Abstract: Novel nanoscale discotic liquid crystalline porphyrins, methods for their preparation, and device fabrication are disclosed. These compounds are capable of being used as high-efficiency photovoltaic materials, organic semiconducting materials, and organic light emitting materials.

Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.

Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.

Abstract: Devices and systems for the detection of ligands comprising at least one receptor and an amplification mechanism comprising a liquid crystalline, where an amplified signal is produced as a result of receptor binding to a ligand are provided. Also provided are methods for the automatic detection of ligands.

Abstract: A method for inducing movement of an object in contact with a fluid, includes providing a flexible object, and exposing the object to an energy source. The energy source induces a change in the shape of the object, and movement occurs as a result of the change in shape of the object. The flexible object may be a liquid crystal elastomer object. An apparatus for producing work, including a liquid crystalline elastomer capable of changing shape upon exposure to an energy source is also disclosed.

Abstract: An apparatus (10, 10?) for producing an alignment surface on an associated substrate (12, 12?) of a liquid crystal display. An electron source (40) produces a collimated electron beam (50). A substrate support (20, 20?) supports the associated substrate (12, 12?) with a surface normal (80) of the substrate arranged at a preselected angle (?) relative to the collimated electron beam (50). The collimated electron beam (50) is rastered across the associated substrate (12, 12?) at the preselected angle (?) while the substrate moves through the electron beam.

Abstract: The present invention provides a method of inhibiting the formation of infectious herpes virus particles, particularly infectious herpes simplex virus (HSV) particles, in a host cell. The method involves administering an effective amount of a hydroxylated tolan, particularly a polyhydroxylated tolan, to a herpes virus infected host cell. The present invention also provides a method of treating a herpes virus infection, particularly an HSV infection. The method comprises administering a topical composition comprising a therapeutically effective amount of a hydroxylated tolan to a herpes virus-infected site. The present invention also relates to a topical composition for treating a herpes virus infection selected from the group consisting of an HSV infection, a cytomegalovirus infection, and a varicella zoster virus infection. The present invention also provides a method of treating a subject infected with Neisseria gonorrhea.

Abstract: The present invention provides a method of preparation of optical compensation films using a polymer stabilization technique so as to enable continuous roll-to-roll production. The films can be applied for reflective liquid crystal displays. They are prepared by photo-polymerizing a mixture comprising a reactive monomer (or mixture of monomers), a small amount of photoinitiator and liquid crystal. The concentration of the reactive monomer (mesogenic or non-mesogenic) in the reactive mixtures can be as low as 5% or as high as 99% by weight. The materials that can function as the optical compensation films in the present invention include, but are not limited to, mixtures of liquid crystal and reactive mesogenic monomers (rod-like, bent-shaped, and disc-like mesogenic monomers) containing polymerizable groups (monofunctionaly or multifunctional) selected from acrylate, methacrylate, vinyls, butadiene, vinyl ethers, or epoxide.

Abstract: A liquid crystal display device comprises two substrates facing and spaced from each other, at least one of the substrates being transparent; an electro-optical material filling a first portion of the space between the substrates, the electro-optical material comprising molecules whose spatial orientation can be altered by application of an electric field across the two substrates; and a polymeric material filling a second portion of the space between the substrates, the polymeric material having been polymerized in situ between the plates, wherein the polymeric material forms a multiplicity of microscopic polymer columns extending between the two substrates, and the columns provide both a structural bond between the two substrates for maintaining the spacing between the substrates and alignment of the molecules of the electro-optical material, with the alignment resulting from the close spacing of the microscopic columns.

Abstract: An electro-optic device includes a liquid crystal cell (10, 10?) and at least one electrode (40, 42, 40?, 42?) arranged to selectively electrically bias the liquid crystal cell (10, 10?). A chiral or cholesteric liquid crystal (30, 30?) is disposed in the liquid crystal cell (10, 10?). The liquid crystal (10, 10?) has an optic axis substantially along a selected optic axis direction in the absence of an electrical bias. A polymeric network (32, 32?, 72) is disposed at an inside surface of the liquid crystal cell (10, 10?). The polymeric network (32, 32?, 72) extends partway into the liquid crystal cell (10, 10?) leaving at least a portion of the liquid crystal cell (10, 10?) substantially free of the polymeric network (32, 32?, 72).

Abstract: A new light modulating material using unidirectionally oriented micro-domains of liquid crystal separated by polymer chains is provided. Liquid crystal/polymer films are produced by a one step production process involving a photopolymerizable monomer mixed with a liquid crystal then exposed to UV light. In one embodiment, force deformations are applied to the films resulting in diffraction efficiencies of more than 95%. In another embodiment, applying a planar force to a thick film that produced a 2 ?m shift of phase retardation in several hundred microseconds when an appropriate field is applied. Use of this invention provides fast response time and a low required driving voltage. The new cell can be used as spatial light modulators for manufacturing information displays, electro-optical devices, telecommunications system, optical data processing, adaptive optics applications, color projection displays and switchable micro-lens optics.

