Patents Assigned to Kaohsiung Medical University
  • Methods and Compositions for Inhibition of ATR and FANCD2 Activation
    Publication number: 20160158190
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 9, 2016
    Applicant: Kaohsiung Medical University
    Inventors: Hui-Chun WANG, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung WU
  • Chemical profile of detecting bioactive components of quinones, stilbenes, flavones and alkaloids
    Patent number: 9341605
    Abstract: Disclosed are a method for analyzing chemical profiles of components from a herbal medicine product. Components may include quinone (including rhein, sennoside A and/or aloe-emodin), stilbene containing resveratroloside, flavone including baicalin, and/or alkaloid including berberine and/or palmatine. The method includes steps of: (a) respectively chromatographing a methanol extract of product and standard(s) corresponding to the component(s) using HPLC; (b) comparing HPLC chromatogram of extract and standard(s); and (c) analyzing the chemical profiles of the product from the comparison results.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: May 17, 2016
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Fang-Rong Chang, Tung-Ying Wu, Yang-Chang Wu
  • Preparation of anti-PEG antibody expressing cell and application thereof
    Patent number: 9329180
    Abstract: The present invention provides a method for preparing an isolated eukaryotic cell which presents an anti-polyethylene glycol (PEG) antibody on a cell membrane. The present invention also provides a method for a quantitative analysis of a polyethylene glycol (PEG) by said anti-PEG antibody expressing cell. The cell-based quantitative analysis of the present prevention could sensitively quantify free PEG and PEG-modified macromolecules (proteins, nanoparticles and liposomes) as sensitive as nano-gram level.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: May 3, 2016
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Tian-Lu Cheng, Steven R. Roffler, Kuo-Hsiang Chuang, Ssu-Jung Lu
  • Diagnosis and treatment of endometriosis
    Patent number: 9322017
    Abstract: The invention discloses a diagnosis of endometriosis, by determining a level of miR-199a-5p as a biomarker to diagnose endometriosis. The invention also discloses a treatment of endometriosis, by administering pre-miR-199a to a subject in need thereof in a dosage of 4 to 8 mg/per kilogram of body weight per 1 to 3 days for 4 weeks to inhibit the processes of endometriosis development.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: April 26, 2016
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Eing-Mei Tsai, Chia-Yi Hsu
  • Conformations of divergent peptides with mineral binding affinity
    Patent number: 9314533
    Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: April 19, 2016
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
  • Sustained release systems and preparation method thereof
    Patent number: 9314503
    Abstract: The present invention relates to a hydrophilic drug and ?-tricalcium phosphate (?-TCP) coating on a surface area of biopolymer matrix to form a sustained release system. The present invention also provides a method for preparing a sustained release system, comprising providing a surface are of biopolymer matrix coated with a hydrophilic drug and ?-TCP.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: April 19, 2016
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yin-Chin Fu, Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang, Cherng-Chyi Tzeng
  • Methods of using microRNA 195 in providing neuroprotection
    Patent number: 9315812
    Abstract: The invention relates to a method for providing neuroprotection comprising administering to a subject an effective amount of a miRNA or a variant thereof. By providing neuroprotection, stroke or ischemic stroke can be prevented and/or treated.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: April 19, 2016
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Suh-Hang H Juo, Yung-Song Wang, Hsin-Yun Cheng
  • Water extract of for immunostimulatory effect and preparation method thereof
    Patent number: 9241962
    Abstract: A preparation method for a water extract of the fruiting body of Antrodia camphorata (ACW) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract. This polysaccharide-rich water extract from A. camphorata induces the maturation of dendritic cells, enhances T cell proliferation and INF-? production, and polarizes them toward the Th1 pathway. ACW can be effectively applied in cancer immunotherapy.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 26, 2016
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, Mei-Chin Lu, Fang-Rong Chang, Ying-Chi Du, Tung-Ying Wu
  • METHOD FOR MONITORING LEVEL OF PARABEN IN COSMETICS
    Publication number: 20160020077
    Abstract: The invention discloses a method for monitoring level of paraben comprising: dissolving a sample in a solvent and obtaining a supernatant containing paraben by ultrasonic vibration and high speed centrifugation; performing a derivatization reaction between a derivatization reagent and paraben by adding the derivatization reagent into the supernatant to obtain a derivatization solution containing a tagged paraben; extracting the derivatization solution by an extractant to obtain an extract containing the tagged paraben; and ionizating the tagged paraben by a laser beam and analyzing mass-to-charge ratio of the tagged paraben by an analyzer to determine molecular weight thereof.
