Patents Assigned to INSTITUTE
  • Publication number: 20060185577
    Abstract: A highly pure hexagonal boron nitride single crystal not influenced by impurities and capable of high-luminance short wave ultraviolet light emission reflecting inherent characteristics is provided; a high-luminance ultraviolet light emitting element is provided by using the above single crystal; and utilizing the above element, a simple compact low-cost long-lived far ultraviolet solid-state laser and far ultraviolet solid-state light emitting apparatus are provided. A highly pure hexagonal boron nitride single crystal having a single light emission peak in the far ultraviolet region of up to a wavelength of 235 nm is produced by melting said boron nitride crystal as raw material in the presence of a highly pure solvent under high-temperature and high-pressure, followed by crystallization. A light emitting element or a light emitting layer comprised of the obtained crystal is excited with electron beams, and the thus generated far ultraviolet light resonated or without resonation is taken out.
    Type: Application
    Filed: November 17, 2004
    Publication date: August 24, 2006
    Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
    Inventors: Kenji Watanabe, Takashi Taniguchi, Satoshi Koizumi, Hisao Kanda, Masayuki Katagiri, Takatoshi Yamada, Nesladek Milos
  • Publication number: 20060189793
    Abstract: The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptdes. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.
    Type: Application
    Filed: April 27, 2006
    Publication date: August 24, 2006
    Applicant: Serono Genetics Institute S.A.
    Inventors: Frances Yen, Blake Denison, Aymeric Duclert, Lydie Bougueleret, Catherine Clusel, Jean-Baptiste Dumas Milne-Edwards, Bernard Bihain, Barbara Bour, Dana Ebbets-Reed, Luisa Salter-Cid
  • Publication number: 20060188869
    Abstract: A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 seconds or less and one or more components with a wavelength of between about 150 nm to about 300 nm. The light pulse may be arranged so as to minimize or eliminate any detrimental effect on the functioning of the subject, e.g., on a living cell. A concentration, mass, quantum yield, absorbance or other characteristics of one or more compounds in the subject may be determined based on one or more 2-dimensional images obtained of the subject. An illumination beam having left and right circularly polarized components may be generated, e.g., for circular dichroism analysis of a subject.
    Type: Application
    Filed: January 13, 2006
    Publication date: August 24, 2006
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Benjamin Zeskind, Paul Matsudaira, Daniel Ehrlich
  • Publication number: 20060188928
    Abstract: The RecQ4 helicase gene, belonging to the RecQ helicase gene family, is revealed herein to be the causative gene of Rothmund-Thomson syndrome. The present inventors found out that it is possible to diagnose Rothmund-Thomson syndrome by detecting mutation of this gene. Further, they uncovered that it is possible to treat patients of Rothmund-Thomson syndrome by utilizing normal RecQ4 helicase gene or proteins thereof.
    Type: Application
    Filed: May 2, 2006
    Publication date: August 24, 2006
    Applicant: Agene Research Institute Co., Ltd.
    Inventors: Saori Kitao, Akira Shimamoto, Yasuhiro Furuichi
  • Publication number: 20060189830
    Abstract: Nonmetallic, chiral organic catalysts are used to catalyze enantioselective fluorination of enolizable aldehydes. Reaction systems composed of an enolizable aldehyde, an electrophilic fluorination reagent, and a nonmetallic chiral catalyst in the form of an imidazolidinone salt are also provided.
