Patents Assigned to INSTITUTE
  • Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment
    Patent number: 7094555
    Abstract: The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: August 22, 2006
    Assignee: Benaroya Research Institute at Virginia Mason
    Inventors: William W. Kwok, Gerald Nepom, John Gebe, Helena Reijonen, Andrew Liu
  • Method for fabricating Bi thin film and device using the same
    Patent number: 7095070
    Abstract: In a method for fabricating a Bi thin film having a great MR (magnetoresistance) at room temperature and a method for fabricating a spintronics device using the same, the Bi thin film is fabricated by an electrodepostiting method and a sputtering method and has very great MR characteristics at room temperature, and it can be applied to various spintronics devices.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: August 22, 2006
    Assignee: Korea Institute of Science and Technology
    Inventors: Woo Young Lee, Kyung Ho Shin, Suk Hee Han, Joon Yeon Chang, Hi Jung Kim, Dal Young Kim, Kwan Hyi Lee, Kyoung Il Lee, Min Hong Jeun
  • Method of observing sea ice
    Patent number: 7095359
    Abstract: An ice thickness/drifting velocity observation of sea ice by using an ice thickness measurement sonar and a current meter moored into the sea and a sea ice observation by a high-resolution airborne SAR are synchronously performed, a correlation between a draft profile of sea ice passing over the sonar and an SAR backscattering coefficient profile is calculated, and an ice draft of desired sea ice is calculated from the relational expression and an SAR backscattering coefficient. As the SAR backscattering coefficient, a backscattering coefficient of L-band HV polarization may be used. A backscattering coefficient of X-band VV polarization is preferably used as the SAR backscattering coefficient to detect thin ice having a thickness of not more than approximately 10 cm.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: August 22, 2006
    Assignees: National Institute of Informantion and Communications Technology, Incorporated Administrative Agency, Japan Aerospace Exploration Agency, Agency of Industrial Science and Technology
    Inventors: Takeshi Matsuoka, Seiho Uratsuka, Makoto Satake, Tatsuharu Kobayashi, Akitsugu Nadai, Toshihiko Umehara, Hideo Maeno, Hiroyuki Wakabayashi, Yasushi Fukamachi, Fumihiko Nishio
  • Semiconductor laser and method for manufacturing the same
    Patent number: 7095057
    Abstract: Provided is a semiconductor laser including a substrate etched into a mesa structure, an active layer, clad layers, a current blocking layer, an etch-stop, an ohmic contact layer, and electrodes, and a method for manufacturing the same, whereby it is possible to improve a ratio of light output to input current by blocking a leakage current flowing outside an active waveguide in a BH laser.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: August 22, 2006
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Jung Ho Song, Chul Wook Lee, Ki Soo Kim, Yong Soon Baek
  • Antibodies specific for ungulate PrP
    Patent number: 7094553
    Abstract: The present invention provides antibodies that specifically bind with a high degree of binding affinity to a native ungulate PrPC and/or a denatured ungulate PrPSc, but not to a native ungulate PrPSc. Preferred antibodies find native bovine PrPC and treated PrPSc but not native bovine PrPSc and can be used in an assay to determine if a sample is infected with infectious prions, i.e. PrPSc.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: August 22, 2006
    Assignees: The Regents of the University of California, The Scripps Research Institute
    Inventors: Stanley B. Prusiner, Jiri G. Safar, R. Anthony Williamson, Dennis R. Burton
  • Frequency auto-correction apparatus for CDMA multipath fading channel
    Patent number: 7095993
    Abstract: An automatic frequency correction (AFC) apparatus used for CDMA multipath fading channels comprises a frequency-offset evaluator, an automatic frequency correction loop filter and a carrier frequency adjuster. The present invention provides a “multipath energy window” designing method for the non-determinacy of multipath signals in mobile communication environment. Frequency-offset information can be extracted from the multipath energy window by a simple calculation and evaluated by a maximal SNR weight process. This invention also provides a step-variable accumulation adjusting method and greatly improves the response speed of the AFC apparatus as compared with a conventional loop filter, whereby supplies better AFC required for CDMA mobile terminals.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: August 22, 2006
    Assignee: The MITT Research Institute of Telecommunication Transmission
    Inventors: Xiaohu You, Yan Zhang, Ling Wang, Liangcheng Jiang, Shixin Cheng
  • System and method for determining use of STTD encoding of base system
    Patent number: 7095727
    Abstract: A system in an asynchronous mobile communications system and located in a mobile station for determining use of space-time block-coding-based transmit diversity encoding in a base station including transmission antennas, comprises: a cell search unit for detecting frame timing information and scrambling codes of the base station from signals output from the base station; a descrambling unit for descrambling the signals output from the base station using the frame timing information and the scrambling codes; an accumulation processor for despreading the descrambled signals; a depatternization unit for depatternizing the despread signals using pilot symbol patterns corresponding to the two transmission antennas; and an accumulator bank unit for performing accumulation and addition processes of the depatternized signals to output signals corresponding to the transmission antennas.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: August 22, 2006
