Abstract: Many GTPases such as Ras, Ral and Rho require post-translational farnestylation or geranylgeranylation for mediating malignant transformation. Dual farnesyltransferase (FT) (FTI) and geranylgeranyltransferase-I (GGT-1) inhibitors (GGTI) were developed as anticancer agents from based on an ethylenediamine scaffold. On the basis of a 4-fold substituted ethylenediamine scaffold, the inhibitors are structurally simple and readily derivatized, facilitating extensive structure-activity relationship studies. The most potent inhibitor is compound exhibited an in vitro hFTase IC50 value of 25 nM and a whole cell H-Ras processing IC50 value of 90 nM. Several of the inhibitors proved highly selective for hFTase over the related prenyltransferase enzyme geranylgeranyltransferase-I (GGTase-I).

Abstract: A method is for molding a gas hydrate pellet for improving convenience of handling of a natural gas hydrate during transportation and storage, and thereby improving the practical use of the natural gas hydrate. Gas hydrate slurry is fed in a compression chamber, and pressure and compression are applied to the gas hydrate slurry by advancing a compression plunger. At that time, a stroking speed of the compression plunger is set minimum, preferably less than a value expressed by a stroke length of the compression plunger at compression×10?2 (m/min. By advancing the compression plunger at low speed, binding between particles of the gas hydrate is tightened, thereby the gas hydrate pellet with increased shearing strength can be molded.

Abstract: An apparatus and method of implementing haptic-based networked virtual environments supporting high-resolution tiled displays. A haptic rendering process of detecting collision between a user of a haptic-device over a virtual environment and each of at least one virtual object and providing a physical force corresponding to a detection result to the haptic-device is performed, and a graphic rendering process of converting each virtual object represented as 3-D data into an object stream represented as 2-D data such that each virtual object is displayed as a 2-D image, and assigning a priority and a frame rate to each converted object stream according to a preset assignment criterion is performed. A plurality of displays provide a display image, including object streams of the virtual objects and background pixels, so that a virtual environment allowing the user of the haptic-device to visually and tactilely immerse thereto is effectively realized by utilizing limited resources.

Abstract: Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.

Abstract: Disclosed is a magnetic bearing structure including a permanent magnet, levitating a rotation body without a bias current, and easily magnetizing the permanent magnet. The magnetic bearing structure includes a ring-shaped permanent magnet provided on a side of a rotation shaft and magnetized in a direction parallel with a shaft direction of the rotation shaft, a coil installed on a side of the permanent magnet, and a conductor installed on an external side of the coil and used to form a magnetic field path. According to the configuration, when an additional bias current is not supplied to the coil installed in the magnetic bearing, a rotation body levitates according to the magnetic field caused by the permanent magnet, and a magnetized direction of the permanent magnet is in parallel with a shaft direction of the rotation shaft thereby allowing easy magnetization and increasing productivity of the magnetic bearing.

Abstract: Provided are an oxide sintered body and a sputtering target that are ideal for the production of an oxide semiconductor film for a display device. The oxide sintered body and sputtering target that are provided have both high conductivity and high relative density, are capable of forming an oxide semiconductor film having a high carrier mobility, and in particular, have excellent direct-current discharge stability in that long-term, stable discharge is possible, even when used by the direct-current sputtering method. The oxide sintered body of the invention is an oxide sintered body obtained by mixing and sintering zinc oxide, tin oxide, and an oxide of at least one metal (M metal) selected from the group consisting of Al, Hf, Ni, Si, Ga, In, and Ta. When the in-plane specific resistance and the specific resistance in the direction of depth are approximated by Gaussian distribution, the distribution coefficient ? of the specific resistance is 0.02 or less.

Abstract: The present invention provides to a default current testing method of the high voltage direct current converter valve composited by impulse voltage. The technical scheme of the invention composites the symmetrical positive and negative voltage and the impulse into asymmetric positive and negative high voltage, it makes the test valve voltage accurately achieve required peak value at the set time. The test circuit is simple relatively; the high voltage source of the default current test circuit is instead by surge generators. The test method is flexible, safe, and suitable for different DC project converter valves.

Abstract: The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of an information transmission domain (ITD). The improved ITD eliminates free-floating ends of the switching and the competing strands, and localizes competitive hybridization events to a contiguous strand of competing and switching strands in a strand-displacement mechanism-based switch, thereby improving the kinetics of strand-displacement. The improved regulatory systems have many uses in various biological systems, including gene expression control or ligand-concentration sensing.

Abstract: Disclosed are various embodiments for echoperiodontal imaging. In one embodiment, a system includes a transducer configured to transmit a series of ultrasonic signals at a plurality of corresponding locations along soft tissue of a jaw and receive a plurality of echo signals; and an imaging system controller configured to obtain a plurality of echo signal data of the soft tissue and a plurality of transducer positions, where each echo signal data corresponds to one of the plurality of transducer position.

