Patents Assigned to INSTITUTE
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Patent number: 7250402Abstract: A compound represented by the general formula (I) or a salt thereof: wherein represents —CH?CH—, —CH2—CH2— or the like, between R1 and the carbon atom at 4?-position represents a single bond or a double bond, between R2 and the carbon atom at 5-position represents a single bond or a double bond, and for example, 1) when represents —CH?CH— or —CH2—CH2—, and between R1 and the carbon atom at 4?-position represents a double bond, R1 represents ?C(R11)(R12) (wherein R11 represents a lower alkyl group or the like and R12 represents a hydrogen atom or the like) or the like, and R2 represents a hydroxyl group or the like, or R2 may be combined together with the carbon atom at 5-position to form a carbonyl group, and 2) when represents —CH?CH— or —CH2—CH2—, and between R1 and the carbon atom at 4?-position represents a single bond, R1 represents —OCH(R1a)(R1b) (wherein R1a represents a lower alkyl or the like and R1b represents a hydrogen atom or the like) or the like, and R2 reType: GrantFiled: November 29, 2004Date of Patent: July 31, 2007Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kenichiro Nagai, Toshiaki Sunazuka
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Patent number: 7250232Abstract: Processes, techniques, and compositions used to fabricate high performance solid acid fuel cell membrane electrode assemblies are disclosed. The techniques include preparing the solid acid electrolyte material, depositing the electrolyte membrane, depositing the electrocatalyst layer, preparing the electrodes, fabricating the gas seals, and constructing the membrane electrode assembly.Type: GrantFiled: June 10, 2005Date of Patent: July 31, 2007Assignee: California Institute of TechnologyInventors: Dane Boysen, Calum Chisholm, Sossina M. Haile, Tetsuya Uda
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Patent number: 7250359Abstract: A semiconductor structure including a semiconductor substrate, at least one first crystalline epitaxial layer on the substrate, the first layer having a surface which is planarized, and at least one second crystalline epitaxial layer on the at least one first layer. In another embodiment of the invention there is provided a semiconductor structure including a silicon substrate, and a GeSi graded region grown on the silicon substrate, compressive strain being incorporated in the graded region to offset the tensile strain that is incorporated during thermal processing. In yet another embodiment of the invention there is provided a semiconductor structure including a semiconductor substrate, a first layer having a graded region grown on the substrate, compressive strain being incorporated in the graded region to offset the tensile strain that is incorporated during thermal processing, the first layer having a surface which is planarized, and a second layer provided on the first layer.Type: GrantFiled: December 17, 2001Date of Patent: July 31, 2007Assignee: Massachusetts Institute of TechnologyInventor: Eugene A. Fitzgerald
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Patent number: 7251461Abstract: This invention includes a wireless transmitter comprising an IF-signal generator that modulates input signals into those of an intermediate frequency band, signal distributors that distribute signals from the IF-signal generator, and a plurality of signal-transmission units that convert the signals distributed by the signal distributors into those of a radio frequency band, and then transmit the converted radio signals. The invention also includes a wireless receiver that receives the radio-frequency-band modulated signals and restores the signals of the intermediate frequency band. In this way, effective diversity is realized and signal interruptions are prevented. In addition, a handy, low-cost wireless communications system is provided.Type: GrantFiled: October 17, 2002Date of Patent: July 31, 2007Assignee: National Institute of Information and Communication TechnologyInventors: Yozo Shoji, Kiyoshi Hamaguchi, Hiroyo Ogawa
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Patent number: 7251382Abstract: Disclosed herein is a functional tunable multichannel filter which is capable of adjusting channel spacing and/or a wavelength location using polarization controllers (?/2, (?/4). The functional tunable multichannel filter includes one or more polarization maintaining fibers, a first polarization controller (?/2), a second polarization controller (?/4) and a 3 dB coupler. Additionally, the functional tunable multichannel filter is configured to tune a wavelength and adjust channel spacing by adjusting polarization of an optical signal passing through each of the polarization maintaining fibers using the first and second polarization controllers.Type: GrantFiled: June 29, 2005Date of Patent: July 31, 2007Assignee: Korea Institute of Science and TechnologyInventors: Young Geun Han, Sang Hyuck Kim, Sang Bae Lee
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Patent number: 7251066Abstract: A method, apparatus, and system provide the ability for storing holograms at high speed. A single laser diode emits a collimated laser beam to both write to and read from a photorefractice crystal. One or more liquid crystal beam steering spatial light modulators (BSSLMs) steer a reference beam, split from the collimated laser beam, at high speed to the photorefractive crystal.Type: GrantFiled: August 4, 2006Date of Patent: July 31, 2007Assignee: California Institute of TechnologyInventors: Tien-Hsin Chao, Jay C. Hanan, George F. Reyes, Hanying Zhou