    Type: Application
    Filed: January 18, 2006
    Publication date: August 24, 2006
    Applicant: California Institute of Technology
    Inventors: David MacMillan, Teresa Beeson
  • Patent number: 7095050
    Abstract: Monolithic, tandem, photonic cells include at least a first semiconductor layer and a second semiconductor layer, wherein each semiconductor layer includes an n-type region, a p-type region, and a given band-gap energy. Formed within each semiconductor layer is a sting of electrically connected photonic sub-cells. By carefully selecting the numbers of photonic sub-cells in the first and second layer photonic sub-cell string(s), and by carefully selecting the manner in which the sub-cells in a first and second layer photonic sub-cell string(s) are electrically connected, each of the first and second layer sub-cell strings may be made to achieve one or more substantially identical electrical characteristics.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: August 22, 2006
    Assignee: Midwest Research Institute
    Inventors: Mark W. Wanlass, Angelo Mascarenhas
  • Patent number: 7095143
    Abstract: A device and method for ferrofluid power generator and cooling system, wherein the waste heat of electronic device is used as a heat source to vaporize fluid and form bubbles as a forwarding pump of the ferrofluid. The fluid with magnetic nano particles is pumped forward and rotated by a fluid mechanism, then passes through a high density coil to result in the time varying magnetic flux and induced current. No additional heat-dissipating device is needed for this invention to dispose the waste heat, which requires the waste heat to produce electricity, which provides cooling and saves power.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: August 22, 2006
    Assignee: Industrial Technology Research Institute
    Inventor: Li-Chieh Hsu
  • Patent number: 7094410
    Abstract: A DNA vaccine effective for inhibiting endothelial cell proliferation comprises a DNA construct operably encoding a vascular endothelial growth factor (VEGF) receptor protein. This invention provides DNA vaccines that encode VEGF receptor-2 (KDR, SEQ ID NO: 2), VEGF receptor-1 (Flt-1, (SEQ ID NO: 4), or Flk-1 (the murine homolog of KDR, SEQ ID NO: 6), DNA sequences SEQ ID NOS: 1, 3, and 5 respectively, as well as methods of using such a DNA vaccine to inhibit vascular endothelial cell proliferation in the tumor micro-environment. Anti-angiogenesis and subsequent decrease in tumor growth and dissemination is achieved.
    Type: Grant
    Filed: March 2, 2002
    Date of Patent: August 22, 2006
    Assignee: The Scripps Research Institute
    Inventors: Ralph A. Reisfeld, Andreas G. Niethammer, Rong Xiang
  • Patent number: 7096288
    Abstract: A reconfigurable radio processor comprises a task interface and an execution kernel. The processor can be applied to a platform comprising a main processor and on-chip bus, and uses a task-based interface between the main processor and the radio processor. The radio processor simplifies the designs for control system, instruction set and data path. The bus interface includes a task dispatcher. The execution kernel comprises a global control unit, at least one function unit, an operation network, and a data network. The radio processor meets the reconfigurable and scalable requirements. It allows system designers to realize many applications on an IC chip, as well as increases the add-on values for the product. It provides system designers with the possibility of replacing another main processor under a special consideration.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: August 22, 2006
    Assignee: Industrial Technology Research Institute
    Inventors: I-Tao Liao, Tse-Hao Lee, Chung-Chieh Kang, Chia-Hung Shih, Chih-Wei Liu
  • Patent number: 7094675
    Abstract: A method for producing quantum dots. The method includes cleaning an oxide substrate and separately cleaning a metal source. The substrate is then heated and exposed to the source in an oxygen environment. This causes metal oxide quantum dots to form on the surface of the substrate.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: August 22, 2006
    Assignee: Battelle Memorial Institute
    Inventors: Yong Liang, John L. Daschbach, Yali Su, Scott A. Chambers
  • Patent number: 7094402
    Abstract: Polynucleotides encoding the human IL-11 receptor and fragments thereof are disclosed. IL-11 receptor proteins, methods for their production, antibodies to human IL-11 receptor, inhibitors of binding of human IL-11 and its receptor and methods for identification of their receptor are also disclosed.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: August 22, 2006
    Assignee: Genetics Institute, LLC
    Inventor: James Tobin
  • Patent number: 7094570
    Abstract: The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules encoding the proteins, and uses of the protein, are also described.
