Abstract: The present application relates to compositions and methods for eliciting an immune response in a subject using an Adeno-Associated Virus (AAV) AAV11 vector comprising an AAV11 capsid protein and a nucleic acid encoding a transgene operably linked to a promoter, wherein the transgene encodes an immunogenic polypeptide. Further disclosed are immunogenic polypeptides that are used for the compositions and methods.

Abstract: Methods and structures are disclosed for creating a physical linkage between two or more viral particles, which can covalently link the viral particles together. The methods and structures described herein are designed for purposes of improving efficiency and effectiveness of vector delivery into cells and tissues for purposes of gene therapy. Methods for linking two or more viral vectors comprise functionalizing a first vector with a first surface moiety and functionalizing a second vector with a second surface moiety. Thereafter, the first functionalized vector and second functionalized vector are combined so that the two surface moieties can react. During this reaction, the first surface moiety and the second surface moiety form a covalent linkage, thereby resulting in the physical linkage of both vectors to each other.

Abstract: Disclosed are methods and apparatuses for image data encoding/decoding. A method for decoding a 360-degree image includes the steps of: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; adding the generated prediction image to a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format. Therefore, the performance of image data compression can be improved.

Abstract: The present invention discloses the use of RNA inhibitory molecules, particularly siRNA molecules silencing the expression of Voltage-Dependent Ion Chanel-1 (VDAC1) for the induction of cancer stem cell differentiation and reduction of TAMs abundance and tumor angiogenesis, thereby preventing tumor invention and recurrence.

Abstract: An exemplary embodiment of the invention relates to a method of fabricating a radiation emitter (100) comprising the steps of fabricating a lower layer stack (20) on top of a substrate (10), the lower layer stack (20) comprising a lower contact layer (21) and at least one lower reflector (22), fabricating an intermediate layer stack (30) on top of the lower layer stack (20), the intermediate layer stack (30) comprising at least one active layer (31) and at least one aperture layer (32), fabricating an upper layer stack (40) on top of the intermediate layer stack (30), the upper layer stack (40) comprising at least one upper reflector (42) and an upper contact layer (41), and forming a mesa that at least comprises a mesa section of the upper layer stack (40), by locally removing at least the upper layer stack (40).

Abstract: The present disclosure discloses a sensing function control node for an Internet of Things (IoT), and relates to technical field of electrical communication. The node includes an accessing module for sensors and actuators, a data format analyzing and integrating module and a transmission accessing and connecting module. Software-defined optical access technologies are utilized to control original sensing data in the IoT to access the accessing module for the sensors and the actuators. Status information of modules in the node is sensed in real time through a software-defined unified control plane, to adjust upload rates of modules and control the connections between sensing function control node and EAN. The original sensing data in IoT are transmitted to the transmission accessing and connecting module after being pre-processed. The pre-processed data are transmitted to EAN through upload channels between the sensing function control node and EAN established.

Abstract: Provided is a method for preventing, ameliorating, or treating inflammatory diseases by administering a composition containing extracellular vesicles (EVs) derived from Roseburia spp. strains and/or Bifidobacterium spp. strains, wherein the EVs exhibits effectiveness in improving inflammatory bowel disease (IBD), and additionally, all EVs derived from congeneric strains corresponding to Roseburia spp. strains or Bifidobacterium spp. strains. have been confirmed to exhibit strong anti-inflammatory effect, and the strains and EVs derived therefrom can be provided as a composition for preventing, ameliorating, or treating a variety of inflammatory diseases.

Abstract: One or more temperature control units are distributed throughout an environment to provide localized heating and cooling. The temperature control units include a thermal storage system including one or more substances of high latent heat capacity, a heat distribution surface, a solid-state heat pump positioned between the thermal storage system and the heat distribution surface, an environmental sensing module including a proximity sensor, and unit control modules in communication with the solid-state heat pumps. The solid-state heat pumps are individually controllable so that heating and cooling can be provided simultaneously from separate heat pumps in the same temperature control unit, or separate temperature control units in the same environment.

Abstract: Methods for growing an epitaxial layer are described herein. In some embodiments, an epitaxial layer is grown over a structure comprising a crystalline substrate and a mask. The mask can be patterned with a plurality of elongated domains that help may facilitate the growth of the epitaxial layer with a reduced number of defects on the crystalline substrate. The mask may also facilitate the separation of the epitaxial layer from the crystalline substrate to form a separated epitaxial layer that is freestanding. In some embodiments, the method for growing an epitaxial layer may allow for heteroepitaxy of compound semiconductors on elemental substrates with a reduced number of defects despite polarity and/or lattice mismatches.

