Abstract: Catalysts and catalyst systems useful for the olefin polymerization and copolymerization, and their synthesis procedure and usage are disclosed.

Abstract: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for ?-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.

Abstract: A particle beam generator has a vacuum chamber, a magnet which generates a constant magnetic field in the vacuum chamber, acceleration electrodes which generates a magnetic field in a direction perpendicular to the direction of the magnetic field generated by the magnet in the vacuum chamber, a take-out electrode which takes out charged particles accelerated in the vacuum chamber; and a target cell provided at a position at which the charged particles taken out by the taken-out electrode strikes. At least a part of surfaces exposed to the charged particles of the vacuum chamber, the acceleration electrodes, the take-out electrode and/or the target cell is made of a material including an element having atomic number larger than copper.

Abstract: The invention discloses a fire-resistant composite comprising inorganic particles well dispersed in a polymer, oligomer or copolymer having reactive functional groups. The inorganic particles also contain reactive functional groups, originally or after surface modification, that can react with the corresponding reactive functional groups of the organic component to form organic/inorganic composite materials. When the composite material is burned or exposed to fire, the organic component forms a char layer and the inorganic particles radiate absorbed heat. The inorganic particles also strengthen the mechanical properties of the structure through the reaction between inorganic and organic materials. The invention also discloses a fire-resistant plate containing the organic/inorganic component.

Abstract: A culture device to apply uniform stress to cells is proposed. A culture device is formed in a rectangular box shape from a deformable material, comprising a bottom membrane and side walls upstanding from the entire periphery of said bottom membrane, wherein an engaging member is formed in opposing side walls on a line extended from a peripheral edge of said bottom membrane. By providing the latching member in the culture membrane so as to latch the cells to the latching member, the slippage between the bottom membrane and sample cells is forestalled upon the extension of the culture membrane.

Abstract: In Cu-based bulk amorphous matrix composite materials, comprising a Cu-based amorphous alloy containing high fusion point element(s) selected from a group of Ta, W or combination thereof, wherein the high fusion point element(s) has(have) a shape of crystalline grain and is(are) dispersed around a Cu-based amorphous matrix. Cu-based bulk amorphous matrix composite materials have the composition expressed as the following Chemical formula 1; [Chemical formula 1] CuaZrbTicRd where R is Ta, W or combination thereof, a, b, c and d are atomic weight ratio, a+b+c+d equals 100, a, b, c, and d have the range of 45?a?65, 10?b?35, 5?c?30, and 5?d?10, respectively.

Abstract: An expert system for assigning and tracking physical activity programs for patients with coronary artery disease provides user interfaces for recruiters who screen and enroll the patients as program participants in the physical activity programs; for coaches who monitor program participants and guide them through the physical activity program; and for program participants who create their own physical activity schedules,and log their physical activities. Expert system algorithms assign predefined physical activity programs to the program participants at predefined program milestones based on predefined criteria.

Abstract: A method for detecting DNA damage in a tissue sample involves contacting an immobilized biological sample with a labeled ligand which binds to human 53Bp1, and examining the immobilized sample for the presence of a label generated-detectable signal concentrated in foci in said sample. The presence of concentrated foci is indicative of DNA damage and the presence of diffuse signal is indicative of a normal sample. Diagnostic reagents contain a ligand that binds to human 53Bp1 associated with a detectable label. Diagnostic kits for detecting DNA damage in a biological sample contain such diagnostic reagents and signal detection components. Compositions that inhibit or antagonize the biological activity of 53Bp1 are identified by suitable assays, and are employed in methods of retarding the growth of a cancer cell.

Abstract: Fusion proteins including zinc finger tags that bind in a sequence-specific manner and a peptide, polypeptide, or protein can be prepared and expressed. Such fusion proteins can be used to generate protein arrays by binding the zinc finger tags to a DNA array. The fusion proteins can also be used to label cell surfaces with DNA tags. Fusion proteins according to the invention can be used to localize the peptide, polypeptide, or protein that is incorporated into the fusion protein by using a labeled DNA, such as a fluorescent DNA. The invention further includes vectors and host cells, as well as a method of analyzing double-stranded DNA.

Abstract: An interlayer interconnect structure of a three-dimensional memory includes memory cell groups, each composed of a plurality of memory cells and connected to their respective selection transistors, because of special arrangement of lines and first plugs as well as line layouts. The line layouts involve disposing a plurality of lines on each of a plurality of horizontal levels, and selectively forming second plugs between adjoining lines disposed on upper and lower horizontal levels, such that the plugs selectively connect the adjoining upper and lower lines to each other. Since identical layout patterns are adopted in individual stacking states of stacking layers disposed in the three-dimensional memory, the upper lines and the lower lines of the stacking layers of the three-dimensional memory share the same layouts, leading to a reduction in the number of masks used, simpler process adjustment, and lower costs.