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Patent number: 7250409Abstract: Anlogs of ningalin B lacking inherent cytotoxic activity may be employed to reverse multi-drug resistant (MDR) phenotype and to resensitize transformed cells, including a human colon cancer cell line (HCT116/VM46), with respect to a variety of cytotoxic agents, e.g., vinblastine and doxorubicin. In many instances, resensitization is achieved at lower doses than the prototypical agent verapamil. Total synthesis of ningalin B and its analogs was achieved using a concise, efficient approach based on a heterocyclic azadiene Diels-Alder strategy (1,2,4,5-tetrazine?1,2-diazine?pyrrole) ideally suited for construction of the densely functionalized pyrrole core found in the natural product is detailed.Type: GrantFiled: March 1, 2001Date of Patent: July 31, 2007Assignee: The Scripps Research InstituteInventor: Dale L. Boger
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Patent number: 7250537Abstract: The present invention provides a novel method of hydrogenating a phenol for hydrogenating a phenol industrially advantageously. The present invention relates, in the case of phenol hydrogenation in which carbon dioxide is made to participate in the reaction, to a method of hydrogenating a phenol characterized by using a supported rhodium and/or ruthenium catalyst, whereby the phenol is hydrogenated efficiently at a lower reaction temperature than with prior art; such a method characterized in that carbon dioxide having a temperature of 20 to 250° C. and a pressure of 0.1 to 50 MPa is used as the carbon dioxide; and such a method characterized in that hydrogen under conditions of a temperature of 20 to 250° C. and a pressure of 0.1 to 50 MPa is used. An environmentally friendly phenol hydrogenation process that uses no harmful organic solvents can be realized.Type: GrantFiled: March 30, 2004Date of Patent: July 31, 2007Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Masayuki Shirai, Chandrashekhar Vasant Rode, Uday Dattopant Joshi, Kazuo Torii, Takafumi Sato
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Patent number: 7251402Abstract: Light transmission is maximized through the pass band of a photonic bandgap (PBG) crystal (having alternating high- and low-index material) while preserving high reflection for stop band. An anti-reflective coating (ARC) is used to coat the PBG crystal wherein the ARC material has a refractive index of n=(nair×nhigh index material)1/2 and thickness around ?c/8 where ?c is center wavelength.Type: GrantFiled: August 23, 2005Date of Patent: July 31, 2007Assignee: Massachusetts Institute of TechnologyInventors: Shoji Akiyama, Ivan Celanovic, Natalija Z. Jovanovic, Francis O'Sullivan, Kazumi Wada
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Patent number: 7251412Abstract: Direct backlight modules using diffraction optical elements are provided. A direct backlight module includes a light source and a diffraction optical element, wherein the diffraction optical element is disposed above the light source. By properly arranging the phase function, the diffraction optical element can substantially modulate the wavefront of the light emitted from the light source and control light distribution as well as light direction.Type: GrantFiled: June 17, 2005Date of Patent: July 31, 2007Assignee: Industrial Technology Research InstituteInventors: Ying-Tsung Lu, Pong Lai, Ching-Chin Wu, Chang-Sheng Chu
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Patent number: 7250212Abstract: A formed article obtained by pressure forming a porous body-coated fiber includes an inorganic fiber and a porous body made of fine inorganic particles associated with one another in a ring-shaped or helical manner to form secondary particles. The inorganic fiber is coated with the porous body. Also provided is a formed article made from porous body-coated fiber on a porous body-coated particle. The porous body-coated particle includes a core particle and a porous body made of fine particles of a first inorganic compound associated with one another in ring-shaped or helical manner to form secondary particles. The core particle is coated with the porous body.Type: GrantFiled: May 28, 2004Date of Patent: July 31, 2007Assignees: Nichias Corporation, Hosokawa Powder Technology Research InstituteInventors: Makio Naito, Hiroya Abe, Yasuo Ito, Takahiro Ohmura, Takehisa Fukui, Masahiro Yoshikawa
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Patent number: 7251301Abstract: Providing a noise signal comprises providing a first signal corresponding to a first band of a frequency spectrum of the noise signal and providing a first signal low corresponding to the first band of the freguency spectrum of the noise signal. Next, providing a noise signal comprises providing a second signal corresponding to a second band of the frequency spectrum of the noise signal, the second signal based on the first signal low. And finally, the first signal and the second signal are summed to provide the noise signal.Type: GrantFiled: October 1, 2002Date of Patent: July 31, 2007Assignee: Industrial Technology Research InstituteInventors: Fang-Chu Chen, Jing-Ling Tsai
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Patent number: 7250432Abstract: The present invention relates to a pharmaceutical composition for the prevention and the treatment of cancers containing diaryl-isoxazole derivatives as an effective ingredient. Diaryl-isoxazole derivatives of the present invention inhibit metastasis of breast cancer cell lines and angiogenesis, so that they can be produced as a metastasis inhibitor and further as a pharmaceutical composition for the prevention and the treatment of angiogenesis related diseases including cancers, rheumatoid arthritis, psoriasis, or angiogenesis diseases caused in eyeball, etc.Type: GrantFiled: October 20, 2004Date of Patent: July 31, 2007Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Byoung-Mog Kwon, Kwang-Hee Son, Dong-Cho Han, Sang-Ku Lee, Ki-Deok Shin, Sun-Bok Jeon, Jung-Hoon Oh
