Abstract: The present invention relates to an immunogenic agent comprising a low dose of an antigenic component from one or more pathogens and an agent capable of increasing an amount of IL-12 in animal, and use thereof for reducing infection or improving recovery from an infection from the pathogen. The immunogenic agent preferably comprises CpG nucleic acid, IL-12 protein and/or IL-12 nucleic acid. The pathogen is preferably an intracellular pathogen comprising one or more species and strains, such as Plasmodium spp. The invention also relates to a pharmaceutical composition comprising the immunogenic agent. The pharmaceutical composition is preferably an immunotherapeutic composition. The immunotherapeutic composition, is preferably a vaccine capable of providing protection against or treating Plasmodium spp infection, the causative agent of malaria in humans.

Abstract: The invention relates to methods of regulating gene expression, e.g., to turn on or off, or up or down gene expression in an organism when and where desired, without the toxic side effects usually associated with other contemporary methods, such as those toxic side effects caused by introducing compounds that do not naturally occur in life.

Abstract: To make it possible to fix various organic molecules in an arbitrary configuration or arrangement on a micro/nano scale as a cheap and simple process by irradiating a photocurable resin containing an organic molecule on a substrate with light, thereby curing the photocurable resin in a given pattern and removing an uncured portion, thereby fixing the organic molecule in the given pattern on the substrate.

Abstract: The present invention relates to a method of processing clinical samples for diagnosing bacterial infections by smear microscopy, culture or PCR as well as a kit for performing the said method. This invention also pertains to two sets of primers specific for the DevR gene of M. tuberculosis as well as to a method of using said primers for screening patients for tuberculosis by PCR.

Abstract: An impact absorber employs dilatant (shear responsive) fluid that is subjected to a controlled, low amplitude, high frequency oscillatory stress which controls the stiffness of the fluid. Piezoelectric transducers, voice coils, and other forms of transducers may be used to apply controlled vibratory stress to the fluid. The energy absorber may be used in protective body armor, medical devices such as splints and casts, vehicle safety absorbers and many other products which benefit from ability to control the stiffness of the energy absorber.

Abstract: Disclosed therein is apparatus and method for in-situ calibration of a vacuum gauge by absolute method and comparison method, which can carry out absolute calibration using a static type standard for measuring pressures of vacuum chambers by expanding and moving gas to the vacuum chambers of different volumes in order and comparison calibration of vacuum gauges in an in-situ state without movement of the vacuum gauges according to a method for controlling gas flow through an orifice using a calibrated standard vacuum gauge. The present invention includes a technology for combining an absolute calibration of a standard vacuum gauge by a static method and a comparative calibration of a vacuum gauge by a method for controlling a gas flow through an orifice, technologies for generating and calibrating standard pressure from a low vacuum to a high vacuum, and a technology of comparative calibration of the vacuum gauge by a method for stabilizing the gas flow through the orifice.

Abstract: Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N3, NH2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting of hydrogen, halo, hydroxy, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, thioaryl, thioalkyl, allylamino, cyano and nitro; tautomers thereof; and pharmaceutically acceptable salts thereof are provided along with methods for their fabrication. Various of these compounds can be used as anticancer agents, or antiviral agents or to inhibit DNA replication.

Abstract: An apparatus for removing ozone. The apparatus includes a reaction tank containing a ferrous (Fe2+) solution to be oxidized to ferric ions (Fe3+) by ozone and a reduction device for reducing the ferric ions (Fe3+) to ferrous ions (Fe2+) supplied for continuous use in the reaction tank. The invention also provides a method for removing ozone.

Abstract: The present invention provides for a monitoring system and method to monitor an analyte, including determining the presence of the analyte and analyzing the analyte; for example, cellular chorography and biological threats. The system and method use a fluidics apparatus (e.g., a flow cytometer), a computer, a probe synthesizer and/or an initial set of fluorophore conjugated probes to monitor the analyte. The fluidics apparatus is adapted to determine the presence of the analyte based on the intrinsic fluorescence of the analyte, and/or to determine the binding of the probes to the analyte in the sample. The binding information is analyzed by the computer by comparing the binding results with a database of information regarding the analyte. The information gained allows the probe synthesizer to synthesize new probes for a subsequent iteration of the process, wherein additional information regarding the analyte is gained with every iteration.

