Abstract: Provided is a polynucleotide, including a cis-regulatory element and a nucleotide sequence encoding a vestigial like 4 protein, wherein the cis-regulatory element includes an uncoupling protein 1 enhancer and an uncoupling protein 1 promoter. Also provided is a viral vector including said polynucleotide. Also provided is a method of transfecting a cell or a subject with said polynucleotide or said viral vector.
Abstract: The present specification relates to a connecting material for a solid oxide fuel cell, comprising a conductive substrate; and a ceramic protective film provided on one surface of the conductive substrate, in which the ceramic protective film comprises an oxide represented by Formula 1, a manufacturing method thereof, and a solid oxide fuel cell comprising the same.
Type:
Application
Filed:
June 20, 2019
Publication date:
January 14, 2021
Applicants:
LG CHEM, LTD., DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Hunhyeong LEE, Sanghyeok IM, Doyeon JEON, Kang Taek LEE, Kwangwook CHOI, Tai Min NOH, Dong Woo JOH, Imdadullah THAHEEM
Abstract: A method for certified control of a self-driving ego vehicle is described. The method includes analyzing a safety situation of the self-driving ego vehicle to determine a proposed vehicle control action using a main controller of the self-driving ego vehicle. The method also includes presenting, by the main controller, the proposed vehicle control action to an interlock controller, including a certificate of the proposed vehicle control action. The method further includes checking a safety certification evidence from the certificate by the interlock controller using a predefined safety argument to verify the safety certification evidence of the certificate. The method also includes directing, by a low-level controller, the self-driving ego vehicle to perform a certified vehicle control action.
Type:
Application
Filed:
November 26, 2019
Publication date:
January 14, 2021
Applicants:
TOYOTA RESEARCH INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors:
Daniel JACKSON, Jonathan DECASTRO, Soon Ho KONG, Nikos ARECHIGA GONZALEZ, Dimitrios KOUTENTAKIS, Feng Ping Angela LEONG, Mike Meichang WANG, Xin ZHANG
Abstract: The disclosure provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.
Type:
Application
Filed:
May 13, 2020
Publication date:
January 14, 2021
Applicants:
THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors:
Feng Zhang, Jonathan Gootenberg, David Benjamin Turitz Cox, Omar Abudayyeh, Soumya Kannan
Abstract: The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.
Type:
Application
Filed:
October 4, 2018
Publication date:
January 14, 2021
Applicants:
THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors:
Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh
Abstract: The present invention is related to a separator of a microbial fuel cell comprising: a porous supporting material and a C hydrogel, wherein the hydrogel is introduced in pores of the porous supporting material.
Type:
Application
Filed:
February 14, 2019
Publication date:
January 14, 2021
Applicant:
OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
Inventors:
Viacheslav FEDOROVICH, Georgy FILONENKO, Igor GORYANIN, Geoffrey Kellogg SCHAFFER-HARRIS, David James Wilpault SIMPSON, Peter BABIAK
Abstract: An automated classification apparatus includes a 3D (three dimensional) Inception-Resnet block structure, a global average pooling structure and a fully connected layer. The 3D Inception-Resnet block structure includes a 3D Inception-Resnet structure configured to receive 3D medical image of a patient's shoulder and extract features from the 3D medical image and 3D Inception-Downsampling structure configured to downsample information of a feature map including the features. The global average pooling structure is configured to operate an average pooling for an output of the 3D Inception-Resnet block structure. The fully connected layer is disposed after the 3D global average pooling structure. The automated classification apparatus is configured to automatically classify the 3D medical image into a plurality of categories.
Type:
Application
Filed:
July 8, 2020
Publication date:
January 14, 2021
Applicant:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Youngjun KIM, Eungjune SHIM, Laehyun KIM
Abstract: A quantum simulator includes a pseudo speckle pattern generator, a main vacuum chamber, an atomic gas supply unit, a light beam generator, a photodetector, and an atom number detector. The pseudo speckle pattern generator generates a pseudo speckle pattern in the inside of the main vacuum chamber by light allowed to enter the inside of the main vacuum chamber through the second window. The pseudo speckle pattern generator includes a controller, a light source, a beam expander, a spatial light modulator, and a lens. The controller sets a modulation distribution of the spatial light modulator based on a two-dimensional pseudo random number pattern.
Type:
Application
Filed:
September 23, 2020
Publication date:
January 14, 2021
Applicants:
HAMAMATSU PHOTONICS K.K., INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES
Abstract: The present invention discloses a method of tracking control for a foot force and moment of a biped robot. According to the method, a double-spring damping model is designed, and a force tracking controller is designed by using an LQR optimization method, so as to realize tracking of the foot force and moment of the biped robot. Further, a desired force on a foot and a desired moment on the foot are calculated through a planned ZMP distribution method, thereby eventually achieving better ZMP tracking of the biped robot and adapting to ground of certain unevenness.
Abstract: A urolithiasis removing device according to one embodiment can comprise: an insertion tube; a guide which is inserted into the insertion tube and which is relatively movable with respect to the insertion tube; a wire which is inserted into the guide and which is relatively movable with respect to the guide; a basket positioned in front of the wire and capable of holding urolithiasis; and a control unit for determining the size of the urolithiasis on the basis of the relative movement of the guide with respect to the insertion tube or the relative movement of the wire with respect to the guide.
Type:
Application
Filed:
September 23, 2020
Publication date:
January 14, 2021
Applicants:
EASYENDO SURGICAL, INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Byung Sik CHEON, Dong Soo KWON, Deok Gyoon CHUNG
Abstract: The present invention relates to an image encoding and decoding method. An image decoding method for the same includes: determining a reference sample of a current block; performing filtering for the reference sample on the basis of a feature of an area where the reference sample is included; and performing intra-prediction by using the reference sample for which filtering is performed.
