Patents Assigned to INSTITUTE
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Publication number: 20220395509Abstract: Provided herein are methods of treating diseases (e.g., proliferative disease (e.g., cancer (e.g., breast cancer, colon cancer, testicular cancer, CNS cancer, stomach cancer, lymphoma (e.g., B-cell lymphoma (e.g., lymphoplasmacytic lymphoma (e.g., IgM secreting lymphoplasmacytic lymphoma (i.e., Waldenstrom's Macroglobulinemia), non-IgM secreting lymphoplasmacytic lymphoma)), diffuse large B-cell lymphoma (e.g., activated B-cell-like (ABC)-DLBCL, germinal center B-cell-like (GBC)-DLBCL), follicular lymphoma, marginal zone B-cell lymphoma, small lymphocytic lymphoma, mantle cell lymphoma), and leukemia (e.g., chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia, myelogenous leukemia (e.g., chronic myelogenous leukemia, acute myelogenous leukemia))))) comprising administering to the subject in need thereof a therapeutically effective amount of Compound (I). Further provided are methods for treating disease resistant to treatment with BTK inhibitors (e.g., ibmtinib).Type: ApplicationFiled: October 7, 2020Publication date: December 15, 2022Applicant: Dana-Farber Cancer Institute, Inc.Inventors: Steven P. Treon, Guang Yang, Jinhua Wang, Li Tan, Nathanael S. Gray, Sara Jean Buhrlage
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Publication number: 20220400203Abstract: Disclosed are an omnidirectional ghost imaging method and an omnidirectional ghost imaging system based on the mechanism of bio-inspired retina-like. According to the application, the logarithmic polar mapping characteristic of the bio-inspired retina-like structure is utilized to generate an annular pattern sequence of the bio-inspired retina-like, and the pattern sequence is utilized to modulate a light source. After being reflected by the target around the curved mirror, the light is projected onto the curved mirror and diffusely reflected. According to the reversible characteristics of the optical path, the light after diffuse reflection is reflected to the original light source by the half mirror and half lens, and the reflected light intensity with target information is received by the bucket detector. The reflected light intensity measurement value with target information is correlated with the annular pattern sequence of bio-inspired retina-like used for modulating the light source.Type: ApplicationFiled: April 21, 2022Publication date: December 15, 2022Applicant: Beijing Institute of TechnologyInventors: Jie CAO, Qun HAO, Huan CUI, Yingqiang ZHANG
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Publication number: 20220397860Abstract: Disclosed herein a device acquiring holography and system including the same. The device includes: a beam splitter module splitting a light emitted from an object into a first beam and a second beam which have polarizations in different states; and an optical control module equipped with a first reflective optical element, which is disposed at one side of the beam splitter module and receives and emits the first beam to the beam splitter module, and a second reflective optical element which is placed at the other side of the beam splitter module, receives the second beam and emits the second beam to the beam splitter module so as to have differences of optical path and wavefront from the first beam. The beam splitter module, the first reflective optical element and the second reflective optical element are monolithically installed by being fixed to each other.Type: ApplicationFiled: June 10, 2022Publication date: December 15, 2022Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Kee Hoon HONG, Ki Hong CHOI
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Publication number: 20220398699Abstract: Disclosed herein are an image processing method and apparatus for machine vision. The image processing method for machine vision includes generating an image with machine-unrecognizable distortion based on an input image, and encoding the image with machine-unrecognizable distortion.Type: ApplicationFiled: June 13, 2022Publication date: December 15, 2022Applicant: Electronics and Telecommunications Research InstituteInventors: Hyon-Gon CHOO, Jeong-Il SEO, Jin-Young LEE, Hee-Kyung LEE, Han-Shin LIM, Won-Sik CHEONG
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Publication number: 20220395476Abstract: Provided are a drug for treating artery-related diseases and the use thereof. Specifically, provided are the use of a class of compounds of formula I in the treatment of artery-related diseases. Experiments show that the compounds of formula I have a significant effect on aneurysm, intramural hematoma and/or atrerial dissection.Type: ApplicationFiled: September 29, 2020Publication date: December 15, 2022Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCESInventors: Baohong JIANG, Xianjing ZHANG, Yuchao DING, Ziyi ZHAI
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Publication number: 20220396805Abstract: A key DNA sequence for regulating a maize leaf angle and a mutant thereof are provided, which have polynucleotide sequences shown in SEQ ID No. 1 and SEQ ID No. 2, respectively. The DNA sequence for regulating a maize leaf angle and the mutant thereof provided by present disclosure can regulate the expression of ZmNAC16 gene in a maize pulvinus, and thus can be used for the improvement of maize leaf angle and plant type and further for the cultivation of new maize varieties. The present disclosure further provides specific detection primers for detecting mutations of the DNA key sequence and the mutant, and detection primers for detecting an expression level of ZmNAC16 gene in maize. These detection primers can be used to directionally improve a maize leaf angle and also shows application potential for breeding of dense-planting-tolerant and high-yield maize.Type: ApplicationFiled: October 21, 2020Publication date: December 15, 2022Applicants: SOUTH CHINA AGRICULTURAL UNIVERSITY, BIOTECHNOLOGY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Haiyang WANG, Baobao WANG, Yurong XIE, Xing LI, Bingbing ZHAO, Yongping ZHAO
