Abstract: The invention relates to the three-dimensional structure of a crystal of an EphB4 receptor complexed with a ligand. The three-dimensional structure of a Receptor-Ligand Complex is disclosed. The receptor-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug screening and drug design processes. Thus, the invention also relates to methods for utilizing the crystal structure of the Receptor-Ligand Complex for identifying, designing, selecting, or testing inhibitors of the EphB4 receptor protein, such inhibitors being useful as therapeutics for the treatment or modulation of i) diseases; ii) disease symptoms; or iii) the effect of other physiological events mediated by the receptor.
Abstract: The invention relates generally to hierarchical inorganic materials and a method for making and using same. The materials of the invention have a controlled hardness, porosity, and surface area ideally suited for use as, e.g., durable catalyst supports for reactions conducted in severe and/or hydrothermal environments. The materials of the invention are prepared by infusing hierarchical templates of suitably shaped sized cellulosic or lignocellulosic particles (e.g., from wood, bamboo, and the like) with soluble transition-metal and/or ceramic precursors. Infused templates are heated in a gaseous atmosphere until volatile chemical components are removed. After drying, the infused templates are heated under flowing argon, helium, or air atmosphere for several hours to remove volatiles and convert all or part of the transition-metal and/or ceramic precursors to respective carbide, oxycarbide, or other chemical forms.
Type:
Application
Filed:
July 18, 2006
Publication date:
January 24, 2008
Applicant:
Battelle Memorial Institute
Inventors:
Yongsoon Shin, James F. White, Gregory J. Exarhos, Yong Wang
Abstract: The present invention is directed to (S)-(?)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4-homopiperazine hydrochloride dihydrate, to a method producing the dihydrate, and to a drug composition containing the dihydrate. The compound of the present invention has less hygroscopicity as compared with (S)-(?)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4-homopiperazine hydrochloride anhydrous crystals and thus, exhibits excellent chemical stability.
Type:
Application
Filed:
November 29, 2005
Publication date:
January 24, 2008
Applicants:
Kowa Co., Ltd, D. Western Therapeutics Institute, Inc.
Abstract: A null packet insertion apparatus including a null packet remover for removing an irregularly inserted null packet from an externally received video/audio transport stream; a null packet bit rate calculator for calculating a bit rate of the removed null packet; a GUI for determining the transmission period of a periodic null packet to be newly inserted, based on the calculated bit rate, by an external user; a periodic null packet generator; a multiplexer for regularly inserting the periodic null packet preferentially and inserting the video/audio transport stream with the irregular null packet removed, and performing multiplexing; a non-periodic null packet generator; and a PCR corrector.
Type:
Grant
Filed:
April 4, 2003
Date of Patent:
January 22, 2008
Assignee:
Electronics and Telecommunications Research Institute
Abstract: The invention refers to a method for breeding of a variety of Pacific abalone with orange shell. A new strain with uniform shell color of Pacific abalone is established by single mating or mass mating. The detailed procedures are as follows. The mature individuals with orange shell color are selected as breeders, and conditioned in the seawater. Macroalgae are fed and gentle aeration is provided daily. The gonad of breeders will eventually reach full ripeness; Artificial induction to spawn is conducted by combined desiccation, thermal shock and exposure to UV-irradiated seawater; The released gametes were fertilized by single mating or mass mating; A routine procedure is used for fertilized eggs incubation, larval and spat rearing. A new Pacific abalone strain of uniformly orange shell color is produced. In the invention, the new strain is produced by shell color mutant type abalone from natural populations or artificially cultivated stocks. No foreign genes are introduced.
Type:
Grant
Filed:
July 7, 2003
Date of Patent:
January 22, 2008
Assignee:
Institute of Oceanology Chinese Academy of Sciences
Abstract: A method for training a visual prosthesis includes presenting a non-visual reference stimulus corresponding to a reference image to a visual prosthesis patient. The visual prosthesis including a plurality of electrodes. Training data sets are generated by presenting a series of stimulation patterns to the patient through the visual prosthesis. Each stimulation pattern in the series, after the first, is determined at least in part on a previous subjective patient selection of a preferred stimulation pattern among stimulation patterns previously presented in the series and a fitness function optimization algorithm. The presented stimulation patterns and the selections of the patient are stored and presented to a neural network off-line to determine a vision solution.
