Patents Assigned to INSTITUTE
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Patent number: 7238775Abstract: Analogs of SRIF which are selective for SSTR4 in contrast to the other cloned SRIF receptors are useful in determining tissue and cellular expression of the receptor SSTR4 and its biological role in regulating tumor growth. SRIF analog peptides, such as des-AA1,2,4,5,12,13[Ala7]-SRIF; des-AA1,2,4,5,12,13[Aph7]-SRIF, des-AA1,2,4,5,12,13[Aph7]Cbm-SRIF; des-AA1,2,4,5,12,13[Tyr2,Ala7]-Cbm-SRIF, and des-AA1,2,4,5,12,13[Tyr7,C?Me-L-2Nal8]-SRIF, and counterparts incorporating D-Cys3 and/or D-Trp8 and/or Ala11, bind with high affinity to the cloned human receptor SSTR4 and activate the receptor, but they do not bind with significant affinity to human SSTR1, SSTR2, SSTR3 or SSTR5. By incorporating an iodinated tyrosine in position-2 in these SSTR4-selective SRIF analogs, a labeled compound useful in drug-screening methods is provided. Alternatively, for use in therapy, cytotoxins or highly radioactive elements can be N-terminally coupled or complexed thereto.Type: GrantFiled: January 24, 2005Date of Patent: July 3, 2007Assignee: The Salk Institute for Biological StudiesInventors: Jean E. F. Rivier, Jean Claude Reubi, Judit Erchegyi, Roland Riek
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Patent number: 7238797Abstract: The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft source for transplation and as an animal model close to human for illustrating the protective roles of HSP. Furthermore, the transgenic pig of the invention has a better meat quality and exhibits an increased growth rate and a reduced backfat thickness.Type: GrantFiled: March 8, 2005Date of Patent: July 3, 2007Assignee: Animal Technology InstituteInventors: Wen-Chuan Lee, Ming-Yu Chen
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Patent number: 7239775Abstract: An optical delay line for use with an optical source including input/output optics optically coupled to the optical source and a curved mirror with a reflective surface that is centered about an evolute curve of the delay line to retro-reflect light traveling along a delay line beam path tangent to the edge of the evolute curve. The input/output optics direct light from the optical source along the delay line beam path and direct delayed light from the delay line beam path out of the optical delay line along an output beam path. The input/output optics and/or the curved mirror rotate about the evolute curve at a selected angular speed. The reflective surface has a curvature based on a parametric curve that is calculated from the evolute curve such that the delay of the delay line varies according to a predetermined function as the input/output optics and/or the curved mirror rotate.Type: GrantFiled: March 8, 2005Date of Patent: July 3, 2007Assignee: Rensselaer Polytechnic InstituteInventors: Jingzhou Xu, Xi-Cheng Zhang
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Patent number: 7238265Abstract: The present invention provides a fountain-type electroplating apparatus with functions of voltage detection and flow rectification, comprising: an electroplating tank, a rectification device, and an overflow tank, wherein the electroplating tank is positioned inside the overflow tank, and the rectification device is arranged under the electroplating tank, in addition, the electroplating tank is composed of a shell, a cathode electrode, and an mesh shaped anode. The apparatus of the present invention further comprises: a power supplier, a switcher, a plurality of detection circuits, and a plurality of connecting line, which is used for monitoring the same.Type: GrantFiled: December 23, 2003Date of Patent: July 3, 2007Assignee: Industrial Technology Research InstituteInventors: Chih-Cheng Wang, Chih-Yuan Tseng, Jen-Rong Huang, Sheng-Lang Lee, Chia-Ming Chen, Pang-Ming Chiang
