Patents Assigned to INSTITUTE
  • Publication number: 20160194345
    Abstract: Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity.
    Type: Application
    Filed: March 19, 2014
    Publication date: July 7, 2016
    Applicants: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRY
    Inventors: Baoquan ZHU, Yongzhi SHU, Jun LIN, Haifeng HU, Quanhai LIU, Bin ZHOU
  • Publication number: 20160193479
    Abstract: A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the microspheres from the polymer matrix. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding or minimizing undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method.
    Type: Application
    Filed: March 14, 2016
    Publication date: July 7, 2016
    Applicants: Battelle Memorial Institute, University of Utah Research Foundation
    Inventors: Darrell R. Fisher, You Han Bae, Zhonggao Gao
  • Publication number: 20160198191
    Abstract: According to the present invention, an image encoding/decoding method comprises the steps of: performing an intra prediction on a current block so as to generate a prediction block; performing filtering on a filtering target pixel in the prediction block on the basis of the intra prediction mode of the current block so as to generate a final prediction block; and generating a reconstructed block on the basis of a reconstructed differential block corresponding to the current block and on the final prediction block. According to the present invention, image encoding/decoding efficiency can be improved.
    Type: Application
    Filed: March 15, 2016
    Publication date: July 7, 2016
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Jin Ho LEE, Hui Yong KIM, Sung Chang LIM, Jin Soo CHOI, Jin Woong KIM
  • Publication number: 20160193861
    Abstract: A printing plate, its preparation method, and a printing method. The printing plate comprises a substrate, an ink repulsive layer attaching to the surface of the substrate and a graphic-text layer attaching to partial surface of the ink repulsive layer, the ink repulsive layer comprises fluoropolymer and silicon-containing nano-particle dispersed in the fluoropolymer, the fluoropolymer comprises fluorine-containing structural unit and optional acrylate-based structural unit. The present invention constitutes a graphic-text area which is affinity to water-based printing ink and an area without graphic-text which is repulsion to water-based printing ink on the surface of the planographic printing plate.
    Type: Application
    Filed: January 5, 2016
    Publication date: July 7, 2016
    Applicant: Institute of Chemistry, Chinese Academy of Sciences
    Inventors: Ming YANG, Yanlin SONG, Yunxia LIU, Meili LI, Kunchan WANG
  • Publication number: 20160194572
    Abstract: Systems, processes, and catalysts are disclosed for obtaining fuels and fuel blends containing selected ratios of open-chain and closed-chain fuel-range hydrocarbons suitable for production of alternate fuels including gasolines, jet fuels, and diesel fuels. Fuel-range hydrocarbons may be derived from ethylene-containing feedstocks and ethanol-containing feedstocks.
    Type: Application
    Filed: October 30, 2014
    Publication date: July 7, 2016
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: Michael A. Lilga, Richard T. Hallen, Karl O. Albrecht, Alan R. Cooper, John G. Frye, Karthi Ramasamy
  • Publication number: 20160194730
    Abstract: The invention relates to a high-impact-toughness steel rail and a production method thereof, and belongs to the field of steel rail material production. The present invention is to provide a high-impact-toughness steel rail. The high-impact-toughness steel rail provided in the present invention is a pearlite steel rail with 0.05˜0.09 ?m of inter-lamellar spacing and 30˜35 J of ballistic work at normal temperature; the chemical components of the steel rail in weight percentage are: C: 0.71-0.82 wt %, Si: 0.25-0.45 wt %, Mn: 0.75-1.05 wt %, V: 0.03-0.15 wt %, P: ?0.030 wt %, S: ?0.035 wt %, Al: ?0.020 wt %, and Fe and inevitable impurities of the remaining content. The U-type impact toughness of rail head of the steel rail manufactured with the method disclosed in the present invention can be 30 J or more, and the tensile strength is about 1,300 MPa or higher.
    Type: Application
    Filed: January 7, 2016
    Publication date: July 7, 2016
    Applicants: PanGang Group Panzhihua Iron & Steel Research Institute Co., Ltd., Pangang Group Panzhihua Steel & Vanadium Co., Ltd.