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Publication number: 20220400051Abstract: A method for device provisioning so that a new device can connect a first repeater in a smart terminal is provided. The method for device provisioning includes changing network setting information of a second repeater constituting a network for installation based on initial setting information of the new device, and when the new device connects to the second repeater using the initial setting information of the new device, changing the network setting information of the new device to the network setting information of the first repeater.Type: ApplicationFiled: June 2, 2022Publication date: December 15, 2022Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Mi-Ryong PARK, Jung Sik SUNG, Dae Ho KIM, Hoyong KANG, Seung Sik LEE
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Publication number: 20220396554Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I) in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: July 14, 2022Publication date: December 15, 2022Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.Inventors: Manuel ELLERMANN, Stefan Nikolaus GRADL, Charlotte Christine KOPITZ, Martin LANGE, Adrian TERSTEEGEN, Philip LIENAU, Christa HEGELE-HARTUNG, Detlev SÜLZLE, Timothy A. LEWIS, Heidi GREULICH, Xiaoyun WU, Matthew MEYERSON, Alex BURGIN
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Publication number: 20220400217Abstract: A coherent imaging system including a transmitter and a receiver. The transmitter includes a coherent source and a power splitter for splitting the electromagnetic radiation into a reference and a signal beam. The receiver includes an image forming device and an array of pixels. Each of the pixels include means for collecting at least a portion of the signal beam imaged on the pixel by an image forming device, as a collected signal; means for splitting the collected signal into a plurality of collected signals each having different phase shifts; means for mixing each of the collected signals with the reference beam so as to form a plurality of mixed signals; and means for detecting the mixed signals and outputting a plurality of output electrical signals in response to the mixed signals.Type: ApplicationFiled: April 22, 2022Publication date: December 15, 2022Applicant: California Institute of TechnologyInventors: Aroutin Khachaturian, Behrooz Abiri, Seyed Mohammadreza Fatemi, Seyed Ali Hajimiri
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Publication number: 20220399353Abstract: A flash memory device is provided. The flash memory device is disposed on a substrate, a channel layer made of a two-dimensional material, sources and drains disposed at both ends of the channel layer, a tunneling insulating layer having a first dielectric constant and a tunneling insulating layer disposed on the channel layer, a floating gate made of a two-dimensional material, a blocking insulating layer disposed on the floating gate and having a second dielectric constant greater than the first dielectric constant, and an upper gate disposed on the blocking insulating layer.Type: ApplicationFiled: November 30, 2021Publication date: December 15, 2022Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Joon Young KWAK, Eunpyo PARK, Suyoun LEE, Inho KIM, Jong-Keuk PARK, Jaewook KIM, Jongkil PARK, YeonJoo JEONG
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Publication number: 20220394933Abstract: A plant disease control method and a plant disease control apparatus that can irradiate a plant under cultivation with an appropriate amount of near-infrared light to obtain an effect of controlling diseases while efficiently using light energy. The plant under cultivation is irradiated with the near-infrared light including a wavelength set within a wavelength range of 800 to 1000 nm so as to satisfy all following Equations 1 to 3 where X is an irradiance (W/m2) and Y is an irradiation time (second), so that the effect of controlling diseases can be obtained. 644893X?1.873?Y?5901.9X?1.856??Equation 1: X?1??Equation 2: Y?0.Type: ApplicationFiled: September 11, 2020Publication date: December 15, 2022Applicant: SHIKOKU RESEARCH INSTITUTE INCORPORATEDInventors: Yutaka ISHIDA, Kazumasa KAKIBUCHI, Ayako HADA
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Publication number: 20220399696Abstract: Disclosed is a laser system including a first laser and a second laser. The first laser includes a laser cavity, and a gas phase molecular gain medium disposed in the laser cavity, the gain medium having an absorption band. The second laser is a solid state laser configured to be continuously tunable, with respect to an emission wavelength of the second laser, over the absorption band of the gain medium, and the second laser is tuned to pump rotational vibrational transitions in the gain medium to achieve a rotational population inversion.Type: ApplicationFiled: November 12, 2020Publication date: December 15, 2022Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Massachusetts Institute of Technology, The United States of America as Represented by the Secretary of the ArmyInventors: Paul Chevalier, Arman Amirzhan, Marco Piccardo, Fan Wang, Steven Glen Johnson, Henry O. Everitt, Federico CAPASSO
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Publication number: 20220396354Abstract: A patient transfer device. According to one embodiment, there is provided a patient transfer device: a support part including a patient seating surface on which a patient is supported; a plurality of propeller parts, connected to the support part, for moving the support part; a power supply unit to be transported while being borne by the user, the power supply unit serving to supply power to the plurality of propeller parts; and a connection member connecting the power supply unit and the support part, wherein the support part is configured to move to follow the power supply unit.Type: ApplicationFiled: October 27, 2020Publication date: December 15, 2022Applicants: ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY, DRONEDOM CO., LTD.Inventors: Yunwoo JEONG, Sungbin SEO
