Patents Assigned to Kaohsiung Medical University
  • Composition for treating influenza A (HN) virus and a preparation method therefor
    Patent number: 8993618
    Abstract: New pharmaceutical compositions extracted from Ferula assa-foetida are confirmed to effectively treat influenza A (H1N1) virus. The extraction method of the new pharmaceutical compositions mainly includes steps of: (a) extracting F. assa-foetida with methanol to obtain a crude extract; (b) fractioning the crude extract with n-hexane-methanol to obtain a methanol extract; (c) fractioning the methanol extract with chloroform-water to obtain a chloroform extract; and (d) chromatographing the chloroform extract to obtain the pharmaceutical compositions, which can be further fractioned and chromatographed to obtain various sesquiterpene coumarins.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: March 31, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, Fang-Rong Chang, Lien-Chai Chiang
  • Anti-bacterial infection, inflammation, and leukemia composition and use thereof
    Patent number: 8975234
    Abstract: A method of inhibiting the growth of Gram-positive bacteria comprising administering an effective amount of Tellimagrandin II, its pharmaceutically acceptable salt, enantiomer, isomer or tautomer to a subject is provided. The Gram-positive bacteria comprise methicillin-resistant Staphylococcus aureus. A method of treating sepsis comprising administering an effective amount of Tellimagrandin II, its pharmaceutically acceptable salt, enantiomer, isomer or tautomer to a subject is also provided. A method of treating leukemia comprising administering an effective amount of Tellimagrandin II, its pharmaceutically acceptable salt, enantiomer, isomer or tautomer to a subject is further provided.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: March 10, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Lih-Geeng Chen, Yen-Hsu Chen, Chin Hsu, Hsin-Ju Chien, Shih-Han Kao, Yu-Wei Chang, Wan-Chun Huang
  • 18?-Glycyrrhetinic acid derivatives and synthetic method thereof
    Patent number: 8969617
    Abstract: The present invention provides a chemical compound having the structure being one selected from a group consisting of wherein R1 is one selected from a group consisting of COOCH3, COOCH2Ph, CONHCH(CH3)2 and CONHC6H5, R2 is one selected from a group consisting of H, CH3 and CH(CH3)2, R3 is one selected from a group consisting of H, CH3, CH(CH3)2 and CH2Ph, and R4 is one of CH(CH3)2 and C6H5.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: March 3, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Chun-Nan Lin, Dravidum Maitraie, Jih-Pyang Wang, Chi-Feng Hung, Huang-Yao Tu, Ya-Ting Liou, Bai-Luh Wei, Shyh-Chyun Yang
  • 4-anilinofuro[2,3-b]quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same
    Patent number: 8952033
    Abstract: Disclosed herein are novel 4-anilinofuro[2,3-b]quinoline derivatives of formula (I): or a pharmaceutically acceptable salt thereof, wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these derivatives and their uses in the manufacture of pharmaceutical compositions and in the treatment of cancers.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: February 10, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Cherng-Chyi Tzeng, Yeh-Long Chen, Yu-Wen Chen, Pei-Jung Lu
  • hnRNP A1 knockout animal model and use thereof
    Patent number: 8946503
    Abstract: A nucleic acid construct comprising a genetic engineered heterogeneous nuclear ribonucleoprotein (hnRNP) A1 gene is provided. A transgenic mouse in which the expression of hnRNP A1 gene has been disrupted is also provided. The mouse is useful for studying the role of hnRNP A1 gene in normal and disease states of a developmental disorder and muscular diseases. Therefore, a method of screening a compound for potential use in prevention and/or treatment of developmental disorder and muscular diseases is further provided.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: February 3, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Yung-Fu Chang, Ting-Yuan Liu, Yuh-Jyh Jong, Jan-Gowth Chang
  • Method for preparing composition comprising porous ceramic with thermo-response hydrogel
    Patent number: 8940203