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Patent number: 7251574Abstract: A bit error rate test on a transceiver is accelerated by adding a phase offset to data phase encoding and decoding in the transceiver and by mapping bit error rate test results from an elevated error rate condition to a normal error rate condition for the transceiver. The elevated error rate is accomplished by adjusting the phase of the phase encoder and decoder with the value of the phase offset so that the encoded data transmission signal is not as robust against noise as it normally would be. Noise in the form of an interference signal is introduced during the transmission, and the bit error rate is measured after the receiver has decoded the signal. The bit error rate (BER) data with an elevated propensity for error is mapped against bit error rate data for normal operations. A mapping function is built to map BERE (bit error rate elevated) data—data from the elevated error rate condition for data encoding, to BERN (normal bit error rate) data—data from the normal error rate condition for data encoding.Type: GrantFiled: March 24, 2006Date of Patent: July 31, 2007Assignee: Georgia Institute of TechnologyInventors: Soumendu Bhattacharya, Rajarajan Senguttuvan, Abhijit Chatterjee
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Patent number: 7250128Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.Type: GrantFiled: April 20, 2005Date of Patent: July 31, 2007Assignee: California Institute of TechnologyInventors: Marc A. Unger, Hou-Pu Chou, Todd A. Thorsen, Axel Scherer, Stephen R. Quake, Jian Liu, Mark L. Adams, Carl L. Hansen
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Patent number: 7250291Abstract: The invention features tumor antigens; tumor antigen-encoding nucleic acids; antibodies specific for tumor antigens and methods of using the antibodies; methods of identifying tumor antigens and the nucleic acids that encode them; methods of monitoring or diagnosing tumors in patients; methods of testing patients for the increased likelihood of developing a tumor; and methods and compositions for treatment of a tumor or prophylaxis against developing a tumor.Type: GrantFiled: August 6, 1999Date of Patent: July 31, 2007Assignee: Dana-Farber Cancer InstituteInventors: Glenn Dranoff, Jan Schmollinger, F. Stephen Hodi, Joseph Mollick
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Patent number: 7250509Abstract: A method for preparing a melamine salt of pentaerypolyol phosphoric acid is provided. The method comprises the following steps of: ball milling a mixture of pentaerypolyol and phosphorus pentoxide (P2O5) under a solvent-free reacting environment to obtain a pentaerypolyol phosphoric acid, and ball milling a mixture of a pentaerypolyol phosphoric acid and melamine without organic solvent reacting environment to obtain a melamine salt of pentaerypolyol phosphoric acid.Type: GrantFiled: May 31, 2006Date of Patent: July 31, 2007Assignee: Chung Shan Institute of Science and TechnologyInventors: Yu-Sheng Lin, Wen-Chiung Su, Chong Ma, Yuen-Hsin Peng
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Patent number: 7250266Abstract: Disclosed is a method of analyzing mass of the phosphoproteins or phosphopeptides and of analyzing phosphorylated positions at a phosphoprotein or phosphopeptide, comprising the steps of: 1) dephosphorylating at least one Ser and/or Thr residue of the phosphoprotein or phosphopeptide; 2) tagging the dephosphorylated amino acid residues with a tag having a R-L-G moiety wherein R is a nucleophilic functional group that selectively bind with dephosphorylated amino acid residues, G is selected from the group consisting of guanidine moiety or protected guanidine moiety such as a mono-N-protected guanidino group, a di-N,N?-protected guanidino group and an N?-protected guanidino group, and L is a linker linking the R and the G; and 3) subjecting the tagged proteins or peptides to mass spectrometry. The method is capable of precisely analyzing mass of phosphoproteins of trace amounts as well as positions of phosphoryated amino acids.Type: GrantFiled: April 21, 2005Date of Patent: July 31, 2007Assignee: Korea Basic Science InstituteInventors: Yeong Hee Ahn, Jong Shin Yoo, Jin Young Kim, Kun Cho
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Patent number: 7250283Abstract: The invention provides isolated nucleic acid molecules, designated PGC-1b and PGC-1c nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.Type: GrantFiled: July 3, 2002Date of Patent: July 31, 2007Assignee: Dana-Farber Cancer InstituteInventors: Bruce M. Spiegelman, Guillaume Adelmant, Pere Puigserver
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Patent number: 7250719Abstract: An organic light emitting diode (OLED) with a brightness enhancer. The OLED comprises a substrate having a first surface and a second surface oppositely. An anode electrode is disposed on the first surface of the substrate. An organic light emitting layer is disposed on the anode electrode. A cathode electrode is disposed on the organic light emitting layer. A brightness enhancer is disposed on the second surface of the substrate.Type: GrantFiled: August 16, 2005Date of Patent: July 31, 2007Assignee: Industrial Technology Research InstituteInventors: Liang-Bin Yu, Tien-Shou Shieh, Hui-Lung Kuo, Mei-Rurng Tseng, Pin-Sien Yu