Type:
Grant
Filed:
April 30, 2004
Date of Patent:
January 22, 2008
Assignees:
California Institute of Technology, Doheny Eye Institute
Abstract: A fluid analytical device for separating and analyzing a fluid including a first component and a second component. The specific weight of the first component exceeds that of the second component. A rotating base includes a receiving chamber, a first separation well, a second separation well, a first connection channel, a second connection channel, and a vent channel. The receiving chamber receives the fluid. The first connection channel connects the receiving chamber to the first separation well. The second connection channel connects the first separation well to the second separation well. The vent channel is connected to the receiving chamber. The distance from the first separation well to the receiving chamber exceeds that from the second separation well to the receiving chamber. When the rotating base rotates, the first and second components of the fluid flow into the first and second separation wells by centrifugal force, respectively.
Type:
Grant
Filed:
July 5, 2005
Date of Patent:
January 22, 2008
Assignees:
Industrial Technology Research Institute, Apex Biotechnology Corp.
Abstract: A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to the recipient cytoplasm for a period of time. The diploid nucleus can be donated by a cell in either the G0 or G1 phase of the cell cycle at the time of transfer. Subsequently, the reconstituted embryo is activated. Correct ploidy is maintained during activation, for example, by incubating the reconstituted embryo in the presence of a microtubule inhibitor such as nocodazole. The reconstituted embryo may then give rise to one or more live animal births. The invention is useful in the production of transgenic animals as well as non-transgenics of high genetic merit.
Type:
Grant
Filed:
August 10, 2004
Date of Patent:
January 22, 2008
Assignee:
Roslin Institute
Inventors:
Keith Henry Stockman Campbell, Ian Wilmut
Abstract: Disclosed is a soft decision decoder, and a log likelihood ratio calculator for soft decision decoding and a method thereof, for realizing a generalized log likelihood ratio algorithm in consideration of channel estimation errors for performing soft decision decoding on QAM signals, which comprises multipliers for multiplying reference signals and channel estimation signals, subtractors for subtracting a receive signal of a receiver from output signals of the multipliers, first and second square calculators for squaring the subtractors' output signals and reference signals, dividers for dividing output signals of the first and second square calculators by addition values, and a comparator for comparing output signals of the dividers.
Type:
Grant
Filed:
September 12, 2003
Date of Patent:
January 22, 2008
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Dae-Ig Chang, Dong-Weon Yoon, Nae-Soo Kim
Abstract: An equalization method suitable for use in a receiver in an orthogonal frequency division multiplexing (OFDM) system utilizing a plurality of sub-carriers. The receiver includes an outer receiver for decoding. The equalization method includes receiving an input signal including at least one preamble symbol containing a training sequence and a plurality of informative OFDM symbols each containing a serial stream of samples, and performing compensations for each of the informative OFDM symbols. Compensation for each of the informative OFDM symbols includes converting the serial stream of samples into parallel samples, performing a fast Fourier transform (FFT) of the parallel samples to obtain a plurality of data symbols, each data symbol corresponding to a sub-carrier, compensating the data symbols for at least one first phase distortion and at least one second phase distortion, and providing at least one amplitude distortion factor to the outer receiver.
Type:
Grant
Filed:
February 17, 2004
Date of Patent:
January 22, 2008
Assignee:
Industrial Technology Research Institute
Inventors:
Yung-An Kao, Chang-Lung Hsiao, Po-Lin Chiu, Shih-Kai Lee
Abstract: Disclosed is an algorithm for dynamically changing an RTS threshold, which is a threshold for RTS-CTS frame exchange, depending on the traffic load in the BSS so as to maximize the MAC throughput of an IEEE 802.11 wireless LAN system. The present invention defines a new performance index based on the total time taken to transmit a frame and the time taken to successfully transmit a data frame. The RTS threshold is dynamically increased/decreased in a predefined range depending on the change in the new performance index.
Type:
Grant
Filed:
July 21, 2004
Date of Patent:
January 22, 2008
Assignee:
Electronics and Telecommunications Research Institute
Abstract: A low-complexity and low-latency method and apparatus in multicarrier communication systems is used for protection and transmission of the side information related to peak-to-average power ratio (PAPR) reduction. The side information is encoded by an error-correction code and transmitted through a plurality of reserved sub-carriers. Modulation of the coded side information over the reserved sub-carriers is performed separately without re-performing data modulation. Therefore, the invention dramatically reduces implementation complexity. Determination of the related parameters for PAPR reduction can be based on the PAPR level of the data modulated signal with slight degradation in PAPR reduction performance or that of level of the transmitted signal with no degradation in PAPR reduction performance.
