Abstract: The present disclosure provides nucleic acid-based nanoswitch catenanes and methods of use. A nanoswitch catenane may include a single-stranded nucleic acid comprising a first and second terminal domain linked to each other to form a host ring by one of a first, second or third switchable bridges, wherein the first switchable bridge is formed in the presence of a reaction agent through the reaction of two cognate functional groups, each linked to a terminal domain of the single-stranded nucleic acid, wherein the second switchable bridge is formed in the presence of a biomolecule of interest through binding of the bio-molecule of interest to two cognate antibodies, each linked to a terminal domain of the single stranded nucleic acid, and wherein the third switchable bridge is a link between two cognate functional groups that breaks in the presence of a dissociation agent. A nanoswitch catenane may also include a circular nucleic acid guest ring catenated with the host ring.

Abstract: Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

Abstract: Provided are a device and method for analyzing spatiotemporal data of a geographical space including one or more regions. The method includes imaging spatiotemporally varying data, selecting a representative image according to each transition state based on a spatiotemporal change in the imaged data, grouping pixels in the selected image by clustering the pixels, and performing group-specific data analyses.

Abstract: A method for configuring a cluster may comprise selecting cluster members from among a plurality of communication nodes; identifying radio signal strength deviations between the cluster members; generating sensor groups by classifying the cluster members according to sensor types; selecting a head candidate group and a sensor candidate group of each of the sensor groups based on the radio signal strength deviations; selecting a cluster head in the head candidate group; selecting operating sensor nodes in the sensor candidate group; and configuring one among the operating sensor nodes as a virtual device, wherein the virtual device operates to transmit information obtained from the operating sensor nodes to the cluster head.

Abstract: A computing device generates synthetic tabular data.

Abstract: A vehicle system is provided. The vehicle system includes a first driving input device, a second driving input device, and an autonomous vehicle control module. The autonomous vehicle control module is configured to monitor a driving behavior of a first driver operating the first driving input and to automatically transfer vehicle control of a vehicle from the first driver to the second driver when one or more requirements are met based on the driving behavior of the first driver. The autonomous vehicle control module is further configured to analyze switching of vehicle control between the first driver and the second driver.

Abstract: The disclosure relates to methods for treating cancers (e.g., cancers having a BRCA1 and/or BRCA2 mutation(s)) by administering to the subject an effective amount of a ubiquitin-specific protease 1 (USP1) inhibitor.

Abstract: A high-resolution fully polarimetric frequency modulation continuous wave (FMCW) image radar system using an RF switch and an image processing method are provided.

Abstract: A method and an apparatus for generating time series data based on multi-condition constraints, and a medium are provided. The method include the following: a data repair request from a client is received, the data repair request including to-be-repaired data and condition information; normalization processing is performed on the to-be-repaired data to obtain normalized data, and tensor processing is performed on the condition information to obtain a feature label; a trained data repair model is called to perform repair processing on the normalized data according to the feature label to obtain first repaired data, the data repair model being obtained by training according to sample data, a first sample condition, real sample data and a second sample condition, and the sample data being noise data; and the first repaired data is sent to the client.

Abstract: The present invention relates to a method for encoding and decoding an image. The method for decoding an image includes: deriving an initial motion vector from a merge candidate list of a current block; deriving a refined motion vector using the initial motion vector; and generating a prediction block of the current block using the refined motion vector.

Abstract: Disclosed herein are an apparatus and method for searching for a global minimum of a point cloud registration error. The apparatus includes memory in which at least one program is recorded and a processor for executing the program. The program performs collecting multiple registration results in which the registration error between a source point cloud and a target point cloud is a local minimum as candidates and selecting the registration result in which the registration error between the source point cloud and the target point cloud is a global minimum, among the candidates. Collecting the multiple registration results may comprise repeatedly randomly initializing the source point cloud and the target point cloud and registering the initialized source point cloud to the initialized target point cloud to thereby search for a registration result in which the registration error therebetween is a local minimum.

Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.

Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in GABAergic neurons generally; and/or GABAergic neuron cell types such as lysosomal associated membrane protein 5 (Lamp5) neurons; vasoactive intestinal polypeptide-expressing (Vip) neurons; somatostatin (Sst) neurons; and/or parvalbumin (Pvalb) neuron cell types. Certain artificial expression constructs additionally drive selective gene expression in Layer 4 and/or layer 5 intratelencephalic (IT) neurons, deep cerebellar nuclear neurons or cerebellar Purkinje cells.

Abstract: A dehydrogenation reaction device includes a dehydrogenation reactor having a solid chemical hydride and includes an add aqueous solution tank supplying an add aqueous solution to the dehydrogenation reactor. The dehydrogenation reactor includes a heating device, a cooling apparatus, a porous metal foam, or a combination thereof.

Abstract: Disclosed is a rotary steering drilling apparatus.

Abstract: A hydrogen generating method includes generating hydrogen by dehydrogenation-reacting a chemical hydride of a solid state with an acid aqueous solution. The dehydrogenation-reaction is performed by reacting 1 mol of hydrogen atoms of the chemical hydride with an acid and water at a molar ratio of 0.5 to 2.

Abstract: A two-layer hybrid solid wedged etalon was fabricated and combined with a traditional imager to make a compact computational spectrometer. The hybrid wedge was made of Nb2O5 and Infrasil 302 and was designed to operate from 0.4-2.4 ?m. Initial demonstrations used a CMOS imager and operated from 0.4-0.9 ?m with spectral resolutions<30 cm?1 from single snapshots. The computational spectrometer operates similarly to a spatial Fourier Transform infrared (FTIR) spectrometer with spectral reconstruction using a non-negative least squares fitting algorithm based on analytically computed wavelength response vectors determined from extracted physical thicknesses across the entire two-dimensional wedge. This computational technique resulted in performance and spectral resolutions exceeding those that could be achieved from Fourier techniques. With an additional imaging lenses and translational scanning, the system can be converted into a hyperspectral imager.

Abstract: In a method for analyzing isoaspartic acid by dissociating precursor ions derived from a sample component and generating and analyzing product ions, the method includes: generating product ions by irradiating the precursor ions with hydrogen radicals or radicals having oxidizing ability to dissociate the precursor ions; separating and detecting the product ions according to a mass-to-charge ratio; and specifying product ions derived from isoaspartic acid based on a mass-to-charge ratio of the product ions.

Abstract: A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH3 or CH2, Y is null, O or N, Z is O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, —(C?O)-alkyl, —(C?O)-aryl, —(C?O)-alkyl-aryl, —(C?O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO2, —NH2, —NR3R4, carbonyl, alkoxyl, alkyl or —OCF3, wherein R3 and R4 independently are H, alkyl, O2CH3, —(C?O)—CH3 or (C?O)—NH2.

Abstract: Provided is a laser diode and a method for manufacturing the same. The diode includes a substrate including a DBR region having a channel hole, an active region, and a phase shift region, an optical waveguide provided on the substrate and extending from the active region to the DBR region, a lower insulation layer disposed on the optical waveguide, upper electrodes disposed on the lower insulation layer, and a heat blocking layer disposed in the channel hole of the DBR region and thermally separating the optical waveguide from the substrate.