Patents Assigned to Keio University
  • Patent number: 11349522
    Abstract: A communication circuit including a first coupler, a transmission-data change detector configured to detect a change in transmission data input to a transmitter, and a received-data change detector configured to detect a change in received data output from a receiver. In a standby state in which the received-data change detector and the transmission-data change detector do not detect changes in the received data and the transmission data, an input side of the receiver is connected to the first coupler and an output side of the receiver is disconnected from the first port in a receiving path; and an input side of the transmitter is connected to the first port and an output side of the transmitter is disconnected from the first coupler in a transmitting path.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: May 31, 2022
    Assignee: KEIO UNIVERSITY
    Inventor: Tadahiro Kuroda
  • Publication number: 20220152132
    Abstract: Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.
    Type: Application
    Filed: March 6, 2020
    Publication date: May 19, 2022
    Applicants: Keio University, Biomx Ltd.
    Inventors: Kenya HONDA, Koji ATARASHI, Seiko NARUSHIMA, Efrat KHABRA, Hava BEN DAVID, Eyal WEINSTOCK, Yulia MATIUHIN, Naomi Bluma ZAK
  • Patent number: 11332527
    Abstract: A subject of the present invention is to provide an anti AQP3 antibody specifically recognizing the extracellular domain of aquaporin 3 (AQP3), which is one type of a water channel protein. By selecting a monoclonal antibody which specifically binds to an oligopeptide included in loop C as one of the extracellular domains of AQP3, an anti AQP3 antibody that is desired in the present invention is provided. An anti AQP3 monoclonal antibody of the present invention can directly bind, from the outside of a cell, to AQP3 present in a cell membrane. Furthermore, as an anti AQP3 monoclonal antibody of the present invention can have an inhibitory activity, the function of permeating a low molecular weight molecule or the like, which is carried by AQP3, can be suppressed.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: May 17, 2022
    Assignee: Keio University
    Inventors: Mariko Chikuma, Masato Yasui
  • Patent number: 11331039
    Abstract: An image acquisition unit configured to acquire an image representing a three-dimensional shape of a surface of a human body, a spinal-column arrangement estimation-unit configured to estimate spinal-column arrangement of the human body using accumulated data, and an angle calculation unit configured to calculate at least one of a Cobb angle and a rotation angle from the estimated spinal-column arrangement are included.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: May 17, 2022
    Assignee: Keio University
    Inventors: Morio Matsumoto, Kota Watanabe, Yoshimitsu Aoki, Ran Choi
  • Patent number: 11333837
    Abstract: An optical communication system includes a first communication system to communicate first information from a controller to a truck and a second communication system to communicate second information. The first communication system includes a first light emitter to output the first information, a first optical fiber to transport the light output from the first light emitter while letting the light leak therefrom, and a first light receiver to receive the light leaking from the first optical fiber. The second communication system includes a second light emitter to output second information, a second optical fiber to transport the light output from the second light emitter and input to the second optical fiber at some point along the second optical fiber, and a second light receiver to receive the light transported over the second optical fiber.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: May 17, 2022
    Assignees: MURATA MACHINERY, LTD., KEIO UNIVERSITY
    Inventors: Masakazu Ishibashi, Shinichiro Haruyama
  • Patent number: 11332773
    Abstract: The present invention provides a method for evaluating tumorigenicity of a test cell, including transplanting the cell into anterior chamber of an eye of an experimental animal, and observing the presence or absence of tumor formation. According to the present invention, tumorigenicity can be evaluated in a short period and conveniently.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: May 17, 2022
    Assignee: KEIO UNIVERSITY
    Inventors: Shigeto Shimmura, Shin Hatou, Emi Inagaki, Kazuo Tsubota
  • Publication number: 20220142561
    Abstract: An estimation method according to the disclosure for estimating a parameter related to skin function, the estimation method includes an image acquisition step for acquiring a skin image in which unevenness of a skin surface is captured; an extraction step for extracting a feature vector based on topological information on the skin image from the skin image acquired in the image acquisition step; an estimation step for estimating the parameter related to skin function based on the feature vector extracted in the extraction step, using an estimation model constructed based on past actual measurement data in which feature vectors are associated with the parameter related to skin function; and a presentation step for presenting the parameter related to skin function estimated in the estimation step.
    Type: Application
    Filed: March 19, 2020
    Publication date: May 12, 2022
    Applicants: KEIO UNIVERSITY, KOSE Corporation
    Inventors: Hiroshi KAWASAKI, Eiryo KAWAKAMI, Keita KOSEKI, Tamotsu EBIHARA, Masayuki AMAGAI, Eiji NARU, Makoto MIZUNO, Miki ITO, Toru ATSUGI, Yukako KIMURA
  • Publication number: 20220133813
    Abstract: Provided herein are compositions and methods for the induction and/or proliferation of CD8+ T-cells. The disclosure also provides methods of treatment of diseases that can be treated by the induction and/or proliferation of CD8+ T-cells.