    Inventors: Jun YUAN, Ming ZOU, Hua GUO, Dadong LI, Yong DENG, Zhenyu HAN, Yuan WANG, Chongmu CHEN
  • Publication number: 20160193131
    Abstract: An objective of the present invention is to provide a method for reducing surface free energy of an organic solvent and of a mixed solution of water and a water-miscible organic solvent, a composition which has a reduced surface free energy of an organic solvent and of a mixed solution of water and a water-miscible organic solvent and which has high environmental suitability and safety to a living body, and a wet wiper and an antiseptic solution which contains the composition The method for reducing surface free energy of an organic solvent or a mixed solvent of water and a water-miscible solvent according to the present invention is characterized in comprising the step of adding surfactin or a salt thereof to the organic solvent or mixed solvent.
    Type: Application
    Filed: August 11, 2014
    Publication date: July 7, 2016
    Applicants: KANEKA CORPORATION, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Satohiro YANAGISAWA, Masashi IZUMIDA, Toshiaki TAIRA, Tomohiro IMURA, Dai KITAMOTO
  • Publication number: 20160195504
    Abstract: Methods for depositing materials on patterned substrates, and related devices, are generally provided. In some embodiments, a material is deposited on a patterned substrate. In certain embodiments, the substrate comprises a first portion with a material deposited on the first portion and a second portion of the substrate essentially free of the material. The methods described herein may be useful in fabricating sensors, circuits, tags, among other devices. In some cases, devices for determining analytes are also provided.
    Type: Application
    Filed: August 20, 2015
    Publication date: July 7, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Kelvin Mitchell Frazier, Katherine A. Mirica, Joseph Walish
  • Publication number: 20160195488
    Abstract: A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured, and a membrane encasing the fibers and having a thickness ranging from 50 ?m to 5.0 mm. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance.
    Type: Application
    Filed: December 18, 2013
    Publication date: July 7, 2016
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: David S. ENSOR, Li HAN
  • Publication number: 20160192701
    Abstract: Embodiments described herein provide materials and methods for the absorption or filtration of various species and analytes. In some cases, the materials may be used to remove or reduce the amount of a substance in vapor sample (e.g., cigarette smoke).
    Type: Application
    Filed: September 5, 2014
    Publication date: July 7, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Jisun Im
  • Publication number: 20160194257
    Abstract: Systems, processes, and catalysts are disclosed for obtaining fuel and fuel blends containing selected ratios of open-chain and closed-chain fuel-range hydrocarbons suitable for production of alternate fuels including gasolines, jet fuels, and diesel fuels. Fuel-range hydrocarbons may be derived from ethylene-containing feedstocks and ethanol-containing feedstocks.
    Type: Application
    Filed: October 30, 2014
    Publication date: July 7, 2016
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: Michael A. Lilga, Richard T. Hallen, Karl O. Albrecht, Alan R. Cooper, John G. Frye, Karthi Ramasamy
  • Publication number: 20160195517
    Abstract: The present invention discloses a rapid diagnosis method of citrus huanglongbing. In the present invention, the accuracy of diagnosis of citrus huanglongbing is significantly improved in the following manners: eliminating the interference of residual starch by effectively removing the residual starch contained in the leaf; eliminating the interference of chlorophyll by effectively removing chlorophyll; and directly developing the color on the leaf rather than mixing and grinding the leaf in water, so as to avoid the problem that the accuracy of color development reaction conducted by mixing the leaf with water is liable to be interfered since the starch is insoluble in water. Therefore a rapid diagnosis of the citrus huanglongbing with much higher accuracy is achieved, which provides effective detection means for the control of the citrus huanglongbing and is beneficial for the control of the citrus huanglongbing.
    Type: Application
    Filed: July 16, 2013
    Publication date: July 7, 2016
    Applicant: GUANGDONG ENTOMOLOGICAL INSTITUTE
    Inventors: Runqian Mao, Yuhong Zhang, Jihuan Zheng, Zhiping Pan, Jincheng Quan, Mingdu Huang
  • Publication number: 20160194645
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR.
