Patents Assigned to INSTITUTE
  • 3,4-diarylpyrazoles and their use in the therapy of cancer
    Patent number: 7247734
    Abstract: The present invention pertains to the use of certain 3,4-diarylpyazoles of formula (I), both in vitro and in vivo, to inhibit heat shock protein 90 (HSP90), and in the treatment of conditions mediated by HSP90, including, for example, cancer; wherein: Ar3 is independently: a C5-20aryl group, and is optionally substituted; Ar4 is independently: a C5-20aryl group, and is optionally substituted; R5 is independently: hydrogen; halo; hydroxyl; ether; formyl; acyl; carboxy; ester; acyloxy; oxycarbonyloxy; amido; acylamido; aminocarbonyloxy; tetrazolyl; amino; nitro; cyano; azido; sulfhydryl; thioether; sulfonamide; C1-7alkyl; C3-20heterocycyl; or C5-20aryl; R<SP>N</SP> is independently: —H; C1-7alkyl; C3-20heterocycyl; or, C5-20aryl; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: July 24, 2007
    Assignees: Vernalis (Cambridge) Limited, Cancer Research Technology Ltd., Institute of Cancer Research of Royal Cancer Hospital
    Inventors: Martin James Drysdale, Brian William Dymock, Xavier Barril-Alonso, Paul Workman, Laurence Harris Pearl, Chrisostomos Prodromou, Edward McDonald
  • Detection and enforcement of failure-to-yield in an emergency vehicle preemption system
    Patent number: 7248149
    Abstract: An intersection controlled by an intersection controller receives trigger signals from on-coming emergency vehicles responding to an emergency call. The intersection controller initiates surveillance of the intersection via cameras installed at the intersection in response to a received trigger signal. The surveillance may begin immediately upon receipt of the trigger signal from an emergency vehicle, or may wait until the intersection controller determines that the signaling emergency vehicle is in the field of view of the cameras at the intersection. Portions of the captured images are tagged by the intersection controller based on tag signals transmitted by the vehicle or based on detected traffic patterns that indicate a potential traffic violation. The captured images are downloaded to a processing facility that analyzes the images and automatically issues citations for captured traffic violations.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: July 24, 2007
    Assignees: California Institute of Technology, E-Views Safety Systems, Inc.
    Inventors: Aaron Bachelder, Richard Wickline
  • System for solving diagnosis and hitting set problems
    Patent number: 7249003
    Abstract: The diagnosis problem arises when a system's actual behavior contradicts the expected behavior, thereby exhibiting symptoms (a collection of conflict sets). System diagnosis is then the task of identifying faulty components that are responsible for anomalous behavior. To solve the diagnosis problem, the present invention describes a method for finding the minimal set of faulty components (minimal diagnosis set) that explain the conflict sets. The method includes acts of creating a matrix of the collection of conflict sets, and then creating nodes from the matrix such that each node is a node in a search tree. A determination is made as to whether each node is a leaf node or has any children nodes. If any given node has children nodes, then the node is split until all nodes are leaf nodes. Information gathered from the leaf nodes is used to determine the minimal diagnosis set.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: July 24, 2007
    Assignee: California Institute Of Technology
    Inventors: Amir Fijany, Farrokh Vatan
  • Optical deflector
    Patent number: 7248415
    Abstract: Provided is an optical deflector for deflecting radiation beams. The optical deflector includes: a peripheral region having a first effective refractive index; and a deflection pattern region having a predetermined shape and a second effective refractive index, wherein the second effective refractive index differs from the first effective refractive index. Here, due to the deflection pattern region having the predetermined shape, the radiation beams are deflected in a direction starting from a certain point. By using the optical deflector, the locus of a light source can be designed in one of various forms, such as a straight line, a circle, an ellipse, or a parabola.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: July 24, 2007
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Oh Kee Kwon, Kang Ho Kim, Hyun Soo Kim, Jong Hoi Kim, Kwang Ryong Oh
  • Use of DF3/MUC1 regulated expression in gene therapy
    Patent number: 7247297
    Abstract: The present invention provides for improved vectors for use in gene therapy. Utilizing the cancer specific DF3/MUC1 promoter to drive a replication essential gene, vectors are made conditionally replication-competent, permitting wider infection and expression of tumor cells. In addition, therapeutic genes and adjunct therapies further increase anti-tumor efficacy.
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: July 24, 2007
    Assignees: The University of Chicago, Dana-Farber Cancer Institute
    Inventors: Ralph R. Weichselbaum, Donald W. Kufe
  • Dual loop automatic power control for laser driver
    Patent number: 7248610
    Abstract: A laser driver. The laser driver comprises a diode driver, a power detector, a first extreme detector, a second extreme detector and a current controller. The diode driver receives bias and modulation currents to control a laser diode for generating light signals. The power detector detects optical power of the light signals. The first and second extreme detectors, both coupled to the power detector, detect the first and second extreme values among detected optical power. The first extreme value is either the maximum or the minimum optical power of the light signals, while the second extreme value is the other.
