Abstract: Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine -2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.

Abstract: A transformative periodic structure includes a plurality of elastomeric or elasto-plastic periodic solids that experiences a transformation in the structural configuration upon application of a critical macroscopic stress or strain. The transformation alters the geometric pattern changing the spacing and the shape of the features within the transformative periodic structure. For the case of elastomeric periodic structures upon removal of the critical macroscopic stress or strain, the transformative periodic solids are recovered to their original form. For the case of elasto-plastic periodic structures upon removal of the critical macroscopic stress or strain, the new pattern is retained. Polymeric periodic solids can be recovered to their original form by heating or plasticizing.

Abstract: An embedded source/drain MOS transistor and a formation method thereof are provided. The embedded source/drain MOS transistor comprises: a semiconductor substrate; a gate structure on the semiconductor substrate; and a source/drain stack embedded in the semiconductor substrate at both sides of the gate structure with an upper surface of the source/drain stack being exposed, wherein the source/drain stack comprises a dielectric layer and a semiconductor layer above the dielectric layer. The present invention can cut off the path for the leakage current from the source region and the drain region to the semiconductor substrate, thereby reducing the leakage current from the source region and the drain region to the semiconductor substrate.

Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.

Abstract: Semiconductor nanocrystals including III-V semiconductors can include a core including III-V alloy. The nanocrystal can include an overcoating including a II-VI semiconductor.

Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

Abstract: The present invention relates to a method of introducing strain into a channel and a device manufactured by using the method, the method comprising: providing a semiconductor substrate; forming a channel in the semiconductor substrate; forming a first gate dielectric layer on the channel; forming a polysilicon gate layer on the first gate dielectric layer; doping or implanting a first element into the polysilicon gate layer; removing a part of the first gate dielectric layer and polysilicon gate layer to thereby form a first gate structure; forming a source/drain extension region in the channel; forming spacers on both sides of the first gate structure; forming a source/drain in the channel; and performing annealing such that lattice change occurs in the polysilicon that is doped or implanted with the first element in the high-temperature crystallization process, thereby producing a first strain in the polysilicon gate layer, and introducing the first strain through the gate dielectric layer to the channel.

Abstract: The disclosure provides compounds and compositions, and methods of using these compounds and compositions, as positive allosteric modulators of the metabotropic glutamate subtype 2 (mGlu2) receptor, and for treating CNS disorders associated with the mGlu2 receptor including schizophrenia, anxiety, addiction, e.g. cocaine addiction, nicotine addiction, and the like.

Abstract: The present invention provides a semiconductor device. The semiconductor device comprises contact plugs that comprise a first contact plug formed by a first barrier layer arranged on the source and drain regions and a tungsten layer arranged on the first barrier layer; and second contact plugs comprising a second barrier layer arranged on both of the metal gate and the first contact plug and a conductive layer arranged on the second barrier layer. The conductivity of the conductive layer is higher than that of the tungsten layer. A method for forming the semiconductor device is also provided. The present invention provides the advantage of enhancing the reliability of the device when using the copper contact technique.

Abstract: The present invention relates to a method for preparing a multi-metals/activated carbon composite, more particularly to a method for preparing a multi-metals/activated carbon composite, which is prepared by electrochemical electroplating of an alloy plate comprising at least two metals and activated carbons fixed on a conductive support under a predetermined condition. The multi-metals/activated carbon composite prepared in accordance with the present invention has improved adhesion force and specific surface area than those of a conventional composite obtained by continuously plating activated carbons, in which metal salts are impregnated, or metals and good reactivity due to the introduction of pure metals. Since the composition and content of metals can be controlled accurately, the multi-metals/activated carbon composite is useful as an active material for filters for removing gaseous or liquid pollutants, secondary cells, fuel cells, capacitors, hydrogen storage electrodes, etc.