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Patent number: 7239763Abstract: An optical SSB modulator capable of appropriately adjusting a phase difference of light in the MZ waveguides and automatically adjusting a voltage impressed to the bias adjustment electrodes is provided. The above-mentioned object is achieved by an optical SSB modulator (1) provided with a first sub Mach-Zehnder waveguide (MZA) (2), a second sub Mach-Zehnder waveguide (MZB) (3), a main Mach-Zehnder waveguide (MZC) (4), a first bias adjustment electrode (DCA electrode) (5), a second bias adjustment electrode (DCB electrode) (6), a first modulation electrode (RFA electrode) (7), a second modulation electrode (RFB electrode) (8) and a third bias adjustment electrode (DCC electrode) (9), wherein either one of or both of output portions (10, 11) of the MZA and the MZB have an X-branching form, and specifically having one of light paths of the X-branching connected to a photodetector.Type: GrantFiled: March 22, 2005Date of Patent: July 3, 2007Assignees: National Institute of Information and Communications Technology, Incorporated Administrative Agency, Sumitomo Osaka Cement Co., LtdInventors: Tetsuya Kawanishi, Masayuki Izutsu, Kaoru Higuma, Shingo Mori
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Patent number: 7238622Abstract: A method of forming a virtual substrate comprised of an optoelectronic device substrate and handle substrate comprises the steps of initiating bonding of the device substrate to the handle substrate, improving or increasing the mechanical strength of the device and handle substrates, and thinning the device substrate to leave a single-crystal film on the virtual substrate such as by exfoliation of a device film from the device substrate. The handle substrate is typically Si or other inexpensive common substrate material, while the optoelectronic device substrate is formed of more expensive and specialized electro-optic material. Using the methodology of the invention a wide variety of thin film electro-optic materials of high quality can be bonded to inexpensive substrates which serve as the mechanical support for an optoelectronic device layer fabricated in the thin film electro-optic material.Type: GrantFiled: January 20, 2004Date of Patent: July 3, 2007Assignee: California Institute of TechnologyInventors: Harry A. Atwater, Jr., James M. Zahler, Anna Fontcuberta i Morral
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Patent number: 7238324Abstract: A microfluidic device for controlling the flow of a micro amount of fluid is provided. The microfluidic device is manufactured by binding a sensing substrate including a sensing electrode, an electrode interconnect, and a electrode pad, with a channel substrate including at least two fluid inlet ports, a chamber, and a channel, wherein a first fluid injected via one of the fluid inlet ports flows by natural capillary force, and a second fluid injected via another fluid inlet port is forced to flow by an external pump. The microfluidic device controls fluid flow and flow stoppage by a combination of natural capillary flow and an externally applied pressure as a result of the action of a pump.Type: GrantFiled: July 7, 2003Date of Patent: July 3, 2007Assignee: Electronics and Telecommunications Research InstituteInventors: Jong Soo Ko, Hyun Chul Yoon, Hae Sik Yang, Dae-Sik Lee, Kwang Hyo Chung, Hyeon Bong Pyo, Sung Jin Kim, Yun Tae Kim
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Publication number: 20070148756Abstract: A tissue dissociation device (10) includes a container (12) having a sterile interior for holding the tissue to be dissociated and a liquid medium. The device (10) also includes a dissociation element (54), inside the container (12), for engaging the tissue to cause dissociation of the tissue. The device (10) also includes a resistive element (81), inside the container (12), for resisting movement of the tissue in response to the engagement by the dissociation element (54). Relative motion between and the resulting resistance provided by the resistive element (81) allows the dissociation element (54) to effectively dissociate the tissue.Type: ApplicationFiled: September 21, 2004Publication date: June 28, 2007Applicant: BATTELLE MEMORIAL INSTITUTEInventors: Lawrence Bullen, Herbert Bresler, Daniel Kramer
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Publication number: 20070148407Abstract: A water-repellent structure and a method for fabricating the same are provided. The method adopts an atmospheric pressure plasma deposition (APPD) technique to form a hardened coating having a rough surface on a substrate, and form a water-repellent coating on the rough surface. Because the water-repellent structure includes the hardened coating and the water-repellent coating, hardness, abrasion-resistance, transparency and hydrophobicity of the water-repellent structure are improved. The hard water-repellent structure protects the substrate from friction. Moreover, because the present invention adopts the APPD technique to form the water-repellent structure, the cost of production is reduced dramatically. Thus, the present invention can solve drawbacks of prior art.Type: ApplicationFiled: December 26, 2006Publication date: June 28, 2007Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Chih-Wei Chen, Chun-Hung Lin, Tsung-Hui Cheng, Chih-Yuan Chen, Te-Hui Yang, Chen-Der Tsai, Chin-Jyi Wu, Yun-Chuan Tu, Chia-Chiang Chang
