Abstract: A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state. Nuclear transfer may take place by cell fusion. The reconstituted embryo may then give rise to one or more animals. The invention is useful in the production of transgenic animals as well as non-transgenics of high genetic merit.

Abstract: A method for preparing an arylphosphonite antioxidant of the formula (I) below is disclosed, wherein Ar is First, the reactants 2-phenylphenol and phosphorus trichloride are heated under the existence of a zinc chloride catalyst for producing 6-chloro-6H-dibenz[c,e][1,2]oxaphosphorin (CDOP) of the formula (II) below: Next, the excess phosphorus trichloride is removed. Finally, an organic solution of a di-hydroxylphenol compound of the formula (III), Ar—(OH)2??(III) wherein Ar is defined as the above, is heated with the CDOP of formula (II) to form the product of the formula (I).

Abstract: Provided are high voltage metal oxide semiconductor field effect transistor (HVMOSFET) having a Si/SiGe heterojunction structure and method of manufacturing the same. In this method, a substrate on which a Si layer, a relaxed SiGe epitaxial layer, a SiGe epitaxial layer, and a Si epitaxial layer are stacked or a substrate on which a Si layer having a well region, a SiGe epitaxial layer, and a Si epitaxial layer are stacked is formed. For the device having the heterojunction structure, the number of conduction carriers through a potential well and the mobility of the carriers increase to reduce an on resistance, thus increasing saturation current. Also, an intensity of vertical electric field decreases so that a breakdown voltage can be maintained at a very high level. Further, a reduction in vertical electric field due to the heterojunction structure leads to a gain in transconductance (Gm), with the results that a hot electron effect is inhibited and the reliability of the device is enhanced.

Abstract: The present invention relates to improved antibodies against tumor surface antigens and their use in the treatment of tumors. Of particular interest are highly stable, humanized, high affinity antibodies against carcinoembryonic antigen (CEA), especially the antibody we have termed sm3E, which is derived from the scFv antibody MFE-23. Such antibodies have the potential for improved therapeutic efficacy.

Abstract: Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

Abstract: A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferring activity and N-acetylgalactosamine transferring activity.

Abstract: A symbol synchronization apparatus and method for synchronizing symbol digitally is disclosed. In the present invention, digital symbols are generated by an A/D converting unit. Based on digital symbols, a symbol timing value is calculated. The symbol timing value is used for determining a best symbol timing. According to the best symbol timing, a clock phase is determined and A/D converting unit uses newly determined clock for generating digital symbols. As a result, the present invention can perform an over-sampling process in higher resolution than a sampling frequency by using only one A/D converter. Therefore, the present invention may increase economic efficient and reduce complexity of hardware.

Abstract: The present invention relates to methods for gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, novel nucleic acid constructs and packaging cell lines are disclosed, for use in facilitating the development of high-capacity and targeted vectors. The invention also discloses a variety of high-capacity adenovirus vectors and related compositions and kits including the disclosed cell lines and vectors. Finally, the invention discloses methods of preparing and using the disclosed vectors, cell lines and kits.

Abstract: Provided by the present invention are novel and non-obvious nutrient supplements that preferably comprise minerals, vitamins, amino acids, and agents capable of delivering cysteine in vivo. The nutrient supplements desirably are capable of promoting metallothioneins, and optionally, promoting the removal of excess metals from the bloodstream. Also provided by the invention are methods of treating autism involving administration of the nutrient supplements. The methods include treatment to prevent or slow down the onset of autism once a predisposition for the development of autism has been detected, and treatment to alleviate or reverse the symptoms of autism once autism has been diagnosed. The invention further provides methods of administering the nutrient supplements in the treatment of other diseases, disorders and conditions, that would benefit from such administration, especially those that would benefit from metallothionein promotion and/or removal of excess metals from the bloodstream.

Abstract: The subject invention provides a method for detecting the presence of human malignant cells in a sample of tumor cells, which comprises contacting the sample with an antibody directed to an epitope present on the ? subunit of human luteinizing hormone or on intact human luteinizing hormone under conditions such that the antibody forms a complex with cells present in the sample if the epitope is present on the surface of the cells, and determining whether the antibody forms such a complex. The subject invention also provides a method for determining whether a tumor present in a human subject is malignant which comprises obtaining a sample of cells from the tumor and detecting the presence of malignant cells in the sample according to the method of the subject invention.

