Abstract: Provided is a pressure detection device capable of easy installation and removal of a sensor in/from a diaphragm, measurement of a pressure in a wide rage, and manufacture at a low cost while reducing a size. A sensor part (A) has: a magnet (12) being applied with a load produced by pressing of a diaphragm (8); and a magnet cap (11) covering the magnet (12). The diaphragm (8) has an intra-diaphragm magnetic body (9) buried therein. The intra-diaphragm magnetic body (9) has a protrusion part protruding from the diaphragm (8) so as to be in contact with the magnet (12). The magnet cap (11) has an opening part enabling the protrusion part of the intra-diaphragm magnetic body (9) and the magnet (12) to be joined together.

Abstract: A long member 2 is covered with one-side coat member 3 and an other-side coat member 4. The one-side coat member 3 is fixed to the long member 2 by a one-side fixing member 15. The other-side coat member 4 is fixed to the long member by an other-side fixing member 20. The inner peripheral face of the one-side fixing member 15 forms a tapered inner face part for introducing body fluid between the one-side coat member 3 and the long member 2. An insertion guiding member 5 is mounted to the tip end part in an insertion direction of the long member 2. A middle part in the insertion direction of the insertion guiding member 5 has a diameter larger than the base end part thereof.

Abstract: A heat exchange module 12 is formed by stacking pipe groups obtained by fixing a plurality of pipes 1 with use of pipe array holding members 9a to 9d. Flow path forming members 50 are arranged on pipe groups in the uppermost and lowermost layers, and walls 51 and 52 are provided so as to protrude from the outer-side pipe array holding members and the inner-side pipe array holding members. Flow path members 63 are provided between the walls 51 and 52 adjacent to each other so as to allow through holes 53 and 54 to communicate with each other. The heat exchange module 12 is housed in the housing 2, and while rotating the housing 2, a resin material 24 is filled into a space enclosed by the two inner-side pipe array holding members of each pipe group in the housing 2, interstices around the pipes present between an opening 15a of the housing and the outer-side pipe array holding members, and interstices around the pipes present between an opening 15b of the housing and the outer-side pipe array holding members.

Abstract: There are provided a male type connector (1), a protective cap (2), an inner cap (3) that supports a disinfectant-impregnated member therein and is retained in the protective cap, and a female type connector (4) in which an inner cylinder is fixed at an end of an outer cylinder, the inner cylinder including an internal end portion located inside the outer cylinder and an exposed external end portion. The inner cap includes engaging legs at each of which an engaging convexity is formed. A front end portion of the male type connector allows the engaging convexities at the engaging legs to engage therewith from inside. An inner cap retaining portion is formed on an inner wall surface of the protective cap, and a force exerted by the engagement between the inner cap and the male type connector is larger than a force exerted by the inner cap retaining portion to retain the inner cap.

Abstract: The present invention provides antibodies against AGEs derived from carbonyl compounds that are highly reactive with proteins or peptides, and methods of detecting the AGEs derived from the carbonyl compounds. 3,4-dideoxyglucosone-3-ene (3,4-DGE) is allowed to react with proteins, a host animal is immunized with the reaction product thereof, AGEs, and antibodies against the AGEs (anti-AGE antibodies) are isolated from serum recovered from the host animal. These anti-AGE antibodies thus isolated are allowed to react with a sample, and then the antigen-antibody reaction between the AGEs in the sample and the anti-AGE antibodies is detected. Thereby the presence or amount of the AGEs in the sample can be detected.

Abstract: A hemodialysis apparatus that carries out hemodialysis treatment by measuring or calculating the blood volume or its volume change as a blood indication level, and by controlling dialysis conditions according to said target blood indication level, wherein the chronological course of said blood indication level is defined as a target control line, and the primary blood volume (BV0) can be calculated as blood indication level. In the former part of the dialysis operation, the water removal is controlled so that the circulating blood volume in the body approach to the standard blood volume (BV st) with the use of said target control line. After the water removal of the former part of the dialysis operation, when the circulating blood volume in the body attains the standard blood volume (BV st), the latter part of the dialysis operation is started. In said latter part of the dialysis operation, the water removal operation is performed by substantively maintaining said standard blood volume (BV st).

