Abstract: Disclosed is a tumor treatment method, wherein immune effector cells and Gemcitabine are administered to an individual with tumor, and the immune effector cells express receptors having a tumor-specific antigen. Also disclosed is a tumor treatment kit, wherein the kit comprises 1) immune effector cells expressing receptors that recognize tumor antigens; 2) Gemcitabine; 3) a container for containing the substances of 1) and 2) described above; and 4) drug administration instructions for using the kit to treat a tumor.

Abstract: The present invention provides novel compounds according to Formula (I): where Ring A, Ring B, X, L1, L2, RA, RC, RD, RE, m, n, and p are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of human diseases associated with kinase activity, for example, proliferative diseases, neurodegenerative diseases, metabolic disorders, inflammatory diseases, and cardiovascular diseases.

Abstract: Provided is a method of localizing an anomaly in a target image. The method includes training a reconstruction model using a normal image, deriving a reconstructed image by applying a target image, which is subject to detection, to the trained reconstruction model, generating an anomaly map on the basis of a result of comparing the reconstructed image and the target image, and localizing an anomaly through the generated anomaly map.

Abstract: A motion processing method and apparatus are provided. The motion processing method includes obtaining a base-level motion by applying a linear Gaussian model to an input motion, obtaining a controllable motion displacement vector and a residual motion displacement vector by applying the linear Gaussian model to a displacement vector between the input motion and the base-level motion, and synthesizing an output motion based on the base-level motion and the controllable motion displacement vector.

Abstract: A device and method for sealing a leak in a pipe. The device includes a sealing component that is placed against a pipe outer surface and over the leak. A clamp extending from the sealing component clamps partially around a circumference of the pipe and pulls the sealing component against the pipe. A vent in combination with the sealing member releases leaking gas through or around the sealing component while the sealing component is being secured to the pipe. The vent is then closed after full clamping is completed.

Abstract: The present disclosure relates to novel Lactobacillus sakei WIKIM0109 isolated from kimchi and a composition containing the same. The Lactobacillus sakei WIKIM0109 according to the present disclosure is a lactic acid bacterium having an activity of inhibiting IgG and IgG2a production in blood and an activity of inhibiting IFN-?, IL-17 and TNF-? production, and can be used in various applications, such as for preventing and ameliorating arthritis or improving intestinal regulation in human or animals.

Abstract: A method for controlling an elevator by interworking with external devices in an apparatus for controlling an elevator is provided. The method for controlling an elevator includes generating token information for an external device to which a write command is to be performed and transmitting the token information to the external device, receiving a control message including a write command together with the token information from the external device, verifying the token information, and processing the control message when the token information is verified.

Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).

Abstract: Synells are created by encapsulating components and iteratively optimizing each synell for a desired trait. Each synell is tested during each iteration. Failed synells are discarded. Additional synell components are added during each iteration, with iterative optimization being repeated until synells having the trait are created. A method for synell reproduction includes creating a synell having a desired trait, determining a recipe for the synell, digitizing the recipe, and transmitting the digitized recipe to another location. The recipe is reconstituted at the other location and the synell is reproduced using the recipe. On-demand biosynthesis of synells includes generating droplets containing different synell components within a microfluidic device, fusing them into combinations, and storing them until a request for a synell having a particular trait is received.

Abstract: A composition containing colchicine and its uses are disclosed. The composition enhances the expression amount of filaggrin that is highly related to the onset of allergic skin diseases, enhances skin moisturizing effects to thereby improve the skin barrier function, and in addition, controls inflammatory responses by allergic skin diseases. Therefore, methods for prevention and/or treatment of allergic skin diseases and/or pruritus cutaneous and skin moisturization and skin condition improvement are disclosed.

Abstract: The present invention relates to a method and apparatus for setting a reference picture index of a temporal merging candidate. An inter-picture prediction method using a temporal merging candidate can include the steps of: determining a reference picture index for a current block; and inducing a temporal merging candidate block of the current block and calculating a temporal merging candidate from the temporal merging candidate block, wherein the reference picture index of the temporal merging candidate can be calculated regardless of whether a block other than the current block is decoded. Accordingly, a video processing speed can be increased and video processing complexity can be reduced.

Abstract: A method of treating neurodegeneration in a subject that includes administering a non-invasive tactile stimulus having a stimulus frequency of about 30 Hz to about 50 Hz to a subject to induce synchronized gamma oscillations in at least one portion of the peripheral nervous system of the subject, of the spinal cord of the subject, or both.

