Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
Type:
Grant
Filed:
April 7, 2008
Date of Patent:
July 5, 2016
Assignee:
Whitehead Institute for Biomedical Research
Inventors:
Rudolf Jaenisch, Yaqub Hanna, Marius Wernig, Christopher J. Lengner, Alexander Meissner, Oliver Tobias Brambrink, G. Grant Welstead, Ruth Foreman
Abstract: A multi-hop relay maritime communication apparatus installed in a ship is disclosed. The maritime communication apparatus includes a first access module configured to comprise a plurality of directional antennas integrally formed; a second access module configured to comprise an omni-directional antenna; and a bridge configured to be connected to the first access module and the second access module via an Ethernet interface.
Type:
Grant
Filed:
November 13, 2014
Date of Patent:
July 5, 2016
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Dae Seung Yoo, Hyung Joo Kim, Seung Yong Lee, Kyong Hee Lee, Jin Kyu Choi, Gwang Ja Jin, Byung Tae Jang, Dong Sun Lim
Abstract: A novel adjuvant composition is provided that is excellent in safety and convenience as compared to the conventional adjuvant such as Alum. An adjuvant composition comprising citrullines, which are water soluble substance present in the living body, and/or a salt thereof; a vaccine composition comprising said adjuvant composition and an antigen; a process for preparing said adjuvant composition and said vaccine composition; and a method for administering said adjuvant composition and said vaccine composition are provided.
Type:
Grant
Filed:
March 9, 2012
Date of Patent:
July 5, 2016
Assignee:
THE CHEMO—SERO—THERAPEUTIC RESEARCH INSTITUTE
Abstract: A cartridge for tunnel blasting is provided a cartridge for tunnel blasting, which easily breaks a rock, by inserting a cartridge containing water into a bore hole formed in a rock by using a boring device, and injecting liquid nitrogen into the inserted cartridge, so as to induce cracks of the rock by using the characteristic of the water that expands when it is frozen.
Abstract: The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.
Type:
Grant
Filed:
June 22, 2007
Date of Patent:
July 5, 2016
Assignees:
Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
Inventors:
Rohit Karnik, Frank X. Gu, Pamela Basto, Chris Cannizzaro, Alireza Khademhosseini, Robert S. Langer, Omid C. Farokhzad
Abstract: Provided is a method and apparatus for removing a spoofing signal. The apparatus may convert a global positioning system (GPS) signal from an RF signal to an IF signal, and remove a spoofing signal based on whether the spoofing signal is present in the RF signal. The apparatus may obtain and track the spoofing signal using the IF signal, and generate a characteristic of the spoofing signal. The apparatus may generate an anti-spoofing signal by shifting a phase of the spoofing signal 180 degrees based on the characteristic of the spoofing signal.
Type:
Grant
Filed:
October 9, 2013
Date of Patent:
July 5, 2016
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Abstract: A bridge logic device for a heterogeneous computer system that has at least one performance processor, a processor supporting logic supporting the at least one performance processor to execute tasks of the software, and a hypervisor processor consuming less power than the at least one performance processor is disclosed. The bridge logic device comprises a hypervisor operation logic that maintains status of the system under the at least one performance processor; a processor language translator logic that translates between processor languages of the at least one performance and the hypervisor processors; and a high-speed bus switch that has first, second and third ports for relaying data across any two of the three ports bidirectionally. The switch is connected to the at least one performance processor, the hypervisor processor via the processor language translator logic, and to the processor supporting logic respectively at the first, second, and third port.
Abstract: A memory cell of a resistive random access memory and a manufacturing method thereof are provided. The method includes the following steps. A first electrode is formed. A metal oxide layer is formed on the first electrode. An electrode buffer stacked layer is formed on the metal oxide layer and includes a first buffer layer and a second buffer layer, and the first buffer layer is located between the second buffer layer and the metal oxide layer. The second buffer layer reacts with oxygen from the first buffer layer more strongly than the first buffer layer reacts with oxygen from the metal oxide layer. A second electrode layer is formed on the electrode buffer stacked layer.
