Abstract: The present invention relates to a novel fused ring compound having urea structure that exhibits excellent NAMPT activating effect, and a method using the same for treating/preventing metabolic disorder, cardiovascular and kidney disease, mitochondrial disease, neurodegenerative disease, ocular disease, and muscle wasting disorder. The present invention provides a compound represented by following formula (I) or a pharmacologically acceptable salt: wherein A, B, R1, R2 and R3 represent the same meanings as in the claims.

Abstract: Disclosed are a high-entropy alloy (HEA) coating and a preparation method and use thereof. Laser cladding is conducted with an HEA powder to obtain the HEA coating, where the HEA is a FeCoCrNiAl0.5Ti0.5 alloy, and the HEA includes the following chemical components in atomic percentage: Al: 10.01% to 12.30%, Co: 18.1% to 22.5%, Cr: 18.05% to 20.12%, Fe: 18.77% to 21.02%, Ni: 19.21% to 20.99%, and Ti: 8.43% to 11.5%. The HEA material with high hardness and wear resistance provided by the present disclosure is suitable for laser cladding of a surface of a precision mold, an offshore component, or a drilling rod. A powder is prepared from the above alloy components and then prepared into a corresponding HEA coating with high strength, high hardness, and prominent wear resistance through laser cladding. The material has prominent weldability and is a special nickel-based HEA material suitable for laser additive manufacturing.

Abstract: Provided are an odorant receptor marker of microglia and a use thereof, and according to the odorant receptor marker of microglia and a use thereof according to one aspect, microglia may be detected by measuring an activity or expression level of a protein of an odorant receptor (OR) Olfr110 or Olfr111, and OR ligands of microglia may be selected using them, and an inhibitor or activator against the interaction between the OR and 2-pentylfuran is effectively used in treatment of a neuroinflammatory disease or meningitis.

Abstract: The disclosure relates to gene therapy vectors, such as AAV vectors, comprising a polynucleotide encoding ?-sarcoglycan (SGCG) and methods of using such gene therapy vectors to treat subjects suffering from a muscular dystrophy, e.g. limb girdle dystrophy type 2C (LGMD2C).

Abstract: Nickel alloys, methods of making nickel alloys, articles including the nickel alloys, uses of the alloys, and methods of treating nickel alloys are described. The inventive heat resistant structural materials are suitable for applications requiring high yield stress at room temperature and good creep strength at high temperatures, such as in gas turbines, steam turbines, fossil energy boilers, aero engines, power generation systems using fluids such as supercritical carbon dioxide (e.g., advanced ultra-supercritical power plants), concentrated solar power plants, nuclear power plants, molten salt reactors: turbine blades, casings, valves, heat exchangers and recuperators.

Abstract: Provided is a use of nintedanib or a pharmaceutically acceptable salt thereof in preparing a drug for treating tuberculosis. The nintedanib or the pharmaceutically acceptable salt thereof is used in combination with a further anti-tuberculosis drug for treating tuberculosis, or used as an adjuvant drug for the treating tuberculosis, where the further anti-tuberculosis drug is selected from a group consisting of: rifampicin, isoniazid, pyrazinamide, ethambutol, fluoroquinolone, streptomycin, kanamycin, amikacin, capreomycin, sodium para-aminosalicylate, ethionamide, cycloserine, clofazimine, and linezolid.

Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1, or of a nucleic acid sequence of at least 1400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule leads to the specific expression in mouse cortex of an exogenous gene in a particular population of CNR1-positive cells when a nucleic acid sequence coding for said exogenous gene is operatively linked to said isolated nucleic acid molecule, said particular population of CNR1-positive cells being characterized in that it also expresses EFHD1, ENPP6 and GJC2.

Abstract: A hydrophone flow shield and hydrophone assembly including a hollow polyurethane flow shield with one or more features for improving reliable operation and assembly wherein the features include a recess for holding a clamp for securing the shield to the hydrophone, a slot or through hole extending longitudinally in the clamping region but not extending toward a closed end of the shield beyond the clamping region and when sizing of the shield and hydrophone are not closely matched providing for indirect sealing via a gasket that is located between the shield and the hydrophone.

Abstract: The invention provides a D-deoxyribose sugar for use in promoting wound healing wherein the sugar is provided in a carrier and wherein the carrier is a biocompatible matrix material or a hydrogel.