Abstract: A composition includes a contraceptive chimeric virus-like particle with an antigenic carrier domain and one or more antigenic regions from a sperm cell in the antigenic carrier domain, with the antigenic carrier domain including human papillomavirus L1 capsid protein and the antigenic regions including one or more structural elements of the Catsper ion channel complex. When administered to a patient, the contraceptive vaccine stimulates production of anti-sperm antibodies that, upon binding to a sperm cell, inhibit the sperm cell's motility and thus inhibit the ability of the sperm cell to fertilize an egg cell. The induced immunoinfertility of the composition can be reversed for brief or extended lengths of time by overdosing the patient with a reversal agent lacking the antigenic carrier domain but having a protein sequence substantially identical to that of the one or more antigenic regions to sequester the anti-sperm antibodies.

Abstract: A system includes a camera configured to capture image data of an environment, a monitoring system configured to generate a gaze sequences of a subject, and a computing device communicatively coupled to the camera and the monitoring system. The computing device is configured to receive the image data from the camera and the gaze sequences from the monitoring system, implement a machine learning model comprising a convolutional encoder-decoder neural network configured to process the image data and a side-channel configured to inject the gaze sequences into a decoder stage of the convolutional encoder-decoder neural network, generate, with the machine learning model, a gaze probability density heat map, and generate, with the machine learning model, an attended awareness heat map.

Abstract: Disclosed is a transmitter which includes a channel driver that includes a pull-up transistor and a pull-down transistor connected between a power node and a ground node and outputs a voltage between the pull-up transistor and the pull-down transistor as a transmit signal, and a pre-driver that controls the pull-up transistor and the pull-down transistor in response to a driving signal and controls the channel driver such that the transmit signal is overshot at a rising edge of the driving signal and the transmit signal is undershot at a falling edge of the driving signal.

Abstract: A photoacoustic-ultrasonic dual-mode endoscope includes: a probe and a probe driving unit, wherein the probe includes: a coaxially configured optical and electromagnetic rotary waveguide assembly including an optical fiber, the optical fiber including a core and a cladding, and a conductive path coaxially arranged with the optical fiber; a scanning tip located at an end of the coaxially configured optical and electromagnetic rotary waveguide assembly and configured to deliver a laser beam to an object to be examined and detect a photoacoustic signal and an ultrasonic signal generated from the object to be examined; and a plastic catheter surrounding outer surfaces of the coaxially configured optical and electromagnetic rotary waveguide assembly and the scanning tip, wherein the conductive path includes: a first conductive path including a portion coaxially arranged with the optical fiber; and a second conductive path including a portion coaxially arranged with the optical fiber and insulated from the first co

Abstract: The present invention relates to a method and apparatus for setting a reference picture index of a temporal merging candidate. An inter-picture prediction method using a temporal merging candidate can include the steps of: determining a reference picture index for a current block; and inducing a temporal merging candidate block of the current block and calculating a temporal merging candidate from the temporal merging candidate block, wherein the reference picture index of the temporal merging candidate can be calculated regardless of whether a block other than the current block is decoded. Accordingly, a video processing speed can be increased and video processing complexity can be reduced.

Abstract: Provided are a black phosphorus-two dimensional material complex and a method of manufacturing the black phosphorus-two dimensional material complex. The black phosphorus-two dimensional material complex includes: first and second two-dimensional material layers, which each have a two-dimensional crystal structure and are coupled to each other by van der Waals force; and a black phosphorus sheet which between the first and second two-dimensional material layers and having a two-dimensional crystal structure in which a plurality of phosphorus atoms are covalently bonded.

Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences, including multiplex lateral flow diagnostic devices and methods of use, are provided.

Abstract: Methods and devices for generating hydrogen gas with an electrocatalytic energy conversion cell by introducing a tri-transition metal phosphide catalyst at or on an electrode of the electrocatalytic energy conversion cell. The electrocatalytic energy conversion cell includes a first electrode including a tri-transition metal phosphide catalyst, such as M03P, a second electrode of an anodic material, an electrolyte disposed between the first electrode and the second electrode, and an electric potential source connected to both electrodes. Oxidation and reduction reactions, such as hydrogen evolution reactions, occur at the first electrode.