Patents Assigned to Korea Basic Science Institute
  • Patent number: 12274705
    Abstract: The present invention relates to a composition comprising a CYP4A-inhibiting compound as an active ingredient for preventing or treating metabolic diseases, more specifically to a composition comprising the compound expressed by chemical formula 1 of the present invention or pharmaceutically acceptable salt thereof as an active ingredient for preventing, ameliorating or treating metabolic diseases.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: April 15, 2025
    Assignee: Korea Basic Science Institute
    Inventors: Gun Hwa Kim, Min Ji Lee, Koon Soon Kim, Hyo Kyun Chung, Ji Hoon Lee, Se Jin Jung, Da Rong Kim
  • Patent number: 11181531
    Abstract: The present invention relates to a bioinformation processing analysis method for the identification and quantification of O-linked glycopeptide using high resolution mass spectrum. Particularly, according to the bioinformation processing analysis method of the present invention, the quantitative changes of O-linked glycopeptide containing non-informed sugar chains included in various samples can be efficiently and accurately analyzed; the prediction or diagnosis of disease including cancer can be made easy by using a high resolution mass spectrometer; or the investigation of O-linked glycopeptide structure of a therapeutic glycoprotein can be efficiently achieved.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: November 23, 2021
    Assignee: Korea Basic Science Institute
    Inventors: Gun Wook Park, Jong Shin Yoo, Jin Young Kim, Ju Yeon Lee, Hyun Kyoung Lee
  • Patent number: 11069506
    Abstract: A sample stage includes a sample holder that accommodates a sample and a first drive module, a second drive module, and a third drive module that are radially connected to the sample holder and allow the sample holder to have translational degrees of freedom in three directions and rotational degrees of freedom in at least two directions.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: July 20, 2021
    Assignee: Korea Basic Science Institute
    Inventors: Sang-Chul Lee, Jongman Jeong, Jin-Gyu Kim, Cheolsu Han
  • Patent number: 11061170
    Abstract: Disclosed is a broadband objective lens and a method of manufacturing the objective lens. The objective lens includes a plurality of lenses, and each of the lenses includes a coating layer on which a nanopattern is formed.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: July 13, 2021
    Assignee: Korea Basic Science Institute
    Inventors: Ki Soo Chang, Kye Sung Lee, Dong Uk Kim, Jung Dae Kim
  • Publication number: 20200408774
    Abstract: The present invention relates to a bioinformation processing analysis method for the identification and quantification of O-linked glycopeptide using high resolution mass spectrum. Particularly, according to the bioinformation processing analysis method of the present invention, the quantitative changes of O-linked glycopeptide containing non-informed sugar chains included in various samples can be efficiently and accurately analyzed; the prediction or diagnosis of disease including cancer can be made easy by using a high resolution mass spectrometer; or the investigation of O-linked glycopeptide structure of a therapeutic glycoprotein can be efficiently achieved.
    Type: Application
    Filed: December 15, 2017
    Publication date: December 31, 2020
    Applicant: Korea Basic Science Institute
    Inventors: Gun Wook PARK, Jong Shin YOO, Jin Young KIM, Ju Yeon LEE, Hyun Kyoung LEE
  • Patent number: 10765322
    Abstract: Provided is a fast parallel optical coherence tomographic image generating method including dispersing light into N spectral regions ??1 through ??N sequentially from a low frequency wavelength to a high frequency wavelength, the light being emitted from a broadband light source of a fast parallel optical coherence tomographic image generating apparatus, N being an integer greater than or equal to 2, splitting the light emitted from the broadband light source to be incident on a sample and a reference mirror, partitioning the sample into N image regions P1 through PN, discretely controlling a beam scanner such that the light emitted from the broadband light source is incident on the sample at a position changed by a preset distance, acquiring an interference spectral image through interference light formed in response to interference of measurement light and reference light, and generating a tomographic image of the sample using the interference spectral image.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: September 8, 2020
    Assignee: Korea Basic Science Institute
    Inventors: Kye Sung Lee, Ki Soo Chang
  • Patent number: 10761309
    Abstract: Disclosed is a laser scanning based microscope apparatus including a light source configured to output a laser signal, a scanning unit configured to scan a heating sample with a first laser signal corresponding to a portion of the output laser signal, and output an optical signal reflected from the sample by the scanning to a first detector, the first detector configured to generate a first electrical signal through the reflected optical signal, a second detector configured to generate a second electrical signal through a second laser signal corresponding to a remaining portion of the output laser signal, and a controller configured to acquire a thermal image of the sample by performing a frequency domain analysis based on the first electrical signal and a differential electrical signal.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: September 1, 2020
    Assignee: Korea Basic Science Institute
    Inventors: Dong Uk Kim, Ki Soo Chang
  • Patent number: 10716312
    Abstract: The present invention relates to an ethylene disposal apparatus comprising: a plasma discharge part having an inlet and an outlet and being filled with an adsorbent; and an electrode part for generating plasma inside the plasma discharge part, wherein the adsorbent has a catalyst supported thereon. The present invention relates to an ethylene disposal method using the ethylene disposal apparatus, the method comprising the steps of: (a) injecting ethylene-containing gas into a plasma discharge part filled with the adsorbent; (b) applying voltage to the electrode part and generating plasma in the plasma discharge part, thereby degrading the injected ethylene; and (c) cooling the plasma discharge part.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: July 21, 2020
    Assignee: Korea Basic Science Institute
    Inventors: Young Sun Mok, Quang Hung Trinh, Suk Jae Yoo
  • Publication number: 20190137175
    Abstract: Disclosed is an adiabatic collector for recycling gas, a liquefier for recycling gas, and a recovery apparatus for recycling gas using the same. More specifically, gas to be recycled is collected in an adiabatic manner, cooled to a temperature lower than the dew point thereof, and stored in the liquid state through a phase change, thereby saving energy required for re-cooling the gas. Particularly, the present invention relates to an adiabatic collector for recycling gas, a liquefier for recycling gas, and a recovery apparatus for recycling gas using the same, in which recycling gas is compressed through a natural inducement method using a difference in temperature and pressure while being collected and liquefied, thereby reducing noise, vibration, and size of the collector.