Abstract: Systems and methods for concentrating solar energy without tracking the sun are provided. In one embodiment, the invention relates to a solar collector assembly for collecting and concentrating light for solar cell assemblies, the collector assembly including an array of solar collectors, each including a funnel shaped collector including a side wall defining a tapered opening having a base aperture and an upper aperture, the side wall including an outer surface, and a solar cell assembly positioned at the base aperture, where the outer surface is coated with a material that substantially reflects light, where the upper aperture is wider than the base aperture, where the funnel shaped collector is configured to substantially confine light, incident via the upper aperture, within the funnel shaped collector until the light exits proximate the base aperture, and where the solar cell assembly is configured to capture light exiting the base aperture.

Abstract: The present invention relates to an siRNA inhibiting expression of the OTUB1 protein and a composition for preventing or treating cancer containing same as an active ingredient. In accordance with the present invention, cancer cell growth can be remarkably inhibited by inhibiting OTUB1 expression using the siRNA of the present invention.

Abstract: A continuously variable transmission system and a method of making a continuously variable transmission system is described. The present invention includes a gear set having at least a sun gear, one or more planetary gears, and a planetary gear carrier arm on which the one or more planetary gears are mounted for rotational movement. The sun gear and the one or more planetary gears are mounted for rotational engagement and movement with respect to each other, and one of the sun gears and the planetary gear carrier arm couples to an input shaft and another portion of the gear set couples to an output shaft to receive feedback. A rotary coupling unit having an input rotationally coupled to at least one of the one of the sun gears and the planetary gear carrier arm and an output that rotationally couples to the output shaft is also provided.

Abstract: A method and system for using Equivalent Time Sampling to improve the effective sampling rate of sensor data, and using the improved-resolution data for diagnosis and control. Data samples from existing sensors are provided, where the sampling rate of the existing sensors is not sufficient to accurately characterize the parameters being measured. High-resolution data sets are reconstructed using Equivalent Time Sampling. High-resolution input data sets are used in a system model to simulate the performance of the system being measured. Results from the system model, and high-resolution output data sets from Equivalent Time Sampling, are provided to an estimator, which provides accurate estimation of measured quantities and estimation of quantities not measured. Output from the estimator is used for fault diagnosis and control of the system being measured.

Abstract: An embodiment of the invention provides a neural probe containing a plurality of nanoscale recording electrodes. The recording electrodes have a width of 1 micron or less and a distance between adjacent recording electrodes is 10 microns or less. Another embodiment of the invention provides a neural probe comprising a plurality of microfabricated recording electrodes located on a polymer base material, such as a flexible polymer cantilever.

Abstract: Provided are an apparatus and method for controlling program conversion according to program protection information. The method for controlling conversion of a broadcasting program includes: demultiplexing a broadcasting program into broadcasting program data and program protection information; encrypting the broadcasting program data based on distribution condition of the program protection information when recordation of the broadcasting program data is requested; and recording the encrypted broadcasting program data.

Abstract: The present invention are methods for removing preselected substances from a mixed flue gas stream characterized by cooling said mixed flue gas by direct contact with a quench liquid to condense at least one preselected substance and form a cooled flue gas without substantial ice formation on a heat exchanger. After cooling additional process methods utilizing a cryogenic approach and physical concentration and separation or pressurization and sorbent capture may be utilized to selectively remove these materials from the mixed flue gas resulting in a clean flue gas.

Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

Abstract: Disclosed is a DC voltage conversion circuit of a liquid crystal display apparatus, including: a main pumping circuit including a plurality of thin film transistors and configured to output voltage for driving a liquid crystal display apparatus when the plurality of thin film transistors are alternately turned on or off; and a switch control signal generator configured to control voltages applied to gates of the plurality of thin film transistors by inversion of a clock signal, in which each thin film transistor is turned on when positive gate-source voltage is applied thereto, and turned off when negative gate-source voltage is applied thereto.

Abstract: A new and distinct cherry tree that produces sweet cherry fruits in high quantities.