Abstract: Provided herein are compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein bind an E3 ubiquitin ligase (e.g., Cereblon) and induce degradation of a transcription factor (e.g., IKZF1, IKZF3). Also provided are pharmaceutical compositions comprising the compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers (e.g., carcinoma); leukemia, lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, ovarian cancer, colon cancer, colorectal cancer, multiple myeloma, and acute myeloid leukemia (AML))). Further provided are methods of inducing the degradation of a transcription factor (e.g., IKZF1, IKZF3) by administering a compound or composition described herein to a subject and/or to a biological sample (e.g., cell or tissue).

Abstract: One embodiment provides a method of making an oxidation and corrosion resistant nuclear fuel. The method includes refining, by high energy ball milling (HEBM), a nuclear fuel powder comprising at least one nuclear fuel component and sintering the refined powder to form a nuclear fuel pellet. The method may further include adding a powdered dopant to the nuclear fuel powder. The refined powder includes the nuclear fuel powder and the powdered dopant.

Abstract: The present disclosure discloses a storage method, a data processing method, a device and an apparatus based on a non-volatile memory, the method comprising: acquiring a weight value that needs to be stored in the non-volatile memory; determining a conductivity value corresponding to the weight value according to a first conversion method if the non-volatile memory is a high-resistance storage device; determining a conductivity value corresponding to the weight value according to a second conversion method which is different from the first conversion method if the non-volatile memory is a low-resistance memory device; and setting the non-volatile memory according to the conductivity value to store the weight value.

Abstract: An operation method of a receiving apparatus may comprise: receiving an N-th data block belonging to a frame including a plurality of data blocks from a transmitting apparatus, each of the plurality of data blocks including a data period and a UW period; storing a first UW received in a UW period of the N-th data block in a buffer; receiving an (N+1)-th data block belonging to the frame from the transmitting apparatus; estimating a phase noise in a time domain by combining the first UW with a second UW received in a UW period of the (N+1)-th data block; and applying time-domain compensation according to the estimated phase noise to the (N+1)-th data block, and demodulating data of the (N+1)-th data block, wherein the first UW and the second UW are configured with a same sequence.

Abstract: A composition for enhancing the production of a homeoprotein includes an inhibitor of lysosomal function. A method for enhancing the production of a homeoprotein, includes treating cells with an inhibitor of lysosomal function, a method for producing an animal cell line continuously expressing a homeoprotein and a method for mass-producing a homeoprotein using the animal cell line.

Abstract: The present disclosure relates to, inter alia, a modified surface comprising an optically active monomer, a polymeric material having a surface onto which the optically active monomer is covalently bound. In one aspect, a membrane comprising an optically active monomer, a poly(aryl sulfone) membrane having a surface onto which the optically active monomer is covalently bound. The present disclosure also relates to a method of modifying a surface, the method comprising applying sufficient energy to a surface to induce covalent bonding with an optically active monomer, and contacting the optically active monomer with the surface. In one aspect, a method of modifying a surface of a poly(aryl sulfone) membrane is disclosed. In another aspect, a method of synthesizing an optically active monomer is disclosed. In one aspect, a method of filtration of chiral compounds is disclosed.

Abstract: This invention relates to herbal medicine compositions for the treatment of dengue and their production. The herbal medicine compositions consist of dried and finely powdered leaves of Lagerstroemia speciosa; dried and finely powdered aerial parts of Euphorbia hirta; dried and finely powdered rhizome of Zingiber officinale; and a fixed-dose combination of all three. In another version of the formulation, the spray-dried aqueous, ethanolic, methanolic or hydroalcoholic extract of the mentioned plants were used instead.

Abstract: Disclosed herein are a video encoding/decoding method and apparatus. The video decoding method of the present disclosure includes: obtaining block partitioning information of a current block; based on the block partitioning information, partitioning the current block into a first sub-block and a second sub-block; deriving motion information of the first sub-block and notion information of the second sub-block respectively; based on the notion information of the first sub-block and the motion information of the second sub-block, generating a prediction sample of the first sub-block and a prediction sample of the second sub-block respectively; and through a weighted-sum of the prediction sample of the first sub-block and the prediction sample of the second sub-block, generating a prediction sample of the current block. Herein, the block partitioning information is index information indicating an index of a table including information indicating a plurality of predefined asymmetric partition shapes.

Abstract: A deep-sea ore hydraulic lifting system with a deep-sea single high-pressure silo feeding device, which comprises a water injection pump, a water injection riser, a deep-sea single high-pressure silo feeding device, a lifting riser, a dewatering device and a pipeline. The water injection pump and the dewatering device are fixed on a mining ship. The water injection pump is connected to the deep-sea single high-pressure silo feeding device through the water injection riser. The deep-sea single high-pressure silo feeding device is connected to the dewatering device through the lifting riser. The water injection pump is connected to the dewatering device through the pipeline. Seawater is pumped into the water injection riser by the water injection pump, then ore is fed into a high-pressure hydraulic pipeline by the deep-sea single high-pressure silo feeding device to be mixed with the seawater, and an obtained ore and seawater mixture is lifted.

