Abstract: The present invention is inter alia directed to artificial nucleic acid constructs, preferably RNA, comprising at least one coding sequence encoding at least one transcription factor inhibitor for reducing or inhibiting the activity of a target transcription factor in a cell. A preferred transcription factor inhibitor according to the invention is a Runt-related transcription factor (RUNX) inhibitor, for example a RUNX trap comprising at least one amino acid sequence for binding a RUNX transcription factor and at least one amino acid sequence for capturing or trapping RUNX. Further provided are pharmaceutical compositions comprising the artificial nucleic acid, preferably formulated in polyethylene glycol/peptide polymers, polymeric carriers, or lipid-based carriers. Also provided are methods of treating or preventing disorders, diseases, or conditions, and medical uses.

Abstract: An all-oxide transistor structure includes a substrate, a first transistor, a second transistor, a third transistor and a fourth transistor. The substrate has an upper surface. The first transistor is disposed on the upper surface of the substrate. The second transistor is disposed on the upper surface of the substrate, wherein the second transistor is electrically connected to the first transistor. The third transistor is electrically connected to the second transistor and overlapped with the second transistor in a first direction, wherein the first direction is parallel to a normal direction of the upper surface of the substrate. The fourth transistor is disposed on the upper surface of the substrate, wherein the fourth transistor is electrically connected to the first transistor, the second transistor and the third transistor.

Abstract: A method for decoding a 360-degree image includes: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; combining the generated prediction image with a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format. Here, generating the prediction image includes: checking, from the syntax information, prediction mode accuracy for a current block to be decoded; determining whether the checked prediction mode accuracy corresponds to most probable mode (MPM) information obtained from the syntax information; and when the checked prediction mode accuracy does not correspond to the MPM information, reconfiguring the MPM information according to the prediction mode accuracy for the current block.

Abstract: The present invention relates to the technical field of power electronics converters and discloses a grid-forming energy storage converter on/off-grid switching control method and system, where the method includes the following steps: S1: using a single-loop power control strategy in an off-grid state when an on-grid relay of target energy storage drops out; S2: using a parallel virtual impedance loop-based power control strategy in a transient on-grid state when the on-grid relay of target energy storage pulls in; and S3: using a cascaded dual-loop power control strategy with a virtual admittance voltage loop and an inner current loop when a stable on-grid state is established. The present invention solves the problems of large current impact and unstable switching process state in the existing working strategy for on/off-grid switching in the prior art.

Abstract: A block copolymer is described, such as one including a first polymer block and a second polymer block that have different structures, wherein the first polymer block includes a first unit derived from an acrylic acid ester, and the second polymer block includes an inorganic material-containing random block, in which a second unit including an inorganic material-containing group and a third unit that is devoid of an inorganic material-containing group are connected to each other to provide a concentration gradient.

Abstract: Reaction schemes involving acids and bases; reactors comprising spatially varying chemical composition gradients (e.g., spatially varying pH gradients), and associated systems and methods, are generally described.

Abstract: The present invention relates to a light-emitting device including a first luminescent material and a second luminescent material which emits visible light by irradiation with light from the first luminescent material, in which the second luminescent material contains at least a red phosphor which satisfies the following (A) and (B): (A) An emission spectrum has at least one emission peak having a full width at half maximum (FWHM) of 20 nm or more and 65 nm or less, and (B) Chromaticity coordinates of a light emission color are present between two straight lines represented by the following equation (a) and equation (b) based on coordinates represented by (x, y) in a CIE 1931 chromaticity coordinate system: (a) y=0.992?x, (b) y=1.000?x, and 0.290?y?0.350, an illumination device, an image display device, and an indicator lamp for a vehicle.

Abstract: Systems, methods, and storage media for robot-assisted laser osteotomy are disclosed. Exemplary implementations may: receive osteotomy data obtained in connection with robot-assisted laser osteotomy; analyse the osteotomy data to determine one or more attributes associated with osteotomy; and determine, based on the one or more attributes, one or more functions associated with osteotomy.

Abstract: The present disclosure provides Cas protein variants comprising one or more amino acid substitutions relative to wild-type Cas14a1. Fusion proteins comprising the Cas protein variants described herein are also provided by the present disclosure. Further provided herein are methods for modifying a target nucleic acid using the Cas proteins and fusion proteins provided herein. The present disclosure also provides guide RNAs, complexes, polynucleotides, systems, cells, kits, and pharmaceutical compositions.