Type:
Application
Filed:
October 19, 2018
Publication date:
January 14, 2021
Applicant:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Hyun Suk KO, Sung Chang LIM, Jung Won KANG, Jin Ho LEE, Ha Hyun LEE, Dong San JUN, Hui Yong KIM
Abstract: An electrochemical cell and method of use, including an anode of metal, an air permeable cathode, an electrolyte between the anode and the cathode, and a transition metal phosphide catalyst on the cathode or between the cathode and the electrolyte. Also, a method of generating electrical current with an electrochemical cell by introducing a transition metal phosphide catalyst on a cathode side of the electrochemical cell. The catalyst can be in the form of any suitable nanostructure, such as molybdenum phosphide nanoflakes.
Type:
Application
Filed:
March 13, 2019
Publication date:
January 14, 2021
Applicant:
ILLINOIS INSTITUTE OF TECHNOLOGY
Inventors:
Mohammad ASADI, Alireza KONDORI, Mohammadreza ESMAEILIRAD
Abstract: Provided is an apparatus and method for wideband short-range wireless communication using a directional antenna in a millimeter wave band, and the method for wideband short-range wireless communication according to an embodiment may determine a first time interval and a second time interval for a cooperated data frame transfer based on a packet transmission time at each transmission from a source node to a destination node, transmit a frame to a relay node through an antenna pattern directed towards the relay node at a start point of the first time interval, and transmit the frame to the destination node through an antenna pattern directed towards the destination node after a predetermined period of time from a start point of the second time interval.
Type:
Application
Filed:
September 15, 2020
Publication date:
January 14, 2021
Applicant:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Kap Seok CHANG, Hyoung Jin KWON, Sung Geun JIN, Yong Sun KIM, Seung Eun HONG, Woo Yong LEE, Hyun Kyu CHUNG
Abstract: The present invention provides a shape-memory alloy including a Au—Cu—Al alloy having 20 at % or more and 40 at % or less Cu and 15 at % or more and 30 at % or less Al, with the balance being Au and inevitable impurities. The shape-memory alloy has a Vickers hardness of 360 Hv or less. The Au—Cu—Al alloy of the present invention is an alloy capable of developing both biocompatibility and a shape-memory effect, and further capable of achieving artifactlessness in a magnetic environment. The Au—Cu—Al alloy can be produced by heat-treating a clad material formed of a combination of a hollow material made of a Au—Cu alloy and a core material made of metallic Al at 500° C. or more and 700° C. or less.
Type:
Application
Filed:
February 28, 2019
Publication date:
January 14, 2021
Applicants:
TOKYO INSTITUTE OF TECHNOLOGY, TANAKA KIKINZOKU KOGYO K.K.
Abstract: Systems and methods for classifying binary data based training data having a predefined sample size is obtained. The training data is composed of separable binary datasets. An exact bound on Vapnik-Chervonenkis (VC) dimension of a classifier for the training data is determined. The exact bound is based one or more variables defining the hyperplane. The exact bound may be minimized for generating a classifier for predicting one class to which a given data sample of the training data belongs.
Abstract: A compact apparatus for atomisation of fluid samples comprises a sonotrode (11), placed so that an ultrasonic wave emitted by the sonotrode is directed through a channel (25) in a separate channel device (21) and reflected by from the interface (26) in a high-low impedance transition zone (Tz), so that a standing wave is formed within the channel. A positive air flow through the channel, driven by a pressure differential at each end of the channel, interacts with the working fluid or slurry being delivered by a fluid delivery device (30) to atomise it. The speed of the air flow and the dispersal, homogeneity, and size of particles in the slurry sample can be controlled by varying the shape of the channel outlet.
Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Förster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.
Type:
Grant
Filed:
August 13, 2018
Date of Patent:
January 12, 2021
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Emil P. Kartalov, Aditya Rajagopal, Axel Scherer, Mark D. Goldberg
Abstract: A random access method in a beam division multiple access (BDMA) system including: receiving, by a terminal, a reference signal of at least one beam sector transmitted from an access point (AP) device; estimating, by the terminal, whether the terminal is in a center area of the beam sector provided by the AP device or in the boundary area of the beam sector by using the strength of the reference signal; transmitting, by the terminal, a different preamble to the AP device in accordance with location information of whether the terminal is located in the center area or in the boundary area; and determining, by the AP device, a target beam sector for transmitting information about uplink resources to be used by the terminal, among a plurality of beam sectors on the basis of the received preamble.
Type:
Grant
Filed:
February 22, 2016
Date of Patent:
January 12, 2021
Assignee:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Dong Ho Cho, Byung Chang Chung, Dae Hee Park, Joon Sang Han, Yun Sik Kim
Abstract: The present invention relates to a new pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or related compounds for beneficially influencing the intestinal microbiota and blood lipid levels. In certain embodiments, the pharmaceutical composition is partially or entirely released into the lower small intestine and/or large intestine.
Abstract: The exemplary embodiments describe techniques for a controlled chemical vapor deposition growth and transfer of arrayed TMD monolayers on predetermined locations, which enable the formation of single crystalline TMD monolayer arrays on specific locations. The unique growth process includes the patterning of transition metal oxide (e.g., MoO3) on the source substrate contacting the growth substrate face-to-face, where the growth of single crystalline TMD monolayers with controlled size and location, exclusively on predetermined locations on the growth substrates is accomplished. These TMD arrays can be align-transferred using a unique process that combines the wet and stamping transfer processes onto any target substrate with a pin-point accuracy, which dramatically enhances the integrity of transferred TMDs.
Type:
Grant
Filed:
February 12, 2019
Date of Patent:
January 12, 2021
Assignee:
THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY