Patents Assigned to INSTITUTE
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Publication number: 20220192177Abstract: Provided herein are systems and methods for development and use of a perfusion apparatus comprising a biological phantom created from an ex vivo placenta. In some embodiments, a system is provided for perfusing an ex vivo placenta to be imaged using a magnetic resonance imaging (MRI) device, the system comprising a chamber configured to house the ex vivo placenta therein, the chamber including a first partition separating the chamber into a first portion and a second portion, wherein the ex vivo placenta is housed at least partially in the first portion, and at least one first inlet disposed in the second portion for receiving at least one first tube, the at least one first tube being configured to couple at least one first pump to a fetal compartment of the ex vivo placenta when present in the chamber.Type: ApplicationFiled: December 17, 2021Publication date: June 23, 2022Applicants: Children's Medical Center Corporation, Massachusetts Institute of Technology, The General Hospital CorporationInventors: Patricia Ellen Grant, Drucilla Roberts, Esra Abaci Turk, Jeffrey N. Stout, Lawrence L. Wald, Elfar Adalsteinsson, William Barth
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Publication number: 20220195364Abstract: The current subject matter includes methods, systems, articles, and techniques to deliver material to anucleate cells, such as red blood cells. Using a rapid deformation based microfluidic system, loading of red blood cells with macromolecules of different sizes has been shown. Although delivery to some mammalian cells, such as cancer cell lines and fibroblasts had been previously demonstrated using this technique, those designs were incompatible with RBCs that have dramatically different physical properties. Through the use of smaller constriction sizes, high speeds and different buffers successful delivery to red blood cells can be achieved. By enabling robust delivery to red blood cells in a simple, scalable manner, the current subject matter can be implemented in a diversity of applications that deliver material to study red blood cell diseases and/or use red blood cells as a therapeutic platform. Related apparatus, systems, techniques, and articles are also described.Type: ApplicationFiled: March 8, 2022Publication date: June 23, 2022Applicant: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Klavs F. Jensen, James Robbins Abshire, Jacquin Clarence Niles
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Publication number: 20220193240Abstract: Triggerable hydrogel compositions and related methods are generally disclosed. In some embodiments, the compositions and related methods may be used for medical-related or other applications. For example, the compositions and methods described herein may be useful, for example, in biomedical applications such as articles for (e.g., gastric) retention. In some embodiments, methods for deploying and/or removing an article comprising the composition, such as an article for gastric retention, are provided. The article and/or composition may be removed internally from a subject by, for example, introducing at least one reagent (e.g., one reagent, two reagents) such that at least a portion of the composition disassociates. In certain embodiments, the composition comprises a polymer network comprising two or more interpenetrating polymers. In some cases, a first polymer comprises a first cross-link moiety configured to dissociate upon interaction with a reagent.Type: ApplicationFiled: December 22, 2021Publication date: June 23, 2022Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Carlo Giovanni Traverso, Jinyao Liu, Robert S. Langer
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Publication number: 20220201870Abstract: A fabrication method of a flexible electronic package device including the following steps is provided. A tolerable bending radius of the flexible electronic package device is obtained. A minimum surface curvature radius of a selected portion of an applied carrier is obtained. A relationship of the tolerable bending radius being smaller than the minimum surface curvature radius is ensured. The flexible electronic package device is disposed on the selected portion.Type: ApplicationFiled: December 18, 2020Publication date: June 23, 2022Applicant: Industrial Technology Research InstituteInventors: Chien-Min Hsu, Chih-Ming Shen, Shih-Hsien Wu
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Publication number: 20220201518Abstract: An operation method of a terminal performing CSI-RS measurement may comprise: receiving configuration information for the CSI-RS measurement from a base station; performing switching from a first BWP to a second BWP for the CSI-RS measurement based on the configuration information, and performing the CSI-RS measurement in the second BWP; and performing measurement reporting according to the CSI-RS measurement to the base station in the second BWP and performing switching to the first BWP, or performing switching to the first BWP and performing the measurement reporting according to the CSI-RS measurement to the base station in the first BWP.Type: ApplicationFiled: December 16, 2021Publication date: June 23, 2022Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventor: Ji Hyung KIM
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Publication number: 20220200391Abstract: The disclosure provides a sealing system applicable for an ocean power generation device, which includes at least one first seal and a water leakage protection device. The water leakage protection device is located at a side of at least one first seal away from seawater, and includes a sealed water storage tank and a drain pipe. The sealed water storage tank collects and stores seawater leaked from the at least one first seal. One end of the drain pipe is communicated with the sealed water storage tank, and the seawater stored in the sealed water storage tank is discharged through the drain pipe.Type: ApplicationFiled: March 11, 2022Publication date: June 23, 2022Applicant: HANGZHOU LHD INSTITUTE OF NEW ENERGY, LLCInventors: Fuwei ZHU, Dong LIN, Xiaonan MIAO, Zhenhua WU, Enle LIN, Fang JIANG, Zhendong CHEN, Hongyue TIAN
