type:
Grant
Filed:
January 24, 2014
Date of Patent:
August 9, 2016
Assignees:
H. Lee Moffitt Cancer Center and Research Institute, Inc., University of South Florida
Abstract: The present disclosure relates to a method and an apparatus for preparing nanosized metal or alloy nanoparticles by depositing metal or alloy nanoparticles with superior size uniformity on the surface of a powder as a base material by vacuum deposition and then dissolving or melting the base material using a solvent or heat. The method solves the problems of the existing expensive multi-step synthesis method based on chemical reduction and allows effective synthesis of metal or alloy nanoparticles with very uniform size and metal or alloy catalyst nanoparticles supported on carbon at low cost.
Type:
Grant
Filed:
February 4, 2014
Date of Patent:
August 9, 2016
Assignees:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, GL MATERIALS INC.
Inventors:
Sung Jong Yoo, Hee-young Park, Jong Hyun Jang, Hyoung-Juhn Kim, Tae-Hoon Lim, Sang Young Lee, Sang Hyun Ahn, Namgee Jung, Suk Woo Nam, Eun Ae Cho, Seok Keun Koh
Abstract: A method of collecting samples that are not polluted at the outside of a borehole at a predetermined depth by using a multi-packer and an apparatus therefore. Contaminated water in the borehole between first and second packers of the multi-packer is selectively discharged into a contaminated water discharging vessel installed on a lower end of a sample collecting container by opening or closing an electronic switching valve in the contaminated water discharging vessel.
Type:
Grant
Filed:
July 17, 2014
Date of Patent:
August 9, 2016
Assignee:
KOREA INSTITUTE OF GEOSCIENCE AND MINERAL RESOURCES
Inventors:
Jeong-Chan Kim, Ki-Sung Sung, Gi-Tak Chae, Byoung-Woo Yum
Abstract: The present invention provides a porous material having micropores capable of storing and releasing heat by phase change, which comprises a phase change material inserted into the micropores of a porous material medium such as activated carbon or silica gel so as to be capable of storing and releasing energy, and a preparation method thereof. The method comprises the steps of: pre-treating a porous material medium to remove impurities from the micropores of the porous material medium, thereby opening the micropores; pre-treating a phase change material to make it possible to insert the phase change material into the micropores of the porous material medium; inserting the pretreated phase change material into the pretreated porous material medium; filtering the porous material medium filled with the phase change material to remove the phase change material remaining after the insertion step; and washing the filtered material.
Type:
Grant
Filed:
December 6, 2012
Date of Patent:
August 9, 2016
Assignee:
KOREA INSTITUTE OF CONSTRUCTION TECHNOLOGY
Abstract: A semiconductor device includes a substrate having at least one electrically insulating portion. A first graphene electrode is formed on a surface of the substrate such that the electrically insulating portion is interposed between a bulk portion of the substrate and the first graphene electrode. A second graphene electrode formed on the surface of the substrate. The electrically insulating portion of the substrate is interposed between the bulk portion of the substrate and the second graphene electrode. The second graphene electrode is disposed opposite the first graphene electrode to define an exposed substrate area therebetween.
Type:
Grant
Filed:
September 25, 2014
Date of Patent:
August 9, 2016
Assignees:
INTERNATIONAL BUSINESS MACHINES CORPORATION, KARLSRUHE INSTITUTE OF TECHNOLOGY, TAIWAN BLUESTONE TECHNOLOGY LTD.
Inventors:
Phaedon Avouris, Christos Dimitrakopoulos, Damon B. Farmer, Mathias B. Steiner, Michael Engel, Ralph Krupke, Yu-Ming Lin
Abstract: The subject invention concerns methods and materials for diagnosing, monitoring the progress, and/or providing a prognosis for multiple myeloma and other conditions associated with antibody production in a person or animal. The methods of the invention utilize mass spectrometry for quantitative monitoring and detection of antibody produced by the plasma cells. The methods of the invention can be utilized for diagnosis, monitoring, and/or prognosis of multiple myeloma, monoclonal gammopathy, and other immunological or hematological conditions and disorders. In addition to detecting and quantifying antibody in a sample, other biological markers, such as serum albumin and/or beta-2-microglobulin, can also be detected and quantified using the present invention, and in combination with detection and quantification of antibody.
Type:
Grant
Filed:
May 30, 2013
Date of Patent:
August 9, 2016
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Inventors:
John Matthew Koomen, Elizabeth Renee Remily, Kaaron Benson, Mohamad Hussein
Abstract: Provided is a near field wireless communication apparatus that uses magnetic coupling and a method for operation of the apparatus, in which the magnetic coupling is used to transmit data or clock information with low power and high efficiency. A pulse generator of the near field wireless communication apparatus generates a pulse signal corresponding to transmission digital data to be transmitted. When the transmission digital data is “1,” the near field wireless communication apparatus modulates the data into the pulse signal and transmits the pulse signal. When the data is “0,” the near field wireless communication apparatus does not output the pulse.