Abstract: Provided is a hemodialyzer in which deterioration in membrane performance of a hollow fiber with time can be grasped accurately during dialysis and the performance can be recovered quickly and positively. The hemodialyzer, constituted by connecting an artery side blood circuit (2) having a blood pump (7) to the artery side of a dialyzer (1), connecting a vein side blood circuit (3) to the vein side of the dialyzer (1), and connecting a dialysate supply line (4) and a dialysate discharge line (5), respectively, to the side face of the dialyzer (1), is provided with a detector (15) for determining the pressure in the blood circuit, and a detector (16) for determining the pressure in the dialysate line, in which transmembrane pressure is calculated based on the determined pressures, and reverse filtering is performed by the dialyzer (1) when the transmembrane pressure exceeds a predetermined level.

Abstract: A clip which solves a technical problem that the latching of the clip is not easily released by the external force caused by falling, etc., and is easily released when the clip is used. The clip has opposed clipping arms capable of forming an independent and separate space by pressing and holding a clipped object constituted of a flexible hollow member between them. The clip has a latching means on one end of the opposed clipping arm, which has a latching part capable of latching the clipping arms. The clip further has a latching releasing means capable of releasing the latching by an external force headed to an external direction from the clipping arm. The latching means has a supporting point part acting the latching releasing force, added to the latching means by the latching releasing means, to the direction to release the latching of the latching part.

Abstract: A blood purification method that purifies blood taken from a body by blood dialysis or by hemodiafiltration includes the step of changing an osmotic pressure of the blood to an increasing condition until a blood volume (BV level) attains a standard blood volume, in a former part of a blood purification process and the step of maintaining a standard blood volume and periodically changing the osmotic pressure of the blood in a later part of the blood purification process.

Abstract: The configuration of the present invention includes a winged shield that has a cylindrical shield tube and wings linked to a front end side of the shield tube, a hub that is inserted into an inner bore of the shield tube so as to be movable in an axial direction, and a cannula that is mounted to a front end portion of the hub. By engaging a protrusion with a third annular groove, the hub is held with the winged shield in a state where the cannula protrudes for a predetermined length from a front end of the shield tube. In a state where an inward annular protrusion of the shield tube is engaged with a first holding portion, a tip of the cannula can be stored in the shield tube. By engaging the protrusion of a holding mechanism with a first annular groove, the hub is held with the shield tube so as not to be moved within the shield tube.

Abstract: An apparatus for blood dialysis composed at least of a hemodialyzer (a) whereby blood is brought into contact with a dialysate via a semipermeable membrane and thus purified; a blood circulation system (b) composed of a blood circuit in the arterial side whereby blood is taken out from a patient and flown into the hemodialyzer and another blood circuit in the venous side whereby the blood flown out from the hemodialyzer is returned to the patient; a dialysate supplying/discharging system (c) for supplying and discharging the dialysate composed of a dialysate-supply line for supplying the dialysate to the hemodialyzer and a dialysate-discharge line for discharging the dialysate flown out from the hemodialyzer, and a means (d) of controlling the back-filtration speed. Owing to this constitution, individual steps from the preparation of the dialysis (treatment) to the completion of the treatment and the change from a specific step to the next step can be safely, surely and quickly carried out in most cases.

Abstract: A medical needle device includes a winged shield (4) having a substantially cylindrical shaped shield cylinder (4a) and wings (5, 6) connected to the front end side thereof, a needle base (2) inserted in the shield cylinder (4a), and a needle (1). The wings have wing projections (7, 8) and the shield cylinder has through holes (9, 10) on the wall thereof. By overlaying the wings along the side surface of the shield cylinder, each of the wing projections can be inserted into the inner cavity of the shield cylinder via the through hole. Thereby, without requiring a special operation in the sticking operation, each of the wing projections can prevent the needle base from moving in the axial direction and can hold the needle base in the shield cylinder reliably in a state in which the needle protrudes from the front end of the shield cylinder by a predetermined length.

Abstract: A hemodialysis apparatus which controls dialysis conditions. The hemodialysis treatment is carried out under dialysis conditions determined by defining the course of the chronological target blood indication level as a target control line, measuring the blood indication level at each measurement point (controlling point) in the chronological course, calculating the dialysis conditions using the measured blood indication level and the target blood indication level at the next measurement point (controlling point) of the measurement point in the hemodialysis apparatus carrying out hemodialysis treatment by controlling dialysis conditions using blood volume (BV level) or blood volume change as an indication level (hereinafter blood indication level), to attain the target blood indication level at the next measurement point. This apparatus has a simple control mechanism and has little risk of misoperation or out-of-control. An operator can easily handle it and the control can be quickly and precisely carried out.

