Patents Assigned to INSTITUTE
  • Patent number: 7250402
    Abstract: A compound represented by the general formula (I) or a salt thereof: wherein represents —CH?CH—, —CH2—CH2— or the like, between R1 and the carbon atom at 4?-position represents a single bond or a double bond, between R2 and the carbon atom at 5-position represents a single bond or a double bond, and for example, 1) when represents —CH?CH— or —CH2—CH2—, and between R1 and the carbon atom at 4?-position represents a double bond, R1 represents ?C(R11)(R12) (wherein R11 represents a lower alkyl group or the like and R12 represents a hydrogen atom or the like) or the like, and R2 represents a hydroxyl group or the like, or R2 may be combined together with the carbon atom at 5-position to form a carbonyl group, and 2) when represents —CH?CH— or —CH2—CH2—, and between R1 and the carbon atom at 4?-position represents a single bond, R1 represents —OCH(R1a)(R1b) (wherein R1a represents a lower alkyl or the like and R1b represents a hydrogen atom or the like) or the like, and R2 re
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: July 31, 2007
    Assignee: The Kitasato Institute
    Inventors: Satoshi Omura, Kenichiro Nagai, Toshiaki Sunazuka
  • Patent number: 7250232
    Abstract: Processes, techniques, and compositions used to fabricate high performance solid acid fuel cell membrane electrode assemblies are disclosed. The techniques include preparing the solid acid electrolyte material, depositing the electrolyte membrane, depositing the electrocatalyst layer, preparing the electrodes, fabricating the gas seals, and constructing the membrane electrode assembly.
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: July 31, 2007
    Assignee: California Institute of Technology
    Inventors: Dane Boysen, Calum Chisholm, Sossina M. Haile, Tetsuya Uda
  • Patent number: 7250359
    Abstract: A semiconductor structure including a semiconductor substrate, at least one first crystalline epitaxial layer on the substrate, the first layer having a surface which is planarized, and at least one second crystalline epitaxial layer on the at least one first layer. In another embodiment of the invention there is provided a semiconductor structure including a silicon substrate, and a GeSi graded region grown on the silicon substrate, compressive strain being incorporated in the graded region to offset the tensile strain that is incorporated during thermal processing. In yet another embodiment of the invention there is provided a semiconductor structure including a semiconductor substrate, a first layer having a graded region grown on the substrate, compressive strain being incorporated in the graded region to offset the tensile strain that is incorporated during thermal processing, the first layer having a surface which is planarized, and a second layer provided on the first layer.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: July 31, 2007
    Assignee: Massachusetts Institute of Technology
    Inventor: Eugene A. Fitzgerald
  • Patent number: 7251461
    Abstract: This invention includes a wireless transmitter comprising an IF-signal generator that modulates input signals into those of an intermediate frequency band, signal distributors that distribute signals from the IF-signal generator, and a plurality of signal-transmission units that convert the signals distributed by the signal distributors into those of a radio frequency band, and then transmit the converted radio signals. The invention also includes a wireless receiver that receives the radio-frequency-band modulated signals and restores the signals of the intermediate frequency band. In this way, effective diversity is realized and signal interruptions are prevented. In addition, a handy, low-cost wireless communications system is provided.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: July 31, 2007
    Assignee: National Institute of Information and Communication Technology
    Inventors: Yozo Shoji, Kiyoshi Hamaguchi, Hiroyo Ogawa
  • Patent number: 7251382
    Abstract: Disclosed herein is a functional tunable multichannel filter which is capable of adjusting channel spacing and/or a wavelength location using polarization controllers (?/2, (?/4). The functional tunable multichannel filter includes one or more polarization maintaining fibers, a first polarization controller (?/2), a second polarization controller (?/4) and a 3 dB coupler. Additionally, the functional tunable multichannel filter is configured to tune a wavelength and adjust channel spacing by adjusting polarization of an optical signal passing through each of the polarization maintaining fibers using the first and second polarization controllers.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: July 31, 2007
    Assignee: Korea Institute of Science and Technology
    Inventors: Young Geun Han, Sang Hyuck Kim, Sang Bae Lee
  • Patent number: 7251066
    Abstract: A method, apparatus, and system provide the ability for storing holograms at high speed. A single laser diode emits a collimated laser beam to both write to and read from a photorefractice crystal. One or more liquid crystal beam steering spatial light modulators (BSSLMs) steer a reference beam, split from the collimated laser beam, at high speed to the photorefractive crystal.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: July 31, 2007
    Assignee: California Institute of Technology
    Inventors: Tien-Hsin Chao, Jay C. Hanan, George F. Reyes, Hanying Zhou