Abstract: The present invention provides a binding domain of ABCA1, wherein binding of a ligand to the domain is capable of modulating the biological activity of ABCA1. Also provided are methods for screening compounds capable of modulating ABCA1 activity, and antibodies useful in modulating ABCA1 activity.

Abstract: A method for evaluation of molecules to identify those that can act as therapeutic inhibitors of Hsp90 makes use of a fluorescence polarization (FP) assay and a cell based assay, either individually or in combination. The FP assay uses a fluorescently-labeled Hsp90 binding agent and measure the degree of fluorescence polarization relative to the standard. A decrease in the degree of polarization indicates that fluorescently-labeled Hsp90 binding agent has been wholly or partially displaced by a candidate molecule, and identifies the molecule as having activity as an inhibitor of Hsp90. The cell based assay tests for decrease is an Hsp90-dependent activity of normal or tumor cells.

Abstract: Provided is an apparatus and method for transmitting/receiving signals in a communication system. A base station allocates a quasi-dedicated control channel (QDCCH) to a first mobile station (MS), and allocates the QDCCH allocated to the first MS, to a second MS for a preset time. An MS receives a QDCCH allocated from the base station. If there is data to transmit to the base station, the MS determines whether the QDCCH is allocated to another MS different from the MS. If it is determined that the QDCCH is allocated to the MS itself, the MS transmits the data to the base station over the QDCCH.

Abstract: The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such as p-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2] cycloaddition reactions and Staudinger modifications.

Abstract: The invention provides Al2O3 dispersion-strengthened Ti2AlN composites, wherein Ti2AlN matrix and Al2O3 strengthening phase both are reactively formed in situ. The volume fraction of Al2O3 is 5% to 50%; the particle size of Al2O3 ranges from 500 nm to 2 ?m, with the mean size of Al2O3 particles about 0.8 ?m to 1.2 ?m; the shape of Ti2AlN grain is plate-like about 80 nm to 120 nm thick and 0.5 ?m to 2 ?m long. The composites exhibit excellent deformability at high temperature under compression and flexure stresses, and possess excellent oxidation resistance at 1100° C. to 1350° C. for long time (100 h). The composites show typical metallic conductor behavior and the electrical resistivity at room temperature is 0.3 to 0.8 ??·m. The invention also provides a method for preparing the same: First, nanoparticles in Ti—Al binary system were prepared in continuous way by hydrogen plasma-metal reaction (HPMR) using Ti—Al alloy rods with Al content 20% to 60% by atom, or pure Al rods and pure Ti rods.

Abstract: Disclosed are a method for producing an anode catalyst for a polymer electrolyte fuel cell, comprising a first supporting step of adhering at least one element selected from the group consisting of the elements of group 4, elements of group 5 and elements of group 6 of the periodic table to a conductive support, and subsequently conducting a heat treatment in a non-oxidizing atmosphere, and a second supporting step of adhering platinum and ruthenium on the support obtained in the first supporting step, and subsequently conducting a heat treatment in a non-oxidizing atmosphere; and an anode catalyst for a polymer electrolyte fuel cell obtainable in accordance with this method, the catalyst comprising catalytic metal components supported in a highly dispersed manner on a conductive support.

Abstract: The invention provides methods for determining a prognosis for survival for a cancer patient. One method involves (a) measuring a level of a TUCAN in a neoplastic cell-containing sample from the cancer patient, and (b) comparing the level of TUCAN in the sample to a reference level of TUCAN, wherein a low level of TUCAN in the sample correlates with increased survival of the patient. Another method involves (a) measuring a level of TUCAN in a neoplastic cell-containing sample from the cancer patient, and (b) classifying the patient as belonging to either a first or second group of patients, wherein the first group of patients having low levels of TUCAN is classified as having an increased likelihood of survival compared to the second group of patients having high levels of TUCAN.

Abstract: A method is provided for processing data of a sub-picture of a picture. The method includes: providing an object of the sub-picture, forming a binary bit map of the object, and determining whether the number of bits having a first binary value is greater than the number of bits having a second binary value in the binary bit map. The method further includes: determining whether it is necessary to transform the binary bit map into a transformed binary bit map so that the number of bits having the first binary value is smaller than the number of bits having the second binary value in the transformed binary bit map, and determining a compression rule by determining the most significant two bits of a section of consecutive bits in the binary bit map or the transformed binary bit map.

Abstract: The invention provides isolated nucleic acid molecules, designated PGC-1b and PGC-1c nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.