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Publication number: 20070150700Abstract: A processor implements conditional vector operations in which, for example, an input vector containing multiple operands to be used in conditional operations is divided into two or more output vectors based on a condition vector. Each output vector can then be processed at full processor efficiency without cycles wasted due to branch latency. Data to be processed are divided into two groups based on whether or not they satisfy a given condition by e.g., steering each to one of the two index vectors. Once the data have been segregated in this way, subsequent processing can be performed without conditional operations, processor cycles wasted due to branch latency, incorrect speculation or execution of unnecessary instructions due to predication. Other examples of conditional operations include combining one or more input vectors into a single output vector based on a condition vector, conditional vector switching, conditional vector combining, and conditional vector load balancing.Type: ApplicationFiled: August 28, 2006Publication date: June 28, 2007Applicants: The Board of Trustees of the Leland Stanford Junior University, The Massachusetts Institute of TechnologyInventors: William Dally, Scott Rixner, John Owens, Ujval Kapasi
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Publication number: 20070149685Abstract: The present invention relates to a nanocomposite material, which comprises bedded clay modified by alkyl amino salt with long chain and a silicone compound with functional group, then mix with a polymer compound. The present invention has a high rigidity and tenacity by inserting the polymer compound into the layers of the modified clay.Type: ApplicationFiled: May 25, 2006Publication date: June 28, 2007Applicant: Industrial Technology Research InstituteInventors: Wen-Faa Kuo, Shih-Jung Tsai, Gwo-Yang Chang
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Publication number: 20070146588Abstract: A reflective liquid crystal display device integrating a self-emitting display element and fabrication methods thereof. The reflective liquid crystal display integrating a self-emitting display element comprises a reflective liquid crystal display (LCD) device and a transparent self-emitting display element directly disposed on the reflective LCD device. The reflective LCD includes a reflective cholesterol liquid crystal display, a reflective polymer dispersed liquid crystal display, a reflective twisted nematic liquid crystal display, a reflective smectic liquid crystal display, a vertical aligned liquid crystal (VA-LC) display, or a ferro-electric liquid crystal display.Type: ApplicationFiled: July 24, 2006Publication date: June 28, 2007Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Bo-Ru Yang, Hsing-Lung Wang, Chi-Chang Liao, Kang-Hung Liu, Shie-Chang Jeng, Han-Ping Shieh
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Publication number: 20070145037Abstract: An electro-heating device is provided. The electro-heating device comprises a conductive material and an electro-heating resin. The electro-heating resin is coated on the surface of the conductive material. The material of the electro-heating resin is preferably a conductive resin.Type: ApplicationFiled: September 28, 2006Publication date: June 28, 2007Applicant: TAIWAN TEXTILE RESEARCH INSTITUTEInventors: Han-Hsing Hsiung, Chi-Shu Wei
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Publication number: 20070148158Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.Type: ApplicationFiled: December 20, 2006Publication date: June 28, 2007Applicant: Massachusetts Institute of TechnologyInventors: Ram Sasisekharan, Zachary Shriver, Dongfang Liu, Ganesh Venkataraman