Type:
Grant
Filed:
August 16, 2013
Date of Patent:
August 9, 2016
Assignees:
Samsung Electronics Co., Ltd, Korea Advanced Institute of Science and Technology
Inventors:
Jae-Young Huh, Hoi-Jun Yoo, Dong-Churl Kim, Kyu-Sub Kwak, Jea-Hyuck Lee, Hyun-Woo Cho, Tae-Hwan Roh, Un-Soo Ha
Abstract: A system for introspection and annotation of electronic design data includes a tracked probe that interacts with an electronic circuit, a tracking system, schematics, design files, or models for the circuit, electronic design system software, and a user interface. The probe has a sensor that tracks the position of the probe within the circuit. The tracking system receives data from the sensor and translates it into coordinates reflecting the location of the probe within the circuit. The software uses the probe coordinates to locate the position of the probe on the circuit schematic, identify the circuit component at the probe location, and display information about the identified component. The displayed information preferably includes an annotated version of the circuit schematic. The system may include a measurement or instrumentation device, the probe may include at least one parameter measurement device, and the display may include information derived from the parameter measurements.
Abstract: Enhanced real-time realizable AF algorithm for accurate detection of, and discrimination between, NSR, AF, PVC, and PAC. The method of these teachings includes an AF detection method having a modified Poincare approach in order to differentiate various patterns of PAC and PVC from NSR and AF. The method of these teachings can also apply to the Kullback-Leibler divergence or the Turning Point Ratio (TPR) to differentiate between various patterns of PAC and PVC from NSR and AF.
Abstract: Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula (I). Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.
Type:
Grant
Filed:
March 7, 2013
Date of Patent:
August 9, 2016
Assignees:
H. Lee Moffitt Cancer Center and Research Institute, Inc., Board of Trustees of the University of Illinois
Inventors:
Eduardo M. Sotomayor, Joel Bergman, Alan Kozikowski, Karrune Veeraprasert Woan, Alejandro V. Villagra
Abstract: Vaccines are disclosed against parasites. The vaccines include peptides in an immunological composition. In particular, the parasite is Toxoplas gondii.
Type:
Grant
Filed:
November 3, 2011
Date of Patent:
August 9, 2016
Assignees:
The University of Chicago, Infectious Disease Research Institute, Paxvax, Inc.
Inventors:
Rima McLeod, Tze Guan Tan, Jeffery L. Alexander, Hua Cong, William H. Witola, Kamal El Bissati, Ernest J. Mui, Steven G. Reed
Abstract: A controlling method for mitigating a rogue behavior of an Optical Network Unit (ONU) having a wavelength-tunable function in a hybrid Passive Optical Network (PON) system. The controlling method includes determining whether a first wavelength for an upstream signal received from the ONU strays away from an allowable range for a second wavelength assigned to the ONU, and, in response to a determination that the first wavelength strays away from the allowable range for the second wavelength, transmitting an upstream wavelength adjustment request message to the ONU to adjust a wavelength for the upstream signal. At this point, a determination on whether the first wavelength strays away from the allowable range for the second wavelength is made by calculating wavelength drift of the first wavelength and determining whether the calculated wavelength drift is greater than a drift threshold.
Type:
Application
Filed:
April 24, 2014
Publication date:
August 4, 2016
Applicant:
Electronics and Telecommunications Research Institute
Inventors:
Jie-Hyun LEE, Kyeong-Hwan DOO, Sil-Gu MUN, Han-Hyub LEE
Abstract: A system for controlling excess bias of a single photon avalanche photo diode (SPAD) is provided. The system includes a power supply, a SPAD, a control circuit and a load. The power supply generates a supply voltage. The SPAD has a first terminal receiving the supply voltage and a second terminal generating an output voltage signal. The control circuit is connected to the second terminal of the SPAD. The load has a first terminal connected to the second terminal of the SPAD, and a second terminal connected to the control circuit for receiving a reset level. The control circuit is capable of monitoring a swing of the output voltage level and generating the reset level in response to the excess bias level and the swing of the output voltage level.
Type:
Application
Filed:
June 29, 2015
Publication date:
August 4, 2016
Applicant:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventors:
Chia-Ming TSAI, Po-Hsuan CHANG, Ming-Ching KUO, Tzu-Yi YANG
Abstract: The present invention relates to a method for controlling land surface temperature using stratospheric airships and a reflector. In the method for controlling land surface temperature using stratospheric airships and a reflector, four corners are connected to a lower end of support lines coupled to be disposed vertically downward from a plurality of airships, and sunlight is reflected by a reflector unfolded into a tetragonal shape in the air, wherein the reflecting surface of the reflector plate is maintained at an angle to remain perpendicular to an incident angle of sunlight to shield, or redirect, the land surface from incident sunlight.
Abstract: Provided is a method for determining network link quality between a master station and slave stations in a wireless network system having a synchronous superframe structure. The method for determining link quality in a wireless network system includes determining whether the current station is a master or a slave, when the current station is a master, comparing a time value during which the latest packets were received from slaves and a maximum time value during which the slaves are not obliged to exchange packets with the master after accessing a network, and determining link quality between the slaves and the master according to the comparison result.
Type:
Application
Filed:
April 6, 2015
Publication date:
August 4, 2016
Applicant:
Korea Electronics Technology Institute
Inventors:
Tai Gil KWON, Jin Woong CHO, Yong Seong KIM