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Publication number: 20220199706Abstract: Provided is a display device. The display device includes a substrate having a pixel area including a first sub-pixel area, a second sub-pixel area, and a third sub-pixel area, a first control layer on the substrate, a second control layer on the first control layer, an intervening layer disposed between the first control layer and the second control layer on the first sub-pixel area and the second sub-pixel area, first quantum dots on the intervening layer of the first sub-pixel area, second quantum dots on the intervening layer of the second sub-pixel area, and an organic layer configured to cover a top surface and a side surface of the intervening layer between the first control layer and the second control layer.Type: ApplicationFiled: November 12, 2021Publication date: June 23, 2022Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Chan-mo KANG, Sukyung CHOI, CHUNWON BYUN, Jin Wook SHIN, Hyunsu CHO
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Publication number: 20220200628Abstract: A zero padding apparatus and method for variable length signaling information are disclosed. A zero padding apparatus according to an embodiment of the present invention includes a processor configured to generate a LDPC information bit string by deciding a number of groups whose all bits are to be filled with 0 using a difference between a length of the LDPC information bit string and a length of a BCH-encoded bit string, selecting the groups using a shortening pattern order to fill all the bits of the groups with 0, and filling at least a part of remaining groups, which are not filled with 0, with the BCH-encoded bit string; and memory configured to provide the LDPC information bit string to an LDPC encoder.Type: ApplicationFiled: March 15, 2022Publication date: June 23, 2022Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Sung-Ik PARK, Sun-Hyoung KWON, Jae-Young LEE, Heung-Mook KIM
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Publication number: 20220193112Abstract: A hetero-structured RNA with two 3?-overhangs and use thereof as an immune stimulant are provided.Type: ApplicationFiled: October 26, 2021Publication date: June 23, 2022Applicant: NA VACCINE INSTITUTEInventors: Dong Ho KIM, Myung Soo KANG
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Publication number: 20220193146Abstract: The present invention relates to a composition for inhibiting non-fluorescent advanced glycation end products, and a use thereof. More specifically, the present invention relates to: a composition for inhibiting non-fluorescent advanced glycation end products, comprising one or more strains selected from the group consisting of Lactobacillus sp. strains, Lactococcus sp. strains, Enterococcus sp. strains, Bifidobacterium sp. strains, Bacillus sp. strains, Saccharomyces sp. strains, Pediococcus sp. strains, and Leuconostoc sp. strains; and a food composition, a pharmaceutical composition, a composition for intestinal regulation, a probiotic composition, a feed composition, and a fermented product, which have an activity of reducing non-fluorescent advanced glycation end products and comprise the composition. In addition, the present invention relates to a method for producing a non-fluorescent advanced glycation end product inhibitor and a method for inhibiting non-fluorescent advanced glycation end products.Type: ApplicationFiled: July 17, 2019Publication date: June 23, 2022Applicant: Korea Food Research InstituteInventors: Ho Young Park, Yoon Sook Kim, Mi Jin Oh, Sang Hoon Lee, Sang Keun Ha, Sang Yoon Choi, Yong Kon Park
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Publication number: 20220200525Abstract: The disclosed embodiments relate to a photovoltaic mobile lab configured for performing on-site test in a photovoltaic module. The photovoltaic mobile lab includes a transport vehicle, a first container, a second container, and a light source. The first container is fixed on the transport vehicle. The second container is slidably sleeved on the first container. The second container and the first container together form a testing chamber. The light source is configured for providing illumination to the photovoltaic module. The light source and the photovoltaic module are respectively accommodated in the first container and the second container and are respectively located at two opposite ends of the testing chamber so that a distance between the light source and the photovoltaic module is changeable while the second container is sliding with respect to the first container.Type: ApplicationFiled: December 23, 2020Publication date: June 23, 2022Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Si-Xian LI, Teng-Chun WU, Cho-Fan HSIEH, Chin LIEN
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Publication number: 20220196505Abstract: A pressure sensor with calibration function includes a casing, a diaphragm, a sensing element, a medium, and at least one calibration element. The diaphragm is disposed on the casing, wherein the casing and the diaphragm define an accommodating space. The sensing element is disposed in the casing. The medium is filled in the accommodating space and in contact with the sensing element. The at least one calibration element is adjustably disposed at the casing and extended into the accommodating space to be in contact with the medium, wherein when the at least one calibration element is moved relative to the casing, the at least one calibration element changes the pressure applied to the medium.Type: ApplicationFiled: July 9, 2021Publication date: June 23, 2022Applicant: Industrial Technology Research InstituteInventors: Che-Kai Yeh, Tzung-Ching Lee, Yu-Wen Hsu, Chao-Ta Huang
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Publication number: 20220201743Abstract: The present application relates to a scheduling device and method of a mobile communication system. In the packet scheduling method, a base station performs packet scheduling for a terminal station in a mobile communication system, and a transport channel comprising an uplink shared channel (UL-SCH) and a physical channel comprising an uplink grant channel (UL-GCH) between the terminal and the base station are classified into a plurality of channels. In addition, in the packet scheduling method: a) the base station receives scheduling information from the terminal; b) the base station allocates an uplink resource for uplink traffic transmission for terminal based on the received scheduling information; and c) information for the allocated uplink resource is transmitted to the terminal through the UL-GCH of the physical channel.Type: ApplicationFiled: March 13, 2022Publication date: June 23, 2022Applicant: Electronics and Telecommunications Research InstituteInventors: Geon-Min YEO, Byung-Han RYU