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Young-Hoon Kim, Kyung Yeol Sohn, KyungHi Chang
  • Method of generating area light source by scanning, scanning area light source and laser projection television using the same
    Patent number: 7095541
    Abstract: A method of generating an area light source by scanning, an area light source and a laser projection television using the same. The method comprising the steps of illuminating a light beam onto a rotating polygon mirror rotating at a high speed on which each plane mirror has a predetermining slope angle with respect to it own rotating axis, and generating a 2-D scanning area. The invention provides a scanning area light source having uniform brightness, non-interference and high efficiency by uniform illumination of the spatial light modulator in a video display. Its scanning characteristics are that each of scanning points can cover many pixels, and that the adjacent scanning lines overlap a relatively large part to ensure uniform luminance of the scanning plane.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: August 22, 2006
    Assignee: Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science
    Inventor: Weiqi Liu
  • High-resolution 3D ultrasonic transmission imaging
    Patent number: 7094205
    Abstract: A system for providing high resolution imaging of objects having sub-millimeter dimensions comprised of at least one transmitter, at least one receiver, a coupling chamber, and a processor for recording attenuation and time of flight profiles of the transmitted signals. The signals are conditioned in a manner to provide high signal-to-noise ration (SNR) and minimal crosstalk and multipath effects at the receiver.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: August 22, 2006
    Assignee: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California
    Inventor: Vasilis Z. Marmarelis
  • Covalently fixed porphyrin polymer having porphyrin metal complex substituted with coordinating hetero aromatic ring as constituting unit thereof,and method of producing the same
    Patent number: 7094866
    Abstract: A covalently linked linear porphyrin polymer represented by formula (1): wherein R represents an alkyl group or ?(wherein a, b and d independently represent H, an alkyl group or aryl group); X represents —O—, —S—, >NR101 (wherein R101 represents H or an alkyl group), —CH2— or a single bond; Y represents ?O, ?S, or 2H; m represents an integer of 0 to 4; n represents an integer of 0 to 6; Z represents a five- or six-membered, nitrogen-containing, coordinating hetero aromatic ring group; M represents an ion of metal selected from typical metals and transition metals; Q1 represents a single bond or a linear, divalent linking group; and p1 represents an integer of 2 or more.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: August 22, 2006
    Assignee: Nara Institute of Science and Technology
    Inventors: Yoshiaki Kobuke, Akiharu Satake
  • Method of forming poly-silicon thin film transistors
    Patent number: 7094656
    Abstract: A method of forming poly-silicon thin film transistors is described. An amorphous silicon thin film transistor is formed on a substrate, and then the Infrared (IR) heating process is used. A gate metal and source/drain metal are heated rapidly, and conduct heat energy to an amorphous silicon layer. Next, crystallization occurs in the amorphous silicon layer to form poly-silicon. Therefore a poly-silicon thin film transistor is produced.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: August 22, 2006
    Assignee: Industrial Technology Research Institute
    Inventors: Chi-Lin Chen, Shun-Fa Huang, Liang-Tang Wang
  • System and method for object state persistence
    Patent number: 7096419
    Abstract: A computer-implemented method and system for persisting public and private object state data created within an object development environment. A node tree is generated whose nodes store the public and private object state data. The nodes of the node tree are used to generate nodes in an XML tree such that the nodes in the XML tree correspond to an XML tag structure. XML tags are generated based upon the nodes in the XML tree and are structured so as to persist the public and private object state data.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: August 22, 2006
    Assignee: SAS Institute Inc.
    Inventors: Christine Michelle Barnes, Charles Richard Main
  • Method for measuring lanthanide content dissolved in uranium oxide
    Patent number: 7094608
    Abstract: The present invention relates to a method for measuring the content of Lanthanides dissolved in uranium oxide, wherein the Lanthanides content in the nuclear fuel pellet is measured using the thermo gravimetric analysis which measures the weight variation caused by the oxidation and heat treatment of the nuclear fuel pellet. This method provides an advantage in that the Lanthanide content can be measured using relatively simple equipments such as an electric furnace and a balance.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: August 22, 2006
    Assignees: Korea Atomic Energy Research Institute, Korea Hydro & Nuclear Power Co., Ltd.