Abstract: A surgical device mitigates over-puncture with a bias spring that biases a leading, cutting edge in the opposite direction of the anticipated over-puncture. An associated locking mechanism is configured to release the force of the bias spring in a direction counter to the direction of insertion when the tension force of tissue against the cutting edge is released. Thus, when an opening in the tissue forms, the tension is released and the cutting edge can move opposite to the direction of insertion of the surgical device at the same time that an applied force drives the instrument in the direction of insertion. In this manner, the spring and locking mechanism cooperate to move the cutting edge opposite to the direction of insertion as soon as an incision is made.

Abstract: The present disclosure provides an apparatus for treating air by using porous organic-inorganic hybrid materials as an absorbent, which comprises an inlet passage for receiving air from outside; a dehumidifying part comprising porous organic-inorganic hybrid materials as an adsorbent for removing moisture from the air receiving through the inlet passage; a regenerating unit for regenerating the adsorbent of the dehumidifying part; and an outlet passage for discharging the dehumidified air to outside. Said apparatus preferably comprises two dehumidifying parts of two-bed switching type and two switch valves, wherein said two dehumidifying parts are alternatively operated for dehumidification and for regeneration by switching said switch valves to convert direction of air flow.

Abstract: Provided is an operating method of a sensor node. The operating method of a sensor node includes receiving a sensing request, adjusting a sensing condition on the basis of the received sensing request, and sensing according to the adjusted sensing condition.

Abstract: A method for accessing files on a storage system is provided. A hash memory table including a plurality of hash buckets respectively corresponding to a plurality of index hash codes is built. Each of the hash buckets has a pointer pointing towards at least one entry. Each of the entries has a physical address field and a hash code field. The physical address fields respectively record physical addresses storing the files, and the hash code fields respectively record verification hash codes corresponding to the files. The index hash codes are generated by inputting keys of the files to an index hash function and the verification hash codes are generated by inputting keys of the files to a verification hash function. Then, the hash memory table is loaded into the buffer with a bucket-based replacement policy so that the files are able to be accessed according to the hash memory table.

Abstract: A direct feeding apparatus for impedance matching of a wireless power transmission device includes a helical type resonator, and a feeding unit configured to directly feed power to a region having a relatively small current value as compared to a center of a conductive line of the resonator.

Abstract: A frequency comb generator fabricated on a chip with elimination of a disadvantageous reflow process, includes an ultra-high Q disk resonator having a waveguide that is a part of a wedge structure fabricated from a silicon dioxide layer of the chip. The disk resonator allows generation of a frequency comb with a mode spacing as low as 2.6 GHz and up to 220 GHz. A surface-loss-limited behavior of the disk resonator decouples a strong dependence of pumping threshold on repetition rate.

Abstract: A method for forming doping regions is disclosed, including providing a substrate, forming a first-type doping material on the substrate and forming a second-type doping material on the substrate, wherein the first-type doping material is separated from the second-type doping material by a gap; forming a covering layer to cover the substrate, the first-type doping material and the second-type doping material; and performing a thermal diffusion process to diffuse the first-type doping material and the second-type doping material into the substrate.

Abstract: The present disclosure provides an apparatus for manufacturing a single crystal silicon ingot having a dual crucible for silicon melting which can be reused due to a dual crucible structure. The apparatus includes a dual crucible for silicon melting, into which raw silicon is charged, a crucible heater heating the dual crucible to melt the raw silicon into molten silicon, a crucible drive unit controlling rotation and elevation of the dual crucible, and a pull-up drive unit disposed above the dual crucible and pulling up a seed crystal dipped in the molten silicon to produce a silicon ingot. The dual crucible has a container shape open at an upper side thereof, and includes a graphite crucible having an inclined surface connecting an inner bottom and an inner wall, and a quartz crucible inserted into the graphite crucible and receiving the raw silicon charged into the dual crucible.

Abstract: A wideband acoustic echo cancellation apparatus with an adaptive tail length in an embedded system, and a wideband acoustic echo cancellation method are provided, and the wideband acoustic echo cancellation apparatus may include a delay length calculating unit to calculate a delay length of an echo path, using a near-end signal and a far-end signal, an adaptive filter implementing unit to implement an adaptive filter based on the calculated delay length, using selected coefficients, and an error calculating unit to search for three intervals having a largest impulse response value from all intervals of a tail of the adaptive filter, and to calculate an error during an interval in which the selected coefficients are used.

Abstract: This disclosure relates to a composition for prevention or treatment of neurodegenerative disease comprising longan arillus extract, or combined extract comprising longan arillus. The composition exhibits remarkably excellent prevention or treatment effect of neurodegenerative disease by containing longan arillus extract or combined extract comprising longan arillus, and particularly, it may effectively prevent or treat neurodegenerative disease by significantly protecting dopaminergic neurons from neurotoxicity due to MPTP selectively acting on dopaminergic nervous system and neurotoxicity due to aggregation of alpha-synuclein proteins.

Abstract: Chiral amino compounds, methods of preparation and uses thereof. Tamiflu can be obtained from the said compounds. Multi-substituted chiral tetrahydropyrrolyl amine which can be used as intermediate compounds of medicament can also be produced by the said compounds.