Type:
Grant
Filed:
July 3, 2003
Date of Patent:
January 22, 2008
Assignee:
Industrial Technology Research Institute
Inventors:
Chih-Chun Feng, Yung-Hua Hung, Chih-Yaw Wang, Chun-Yu Lin
Abstract: The present invention provides a system for analyzing a time series signal by a method of Chaos Theory and calculating a chaos theoretical exponent value.
Type:
Grant
Filed:
December 26, 2003
Date of Patent:
January 22, 2008
Assignees:
Electronic Navigation Research Institute, an Independent Admiinistrative Institution
Abstract: A waveguide structure includes a core structure that has low index materials. A photonic crystal cladding structure utilized in guiding optical modes in the core. The photonic crystal cladding structure includes alternating layers of Si and Si3N4.
Type:
Grant
Filed:
September 19, 2005
Date of Patent:
January 22, 2008
Assignee:
Massachusetts Institute of Technology
Inventors:
Shoji Akiyama, Xiaoman Duan, Lionel C. Kimerling, Yasha Yi
Abstract: A number of thalidomide metabolites having superior anti-angiogenic properties have now been isolated and identified. In addition, thalidomide analogs that mimic the effects of the isolated and identified active thalidomide metabolites, and variations of such thalidomide analogs, have been developed. Such thalidomide analog compounds show enhanced potency in the inhibition of undesirable angiogenesis without the undesirable effects of administration of thalidomide.
Type:
Grant
Filed:
February 26, 2002
Date of Patent:
January 22, 2008
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health
Inventors:
William D. Figg, Kurt Eger, Uwe Teubert, Michael Weiss, Michael Guetschow, Thomas Hecker, Sunna Hauschildt
Abstract: A method of fabricating a CoSb3-based thermoelectric device is disclosed. The method includes providing a high-temperature electrode, providing a buffer layer on the high-temperature electrode, forming composite n-type and p-type layers, attaching the buffer layer to the composite n-type and p-type layers, providing a low-temperature electrode on the composite n-type and p-type layers and separating the composite n-type and p-type layers from each other to define n-type and p-type legs between the high-temperature electrode and the low-temperature electrode.
Type:
Grant
Filed:
April 1, 2005
Date of Patent:
January 22, 2008
Assignees:
GM Global Technology Operations, Inc., Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Inventors:
Lidong Chen, Junfeng Fan, Shengqiang Bai, Jihui Yang
Abstract: The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations.
Abstract: A cell search system for a mobile station in a time division duplex system includes: a primary synchronization code search module for searching primary synchronization codes and comparing frame values of the primary synchronization codes to determine a position of the maximum value; a correlation module for estimating a phase value and acquiring a first correlation value; a secondary synchronization code search module for generating determinative variables and storing them based on the position of the maximum value; a comparison and decision module for detecting a maximum value of the determinative variables, comparing it with the values stored in the secondary synchronization code search module to count matching values, and comparing the count value with a system value to decide whether slot synchronization and group acquisition is successful; and a base station determination module for determining a second correlation value between midamble codes and the received signals, and selecting a maximum value of it
Type:
Grant
Filed:
September 27, 2002
Date of Patent:
January 22, 2008
Assignee:
Electronics and Telecommunications Research Institute
Abstract: In signal detection system and method implemented to reduce the effects of interference in multi-user detection systems, a receiver defines a frame of symbols containing at least one window based upon a number of user signals contained in a received signal r(t). A symbol amplitude of a single-user in the multi-user system is approximated over the window of the frame based on a number of reflected signal paths of the received user signal. A perturbative correction value is calculated based upon a correlation matrix. An estimation of the symbol amplitude of the single-user signal is calculated over one or a number of windows of the frame. The single-user signal is detected when the symbol amplitudes of the entire signal within the frame has been calculated. To reduce the number of interfering users in a multicell CDMA system, the symbol codes are modified to include an even code and an odd code.
Type:
Grant
Filed:
August 15, 2002
Date of Patent:
January 22, 2008
Assignee:
Industrial Technology Research Institute