    Type: Application
    Filed: January 9, 2014
    Publication date: January 21, 2016
    Applicant: Kaohsiung Medical University
    Inventors: Chi-Yu LU, Yi-Hsuan LEE
  • ALL GOLD FLUORESCENCE RESONANCE ENERGY TRANSFER PROBE AND USE THEREOF
    Publication number: 20150329592
    Abstract: The present invention relates to a gold fluorescence resonance energy transfer nanoprobe comprising a gold fluorescence donor, a gold fluorescence acceptor, and a linker fragment that connects the gold fluorescence donor and the gold fluorescence acceptor, wherein the fluorescence resonance energy transfer is carried out between the gold fluorescence donor and the gold fluorescence acceptor. This all gold probe employing fluorescence resonance energy transfer technique can be used for detecting diseases such as arthritis, osteoporosis, and cancer metastasis.
    Type: Application
    Filed: May 11, 2015
    Publication date: November 19, 2015
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Chih-Kuang Wang, Mei-Ling Ho, Chung-Hwan Chen, Yin-Chih Fu, Jia-Huie Lin, Chih-Yun Lee, Je-Ken Chang
  • CONFORMATIONS OF DIVERGENT PEPTIDES WITH MINERAL BINDING AFFINITY
    Publication number: 20150320876
    Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
    Type: Application
    Filed: July 22, 2015
    Publication date: November 12, 2015
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
  • SECONDARY ANTIBODY DETECTED EPITOPE AND PREPARATION OF SAME
    Publication number: 20150315265
    Abstract: A method of preparing an epitope for a secondary antibody detected protein tag, comprising: constructing a expressing vector, comprising a nucleotide sequence for encoding the secondary antibody detected protein tag comprising at least one epitope selected from at least one primary antibody which is detected by corresponding secondary antibody; expressing the vector in a host cell; and obtaining the secondary antibody detected protein tag which is expressed in the host cell. Further, a method for constructing a protein molecular weight marker ladder, comprising constructing a plurality of recombinant protein tags with different molecular weights, wherein each the recombinant protein tag comprises at least one epitope of primary antibody. Besides, a secondary antibody detected protein tag comprises at least two peptide sequences of epitopes selected from primary antibodies of at least two different species.
    Type: Application
    Filed: November 6, 2014
    Publication date: November 5, 2015
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: TIAN-LU CHENG, Steve ROFFLER, WEN-WEI LIN, I-JU CHEN
  • Biomaterial for wound healing
    Patent number: 9173969
    Abstract: The present invention provides a biomaterial comprising a scaffold consisting of collagen, hyaluronic acid, and gelatin, which are cross-linked via ethyl-3-[3-dimethylaminopropyl]carbodiimide (EDC) between any two of collagen, hyaluronic acid, and gelatin. The present invention further provides a method for preparing the biomaterial and a method for enhancing wound healing with the biomaterial.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: November 3, 2015
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Min Wang, Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yi-Ting Chou, Ching-Ying Wu, Su-Shin Lee
  • POLYMERIC NANOCARRIERS WITH DUAL IMAGES TRACKING PROBE AND METHOD FOR MANUFACTURING THE SAME
    Publication number: 20150265546
    Abstract: The present invention relates to a nanoparticle carrier and the method for manufacturing the same. The nanoparticle carrier comprises hydrophobic molecules grafted with nanogold clusters and hydrophobic molecules grafted with hydrophilic molecules. The hydrophilic molecules are located on the outer layer of the nanoparticle and the nanogold clusters are wrapped inside the nanoparticle.