Abstract: This disclosure relates to methods of and compositions for reducing expression or activity of a variant gene comprising at least one mutation as compared its wild-type gene, comprising introducing into a cell comprising the variant gene one or more DNA sequences encoding two or more gRNAs that are complementary to two or more target sequences in the variant gene, wherein at least one of the gRNAs hybridizes to a target sequence comprising a PAM site in the variant gene that results from a mutation to the variant gene creating the PAM site that does not exist in the wild-type gene or is operably linked to a mutated portion of the wild-type gene, at least one of the gRNAs hybridizes to a target sequence comprising a PAM site in an intron of the variant gene downstream or upstream from the PAM site, and a nucleic acid sequence encoding a CRISPR-associated endonuclease; wherein a CRISPR-associated endonuclease cleaves the variant gene at the target sequences; and expression or activity of the variant gene is redu

Abstract: Disclosed are methods and apparatuses for image data encoding/decoding. A method for decoding a 360-degree image includes the steps of: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; adding the generated prediction image to a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format. Therefore, the performance of image data compression can be improved.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues of organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provide dare methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: Disclosed herein are metabolically engineered cells capable of producing carotenoids from acid whey.

Abstract: A power amplifier comprising a first transistor pair and a first odd mode resistor string. The first transistor pair has a first transistor and a second transistor. A first end of the first transistor is symmetrically disposed to a first end of the second transistor. A plurality of first odd mode resistors are serially coupled between the first end of the first transistor and the first end of the second transistor. A total length of the first odd mode resistor string is substantially equal to a distance between the first end of the first transistor and the first end of the second transistor.

Abstract: An image encoding/decoding method, device and recording medium of the present disclosure may include deriving an atlas boundary from a reference sample region of a current block, determining, in response to the existence of the atlas boundary, whether an index of a reference sample line having the atlas boundary is greater than a threshold value, and adaptively transmitting a multiple reference line (MRL) syntax of the current block encoded by a changed binarization method based on the atlas boundary according to whether an index of a reference sample line having the atlas boundary is greater than a threshold value.

Abstract: The present invention provides a method of screening for psychoactive agents comprising the steps of a) simultaneously assessing in a subject, the activity of neurons of at least two regions of the deep cortical layers in the absence of a potential psychoactive agent and correlating these activities, b) simultaneously assessing in said subject, the activity of said neurons of said at least two regions of the deep cortical layers in the presence of the potential psychoactive agent and correlating said activities, and c) comparing the correlations obtained in step a) and b), wherein any significant change in the correlation obtained in step b) as compared to the correlation obtained in step a) is indicative of a potential psychoactive activity of said potential psychoactive agent.

Abstract: N,N-disubstituted aminocarbonyl compounds and their use as integrin agonists for enhancing the binding of integrin-expressing cells to integrin-binding ligands or receptors.

Abstract: In one example, a system can receive information about a tabular data structure in a memory including a set of data and a first memory allocation. The system can determine a type of the tabular data structure, the type selected from among two types including a native type and a non-native type. The system can, in response to the type being the native type, identify a first proxy data table usable as a proxy for the tabular data structure that shares the first memory allocation. The system can receive a first indication to access the set of data from application code. The system can issue one or more first read commands to the first proxy data table to cause the set of data to be read from the tabular data structure.

Abstract: A method for decoding a 360-degree image includes: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; combining the generated prediction image with a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format. Here, generating the prediction image includes: checking, from the syntax information, prediction mode accuracy for a current block to be decoded; determining whether the checked prediction mode accuracy corresponds to most probable mode (MPM) information obtained from the syntax information; and when the checked prediction mode accuracy does not correspond to the MPM information, reconfiguring the MPM information according to the prediction mode accuracy for the current block.

Abstract: A heat dissipating device. The heat dissipating device may include: a heat dissipating part having a heat dissipating structure formed on one surface thereof, the heat dissipating structure being configured to dissipate heat received from a heat source; and a fluid distributing part disposed on the one surface of the heat dissipating part and formed with an inlet configured to supply a fluid to the heat dissipating part and an outlet configured to discharge the fluid from the heat dissipating part. The heat dissipating structure may have a porous structure that draws the fluid from the inlet by capillary action.