Type:
Grant
Filed:
October 9, 2014
Date of Patent:
July 5, 2016
Assignee:
Industrial Technology Research Institute
Abstract: Provided is a method for transmitting packet-based media data having a header in which an overhead is minimized. A method for media data transmission may comprise the steps of: encapsulating media data to allow a media fragment unit (MFU) header and an M-unit header to share one format; allowing an MMT payload format to include a header field for an operation which is not supported by an RTP header, and transferring the encapsulated media data from a specific entity to another entity; and controlling the transfer of the media data. Therefore, a transmission overhead is minimized, so that it is possible to efficiently transmit media data.
Type:
Grant
Filed:
June 13, 2012
Date of Patent:
July 5, 2016
Assignee:
Electronic and Telecommunications Research Institute
Abstract: Upon producing a transparent polycrystalline material, a suspension liquid (or slurry 1) is prepared, the suspension liquid being made by dispersing a raw-material powder in a solution, the raw-material powder including optically anisotropic single-crystalline particles to which a rare-earth element is added. A formed body is obtained from the suspension liquid by means of carrying out slip casting in a space with a magnetic field applied. On this occasion, while doing a temperature control so that the single-crystalline particles demonstrate predetermined magnetic anisotropy, one of static magnetic fields and rotary magnetic fields is selected in compliance with a direction of an axis of easy magnetization in the single-crystalline particles, and is then applied to them. A transparent polycrystalline material is obtained by sintering the formed body, the transparent polycrystalline material having a polycrystalline structure whose crystal orientation is controlled.
Type:
Grant
Filed:
May 23, 2013
Date of Patent:
July 5, 2016
Assignees:
INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION, NATIONAL INSTITUTES OF NATURAL SCIENCES, GENESIS RESEARCH INSTITUTE, INCORPORATED
Inventors:
Takunori Taira, Jun Akiyama, Shigeo Asai, Kunihiko Hara
Abstract: A detection chip is provided. The detection chip includes a substrate, an active reagent, a hydrophilic droplet and a lipophilic substance. The substrate includes a first containing slot, wherein the first containing slot includes a first space and a second space adjacent to each other. The active reagent is disposed in the first space of the first containing slot. The hydrophilic droplet is disposed in the second space of the first containing slot. The lipophilic substance is disposed in the first containing slot, wherein the lipophilic substance is immiscible to the active reagent and the hydrophilic droplet, and separates the active reagent from the hydrophilic droplet.
Type:
Grant
Filed:
March 21, 2014
Date of Patent:
July 5, 2016
Assignee:
Industrial Technology Research Institute
Abstract: A physical assistive robotic device may include a frame including an upright support member, a lateral member slidably engaged with the upright support member, a handle slidably engaged with the lateral member, an elevation actuator coupled to the upright support member and the lateral member, and a lateral actuator coupled to the lateral member and the handle. The elevation actuator translates the lateral member and the lateral actuator translates the handle to transition a user between a standing position and a non-standing position.
Type:
Grant
Filed:
January 10, 2013
Date of Patent:
July 5, 2016
Assignees:
Toyota Motor Engineering & Manufacturing North America, Inc., Illinois Institute of Technology
Abstract: Provided are a method for providing augmented reality (AR) services, and a user terminal and an access point using the same. The user terminal according to an embodiment of the present invention includes a reception unit that receives AR-related information broadcast by at least one access point (AP), a photographing unit that photographs an image of an object to obtain the photographed image, and a comparison unit that compares the obtained image of the object with the AR-related information received from the at least one AP to identify the object.
Type:
Grant
Filed:
September 18, 2013
Date of Patent:
July 5, 2016
Assignee:
ELECTRONIC AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Abstract: A photocatalytic film structure is provided. The photocatalytic film includes a plurality of micron particles; a plurality of nano particles; and a plurality of block bodies, wherein the volume of each of the block bodies is greater than that of each of the nano particles, and each of the micron particles, the nano particles and the block bodies contains zinc oxide and a doping metal, and wherein the amount of the doping metal is 1 to 5 wt % of the photocatalytic film, and the plurality of micron particles and micron particles take up 10 to 50% of the volume of the photocatalytic film.