  • Patent number: 7250409
    Abstract: Anlogs of ningalin B lacking inherent cytotoxic activity may be employed to reverse multi-drug resistant (MDR) phenotype and to resensitize transformed cells, including a human colon cancer cell line (HCT116/VM46), with respect to a variety of cytotoxic agents, e.g., vinblastine and doxorubicin. In many instances, resensitization is achieved at lower doses than the prototypical agent verapamil. Total synthesis of ningalin B and its analogs was achieved using a concise, efficient approach based on a heterocyclic azadiene Diels-Alder strategy (1,2,4,5-tetrazine?1,2-diazine?pyrrole) ideally suited for construction of the densely functionalized pyrrole core found in the natural product is detailed.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: July 31, 2007
    Assignee: The Scripps Research Institute
    Inventor: Dale L. Boger
  • Patent number: 7250537
    Abstract: The present invention provides a novel method of hydrogenating a phenol for hydrogenating a phenol industrially advantageously. The present invention relates, in the case of phenol hydrogenation in which carbon dioxide is made to participate in the reaction, to a method of hydrogenating a phenol characterized by using a supported rhodium and/or ruthenium catalyst, whereby the phenol is hydrogenated efficiently at a lower reaction temperature than with prior art; such a method characterized in that carbon dioxide having a temperature of 20 to 250° C. and a pressure of 0.1 to 50 MPa is used as the carbon dioxide; and such a method characterized in that hydrogen under conditions of a temperature of 20 to 250° C. and a pressure of 0.1 to 50 MPa is used. An environmentally friendly phenol hydrogenation process that uses no harmful organic solvents can be realized.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: July 31, 2007
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Masayuki Shirai, Chandrashekhar Vasant Rode, Uday Dattopant Joshi, Kazuo Torii, Takafumi Sato
  • Patent number: 7251402
    Abstract: Light transmission is maximized through the pass band of a photonic bandgap (PBG) crystal (having alternating high- and low-index material) while preserving high reflection for stop band. An anti-reflective coating (ARC) is used to coat the PBG crystal wherein the ARC material has a refractive index of n=(nair×nhigh index material)1/2 and thickness around ?c/8 where ?c is center wavelength.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: July 31, 2007
    Assignee: Massachusetts Institute of Technology
    Inventors: Shoji Akiyama, Ivan Celanovic, Natalija Z. Jovanovic, Francis O'Sullivan, Kazumi Wada
  • Patent number: 7251412
    Abstract: Direct backlight modules using diffraction optical elements are provided. A direct backlight module includes a light source and a diffraction optical element, wherein the diffraction optical element is disposed above the light source. By properly arranging the phase function, the diffraction optical element can substantially modulate the wavefront of the light emitted from the light source and control light distribution as well as light direction.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: July 31, 2007
    Assignee: Industrial Technology Research Institute
    Inventors: Ying-Tsung Lu, Pong Lai, Ching-Chin Wu, Chang-Sheng Chu
  • Patent number: 7250212
    Abstract: A formed article obtained by pressure forming a porous body-coated fiber includes an inorganic fiber and a porous body made of fine inorganic particles associated with one another in a ring-shaped or helical manner to form secondary particles. The inorganic fiber is coated with the porous body. Also provided is a formed article made from porous body-coated fiber on a porous body-coated particle. The porous body-coated particle includes a core particle and a porous body made of fine particles of a first inorganic compound associated with one another in ring-shaped or helical manner to form secondary particles. The core particle is coated with the porous body.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: July 31, 2007
    Assignees: Nichias Corporation, Hosokawa Powder Technology Research Institute
    Inventors: Makio Naito, Hiroya Abe, Yasuo Ito, Takahiro Ohmura, Takehisa Fukui, Masahiro Yoshikawa
  • Patent number: 7251301
    Abstract: Providing a noise signal comprises providing a first signal corresponding to a first band of a frequency spectrum of the noise signal and providing a first signal low corresponding to the first band of the freguency spectrum of the noise signal. Next, providing a noise signal comprises providing a second signal corresponding to a second band of the frequency spectrum of the noise signal, the second signal based on the first signal low. And finally, the first signal and the second signal are summed to provide the noise signal.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: July 31, 2007
    Assignee: Industrial Technology Research Institute
    Inventors: Fang-Chu Chen, Jing-Ling Tsai
  • Patent number: 7250432
    Abstract: The present invention relates to a pharmaceutical composition for the prevention and the treatment of cancers containing diaryl-isoxazole derivatives as an effective ingredient. Diaryl-isoxazole derivatives of the present invention inhibit metastasis of breast cancer cell lines and angiogenesis, so that they can be produced as a metastasis inhibitor and further as a pharmaceutical composition for the prevention and the treatment of angiogenesis related diseases including cancers, rheumatoid arthritis, psoriasis, or angiogenesis diseases caused in eyeball, etc.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: July 31, 2007