Abstract: The present invention provides novel compounds of Formula (I), (II), or (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, ovarian cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g.

Abstract: An integrated structure for an optoelectronic device and a method of fabricating an integrated structure for an optoelectronic device. The method comprises the steps of providing a complementary metal-oxide-semiconductor, CMOS, backplane comprising a driver circuit for the optoelectronic device; and providing a plurality of optical elements on the CMOS backplane, wherein the plurality of optical elements are based on a material system different from CMOS and are disposed in different device layers; wherein a first bonding dielectric is provided between the CMOS backplane and a first one of the different device layers for monolithic integration; and wherein a second bonding dielectric is provided between respective ones of the different device layers for monolithic integration, the second bonding dielectric being transparent.

Abstract: The present disclosure provides an oscillating circuit and an electronic device; the oscillating circuit includes a capacitor charging and discharging circuit unit, a voltage comparison circuit unit and a threshold voltage generation circuit unit; the oscillating circuit uses the capacitor charging and discharging and the hysteresis effect of the capacitor charging and discharging circuit unit to achieve oscillation based on the negative feedback regulation constituted by the voltage comparison circuit unit and the threshold voltage generation circuit unit, which is different from the traditional oscillating circuit based on capacitance and inductance; the oscillating circuit does not adopts inductors, has relatively low power consumption, and outputs oscillation signals with frequencies that vary with currents.

Abstract: Cell culture devices, and related methods and kits, for modeling isotropic-to-anisotropic cellular transitions are provided. The devices can include a substrate having an isotropic film surface with one or more regions of aligned fibers dispersed thereon.

Abstract: The present invention relates to a compound of general formula (I) (wherein R1, R2, and R3 are each independently a hydrogen atom or a lower alkyl and X is an alkali metal cation, ammonium cation, or quaternary ammonium cation). This compound is highly soluble in water, and solutions thereof need not be neutralized when administered to the living body. The compound is useful as a medicine, etc.

Abstract: A regeneration method of a nitrogen-containing carbon catalyst includes the following steps: roasting the nitrogen-containing carbon catalyst in a nitrogen-containing atmosphere to obtain a regenerated nitrogen-containing carbon catalyst. The method is a universal method, which is suitable for nitrogen-doped carbon catalysts and can be used to regenerate a nitrogen-containing carbon catalyst for producing vinyl chloride (VC) through 1,2-dichloroethane cracking. The method can greatly reduce the production cost of the catalyst and increase the service life of the catalyst, and a regeneration process thereof is fast, simple, and controllable, and does not require high temperatures.

Abstract: Disclosed are bispecific compounds (degraders) that target EP300/CBP for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.

Abstract: A novel method for producing an olefinic resin porous material is provided. The method for producing an olefinic resin porous material disclosed herein includes the steps of preparing a single phase in which an olefinic resin and a solvent are mixed each other, in a pressure-resistant container, introducing high pressure carbon dioxide into the pressure-resistant container, and releasing the pressure in the pressure-resistant container. In this method, introducing the high pressure carbon dioxide is carried out such that the pressure in the pressure-resistant container reaches 6 MPa or higher.

Abstract: Methods and compositions are provided herein that pertain to the discovery that the crystallin alpha B (CRYAB) gene and gene product provides an effective target for senolytic agents. In certain embodiments, methods of selectively killing one or more senescent cells in a subject in need thereof are provided wherein the method involves administering to the subject an effective amount of an agent that inhibits expression and/or aggregation of a CRYAB protein.

Abstract: The present invention discloses a dendritic reverse underground mining method for a thin coal seam at an end slope of a strip mine. The method includes the following steps: step S1: using a continuous coal mining machine to excavate a main adit toward a boundary of the strip mine along a seam floor; step S2: excavating secondary adits on two sides of the main adit obliquely in a forward direction of the main adit; step S3: transporting the excavated coal out of the main adit by the self-moving belt conveyors; step S4: after the excavating of a secondary adit of the secondary adits is ended, withdrawing the continuous coal mining machine and the self-moving belt conveyor from the secondary adit, and then excavating subsequent secondary adits of the secondary adits in a similar way; step S5: filling the secondary adits, and filling a goaf of the main adit.

Abstract: The present disclosure relates to a polybenzimidazole-based electrolyte membrane for alkaline water electrolysis, which includes a polybenzimidazole-based polymer, wherein the polybenzimidazole-based polymer is a biaxially oriented film. The polybenzimidazole-based electrolyte membrane for alkaline water electrolysis can reduce the concentration of an alkaline solution by improving the crystallinity of a polybenzimidazole-based polymer to increase the resistance against base, significantly improving the long-term stability of alkaline water electrolysis using a polybenzimidazole-based electrolyte membrane through the improved resistance against base, and by increasing the operation temperature to enhance the catalyst activity.