    Inventors: Keon-Sik Kim, Jae-Ho Yang, Kun-Woo Song, Ki-Won Kang, Youn-Ho Jung
  • Glial mitogenic factors, their preparation and use
    Patent number: 7094749
    Abstract: Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells.
    Type: Grant
    Filed: October 22, 1996
    Date of Patent: August 22, 2006
    Assignees: Acorda Therapeutics, Inc., Ludwig Institute for Cancer Research
    Inventors: Andrew Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchioni, Mario Su Chen, Ian Hiles
  • Synthesis of 7-membered carbocyclic compound having diexomethylene groups
    Patent number: 7094913
    Abstract: The present invention relates to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 7-membered carbocyclic compound is a useful intermediate for synthesis of other multicyclic compounds. In Chemical Formula 1, R1 is a C1 to C6 alkyl group, and R2 and R3 is respectively a hydrogen atom, or R1, R2 and R3 may be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: August 22, 2006
    Assignee: Korea Institute of Science and Technology
    Inventors: Yong Seo Cho, Moon Ho Chang, Hun Yeong Koh, Ae Nim Pae, Hyun Jung Kang
  • Resin blends and methods for making same
    Patent number: 7094360
    Abstract: A resin blend and method of producing the resin blend, the resin blend comprising one or more first liquid crystal monomer at a ratio to one or more secondary monomer, said secondary monomer and said ratio being adapted to maintain said resin blend in a nematic liquid crystalline state after addition of an inorganic filler at a temperature of 20° C. for about 30 minutes or more, the resin blend having a polymerization shrinkage of 3 vol. % or less.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: August 22, 2006
    Assignee: Southwest Research Institute
    Inventors: Stephen T. Wellinghoff, Douglas P. Hanson
  • Internal biochemical sensing device
    Patent number: 7096053
    Abstract: A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of time. The biosensing element is connected to an optical fiber terminating outside of the body. The optical fiber is also connected to an information analyzer. The information analyzer directs light through the optical fiber into the biosensing element. The light excites fluorophores, created by a chemical reaction between analytes and biosensing material within the biosensing element. Emitted fluorescent light is redirected through the optical fiber to the information analyzer. Optical gratings within the filtering member of the information analyzer selectively deflect fluorescent emissions into a cladding layer.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: August 22, 2006
    Assignee: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California
    Inventors: Gerald E. Loeb, Thomas George
  • Multiple degree of freedom compliant mechanism
    Patent number: 7093827
    Abstract: A compliant mechanism is provided for accurate and precision alignment of mechanical component parts, surfaces or assemblies and the like, where low-cost, accurate, and repeatable alignment are desired. The compliant mechanism may be used in applications that require high precision alignment and where the relative location of coupled components must be variable or adjustable. The compliant mechanism includes a stage coupled to a plurality of hinges, at least one tab coupled to one of the hinges, and a support coupled to the tab. The relative position of the stage and the support may be adjusted by actuating (i.e., displacing) the tab(s) or other parts of the structure, to enable controlled movement in six degrees of freedom therebetween.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: August 22, 2006
    Assignee: Massachusetts Institute of Technology
    Inventor: Martin L. Culpepper
  • Optoelectronic device having dual-structural nano dot and method for manufacturing the same
    Patent number: 7094617
    Abstract: An optoelectronic device and a method of manufacturing the same which the optoelectronic effect such as light emission or light reception can be increased by forming a dual-structural nano dot to enhance the confinement density of electrons and holes are provided. The optoelectronic device comprises an electron injection layer, a nano dot, and a hole injection layer. The nano dot has a dual structure composed of an external nano dot and an internal dot. The method of manufacturing the optoelectronic device comprises the steps of forming an electron injection layer on a semiconductor substrate; growing nano dot layer on the electron injection layer by an epi-growth method; heating the nano dot layer so that the nano dot has a dual structure composed of an external nano dot and an internal nano dot; and forming a hole injection layer on the overall structure.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: August 22, 2006
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Kyu Hwan Shim, Young Joo Song, Sang Hoon Kim, Jin Yeong Kang
  • Methods for detecting rare polymorphic variants in genomic DNA sequences
    Patent number: 7094543
    Abstract: Methods for detecting low frequency nuclear mutations in a target sequence from a genomic DNA sequence are disclosed.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: August 22, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Xiao-Cheng Li-Sucholeiki, Elena Viktorovna Gostjeva, William G. Thilly