    Type: Application
    Filed: November 9, 2015
    Publication date: July 7, 2016
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH LTD., ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Dinah Sah, Pamela Tan, Webster Cavenee, Frank Furnari, Maria del Mar Inda Perez, Rudy Bonavia
  • Patent number: 9382210
    Abstract: Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 5, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Jeremiah A. Johnson, Aleksandr V. Zhukhovitskiy
  • Patent number: 9383337
    Abstract: The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: July 5, 2016
    Assignee: California Institute of Technology
    Inventors: Stephen R. Quake, Wayne D. Volksmuth
  • Patent number: 9383574
    Abstract: This invention relates to a beam steering mechanism with ultrahigh frequency response and high sensitivity, which is based on the translation of two mirrors. Beam steering is achieved by the translations of two mirrors in the X axial mirror group and Y axial mirror group. The two translation mirrors are located at the output ends of two PZT actuators, and are directly actuated by the two PZT actuators. The dynamic characteristics of the two translation mirrors are always exactly the same as the output characteristics of the PZT actuators. There is no mechanical translation loss in this beam steering mechanism, and so, the beam steering mechanism has an ultrahigh frequency response and high angular deflection sensitivity.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: July 5, 2016
    Assignee: HARBIN INSTITUTE OF TECHNOLOGY
    Inventors: Jiubin Tan, Fan Zhu, Jiwen Cui
  • Patent number: 9382546
    Abstract: There is described a method of synthesizing a family of oligopeptides of predetermined amino acid sequence, which together make up from 7 amino acids to the complete amino acid sequence of a target protein, which comprises: synthesizing a nucleic acid construct which codes for a fusion protein composed of overlapping peptides derived from the desired portion of the target protein, interspersed with regions which code for protease cleavage sites, expressing the nucleic acid construct in a suitable expression vector, harvesting the fusion protein corresponding to the nucleic acid sequence, and digesting the fusion protein with a protease selective for the cleavage sites to generate the oligopeptides. The oligopeptides may be generated in vitro or in vitro and may be used as vaccines against viral infections and in epitope mapping.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: July 5, 2016
    Assignees: ISIS INNOVATION LTD., DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Shisong Jiang, Ruth Ruprecht
  • Patent number: 9381667
    Abstract: In at least one form of the invention, a clamp can be used to attach a saw accessory to a saw. In various embodiments, the clamp can comprise first and second clamping members, an actuator, and a controller. In various embodiments, the saw accessory can be disposed between the first and second clamping members where at least one of the first and second clamping members can be moved by the actuator in order to clamp the saw accessory therebetween. In at least one such embodiment, the controller can be in electrical and/or fluid communication with the actuator to activate the actuator. In various embodiments, the controller can be activated by an operator from a location proximate to the operator but remote from a blade of the saw.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: July 5, 2016
    Assignee: Power Tool Institute
    Inventors: David V. Keller, Mark D. Hickok, Peter L. Domeny, Thornton H. Gogoll, III, David G. Peot, Stan M. Rodrigues, Christopher S. Tennant
  • Patent number: 9385542
    Abstract: A serial battery charger has a battery matrix with switches that are configured by a microcontroller that reads voltages between batteries to determine if each battery is fully-charged, charging, or absent. A switch configuration allows charging and discharging currents to flow simultaneously, and allows discharging current but blocks charging current from fully-charged batteries to prevent over-charging. The charging current flows through all charging batteries in series while the discharging current flows from all fully-charged and charging batteries in series. Blocking and bypass switches route the charging current to all charging batteries in series, but bypass all fully-charged and absent batteries. The blocking and bypass switches route the discharging current serially through all fully-charged and charging batteries in the battery matrix while avoiding absent batteries. The switches are controlled by the switch configuration from the microcontroller.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: July 5, 2016
    Assignee: Hong Kong Applied Science and Technology Research Institute Company, Limited
    Inventors: Po Wah Chang, Chi Chiu Tsang, Chik Wai (David) Ng, Yuanzhe Xu, Wai Kei Or, Kwok Kuen (David) Kwong
  • Patent number: 9385625
    Abstract: A RF-to-DC converter charges a battery or powers a circuit from the energy of received radio waves. The RF energy received is very small for far-field applications, so the converter is highly sensitive. Four capacitor arrays are arranged in two banks. Buffered RF signals pump bottom plates of the capacitors. A series of L-switches in each bank connect between the two capacitor arrays in that bank. Each L switch has a pre-charge switch that charges that stage's input capacitor, and a stage-transfer switch that shares charge from the input capacitor to an output capacitor for that stage. Switches in the two banks alternately pre-charge and pump, with the left bank pumping while the right bank pre-charges. Switches are transistors with substrates tied to their sources or actively driven by substrate control signals. One bank may use n-channel transistors with the other bank uses p-channel transistors. Gate voltages may be boosted.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: July 5, 2016
    Assignee: Hong Kong Applied Science and Technology Research Institute Company, Limited
    Inventors: Kwok Kuen (David) Kwong, Yat Tung Lai, Ka Hung Kwok