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: August 22, 2006
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Jean-Christophe Renauld, Laura Dumoutier
  • Patent number: 7095256
    Abstract: An envelope detector system is disclosed for detecting an envelope in a system input signal. The envelope detector system includes an input node for receiving an input voltage signal, a transconducting amplifier for receiving the input voltage signal and producing an input current signal, a current mirror network for receiving the input current signal and for producing a current output signal, a capacitor for receiving the current output signal, and a rectifier output node for providing a rectifier output current signal. The capacitor is coupled to an input of the transconducting amplifier. The rectifier output current signal is fed into the current-mode wide-dynamic-range peak detector. The peak detector produces the envelope detector output current signal.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: August 22, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Serhii M. Zhak, Michael W. Baker, Rahul Sarpeshkar
  • Patent number: 7094908
    Abstract: A compound represented by a general formula (Ia) or (Ib) and a stereo-selective preparation method thereof using a carbonyl reductase which is separated from Kluyveromyces marxianus. The compound can be prepared by reduction of substituted ?-keto ester and can be used as an intermediate in preparing ?-lactam group antibiotics.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: August 22, 2006
    Assignee: Korea Institute of Science and Technology
    Inventors: Hun Yeong Koh, Kyung Il Choi, Yong Seo Cho, Ae Nim Pae, Joo Hwan Cha, Ye Sun Han, Jong Soo Lee, Hong Chul Yun
  • Patent number: 7095029
    Abstract: A neutron detecting scintillator that has a very short decay time, that can capture neutrons in high efficiency and that is composed of light elements comprises the Li2B4O7 single crystal or the 6Li and 11B or 10B enriched 6Li211B4O7 or 6Li210B4O7 single crystal, in which 6Li and 11B or 10B have large neutron capture cross sections and fluorescence that is emitted from an ionizing radiation generated through their neutron capture reaction has a short-lived component not longer than 10 ns.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: August 22, 2006
    Assignee: Japan Atomic Energy Research Institute
    Inventor: Masaki Katagiri
  • Patent number: 7095935
    Abstract: The present invention provides a method for forming an optical waveguide characterized by applying a paste containing a copper compound to a glass substrate containing an alkali metal as a glass component over the whole surface thereof or in a patterned form, and performing heat treatment at a temperature lower than the softening temperature of the glass substrate. The method of the invention can produce an optical waveguide without the need for a high vacuum as in the thin film deposition method and without the use of a molten salt, and is capable of dispersing Cu+ ions selectively in a glass substrate with excellent controllability.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: August 22, 2006
    Assignees: Isuzu Glass Co., Ltd., National Institute of Advanced Industrial Science and Technology
    Inventors: Tatsuya Suetsugu, Kohei Kadono, Norimasa Kominami, Takeshi Ohtani, Hiroaki Yokoi, Minoru Takada, Takashi Tarumi, Toshihiko Einishi, Tetsuo Yazawa
  • Patent number: 7094876
    Abstract: The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for screening compounds that may be used in the treatment of GENSET-related disorders.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: August 22, 2006
    Assignee: Serono Genetics Institute SA
    Inventors: Stephane Bejanin, Hiroaki Tanaka
  • Patent number: 7095010
    Abstract: A microsensor for sensing a substance comprises a substrate, a source of light, an optical microresonator or semiconductor optical ring microresonator fabricated in the substrate exposed to the substance to allow an interaction between the microresonator and substance, a waveguide coupling the source of light to the optical microresonator, and a detector coupled to the microresonator to measure the resonant frequency of the microresonator, the absorption loss of whispering gallery modes in the microresonator or the quality factor of the microresonator, which are sensitive to interaction of the substance with the optical microresonator. A polymer coating disposed on the microresonator is reactive with the substance. The microsensor may comprise a plurality of microresonators corresponding to a plurality of different resonant frequencies to generate an absorption spectrum of the substance.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: August 22, 2006
    Assignee: California Institute of Technology
    Inventors: Axel Scherer, Alex Dickinson
  • Patent number: 7094208
    Abstract: A spirometer for measuring fluid flow, particularly associated with exhalation of respiratory patients. The spirometer of this invention preferably has a fluidic oscillator wherein the fluid oscillates within a chamber of the fluidic oscillator. An oscillation frequency of the fluid flow within the chamber is correlated to a flow rate. A computer is used to process input data, such as data representing frequency of the oscillatory flow within the chamber, to a flow rate passing through the spirometer. The spirometer of this invention may have no moving parts, which results in the need for only a design calibration and no periodic calibrations throughout use of the spirometer.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: August 22, 2006
    Assignee: Illinois Institute of Technology
    Inventors: David R. Williams, Nicole April Wilson, Kevin Philip Meade, Hansen A. Mansy
  • Patent number: 7094260
    Abstract: A biodegradable common bile duct stent and the method for preparing thereof are provided. The stent is made of biodegradable polymeric material with incorporation of X-ray opaque components. The stent adapts to the anatomical shape of the CBD or it can be sutured together with the wall of the bile duct. After placing the stent in the duct, it maintains its position and does not slip. The circular tube of the stent being suitably sized and having multiple ring-shaped protruding rims at the outer wall and/or with larynx structure, leakage and outflow of the bile are thereby prevented. It can be manufactured by a conventional injection-molding or an extrusion-blowing technique. In surgical operation on the bile duct, the stent can replace the T-tube which is conventionally used to support the duct and guide bile drainage.
    Type: Grant
    Filed: April 12, 2004
    Date of Patent: August 22, 2006
    Assignees: Changhun Institute of Applied Chemistry Chinese Academy of Science, First Hospital, Jinlin University
    Inventors: Xiabin Jing, Tongjun Liu, Xuesi Chen, Shaohui Liu, Xiaoyi Xu, Xinchao Bian, Youzhu Li, Kai Zhang