Abstract: An optical sensor is characterized by comprising a photoconductive material (1) which generates a carrier (4) inside when irradiated with a light or an electromagnetic wave (3), and carbon nanotube (2), and by sensing the carrier (4), which is generated within the photoconductive material (1) by irradiation of the light or electromagnetic wave (3), through change of electrical conduction of the carbon nanotube (2).

Abstract: The present invention provides a reflective liquid crystal display assembly, which includes a first substrate, a second substrate and a liquid crystal layer sealed between them. The present invention designs a specific surface structure of at least one of the first and second substrates relative to the liquid crystal layer so that the helical axes of the cholesteric liquid crystal molecules can incline in different directions as desired in the liquid crystal layer. The reflective spectrum can be broadened and the viewing angle is widened.

Abstract: The invention provides a green fluorescent substance being higher in luminance of green than a conventional rare-earth activated sialon fluorescent substance and more excellent in durability than a conventional oxide fluorescent substance. The inventors have succeeded in acquiring a fluorescent substance which is obtained by solid-dissolving Eu into a nitride or oxy-nitride crystal having a ?-type Si3N4 crystal structure and emits a fluorescent light having a peak within a range of 500 nm to 600 nm in wavelength by being irradiated with an excitation source.

Abstract: Compounds of formula (IA) or (IB) or salts, N-oxides. hydrates or solvates thereof are Inhibitors of HSP90, and useful in the treatment of, for example, cancer: formula (IA), formula (IB) wherein Ar is an aryl or heteroaryl radical which is linked via a ring carbon, and which is substituted by a hydroxy group on a carbon in the 2-position, and which is otherwise either unsubstituted or optionally substituted; R1 is hydrogen or optionally substituted C1-C6 alkyl; R2 is hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C1-C6 alkyl, C1-C6alkenyl, or C1-C6 alkynyl; or a carboxyl, carboxamide or carboxyl ester group; and R3 is a carboxamide group.

Abstract: An intersection ontology may comprise a root node, representing an entire data set, and a second “layer” of nodes, groups of which may be used to represent different types of classifications of the data set. The intersection ontology may then contain one or more layers of nodes that may be represented by intersections of two or more of the second-layer nodes, as may be needed according to a desired application (that is, the intersections may be formed, essentially, on demand). There may be a single layer of intersection nodes, or there may be multiple layers of intersection nodes. In a multiple layer embodiment, each intersection node may be represented as an intersection of second-layer nodes and/or intersection nodes.

Abstract: A memory device is provided. The device comprises a sense amplifier having a cell input terminal and a reference input terminal, a first sub-array coupled to the cell input terminal through a first switch and coupled to the reference input terminal through a second switch, a second sub-array coupled to the cell input terminal through a third switch and coupled to the reference input terminal through a fourth switch, and a reference cell array coupled between the second switch and the fourth switch and coupled to the reference input terminal.

Abstract: Ceramic materials that are highly resistant to strong acids such as concentrated sulfuric acid and halides such as hydrogen iodide are employed to make block elements through which a large number of circular ingress channels extend in perpendicular directions and which are joined and piled in the heat exchanging medium section to provide a compact heat exchanger that excels not only in corrosion resistance but also in high-temperature strength.

Abstract: This invention aims to develop a chitin oligomer composition and/or a chitosan oligomer composition wherein the content of an oligomer from a trimer to a decamer is 60% or more, and to develop a process for preparing the above-mentioned oligomer composition. The object of the invention can be achieved by mixing hydrofluoric acid or hydrohalogenated acid other than hydrofluoric acid and hydrofluoric acid with a chitin-based material and/or a chitosan-based material.

Abstract: A method for inducing in a cell a resistance to an anti-microtubule agent comprising the step of providing in a cell, a nucleic acid molecule that encodes a mutant actin, or providing in a cell, a mutant actin.

Abstract: A collaborative client-server system having performance reliability improvement (PRIM) includes collaboration techniques for sharing server data among two or more servers, each server coupled to one or more client computers. A communication link between a client computer and a server is handed off to another respective one of the two or more servers under a variety of conditions. Hand off conditions include, congestion of the server processing load, congestion of the communication link between the client computer and the server, and loss of data signal integrity between the client computer and the server.

Abstract: A method of transforming a carbon single wall nanotube (SWNT) is provided. The method comprises exposing the SWNT to light having a power sufficient to ignite or reconstruct the SWNT such that the SWNT is ignited or reconstructed by the exposure to the light.