Abstract: A method and apparatus for encoding/decoding a neural network-based personalized speech are provided. The method includes outputting a first bit stream in which an input speech signal is encrypted, based on the input speech signal, and outputting a second bit stream in which speaker information of the input speech signal is encrypted, based on the input speech signal.

Abstract: There is provided a multi-view video coding artifact reduction method and system. According to an embodiment, the multi-view video coding artifact reduction method selects reference fames in neighbors of a current frame constituting a multi-view video, derives unidirectional flows and bilateral flows between the current frame and the reference frames, warps the reference frames based on the derived flows, generates intermediate frames by fusing the current frame, the reference frames, and the warped reference frames, and generates a final frame by fusing the current frame and the intermediate frames. Accordingly, image quality of the multi-view video can be more enhanced.

Abstract: The present invention describes methods and techniques to improve scintigraphic images obtained by using nuclear medicine techniques for diagnostic analysis. The present invention describes a method and technique to up-sample and down-sample nuclear medicine images that models photon counts and noise characteristics of an image at its target resolution.

Abstract: Systems, methods, and other embodiments described herein relate to identifying and generating mechanisms from natural processes by a learning model for accelerating design development. In one embodiment, a method includes identifying mechanisms for a design task using a prompt transformer with seeds from biological processes, and the prompt transformer forms a taxonomy tree using the mechanisms. The method also includes generating functional solutions that expand sparse branches of the taxonomy tree for the mechanisms using the prompt transformer. The method also includes clustering the mechanisms using text embedding for the design task. The method also includes inspecting the mechanisms with the prompt transformer to select a solution associated with the design task.

Abstract: There are provided an apparatus and a method for reconstructing a 3D human object in real time based on a monocular color image. A 3D human object reconstruction apparatus according to an embodiment extracts a pixel-aligned feature from a monocular image, extracts a ray-invariant feature from the pixel-aligned feature, generates encoded position information by encoding position information of a point, predicts a SD of a point from the ray-invariant feature and the encoded position information which are extracted, and reconstructs a 3D human object by using the predicted SD. Accordingly, the ray-invariant feature extracted from the pixel-aligned feature, and the encoded position information are used, so that an amount of computation for predicting SDs of points of a 3D space can be noticeably reduced and a speed can be remarkably enhanced.

Abstract: A method and device for encoding/decoding an audio signal based on dequantization through potential diffusion are provided. The method of decoding an audio signal includes obtaining a discrete latent vector in which a speech signal is quantized and based on the discrete latent vector, outputting a continuous latent vector in which the discrete latent vector is dequantized.

Abstract: A DRAM is configured using a triple-mode memory cell that supports a computation mode, a memory mode, and a data conversion mode by one cell and converts modes as necessary, and an AI accelerator using the same is provided, so that a dataflow may be reconfigured according to a structure and a size of an AI neural network (so-called deep neural network) to be trained.

Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.

Abstract: A method for removing inorganic substances from wastewater is provided. The method includes: providing a fluidized bed reactor, wherein carriers are added into the fluidized bed reactor, and the carriers includes polyvinylidene fluoride (PVDF), ethylene tetrafluoroethylene (ETFE), alumina (Al2O3) with purity more than 95 wt %, or combinations thereof; introducing the wastewater containing the inorganic substances and a first reagent into the fluidized bed reactor; fluidizing the carriers in the fluidized bed reactor, and making the inorganic substances in the wastewater reacting with the first reagent to form crystals, wherein the crystals are formed on the outer surfaces of the carriers.

Abstract: Disclosed are methods and apparatuses for image data encoding/decoding. A method for decoding a 360-degree image includes the steps of: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; adding the generated prediction image to a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format. Therefore, the performance of image data compression can be improved.

Abstract: The present disclosure relates to a method and apparatus for performing enhanced center-based panoptic segmentation. A method according to an embodiment of the present disclosure may comprise: extracting a plurality of image feature maps based on an input image; extracting first image feature data through a transformer-based encoder; extracting second image feature data through a pixel decoder; selecting a query set through a query selection unit; extracting an updated query set through a transformer-based decoder; and generating a predicted class and a predicted segmented image. In this regard, A selection operation may be performed on predicted classes and predicted segment images for at least one query on the object.