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Byoung-Mog Kwon, Kwang-Hee Son, Dong-Cho Han, Sang-Ku Lee, Ki-Deok Shin, Sun-Bok Jeon, Jung-Hoon Oh
  • Patent number: 7251574
    Abstract: A bit error rate test on a transceiver is accelerated by adding a phase offset to data phase encoding and decoding in the transceiver and by mapping bit error rate test results from an elevated error rate condition to a normal error rate condition for the transceiver. The elevated error rate is accomplished by adjusting the phase of the phase encoder and decoder with the value of the phase offset so that the encoded data transmission signal is not as robust against noise as it normally would be. Noise in the form of an interference signal is introduced during the transmission, and the bit error rate is measured after the receiver has decoded the signal. The bit error rate (BER) data with an elevated propensity for error is mapped against bit error rate data for normal operations. A mapping function is built to map BERE (bit error rate elevated) data—data from the elevated error rate condition for data encoding, to BERN (normal bit error rate) data—data from the normal error rate condition for data encoding.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: July 31, 2007
    Assignee: Georgia Institute of Technology
    Inventors: Soumendu Bhattacharya, Rajarajan Senguttuvan, Abhijit Chatterjee
  • Patent number: 7250128
    Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
    Type: Grant
    Filed: April 20, 2005
    Date of Patent: July 31, 2007
    Assignee: California Institute of Technology
    Inventors: Marc A. Unger, Hou-Pu Chou, Todd A. Thorsen, Axel Scherer, Stephen R. Quake, Jian Liu, Mark L. Adams, Carl L. Hansen
  • Patent number: 7250291
    Abstract: The invention features tumor antigens; tumor antigen-encoding nucleic acids; antibodies specific for tumor antigens and methods of using the antibodies; methods of identifying tumor antigens and the nucleic acids that encode them; methods of monitoring or diagnosing tumors in patients; methods of testing patients for the increased likelihood of developing a tumor; and methods and compositions for treatment of a tumor or prophylaxis against developing a tumor.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: July 31, 2007
    Assignee: Dana-Farber Cancer Institute
    Inventors: Glenn Dranoff, Jan Schmollinger, F. Stephen Hodi, Joseph Mollick
  • Patent number: 7250509
    Abstract: A method for preparing a melamine salt of pentaerypolyol phosphoric acid is provided. The method comprises the following steps of: ball milling a mixture of pentaerypolyol and phosphorus pentoxide (P2O5) under a solvent-free reacting environment to obtain a pentaerypolyol phosphoric acid, and ball milling a mixture of a pentaerypolyol phosphoric acid and melamine without organic solvent reacting environment to obtain a melamine salt of pentaerypolyol phosphoric acid.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: July 31, 2007
    Assignee: Chung Shan Institute of Science and Technology
    Inventors: Yu-Sheng Lin, Wen-Chiung Su, Chong Ma, Yuen-Hsin Peng
  • Patent number: 7250266
    Abstract: Disclosed is a method of analyzing mass of the phosphoproteins or phosphopeptides and of analyzing phosphorylated positions at a phosphoprotein or phosphopeptide, comprising the steps of: 1) dephosphorylating at least one Ser and/or Thr residue of the phosphoprotein or phosphopeptide; 2) tagging the dephosphorylated amino acid residues with a tag having a R-L-G moiety wherein R is a nucleophilic functional group that selectively bind with dephosphorylated amino acid residues, G is selected from the group consisting of guanidine moiety or protected guanidine moiety such as a mono-N-protected guanidino group, a di-N,N?-protected guanidino group and an N?-protected guanidino group, and L is a linker linking the R and the G; and 3) subjecting the tagged proteins or peptides to mass spectrometry. The method is capable of precisely analyzing mass of phosphoproteins of trace amounts as well as positions of phosphoryated amino acids.
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: July 31, 2007
    Assignee: Korea Basic Science Institute
    Inventors: Yeong Hee Ahn, Jong Shin Yoo, Jin Young Kim, Kun Cho
  • Patent number: 7250283
    Abstract: The invention provides isolated nucleic acid molecules, designated PGC-1b and PGC-1c nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: July 31, 2007
    Assignee: Dana-Farber Cancer Institute
    Inventors: Bruce M. Spiegelman, Guillaume Adelmant, Pere Puigserver
  • Patent number: 7250719
    Abstract: An organic light emitting diode (OLED) with a brightness enhancer. The OLED comprises a substrate having a first surface and a second surface oppositely. An anode electrode is disposed on the first surface of the substrate. An organic light emitting layer is disposed on the anode electrode. A cathode electrode is disposed on the organic light emitting layer. A brightness enhancer is disposed on the second surface of the substrate.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: July 31, 2007
    Assignee: Industrial Technology Research Institute
    Inventors: Liang-Bin Yu, Tien-Shou Shieh, Hui-Lung Kuo, Mei-Rurng Tseng, Pin-Sien Yu