    Abstract: The present invention provides a method for preparing a composition comprising porous ceramic, comprising the following steps: (a) synthesizing poly(N-isopropylacrylamide-co-methacrylic acid) (p(NIPAAM-MAA)) or similar thermo-response compound thereof; (b) mixing a dispersant with hydroxyapatite or calcium phosphate salt; (c) mixing the p(NIPAAM-MAA) of the step (a) or similar thermo-response compound thereof with water to obtain a hydrogel solution; (d) mixing the hydrogel solution of the step (c) and product of the step (b) to produce a mixture; (e) adding macromolecular particles to the mixture of the step (d) and stirring to produce a slurry; (f) filling the slurry of the step (e) into a template slot; and disposing the template slot filling with the slurry of the step (f) on a crucible, then proceeding high temperature sinter in a furnace to form the composition comprising porous ceramic.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: January 27, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Chih-Kuang Wang, Mei-Ling Ho, Yin-Chih Fu, Gwo-Jaw Wang, Je-Ken Chang
  • MicroRNA based method for anti-colorectal cancer effects and prognosis of colorectal cancer
    Patent number: 8940480
    Abstract: The present invention discloses a method of providing anti-oncogenic effects in a subject suffered from colorectal cancer. The present invention also discloses a method for screening an anti-colorectal cancer agent. The present invention further discloses a method of determining the prognosis of a subject with colorectal cancer.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: January 27, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Suh-Hang Hank Juo, Jaw-Yuan Wang, I-Ping Yang, Hsiang-Lin Tsai
  • Synthesis of 2-(4-aminophenyl)benzothiazole derivatives and use thereof
    Patent number: 8927584
    Abstract: The present invention provides a photodynamic therapy to a patient having at least one tumor comprising the steps of: administering a compound of formula 6 (wherein R1 and R2 are defined as the above) in a pharmaceutically acceptable carrier to the patient; waiting for a sufficient time to allow the administered compound to be taken up by a target tissue having the at least one tumor; and irradiating a region of the patient containing the target tissue, wherein growth of the tumor is inhibited.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: January 6, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Jeh-Jeng Wang, Chao-Cheng Liao, Wan-Ping Hu, Ho-Chuan Shen
  • CONFORMATIONS OF DIVERGENT PEPTIDES WITH MINERAL BINDING AFFINITY
    Publication number: 20140377212
    Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
    Type: Application
    Filed: June 27, 2014
    Publication date: December 25, 2014
    Applicant: Kaohsiung Medical University
    Inventors: Hui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
  • Method of treating airway remolding symptom
    Patent number: 8912231
    Abstract: A method of treating airway remodeling symptom caused by phthalate esters, by providing a medication comprising: a ginger compound selected from one of (a) [6]-shogaol, (b) [6]-shogaol and [10]-gingerol, (c) [6]-shogaol and [8]-gingerol, and (d) [6]-shogaol and [6]-gingerol, and an acceptable carrier or excipient, which can relieve the airway remodeling symptoms of asthma, particularly to phthalate ester-induced airway remodeling, by suppressing the proliferation and migration of bronchial smooth muscle cells and reducing the instances of fatal asthma.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: December 16, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Ying-Chin Ko, Po-Lin Kuo
  • COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF
    Publication number: 20140350304
    Abstract: Disclosed is a chalcone composition for treating diabetes and metabolic syndromes. In particular, the chalcone compound bound with 2-halogen in ring A significantly decreases the blood glucose level in the in vitro anti-diabetic effect experiment. In the in vivo animal model, the leading chalcone compound can prevent the progression of diabetes and control the blood glucose level, and there is no significant difference in the gains in body weight. Throughout the seven-week administration, there are no hepatic or renal toxicity observed.