Type:
Grant
Filed:
April 9, 2014
Date of Patent:
July 5, 2016
Assignee:
Industrial Technology Research Institute
Inventors:
Wu-Han Liu, Wei-Tien Hsiao, Mao-Shin Liu, Ming-Sheng Leu, Cherng-Yuh Su, Fuh-Sheng Shieu, Chin-Te Lu
Abstract: An interference alignment method using multiple antennas in a multi-cell overlapped environment, includes: when at least one transmission and reception ends having at least one or more antennas communicate with each other, establishing at least one or more channels from the transmission end to the reception end. Further, the interference alignment method includes designing a processing filter for a transmission signal transmitted from the transmission end to the reception ends; and designing a processing filter for a reception signal that is received by the reception end.
Type:
Grant
Filed:
January 16, 2014
Date of Patent:
July 5, 2016
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Jinhyung Oh, Gwangzeen Ko, Igor Kim, Myung Sun Song
Abstract: The present invention relates to compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of Glycine max leaves or fractions isolated from the same.
Type:
Grant
Filed:
November 10, 2009
Date of Patent:
July 5, 2016
Assignee:
Korea Reasearch Institute of Bioscience and Biotechnology
Inventors:
Tae-Sook Jeong, Woo Song Lee, Ki Hun Park, Myung-Sook Choi, Ho Yong Park, Jong-Min Han, Hyung-Jae Jeong
Abstract: A modified protein of an extracellular domain of protein A, which has the reduced ability to bind to immunoglobulin in an acidic region, compared with the wild-type extracellular domain of protein A, without impairing a selective antibody-binding activity in a neutral region. On the basis of three-dimensional structure coordinate data on a complex of the extracellular domain of protein A bound with the Fc region of immunoglobulin G, the modified protein is obtained by the substitution of amino acid residues that are located within the range of 10 angstroms from the Fc region and have a 20% or more ratio of exposed surface area, by histidine residues. Preferably, the modified protein is obtained by the substitution of amino acid residues at sites identified from the analysis of sequences selected from a library constituted by the protein group, by histidine residues. These substitutions may be combined.
Type:
Grant
Filed:
December 3, 2013
Date of Patent:
July 5, 2016
Assignee:
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
Abstract: A wearable robotic system assists a wearer in performing manual tasks. One or more robotic arms are mounted to a wearer, and an sensor monitors the orientation(s) (e.g., position and movement) of the wearer's upper body and one or both arms. A controller detects a task being performed by the wearer based on the orientation(s) as indicated by the orientation sensors. In response, the controller causes the robotic arm to perform an action independent of the orientation(s) of the wearer's arms and complementary to the task, thereby aiding the wearer to accomplish the detected task.
Type:
Grant
Filed:
January 13, 2015
Date of Patent:
July 5, 2016
Assignee:
Massachusetts Institute of Technology
Inventors:
Haruhiko Harry Asada, Baldin Adolfo Llorens-Bonilla
Abstract: A packaging substrate includes a carrier and an interposer. The carrier has opposite top and bottom surfaces. A recess is formed on the top surface and a plurality of first conductive terminals are formed on the recess. Further, a plurality of second conductive terminals are formed on the bottom surface of the carrier. The interposer is disposed in the recess and has opposite first and second surfaces and a plurality of conductive through vias penetrating the first and second surfaces. A first conductive pad is formed on an end of each of the conductive through vias exposed from the first surface, and a second conductive pad is formed on the other end of each of the conductive through vias exposed from the second surface and electrically connected to a corresponding one of the first conductive terminals. Compared with the prior art, the invention improves the product reliability.
Type:
Grant
Filed:
August 3, 2012
Date of Patent:
July 5, 2016
Assignees:
Unimicron Technology Corporation, Industrial Technology Research Institute
Abstract: The invention provides a class of copolymers having useful properties, including brush block copolymers, wedge-type block copolymers and hybrid wedge and polymer block copolymers. In an embodiment, for example, block copolymers of the invention incorporate chemically different blocks comprising polymer size chain groups and/or wedge groups that significantly inhibit chain entanglement, thereby enhancing molecular self-assembly processes for generating a range of supramolecular structures, such as periodic nanostructures and microstructures. The present invention also provides useful methods of making and using copolymers, including block copolymers.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
July 5, 2016
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Yan Xia, Benjamin R Sveinbjornsson, Robert H Grubbs, Raymond Weitekamp, Garret M Miyake, Harry A Atwater, Victoria Piunova, Christopher Scot Daeffler, Sung Woo Hong, Weiyin Gu, Thomas P. Russell