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: July 24, 2007
    Assignee: Industrial Technology Research Institute
    Inventors: Day-Uei Li, Li-Ren Huang, Wei-Zen Chen
  • Probe card and method for producing the same
    Patent number: 7248064
    Abstract: A probe card is used in conducting a visual test for a target test object through simultaneous contact of the probe card with each and every electrode pad of the target test object. The probe card includes a plurality of probes composed of conductive wire strands and having elastically deformable contact parts so curved as to make contact with electrode pads of a target test object. The contact parts are oriented in one and the same direction and extend in a parallel relationship with one another. The probe card further includes a first insulating block for fixedly securing one end parts of the probes, a second insulating block for fixedly securing the other end parts of the probes and a mounting plate for holding the first and second insulating blocks in such a manner that the contact parts of the probes protrude outwardly.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: July 24, 2007
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Dai-Gil Lee, Seong-Su Kim, Byung-Chul Kim, Dong-Chang Park
  • Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions
    Patent number: 7247749
    Abstract: Novel monoamidine, monoamidoxime and bisamidine curatives, co-curatives and cure accelerators are provided for use with perfluoroelastomeric compositions as well as novel synthesis methods for making monoamidine- and monoamidoxime-based curatives, co-curatives and cure accelerators. Also provided are diphenyl-based curatives, co-curatives and cure accelerators having sufficiently high molecular weight such that the melting temperature of the curatives, co-curatives and cure accelerators is no greater than about 240° C., and more preferably no greater than about 230° C.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: July 24, 2007
    Assignees: Greene, Tweed of Delaware, Inc., Federal State Unitary Enterprise S.V. Lebedev Institute of Synthetic Rubber
    Inventors: Carl A. Aufdermarsh, Harshad P. Amin, Anestis Logothetis, Victor Gubanov, Margarita Volkova, Lioudmila Karmanova, Alexandr Kollar, Polina Troichanskaia, Gennady Emelianov, Vsevolod Berenblit
  • Transflective electrophoretic display and manufacturing method thereof
    Patent number: 7248394
    Abstract: A transflective electrophoretic display and a method for manufacturing the same are proposed. The transflective electrophoretic display including a top substrate and a bottom substrate, multiple separating walls disposed between the top and bottom substrates, a transflective film, and an electrophoretic display medium, can be designed to display colors by using multicolor electrophoretic display media or color filters. The display can be viewed with or without ambient light by adopting a backlight module, as well as to improve the overall display quality.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: July 24, 2007
    Assignee: Industrial Technology Research Institute
    Inventors: Jau-Min Ding, Chi-Chang Liao, Shie-Chang Jeng
  • Porous aluminum fluoride
    Patent number: 7247289
    Abstract: A porous aluminum fluoride on which SbClxF5-x (wherein x represents a numeral of 0 to 5) is supported, SbClxF5-x being obtainable by supporting SbCl5, or the like on a porous aluminum fluoride and treating it with hydrogen fluoride. The resulting porous aluminum fluoride has a high activity as a fluorinating agent, a fluorination catalyst, or the like, is easy to handle, can be used for a flow-type reaction, and also can be used even at a high temperature.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: July 24, 2007
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Hengdao Quan, Masanori Tamura, Akira Sekiya
  • Doping method and semiconductor device using the same
    Patent number: 7247548
    Abstract: The present invention achieves a shallow junction of a source and a drain, and provides a doping method which makes device properties reproducible and a semiconductor device fabricated using the method. In the present invention, doping for the semiconductor is conducted by attaching a molecular species with a higher electron affinity or lower ionization energy out of fullerene derivatives or metallocenes to the semiconductor surface to induce charge transfer from the molecule to the semiconductor.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: July 24, 2007
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Tetsuya Tada, Toshihiko Kanayama, Hidefumi Hiura
  • Multi-pitch screw, multi-pitch nut, feed screw device using the screw and nut, and method of producing the nut
    Patent number: 7246979
    Abstract: A flat portion 12a and a slope portion 12b are provided on a thread 12 of a multi-pitch screw 10 alternately. The flat portion and the slope portion are provided on the thread of a multi-pitch nut which fastens with this. Consequently, a screw and a nut capable of preventing loosening securely by step are achieved. This enables comfortable and quick feeding and when a torque from a driving source is interrupted, step-like self-lock is activated.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: July 24, 2007
    Assignees: Kabushiki Kaisha Imasen Denki Seisakusho, Nagoya Industrial Science Research Institute
    Inventors: Hiroshi Fujii, Katsuhiro Sugiyama, Masashi Mitsukuchi, Kenichi Katayama, Yoshinori Moriguchi