    Type: Application
    Filed: February 8, 2019
    Publication date: May 5, 2022
    Applicant: Keio University
    Inventors: Kenya Honda, Takeshi Tanoue, Yutaka Kawakami, Koji Atarashi, Satoru Morita, Ashwin Nicholas Skelly
  • Publication number: 20220134542
    Abstract: A position/force controller performs a first conversion for distributing control energy to at least one of velocity or position energy and force energy, in accordance with a function to be realized, based on velocity (or position) and force information, which correspond to information relating to a position based on an operation of an actuator, and information serving as reference of control. The position/force controller calculates at least one of a velocity or position control amount and a force control amount based on at least one of the energies obtained through the distribution. The position/force controller integrates the calculated control amounts, performs a second conversion, and determines input to the actuator. The position/force controller performs a process, corresponding to increasing or decreasing performed on at least one of the velocity or position energy and the force energy together or independently, with satisfaction of a condition set for the control energy.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 5, 2022
    Applicants: KEIO UNIVERSITY, Motion Lib, Inc.
    Inventors: Kouhei OHNISHI, Takahiro NOZAKI, Takahiro MIZOGUCHI
  • Publication number: 20220125858
    Abstract: The present invention provides an antibacterial composition against drug-resistant bacteria or pro-inflammatory bacteria containing an intestinal bacterium as an active ingredient, or a pharmaceutical composition for treating, ameliorating, or preventing an infectious disease or an inflammatory disease.
    Type: Application
    Filed: March 5, 2020
    Publication date: April 28, 2022
    Applicant: KEIO UNIVERSITY
    Inventors: Kenya HONDA, Keiko YASUMA, Koji ATARASHI, Seiko NARUSHIMA, Munehiro FURUICHI, Takaaki KAWAGUCHI
  • Publication number: 20220082564
    Abstract: A marker may determine sensitivity to an anti-cancer agent early after the start of treatment with the anti-cancer agent. The anti-cancer agent may include oxaliplatin or a salt thereof, fluorouracil or a salt thereof, and levofolinate or a salt thereof, the marker including one or more molecules selected from the group consisting of 2AMAD, 2ABA, 2CYPR, 5OPRO, 6AHXA, ADEN, ASP, BETNC, CARB, CSSG, DOPM, GGLCY, GSSG, HYPT, METSF, N6MDA, NOMTR, PHEP, PRO, and RIB5P.
    Type: Application
    Filed: September 26, 2019
    Publication date: March 17, 2022
    Applicants: KEIO UNIVERSITY, KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Shinji SUGIMOTO, Yusuke TANIGAWARA, Mitsuhisa MATSUO, Hiroyuki TAKAHASHI
  • Patent number: 11272833
    Abstract: A treatment-instrument insertion aid (10) for aiding insertion of a treatment instrument into a body includes an inner tube (20) having flexibility into which the treatment instrument is insertable, and an outer tube (30) having flexibility into which the inner tube (20) is insertable. Both end portions (20B) of the inner tube (20) are formed of a hard material, and an intermediate portion (20A) between both the end portions (20B) is formed of a soft material.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: March 15, 2022
    Assignees: KEIO UNIVERSITY, KABUSHIKI KAISHA TOP
    Inventors: Norihito Wada, Takuya Miyazaki, Yoshihiko Himura
  • Publication number: 20220062315
    Abstract: An object of the present invention is to provide an anti-human norovirus agent which can inhibit infection with and proliferation of human norovirus. The present inventors have found that the object can be attained through provision of an anti-human norovirus agent comprising, as an active ingredient, a fucose analog having an inhibitory action on glycosylation by fucosyltransferase (FUT). Examples of the active ingredient include a fucose analog represented by formula (III) or (IV) or a salt thereof. [In the formulas, each of formula (III) and formula (IV) represents an ?-anomer or a ?-anomer; each of R4, R3, and R4 is —OH or -OAc; R2 is a halogen atom, —OH, or -OAc; and R5 is —CH3, —C?CH, —C?CCH3, or —CH2C?CH.