Abstract: An optical, multi-channel, Differential Phase Shift Keying (DPSK) receiver demodulates multiple Wavelength Division Multiplexed (WDM) channels using a single interferometer. This distributes expense of the interferometer over all channels of an optical signal, allowing for deployment of cost-effective, scalable, wideband, WDM DPSK systems. For example, for an 80 channel WDM link, the receiver uses a single interferometer instead of eighty interferometers and associated stabilization hardware, dramatically reducing size, weight, power, and cost. The receiver is architecturally compatible with existing interferometer technologies so previous development and qualification efforts can be leveraged. This allows for expedited technology insertion into existing optical communications networks, including terrestrial and space-based optical networks.

Abstract: A method for mapping higher brain function comprises an fMRI mapping step S1 to map a brain function of the subject TP by fMRI, a head portion structural image acquisition step S3 to acquire a head portion structural image IMGs by an MRI system in a state that a headgear HC having a marker is mounted on the head portion of the subject TP, a three-dimensional image combining step S4 to create a three-dimensionally combined image IMGfs by combining the head portion structural image IMGs and the brain functional image IMGf obtained by the fMRI mapping step S1, an optical probe mounting step S5 to specify positions on the headgear HC where optical probes PR1, PR2 are mounted based on the three-dimensionally combined image IMGfs and to mount the optical probes PR1, PR2 at the specified positions and an NIRS measuring step S6 to conduct the NIRS by a NIRS method in a state that the headgear HC loaded with the optical probes PR1, PR2 is mounted on the head portion of the subject TP.

Abstract: Valve structures formed in elastomer material are electrostatically actuated by applying voltage to a flexible, electrically conductive wire pattern. An actuation force generated between the patterned wire structure and an electrode result in closure of a flow channel formed in elastomer material underlying the wire. In one embodiment of a valve structure in accordance with the present invention, the wire structure is patterned by lithography and etching of a copper/polyimide laminate, with an underlying gold plate positioned on the opposite side of the flow channel serving as an electrode. In an alternative embodiment, a first wire structure is patterned by physically cutting out a first pattern of strips from an Aluminum/Mylar(®) laminate sheet. A second patterned wire structure serving as the electrode is formed by the same method, and positioned on the opposite side of a control channel.

Abstract: In an Automatic Repeat reQuest (ARQ) method for recovering ARQ data by a target base station when handover of a mobile terminal is performed from a serving base station to the target base station in a portable Internet system is provided. First ARQ data, which includes a first service data unit (SDU), a first ARQ block sequence number, and a first sub-ARQ block sequence number, that are buffered in the serving base station are received and second ARQ data, which includes a second SDU, are received from the serving base station. The received first SDU is divided into ARQ blocks and is transmitted to the mobile terminal; and the received second SDU is divided into the ARQ blocks and is transmitted to the mobile terminal.

Abstract: A canted-fiber duplex optical subassembly is disclosed herein. The optical subassembly transmits and receives optical signals by way of a single optical fiber, which has a canted surface on one end. A light source sends transmission optical signals, which are refracted through the canted surface and then enter the optical fiber. Reception optical signals in the optical fiber are reflected by the canted surface and are then received by an optical detector.

Abstract: The present invention includes compositions, systems and methods for the early detection and consistent determination of systemic onset juvenile idiopathic arthritis (SoJIA) using microarrays.

Abstract: A hose compressed peristaltic pump is provided. The pump includes a base, a sidewall structure mounted on the base, and forming a containing space therein, a rotor having a center in the space and further having plural integral protrusions, and a hose disposed between the protrusions and the sidewall structure.

Abstract: A microfluidic dielecttrophoresis separating device is provided. The microfluidic dielectrophoresis separating device includes a primary passage, at least a secondary passage and at least an electrode assembly. The primary passage has a primary flow containing a plurality of particulates flowing therein. The secondary passage has an input path and an output path and is connected with the primary passage. The electrode assembly generates a dielectrophoresis force to drive a specific one of the particulates into the output path.

Abstract: A data encoding method for error correction is provided. Before recording data into a recording media, the data are added with an Error Correction Code (ECC) comprising Check Sum on Row (CSR) and Check Sum on Column (CSC), thereby forming an ECC block. More than one ECC block are integrated into a data matrix, to resist longer burst errors of data. Finally, the data matrix is divided into several sectors and individual sector address information is added for each sector, thereby finishing the encoding process.

Abstract: The present invention relates to a method for generating a decision tree using an inference engine in a ubiquitous environment. In the method, a data table for a data event set is generated based on information collected by at least one sensor. Subsequently, a weight value of the data event set is established, and an entropy is calculated based on the established weight value (here, the entropy is a scale for classifying the information collected by the sensor into respective classes). In addition, the decision tree for the collected information is formed based on the calculated entropy.