    Type: Application
    Filed: August 8, 2012
    Publication date: November 27, 2014
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yang-Chang Wu, Fang-Rong Chang, Tusty-Jiuan Hsieh, Ying-chi Du, Yi-Hong Tsai, Chi-Ting Hsieh
  • Conformations of divergent peptides with mineral binding affinity
    Patent number: 8889828
    Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: November 18, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Hui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
  • Method for controlled release of parathyroid hormone from cross-linked hyaluronic acid hydrogel
    Patent number: 8883862
    Abstract: A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: November 11, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Mei-Ling Ho, Rajalakshmanan Eswaramoorthy, Shun-Cheng Wu, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Cherng-Chyi Tzeng, Hui-Ting Chen, Yao-Hsien Wang
  • Ethanol extract of for inducing apoptosis and preparation method thereof
    Patent number: 8883167
    Abstract: A preparation method for an ethanol extract of the fruiting body of Antrodia camphorata (EEAC) is provided. The preparation method includes steps of: (a) providing the fruiting body of A. camphorata (AC); (b) extracting the fruiting bodies with a first ethanol solution; and (c) obtaining EEAC. EEAC further can be sequentially extracted or fractioned by n-hexane, ethyl acetate and ethanol, and an n-hexane fraction (FC), an ethyl acetate fraction (FA) and an ethanol fraction (FB) respectively are generated. The growth inhibition and apoptosis induction of leukemia cell line HL 60 are effectively mediated by FA product, in which zhankuic acid A is the bioactive marker. The amount of triterpenoid in the fruiting body of AC can be determined by NMR and HPLC analysis.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: November 11, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, Mei-Chin Lu, Fang-Rong Chang, Ying-Chi Du, Tung-Ying Wu
  • Cycloalkyl triamine pentacarboxylate as ligands for paramagnetic metal complexes
    Patent number: 8877163
    Abstract: A cycloalkyl triamine pentacarboxylate compound coordinating to a metal ion to form a high stability metal complex in serum is provided. The metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: November 4, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Yun-Ming Wang, Chih-Wei Chiu, Gin-Chung Liu
  • Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres
    Patent number: 8865220
    Abstract: The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 ?m, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly(lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: October 21, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Cherng-Chyi Tzeng, Eswaramoorthy Rajalakshmanan
  • METHODS OF USING MICRORNA 195 IN PROVIDING NEUROPROTECTION
    Publication number: 20140294943
    Abstract: The invention relates to a method for providing neuroprotection comprising administering to a subject an effective amount of a miRNA or a variant thereof. By providing neuroprotection, or ischemic stroke can be prevented and/or treated.
    Type: Application
    Filed: November 5, 2012
    Publication date: October 2, 2014
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Suh-Hang H Juo, Yung-Song Wang, Hsin-Yun Cheng
  • Composition for treating influenza a (HN) virus and a preparation method therefor
    Patent number: 8815949
    Abstract: New pharmaceutical compositions extracted from Ferula assa-foetida are confirmed to effectively treat influenza A (H1N1) virus. The extraction method of the new pharmaceutical compositions mainly includes steps of: (a) extracting F. assa-foetida with methanol to obtain a crude extract; (b) fractioning the crude extract with n-hexane-methanol to obtain a methanol extract; (c) fractioning the methanol extract with chloroform-water to obtain a chloroform extract; and (d) chromatographing the chloroform extract to obtain the pharmaceutical compositions, which can be further fractioned and chromatographed to obtain various sesquiterpene coumarins.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: August 26, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, Fang-Rong Chang, Lien-Chai Chiang
  • Method for improving tetracycline-resistance of
    Patent number: 8802737
    Abstract: A method for improving tetracycline-resistance of A. baumannii, by providing a ginger compound combined with tetracycline to against A. baumannii infection, wherein the ginger compound comprises [6]-dehydrogingerdione, [6]-shogaol and [6]-gingerol or [10]-gingerol, [6]-shogaol and [6]-gingerol.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: August 12, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Yen-Hsu Chen, Hui-Min Wang, Chung-Yi Chen, Hsi-An Chen, Wei-Ru Lin
  • Random number generating method
    Patent number: 8793296
    Abstract: A random number generating method includes sending a signal source for outputting a data sequence and randomly retrieving a segment of data having an operation length as a seed; converting the seed into a first operation value, determining whether a difference between the first operation value and a second operation value is larger than a threshold value, and determining whether a total number of times the first operation value has been inputted into the operation value processing step is larger than a predetermined value. The first operation value is reset by a reset algorithm; otherwise the sample selection step is re-performed. The operation values are converted into a random number. A total number of bits of the random number is calculated. The operation value setting step is performed or a latest random number having a length equal to the operation length is set as the seed.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: July 29, 2014
    Assignee: Kaohsiung Medical University
    Inventors: I-Te Chen, Jer-Min Tsai, Jeng-Nan Tzeng, Wen-Hsien Ho