    Type: Application
    Filed: December 27, 2019
    Publication date: March 3, 2022
    Applicants: KEIO UNIVERSITY, THE KITASATO INSTITUTE
    Inventors: Kazuhiko KATAYAMA, Akira FUJIMOTO, Kei HAGA, Reiko TODAKA, Toshiro SATO
  • Patent number: 11241200
    Abstract: According to one embodiment, an X-ray computed tomography apparatus includes a gantry body, a column, and fixing equipment. The gantry body includes a bore to form a field of view, and also includes an X-ray tube and an X-ray detector. The column supports the gantry body so that the gantry body is vertically movable with a central axis of the bore extending vertically to a floor face. The fixing equipment fixes a subject holder so that the subject holder is located on a passage of the bore and partially in the bore in a phase of attaching a subject to the subject holder.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: February 8, 2022
    Assignees: CANON MEDICAL SYSTEMS CORPORATION, KEIO UNIVERSITY
    Inventors: Keisuke Oishi, Katsumi Gotanda, Masahiro Jinzaki, Takeo Nagura, Naomichi Ogihara
  • Publication number: 20220034900
    Abstract: An analysis method includes: acquiring data corresponding to a mass spectrum obtained by subjecting a sample containing a microorganism to mass spectrometry; and acquiring information on Group A Streptococcus of emm type 1, based on the presence or absence, or magnitude of a peak in a first range of m/z of 10930 or more to 10945 or less in the mass spectrum.
    Type: Application
    Filed: September 18, 2019
    Publication date: February 3, 2022
    Applicants: KEIO UNIVERSITY, SHIMADZU CORPORATION
    Inventors: Miyuki MOROZUMI, Megumi SAKUMA, Koretsugu OGATA, Keisuke SHIMA, Shinji FUNATSU
  • Publication number: 20220033911
    Abstract: Provided are a method for determining prognosis of endometrial cancer, a method for determining endometrial cancer patient compatible to preservation therapy, and a method for determining risk of endometrial cancer. The methods comprise detecting DNA methylation level at a target CpG site in a genomic DNA derived from an endometrial cell, endometrial cancer cell or tissue containing the cell. Prognosis of endometrial cancer, compatibility to preservation therapy, or risk of endometrial cancer of a subject is determined on the basis of the detected DNA methylation level.
    Type: Application
    Filed: December 5, 2019
    Publication date: February 3, 2022
    Applicants: KEIO UNIVERSITY, SEKISUI MEDICAL CO., LTD.
    Inventors: Yae KANAI, Eri ARAI, Daisuke AOKI, Nobuyuki SUSUMU, Wataru YAMAGAMI, Takeshi MAKABE
  • Publication number: 20220023355
    Abstract: In the present invention, the influence by flora of the skin on dermatitis is examined by analyzing Tmem79-knockout model mice, and a bacterium having a suppressive effect on dermatitis is identified, and the present invention relates to a pharmaceutical composition derived from such a bacterium, containing as active components one or more substances selected from: (a) a bacterial cell of an ampicillin-sensitive bacterium, or a constituent component of the bacterium; (b) a culture supernatant of an ampicillin-sensitive bacterium, or a purified product from the culture supernatant; (c) an extract of an ampicillin-sensitive bacterium; and (d) a metabolite of an ampicillin-sensitive bacterium.
    Type: Application
    Filed: February 3, 2020
    Publication date: January 27, 2022
    Applicants: RIKEN, KEIO UNIVERSITY
    Inventors: Yoshihiro Ito, Kenya Honda, Masayuki Amagai, Eiryo Kawakami
  • Publication number: 20220010271
    Abstract: A method for producing a brain organoid is provided, including a step of culturing a neuroectoderm marker-positive cell aggregate in a medium containing an extracellular matrix with a concentration of more than 10% by volume.
    Type: Application
    Filed: October 10, 2019
    Publication date: January 13, 2022
    Applicants: JSR Corporation, KEIO UNIVERSITY
    Inventors: Hayato HIRAMINE, Mitsuru ISHIKAWA, Hideyuki OKANO
  • Patent number: 11220418
    Abstract: Weighing and filling apparatus for controlling filling device based on a container weight. A linear actuator for driving a drive shaft coupled to container support unit is included, a weight measuring unit determines the container weight from a detected height of the drive shaft detected by a height detecting unit and a drive signal of the linear actuator at the detected height. A first acceleration signal is calculated from a specified height of the container support unit set in advance and the height detected by the height detecting unit, a second acceleration signal is calculated from the container weight and an expected weight expected to be applied to the container support unit. The container support unit is kept at the specified height by a drive signal calculated from the first and second acceleration signals.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: January 11, 2022
    Assignees: KEIO UNIVERSITY, SHIBUYA CORPORATION
    Inventors: Takahiro Nozaki, Kouhei Ohnishi, Toshiaki Naka, Masato Ohta, Takaharu Kikura
  • Publication number: 20210404009
    Abstract: A method for determining a risk of urothelial carcinoma may be based on the methylation level of DNA. A method for determining a risk of canceration of a urothelial tissue may involve detecting the DNA methylation level of a CpG site of at least one gene selected from TENM3, HOXC4, TLR1, CPVL and PRDM16 in genomic DNA preferably derived from a urothelial cell or a tissue containing the urothelial cell; and determining a risk of canceration of the urothelial tissue from the detected DNA methylation level.
    Type: Application
    Filed: March 19, 2019
    Publication date: December 30, 2021
    Applicant: KEIO UNIVERSITY
    Inventors: Yae KANAI, Eri ARAI