Abstract: The configuration of the present invention includes a winged shield that has a cylindrical shield tube and wings linked to a front end side of the shield tube, a hub that is inserted into an inner bore of the shield tube so as to be movable in an axial direction, and a cannula that is mounted to a front end portion of the hub. By engaging a protrusion with a third annular groove, the hub is held with the winged shield in a state where the cannula protrudes for a predetermined length from a front end of the shield tube. In a state where an inward annular protrusion of the shield tube is engaged with a first holding portion, a tip of the cannula can be stored in the shield tube. By engaging the protrusion of a holding mechanism with a first annular groove, the hub is held with the shield tube so as not to be moved within the shield tube.

Abstract: A fluid control device is characterized in that the device is structured of a hollow first fluid path (21) and second fluid path (22), a housing portion (1) formed between the first fluid path and the second fluid path and having a hollow portion with a cross-sectional area larger than cross-sectional areas of both fluid paths, and a valve member (3) that has a main body (31) and a projection portion (32) that are installed in an opening portion where the first fluid path is connected to the hollow portion and that is formed of an elastic material. The fluid control device enables the circulation of liquid when the pressure of liquid flowing from the first fluid path toward the second fluid path is more than a predetermined level. The fluid control device enables accurate and safe measurement of pressure including blood pressure, and, when flushing operation of an infusion circuit etc.

Abstract: An adhesion-preventive film is provided that is excellent in flexibility and can prevent cracks from occurring. The adhesion-preventive film contains a copolymer of lactide and caprolactone. The lactide and the caprolactone of the copolymer has a mole ratio in the range of 65:35 to 80:20. Even when this adhesion-preventive film is used in a curved state in vivo or is wound around an affected part such as a tendon, for example, it can provide an adhesion-preventive function for a sufficiently long period without cracking.

Abstract: A clip that is able to form a separate space in the hollow member such as flexible tube or bag-like article and the like or to block its opening part by clipping hollow member. The clip includes two plate-like members with one plate-like member having a groove formed in a longitudinal direction of the plate-like member and the other plate-like member having a projection part formed in the longitudinal direction. The form of the projection part is made highest in a vicinity of a central part of the clip and lowest at both end parts of the plate-like member.

Abstract: A tube clamp includes a housing 1 that has an inner cavity 2 longitudinally passing through the housing 1 and an upper window 3, and a roller 4 that is mounted in the housing with its cylindrical surface positioned at the upper window and is movable longitudinally in the inner cavity. A pair of guide grooves 6 is formed along the upper window and guides a roller shaft 5. A distance between a bottom face 7 of the inner cavity and the guide grooves is smaller in a pinching region 7b than in an open region 7a. When the roller is positioned in the pinching region, a tube 11 is closed between the roller and the bottom face, and when the roller is positioned in the open region, the flow path in the tube is opened. The tube clamp further includes a slider 8 that is attached over the roller and is movable together with the roller in the inner cavity.

Abstract: A fluid control device is characterized in that the device is structured of a hollow first fluid path (21) and second fluid path (22), a housing portion (1) formed between the first fluid path and the second fluid path and having a hollow portion with a cross-sectional area larger than cross-sectional areas of both fluid paths, and a valve member (3) that has a main body (31) and a projection portion (32) that are installed in an opening portion where the first fluid path is connected to the hollow portion and that is formed of an elastic material. The fluid control device enables the circulation of liquid when the pressure of liquid flowing from the first fluid path toward the second fluid path is more than a predetermined level. The fluid control device enables accurate and safe measurement of pressure including blood pressure, and, when flushing operation of an infusion circuit etc.

Abstract: A pressure detector having a pipe inner pressure receiving opening section comprising a fluid passage for transporting fluid and a diaphragm hermetically sealing an opening made in one side face of the fluid passage, and a pressure detecting section coupled with the pipe inner pressure receiving opening section through the diaphragm and detecting physical variation of the diaphragm, characterized in that the diaphragm is provided loosely at the opening, and the pressure detecting section comprises at least a pressure detector, a load transmitting means having one end connected with the diaphragm and the other end touching the pressure detector, and means for loading the pressure detector.