    Type: Application
    Filed: March 19, 2015
    Publication date: September 24, 2015
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Chih-Kuang Wang, Li-Cheng Pan, Chih-Yun Lee, Hong-Jhe Lin, Che-Wei Lin, Po-Len Liu, Ping-Hsiu Shih
  • Composition for treating diabetes and metabolic diseases and a preparation method thereof
    Patent number: 9085520
    Abstract: Disclosed is a chalcone composition for treating diabetes and metabolic syndromes. In particular, the chalcone compound bound with 2-halogen in ring A significantly decreases the blood glucose level in the in vitro anti-diabetic effect experiment. In the in vivo animal model, the leading chalcone compound can prevent the progression of diabetes and control the blood glucose level, and there is no significant difference in the gains in body weight. Throughout the seven-week administration, there are no hepatic or renal toxicity observed.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: July 21, 2015
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yang-Chang Wu, Fang-Rong Chang, Tusty-Jiuan Hsieh, Ying-Chi Du, Yi-Hong Tsai, Chi-Ting Hsieh
  • INHALED NO DONOR PIPERAZINYL DERIVATIVE PREVENTING ALLERGIC PULMONARY VASCULAR AND BRONCHIAL INFLAMMATION BY REDUCING VEGF AND RESTORING eNOS IN HYPOXIC PULMONARY ARTERY
    Publication number: 20150174157
    Abstract: A method for treating a disease is disclosed. The method includes steps of providing a subject in need thereof; and administering one selected from a group consisting of Piperazinyl Analogs and Piperazinyl Complex Analogs compound represented by formula II or formula III, a pharmaceutically acceptable salts thereof; and a pharmaceutical composition thereof to the subject in a dosage between 1 and 5.0 milligrams per kilogram of body weight, in a liquid mist, dry powder or aerosolized formulation.
    Type: Application
    Filed: February 27, 2015
    Publication date: June 25, 2015
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun CHEN
  • Hybrid superparamagnetic iron oxide nanoparticles and polyethylenimine as a magnetocomplex for gene transfection
    Patent number: 9050362
    Abstract: Disclosed are the nanoparticle and the method for the same, and the preparing method includes steps of mixing polyethylenimine (PEI) with the poly(acrylic acid)-bound iron oxide (PAAIO) to form a PEI-PAAIO polyelectrolyte complex (PEC) and mixing the PEI-PAAIO PEC with genetic material such as plasmid DNA to form the PEI-PAAIO/pDNA magnetic nanoparticle. The PEI-PAAIO/pDNA magnetoplex is highly water dispersible and suitable for long term storage, shows superparamagnetism, low cytotoxicity, high stability and nice transfection efficiency, and thus the PEI-PAAIO PEC can replace PEI as a non-viral gene vector.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: June 9, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Li-Fang Wang, Shuo-Li Sun, Yu-Lun Lo
  • Method of regulating the expression level of survival of motor neuron 1
    Patent number: 9045793
    Abstract: The present invention relates to a method of regulating the expression level of survival of motor neuron 1 (SMN1) comprising administering to a subject in need thereof a therapeutically effective amount of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulator and a pharmaceutically acceptable carrier. The present invention also relates to a method of detecting enzyme activity of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in human fibroblasts comprising detecting protein expression level of survival of motor neuron 1 (SMN1).
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: June 2, 2015
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yuh-Jyh Jong, Shih-Hsien Hsu, Jan-Gowth Chang
  • METHOD OF THERAPY AND DIAGNOSIS OF ENDOTHELIAL DYSFUNCTION
    Publication number: 20150119443
    Abstract: The invention discloses a method of therapy of endothelial dysfunction, by administering microRNA let-7g to a subject in need, wherein the microRNA let-7g inhibits SMAD2 transcription factor from activation and translocation into nucleus, thereby decreasing monocyte cell adhesion, inflammation and thrombosis and increasing angiogenesis.
    Type: Application
    Filed: January 7, 2014
    Publication date: April 30, 2015
    Applicant: Kaohsiung Medical University
    Inventor: Suh-Hang Juo
  • WATER EXTRACT OF ANTRODIA CAMPHORATA FOR IMMUNOSTIMULATORY EFFECT AND PREPARATION METHOD THEREOF
    Publication number: 20150104481
    Abstract: A preparation method for a water extract of the fruiting body of Antrodia camphorata (ACW) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract. This polysaccharide-rich water extract from A. camphorata induces the maturation of dendritic cells, enhances T cell proliferation and INF-? production, and polarizes them toward the Th1 pathway. ACW can be effectively applied in cancer immunotherapy.
    Type: Application
    Filed: December 19, 2014
    Publication date: April 16, 2015
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yang-Chang Wu, Mei-Chin Lu, Fang-Rong Chang, Ying-Chi Du, Tung-Ying Wu