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Publication number: 20220201174Abstract: The present disclosure provides a compound eye-based in-situ monitoring unit, a micro-adjustment unit, and a multi-spectral imaging system thereof. The compound eye-based in-situ monitoring unit includes a spherical installation cover and an imaging assembly disposed on the spherical installation cover, where the spherical installation cover is provided with a spherical grid array, the spherical grid array includes 20 installation points (five rows and four columns), one imaging assembly is installed on each installation point, the imaging assemblies include a charge coupled device (CCD) optical digital camera assembly, a digital image correlation (DIC) light source assembly, an infrared (IR) spectrum assembly, a Raman spectrum assembly, and a terahertz light source assembly.Type: ApplicationFiled: January 14, 2021Publication date: June 23, 2022Applicants: Jilin University, Weihai Institute for Bionics-Jilin UniversityInventors: Zhichao MA, Siguo YANG, Chaofan LI, Bin HUANG, Yue JIANG, Wei ZHANG, Shenghui WANG, Hairui DU, Zixin GUO, Jize LIU, Hongwei ZHAO, Luquan REN, Chuliang YAN
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Publication number: 20220193852Abstract: A monitoring method and a monitoring system for a machine tool to machine a workpiece are provided. The monitoring method includes the following steps. First, a vibration signal of a spindle of the machine tool is detected. Next, a vibration feature value of the vibration signal is obtained. Whether the vibration feature value exceeds a threshold condition is determined, wherein the threshold condition is determined by a training model based on a predetermined surface quality of the workpiece. When the vibration feature value exceeds the threshold condition, a machining parameter of the machine tool is adjusted.Type: ApplicationFiled: April 27, 2021Publication date: June 23, 2022Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Chun-Yu TSAI, Chi-Chen LIN, Sheng-Ming MA, Ta-Jen PENG
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Publication number: 20220197012Abstract: Disclosed herein is a recirculating programmable photonic circuit including a programmable optical coupler including two first programmable waveguides and configured to adjust optical coupling efficiency of an optical signal based on a vertical movement of one of the two first programmable waveguides, a phase shifter including a second programmable waveguide and configured to change a phase of the optical signal based on a horizontal movement of the second programmable waveguide with respect to the first programmable waveguides, a plurality of core cells connected to each of the programmable optical coupler and the phase shifter to form a predetermined shape, the core cells being selectively driven by moving the optical signal from the predetermined shape according to the optical coupling efficiency and the phase, and an actuator electrically connected to one side of each of the plurality of core cells and configured to control the vertical movement and the horizontal movement.Type: ApplicationFiled: December 20, 2021Publication date: June 23, 2022Applicants: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Sangyoon HAN, Kyoung Sik YU
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Publication number: 20220195503Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.Type: ApplicationFiled: December 17, 2021Publication date: June 23, 2022Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard CollegeInventors: Feng ZHANG, Bernd ZETSCHE, Johnathan S. GOOTENBERG, Omar O. ABUDAYYEH, Ian SLAYMAKER
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Publication number: 20220200612Abstract: This atomic resonator for causing a resonance frequency by CPT resonance includes: a gas cell having alkali metal atoms enclosed; a photodetector configured to detect light having passed through the gas cell and convert the light to an electric signal; a high-frequency oscillator configured to receive the electric signal and output the signal after a frequency thereof is divided by two; and a laser light source configured to modulate and introduce, into the gas cell, light based on the signal output from the high-frequency oscillator. The high-frequency oscillator has an injection-locked frequency divider circuit including an acoustic resonator as an oscillation element.Type: ApplicationFiled: March 11, 2022Publication date: June 23, 2022Applicants: National Institute of Information and Communications Technology, Tokyo Institute of TechnologyInventors: Motoaki HARA, Yuichiro YANO, Masatoshi KAJITA, Tetsuya IDO, Hiroyuki ITO
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Publication number: 20220195506Abstract: This present disclosure provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The present disclosure also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.Type: ApplicationFiled: July 22, 2021Publication date: June 23, 2022Applicant: California Institute of TechnologyInventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo, Jose Luis Riechmann
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Publication number: 20220193194Abstract: A method is provided for treating a cancer patient non-responsive to treatment with a immune checkpoint inhibitor (ICI) by treating the patient with said ICI in combination with an agent that blocks the activity of a dominant factor selected among the plurality of host-driven resistance factors generated in response to treatment of the cancer patient with the ICI, these factors having a fold-change predictive of a non-favorable response of the cancer patient to the treatment with the ICI.Type: ApplicationFiled: December 12, 2019Publication date: June 23, 2022Applicant: Rappaport Family Institute for Research in the Medical SciencesInventor: Yuval Shaked