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Publication number: 20070148045Abstract: The invention provides a particle detection system. In one embodiment, the system detects live bacteria by aligning the bacteria in a test specimen with an electric field, illuminating the test specimen, and detecting the optical scattering. This invention uses no biochemical markers and can be applied in a Point-of-Care setting.Type: ApplicationFiled: October 12, 2006Publication date: June 28, 2007Applicant: California Institute of TechnologyInventors: Allen Pu, Demetri Psaltis
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Publication number: 20070147661Abstract: An estimation device estimates a hidden state of an estimation subject from an observable state in a manner of a time series. The observable state is observed from the hidden state of the estimation subject under a procedure that has a hierarchical structure, which includes the hidden state of the estimation subject, the observable state, and an intermediate hidden state therebetween. The estimation device includes an estimation subject hidden state predicting means, an intermediate hidden state predicting means based on the state transition structure of the hidden state of the estimation subject, an intermediate hidden state likelihood observing means, an intermediate hidden state estimating means, an estimation subject hidden state likelihood observing means, estimation subject hidden state estimating means, an intermediate hidden state predicting means based on the state transition structure of the intermediate hidden state, and the mixing means.Type: ApplicationFiled: December 20, 2006Publication date: June 28, 2007Applicants: DENSO Corporation, National University Corporation Nara Institute Of Science and TechnologyInventors: Naoki Fukaya, Mikio Shimizu, Shin Ishii, Tomohiro Shibata, Takashi Bando
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Publication number: 20070148157Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: ApplicationFiled: December 13, 2006Publication date: June 28, 2007Applicant: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Publication number: 20070145627Abstract: This invention provides a method of producing chitosan non-woven fabrics and an apparatus thereof. At first, a chitosan acidic solution is extruded to form a chitosan fibrous stream. Then, a solidifying agent is ejected to form a solidifying agent stream. The solidifying agent stream and the chitosan fibrous stream are combined to form a pre-solidified chitosan fiber. Then, high-pressure air is ejected on the pre-solidified chitosan fiber to stretch the pre-solidified chitosan fiber. Finally, the chitosan fibers are collected to form chitosan non-woven fabrics.Type: ApplicationFiled: September 29, 2006Publication date: June 28, 2007Applicant: Taiwan Textile Research InstituteInventors: Chao-Chun Peng, Tzu-Hsiang Huang, Jian-Min Lin, Jen-Hsiung Lee
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Publication number: 20070149610Abstract: Three pairs of C-2 epimeric xanthones isolated from Garcinia hanburyi and method for efficiently separating the xanthone compounds into individual epimers, each of which possesses varying biological effects. The compounds are useful for their anticancer effects, particularly because they are shown to be non-substrates of the multidrug-resistance transporter. Some of the epimers have significant inhibitory effects on cytochrome P450 systems. The xanthone compounds of the present invention are gambogic acid, epigambogic acid, isogambogic acid, isoepigambogic acid, 30-hydroxygambogic acid and 30-hydroxyepigambogic acid.Type: ApplicationFiled: December 21, 2006Publication date: June 28, 2007Applicant: Hong Kong Jockey Club Institute of Chinese Medicine LimitedInventors: Quan-Bin HAN, Jing-Zheng SONG, Chun-Feng QIAO, Ling YANG, Hong-Xi XU
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Publication number: 20070147388Abstract: The present invention provides a method for setting a quality of service (QoS) in a terminal. The method includes receiving from a base station and displaying information regarding radio resource usage condition in a communication network; receiving and setting a QoS demanded by a user; receiving a data service by using the established QoS; checking the information regarding radio resource usage condition, wherein the radio resource is regularly provided, and changing or resetting QoS.Type: ApplicationFiled: December 7, 2006Publication date: June 28, 2007Applicants: SAMSUNG ELECTRONICS CO., LTD., Electronics and Telecommunications Research Institute, KT Corporation, SK TELECOM CO., LTD, HANARO TELECOM., INC.Inventors: Jun-Sik Kim, Nam-Hoon Park