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Publication number: 20220395585Abstract: Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.Type: ApplicationFiled: May 3, 2022Publication date: December 15, 2022Applicants: Massachusetts Institute of Technology, Kyoto UniversityInventors: Ron Weiss, Liliana Wroblewska, Velia Siciliano, Tasuku Kitada, Maria Hottelet Foley, Katie Bodner, Hirohide Saito, Kei Endo, Darrell J. Irvine, Tyler Wagner, Jacob Becraft
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Publication number: 20220395482Abstract: A method for treating glycogen storage disease by administering an effective amount of a composition that includes ketogenic odd carbon fatty acids that ameliorate the symptoms of these diseases.Type: ApplicationFiled: April 22, 2022Publication date: December 15, 2022Applicant: Baylor Research InstituteInventor: Charles R. ROE
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Publication number: 20220396485Abstract: The present disclosure provides a method for preparing patterned graphene, and the method includes using a silicon carbide base as a solid-state carbon source, decomposing the silicon carbide under the action of high temperature and catalyst, to directly grow graphene on an insulating substrate. Through a first patterned trench and a second patterned trench in an accommodating passage, the pattern of the formed graphene can be directly controlled. Therefore, the present disclosure can accurately locate the position of the patterned graphene on the insulating substrate, it does not require transferring the graphene one more time, thereby avoiding contaminating the graphene and damaging its structure, and there is no need for photo-lithography, ion etching and other processes to treat the graphene in order to obtain patterned graphene, which further avoids damages to the graphene.Type: ApplicationFiled: September 17, 2021Publication date: December 15, 2022Applicant: SHANGHAI INSTITUTE OF MICROSYSTEM AND INFORMATION TECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Hongyan ZHU, Tianru WU, Jiebin GU, Chao ZHANG, Boxiang GAO
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Publication number: 20220395803Abstract: A strengthening oxidation system of the external micro-interfacial unit for producing PTA with PX is provided, including: a reactor, a circulating heat exchange device and a micro-interfacial unit. The reactor includes an outer casing and an inner cylinder disposed concentrically inside the outer casing. The circulating heat exchange device is disposed at an exterior of the reactor, and is connected with the outer casing and the inner cylinder respectively, for regulating reaction temperatures of the first reaction zone, the second reaction zone and the third reaction zone inside the reactor in a reaction process of producing PTA with PX.Type: ApplicationFiled: May 28, 2020Publication date: December 15, 2022Applicant: NANJING YANCHANG REACTION TECHNOLOGY RESEARCH INSTITUTE CO., LTD.Inventors: Zhibing ZHANG, Zheng ZHOU, Feng ZHANG, Lei LI, Weimin MENG, Baorong WANG, Gaodong YANG, Huaxun LUO, Guoqiang YANG, Hongzhou TIAN, Yu CAO
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Publication number: 20220399855Abstract: According to the inventive concept, an apparatus for analyzing a light-induced degradation (LID) phenomenon and healing characteristics of a p-type solar cell module, the apparatus being that analyzes LID reduction characteristics of the solar cell module includes a resonant heating mechanism, an induction coil plate, a treatment unit and a monitoring unit.Type: ApplicationFiled: June 23, 2021Publication date: December 15, 2022Applicant: Gumi Electronics & Information Technology Research InstituteInventors: Soo Min KIM, Junhee KIM, Yonghwan LEE, Min Kwang SEOK
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Publication number: 20220395924Abstract: Provided is a two-photon spectroscopy including a light source configured to generate first laser light having a pulse, a pulse width correction device configured to receive the first laser light to output a second laser light, an optical system through which the second laser light passes, a first two-photon sensor configured to measure a first pulse width of the first laser light generated from the light source, and a second two-photon sensor configured to measure a second pulse width of the second laser light passing through the optical system, wherein the pulse width correction device corrects a difference between the first pulse width and the second pulse width.Type: ApplicationFiled: April 25, 2022Publication date: December 15, 2022Applicant: Electronics and Telecommunications Research InstituteInventors: Dong Hoon SONG, Hong-Seok SEO, CHUL HUH
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Publication number: 20220395002Abstract: The aspects of the present disclosure relate to methods for energy-efficient destruction of organic toxins on the surface of any material, in particular on the surface of organic material. The material contaminated with toxins is exposed to NH2 and H radicals. Said radicals react chemically with toxins causing their transformation to less poisonous or less carcinogenic substances, or destruction to hydrocarbons and nitrogen-containing benign molecules. Exemplary usage for treatment of seeds, grains, beans, food, feedstock.Type: ApplicationFiled: June 9, 2021Publication date: December 15, 2022Applicant: Jo{hacek over (z)}ef Stefan InstituteInventors: Nina RECEK, Gregor PRIMC