Abstract: The invention provides a method for preparing glutathionylcobalamin (GluSCbl) which involves running the reaction in an aqueous solvent with a relatively small excess of glutathione, i.e. GluSH, specifically from one to less than four molar equivalents of GluSH. The formed GluSCbl is precipitated from the aqueous solvent, preferably by the addition of a precipitate inducing solvent. This provides GluSCbl in acceptable purity without the need for an additional chromatographic purification step. Additionally, it has been found that the reaction can be run to an acceptable level of purity by using very high concentrations of the reactants, i.e. around saturation concentrations for aquocobalamin. This has the advantage of eliminating the need for air-free conditions.

Abstract: A method for generating random numbers includes the steps of providing a liquid crystal cell containing a liquid crystal material, wherein a potential difference is applied across said liquid crystal material to cause a chaotic turbulent flow. The resulting flow or physical result of the liquid crystal material is measured to generate a baseline measurement, and subsequently the at least one physical property is measured again to generate a plurality of reading measurements. Determining the difference between each of the reading measurements and the baseline measurement, and setting bits based on the differences generates a sequence of random numbers. An apparatus for generating random numbers is also disclosed. These truly random numbers may then be used to encrypt data prior to transmission.

Abstract: A method for simultaneously fabricating a phase separated organic film and microstructures with liquid crystal having desired alignment is disclosed. The method includes the step of preparing a mixture of liquid crystal material, prepolymer, and polarization-sensitive material. The mixture is disposed on a substrate and a combination of UV or visible light or heat treatment is applied while simultaneously inducing phase separation so as to form a layer or microstructure of appropriately aligned liquid crystal material adjacent the substrate.

Abstract: A method is provided for forming an alignment layer for a liquid crystal cell that is made from a liquid crystal film that has been irradiated with light. The method includes the steps of disposing a liquid crystal film on a substrate and then irradiating the liquid crystal film with light. Also, a liquid crystal display that includes an alignment layer that is a liquid crystal film that has been irradiated with light.

Abstract: A liquid crystal diffractive light valve includes: a pair of opposed substrates wherein one of the substrates is a silicon wafer with associated electronics. The other substrate has an electrode layer facing the silicon substrate. And a ultraviolet curable composite material is disposed between the substrates which is then phase separated to form polymer walls having liquid crystal directors fixed therein regardless of application of an electric field across the electrode layers, and wherein pixel regions are formed between the polymer walls. The pixel regions have liquid crystal directors which are movable when an electric field is applied across the electrode layers. Application of an electric field allows for generation of phase differences between the wall and pixel regions to allow for Liquid Crystal on Silicon devices to be used as diffractive light valves.

Abstract: A liquid crystal device comprising tilted smectic phases of banana-shaped liquid crystal molecules is disclosed. A method for fabricating a light modulating device is also disclosed. The method comprises the steps of providing a pair of substrates with a cell gap therebetween and permanently disposing at least one banana-shaped liquid crystal material into said cell gap. The present invention also provides a method of generating an image, comprising providing a pair of substrates with a cell gap therebetween, providing transparent electrodes on each of the substrates adjacent to the cell gap, disposing at least one banana-shaped liquid crystal material into the cell gap; and applying an electric field across the electrodes. The tilted smectic phases of banana-shaped liquid crystal may be in either a racemic or a chiral state.

Abstract: A liquid crystal device comprises a first and second cell wall structure; at least one liquid crystal material disposed within a space between the first and second cell wall structures; and polymer micro-structures, wherein the micro-structures are formed by polymerizing a prepolymer, and wherein said micro-structures have a shape and spatial location determined by said liquid crystal material. Permanent polymer micro-structures are formed from a liquid crystal with a non-uniform spatially modulated director field. The polymer structures have the shape and spatial location dictated by the non-uniform director field of the liquid crystal. The micro-structures are a backbone that restores the liquid crystal director field that existed during the polymerization process even when other factors, such as electric field, temperature, or surface anchoring, do not favor this restoration.

Abstract: This invention relates to methods of building rigid or flexible arrays of electro-optic devices. A phase separated composite structure technique yields adjacent regions of polymer and liquid crystal (LC) of specific architecture instead of a random dispersion of LC droplets. The above devices can be prepared by producing volutes of LC structure (56) next to a polymer area (58) using anisotropic phase separation of LC from a photopolymer. Initial by UV exposure. The shape, size and placement of these regions inside a cell becomes easily controllable with using optical mask or laser beam. The boundaries of LC volume can be controlled by controlling the chemical composition of the polymer and using an alignment layer (28).

Abstract: An elliptically polarizing plate, comprising a polarizer, a first optical anisotropic layer having positive refractive index anisotropy and an optical axis of the anisotropy that is tilted, and a second optical anisotropic layer having negative refractive index anisotropy and an optical axis that is tilted, have accurate retardation compensation of a liquid crystal cell, and the liquid crystal display maintains a display contrast having a sufficient visibility when the viewing angle is changed and which does not generate colorization.