Abstract: A method of regenerating sodium borohydride includes: pretreating reactants including sodium tetraborate hydrate (Na2B4O7·xH2O, 0<x?10), a metal salt, and a reducing agent; and reacting the pretreated reactants by a ball-milling method, wherein the metal salt includes NaHCO2, KHCO2, LiHCO2, NaHCO3, Na2CO3, NaOH, KHCO3, K2CO3, LiHCO3, Li2CO3, Na2O2, NaH, or a combination thereof.

Abstract: A semiconductor package includes a carrier plate, a photonic integrated circuit chip, an electronic integrated circuit chip and an interposer substrate. The carrier plate has a notch and a first surface and a second surfaces opposite to the first surface, and the notch extends from the first surface toward the second surface. The photonic integrated circuit chip is disposed within the notch. The electronic integrated circuit chip is disposed on the first surface of the carrier plate. The photonic integrated circuit chip and the electronic integrated circuit chip are disposed on the carrier through the interposer substrate.

Abstract: Disclosed are methods and apparatuses for image data encoding/decoding. A method for decoding a 360-degree image includes the steps of: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; adding the generated prediction image to a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format. Therefore, the performance of image data compression can be improved.

Abstract: In one example, a system can receive, from application code including an analysis operation performed on a set of data, an indication to access the set of data included in a tabular data structure using an application programming interface (API), in which the tabular data structure is associated with a memory allocation and a type. The system can determine that the type of the tabular data structure is the native type, the native type characterizing data structures that are accessed using a first programming language and a second programming language. The system can identify a proxy data table that shares the memory allocation, the proxy data table accessed using the API based on the second programming language. The system can issue one or more read commands to the proxy data table to cause the set of data to be read from the tabular data structure.

Abstract: A method for decoding a 360-degree image includes: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; combining the generated prediction image with a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format. Here, generating the prediction image includes: checking, from the syntax information, prediction mode accuracy for a current block to be decoded; determining whether the checked prediction mode accuracy corresponds to most probable mode (MPM) information obtained from the syntax information; and when the checked prediction mode accuracy does not correspond to the MPM information, reconfiguring the MPM information according to the prediction mode accuracy for the current block.

Abstract: Described in various embodiments herein are tiled amplification nucleic acid detection systems and uses thereof. In some embodiments, the nucleic acids amplified and detected are cell free DNA (cfDNA).

Abstract: Disclosed herein are aspects of a system for coupling electrochemical marine carbon capture with photosynthesis. In some aspects of the present disclosure, the system comprises an electrochemical cell that converts saline water into (i) a base stream, (ii) an at least partially deionized water stream, and (iii) an acid stream. In some aspects, the system further comprises a biomass cultivation unit in fluid communication with the acid stream, the biomass cultivation unit comprising a photosynthetic organism. The acid stream catalyzes release of CO2 in a growth medium for the photosynthetic organism to accelerate growth of the photosynthetic organism relative to growth without the acid stream and facilitates CO2 storage by the photosynthetic organism. Also disclosed herein are aspects of a method for coupling electrochemical marine carbon capture with photosynthesis.

Abstract: Disclosed herein are a pharmaceutical composition comprising an inhibitor of Olfr164 for the prevention or treatment of sepsis, a method for the prevention or treatment of sepsis, a use of Olfr164 as a marker for selecting sepsis therapeutic agents, a screening method for sepsis therapeutics using same, and a transgenic animal in which Olfr164 is knocked out. The composition comprising Olfr164 inhibitor can effectively prevent or treat sepsis. Additionally, sepsis therapeutics can be effectively screened by comparing the expression level or activity of Olfr164 before and after administering the candidate substance.

Abstract: An antenna-in-package with a heat dissipation structure includes a circuit board, an antenna substrate, a chip, a plurality of heat dissipation fins, a chassis, and dielectric fluid. The circuit board has a first surface and a second surface opposite to the first surface. The antenna substrate is disposed above the first surface of the circuit board. The chip is disposed between the antenna substrate and the first surface of the circuit board and is electrically connected to the antenna substrate. The plurality of heat dissipation fins protrude from the second surface of the circuit board. The chassis encapsulates the circuit board, the antenna substrate, the chip, and the plurality of heat dissipation fins. The dielectric fluid circulates and flows in the chassis through a cooling circulation device and is in direct contact with the plurality of heat dissipation fins.

Abstract: The present invention provides a composition for transdermal administration comprising a nucleic acid. Specifically, the present invention provides a composition for transdermal administration comprising a nucleic acid, the nucleic acid comprising RNA, wherein the composition is administered by an administration method comprising spraying the composition to the surface of a target tissue, and the spraying of the composition is performed by pressurization of the composition, whereby the composition is sprayed toward the target tissue and penetrates the surface of the target tissue.

Abstract: Provided are a nitrogen-doped composite having a high degree of ordering and a method for producing the same. The composite includes a carbon support and a nitrogen-doped nanoparticle supported on the carbon support, wherein the nanoparticle includes an alloy including platinum and a metal other than platinum and has a coercivity of 7 kOe or more.