  • 2-O sulfatase compositions and methods of hydrolyzing therewith
    Patent number: 7247445
    Abstract: The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: July 24, 2007
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, James R. Myette, Zachary Shriver, Ganesh Venkataraman
  • Roll-pitch-roll wrist methods for minimally invasive robotic surgery
    Patent number: 7248944
    Abstract: A teleoperator system with telepresence is shown which includes right and left hand controllers (72R and 72L) for control of right and left manipulators (24R and 24L) through use of a servomechanism that includes computer (42). Cameras (46R and 46L) view workspace (30) from different angles for production of stereoscopic signal outputs at lines (48R and 48L). In response to the camera outputs a 3-dimensional top-to-bottom inverted image (30I) is produced which, is reflected by mirror (66) toward the eyes of operator (18). A virtual image (30V) is produced adjacent control arms (76R and 76L) which is viewed by operator (18) looking in the direction of the control arms. Use of the teleoperator system for surgical procedures also is disclosed.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: July 24, 2007
    Assignee: Institute Surgical, Inc
    Inventor: Philip S. Green
  • Apparatus and method for compensating I/Q imbalance based on gain-controlled reference channel in orthogonal frequency division multiplex
    Patent number: 7248654
    Abstract: An apparatus and a method for controlling a gain of I-channel signal and compensating Q-channel signal in response to the gain imbalance based on the gain-controlled I-channel signal as a reference channel signal is disclosed. The apparatus includes: an auto gain controller for controlling a gain of a signal selected from the I-channel signal and the Q-channel signal to have a predetermined amplitude, thereby generating a gain-controlled signal; a detector for detecting a gain imbalance between the gain-controlled signal and the remaining channel signal; and a compensator for compensating the gain imbalance of the remaining channel signal based on the detected gain imbalance.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: July 24, 2007
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Yun-Jeong Song, Young-Wan Kim, Ho-Jin Lee
  • Microlensing particles and applications
    Patent number: 7248413
    Abstract: A microscopic lens, of size approximately 1 micron is used for its optical characteristics.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: July 24, 2007
    Assignee: California Institute of Technology
    Inventors: Stephen R. Quake, James P. Brody
  • Temperature-insensitive polymeric optical AWG device and manufacturing method therefor
    Patent number: 7248765
    Abstract: Provided are a temperature-insensitive polymeric optical AWG device and method of manufacturing the same. The temperature-insensitive polymeric optical AWG device includes: polymeric grating channel waveguides interposed between free propagation slab regions on a substrate between the input and output waveguides and having different lengths; a plurality of hollow trenches formed by selectively etching a surface of the substrate under the polymeric grating channel waveguides and allowing the polymeric grating channel waveguides to freely thermally expand from the substrate depending on a temperature variation; and a shield layer shielding entrances of the hollow trenches so that the polymeric grating channel waveguides do not flow into the hollow trenches.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: July 24, 2007
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Jong Moo Lee, Sun Tak Park, Yong Soon Baek
  • Cross-wound bobbin
    Patent number: 7246764
    Abstract: In a cross-wound bobbin (1), the helical lines along which the yarn (4) is wound have a different inclination in adjacent layers. The winding ratios are selected such that the quantity drawn off is greater if the unwinding point is moving from the unwinding end to the bottom end, compared to the quantity drawn off if the unwinding point is moving from the bottom end to the unwinding end.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: July 24, 2007
    Assignee: Deutsch Institute fur Textil-und Faserforschung Stuttgart (DITF)
    Inventors: Heinrich Planck, Christoph Rietmuller, Helmut Weinsdorfer
  • Atomic force microscope with probe with improved tip movement
    Patent number: 7246517
    Abstract: An atomic force microscope probe provides an indentation testing function in a direction along an axis. The probe has a tip and an arm structure holding the tip. The arm structure has one end mounted on a fixed stage, the other end coupled to the AFM tip, and a hollow frame having a shape symmetric with respect to a plane including an axis on which the two ends are positioned.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: July 24, 2007
    Assignee: Korea Institute of Machinery & Materials
    Inventors: Hak-Joo Lee, Jae-Hyun Kim, Chung-Seog Oh, Seung-Woo Han, Shin Hur, Soon-Gyu Ko, Byung-Ik Choi
  • Methods of identifying agents which enhance caspase activity
    Patent number: 7247438
    Abstract: Methods for identifying agents which enhance the activity of a caspase according to the invention are described, as well as methods for enhancing caspase activity and methods for enhancing apoptosis in a lymphocyte.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: July 24, 2007
    Assignee: Dana-Farber Cancer Institute
    Inventors: Ellis Reinherz, Linda Clayton, Timothy D. Ocain, Raymond J. Patch