    Type: Application
    Filed: January 3, 2019
    Publication date: May 9, 2019
    Applicant: Korea Basic Science Institute
    Inventors: Seung Young Park, Yeon Suk Choi, Min Su Seo, Myung Su Kim
  • Patent number: 10258956
    Abstract: Photoluminescent carbon nanoparticles and a method of preparing the same are described herein. A method of preparing photoluminescent carbon nanoparticles includes obtaining carbon nanodots, and treating the carbon nanodots with plasma.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: April 16, 2019
    Assignee: Korea Basic Science Institute
    Inventors: Hyun-Uk Lee, Jouhahn Lee, So Young Park
  • Publication number: 20190066970
    Abstract: A sample stage includes a sample holder that accommodates a sample and a first drive module, a second drive module, and a third drive module that are radially connected to the sample holder and allow the sample holder to have translational degrees of freedom in three directions and rotational degrees of freedom in at least two directions.
    Type: Application
    Filed: October 31, 2018
    Publication date: February 28, 2019
    Applicant: Korea Basic Science Institute
    Inventors: Sang-Chul Lee, Jongman Jeong, Jin-Gyu Kim, Cheolsu Han
  • Patent number: 10209220
    Abstract: Provided are an apparatus for measuring an ionic mobility of a harmful material and a reference data obtaining method thereof. The method includes obtaining a measurement signal by detecting a charge of an ion between electrodes, obtaining a noise signal by insulating the electrodes from the ion, aligning the noise signal with the measurement signal, removing a part of the measurement signal aligned with the noise signal, and calculating reference data from a remaining part of the measurement signal.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: February 19, 2019
    Assignee: Korea Basic Science Institute
    Inventors: Myoung Choul Choi, Jeong-Hoon Kang, Jung-Hwan Kim
  • Patent number: 10037876
    Abstract: The present invention relates to an electron bean injection control of a mass spectrometer. A mass spectrometer of the present invention includes: a reference waveform generator configured to generate a reference waveform signal having one type of a square wave and a sine wave, a waveform generator configured to generate a sync signal synchronized with the reference waveform signal; an RF module configured to generate an RF voltage signal from the reference waveform signal and apply the RF voltage signal to an RF electrode in the ion trap, an electron beam generator configured to control an operation of an ultraviolet (UV) diode for generating an electron beam injected into the ion trap according to an input control signal, and a control circuit configured to generate the control signal by using the square wave signal.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: July 31, 2018
    Assignee: Korea Basic Science Institute
    Inventors: Seung Yong Kim, Mo Yang, Hyun Sik Kim
  • Publication number: 20180177899
    Abstract: Provided are a hydrophilic particle, a method for manufacturing the same, and a contrasting agent using the same. More specifically, the hydrophilic particle according to the inventive concept may include a hydrophobic particle, and an amphiphilic organic dye directly absorbed on a surface of the hydrophobic particle. In this case, the hydrophobic particle includes a center particle, and a hydrophobic ligand covering a surface of the center particle, and the amphiphilic organic dye may be combined to the hydrophobic ligand by a hydrophobic interaction. The hydrophilic particle may have a surface zeta potential lower than a surface zeta potential of the amphiphilic organic dye.
    Type: Application
    Filed: May 19, 2016
    Publication date: June 28, 2018
    Applicants: Korea Basic Science Institute, Korea Research Institute Of Chemical Technology
    Inventors: Kwan Soo HONG, Hye Sun PARK, Sang Hwan NAM, Yung Doug SUH
  • Patent number: 10001363
    Abstract: Provided is a common-path optical fiber-based handheld parallel optical coherence tomography (OCT) apparatus, including a probe configured to receive the light from a broadband light source and illuminate a measurement target, wherein the probe may include an inner space through which the light passes, a collimator configured to collimate the light incident to the inner space, a diffraction grating configured to diffract the light having passed through the collimator, a galvanometer scanner configured to reflect the light having passed through the diffraction grating, an objective lens configured to concentrate the reflected light on a focal point, and an interferer configured to acquire an interfered light by reflecting at least a portion of the light having passed through the objective lens.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: June 19, 2018
    Assignee: Korea Basic Science Institute
    Inventors: Kye Sung Lee, Gun Hee Kim, Hwan Hur, I Jong Kim, Ki Soo Chang
  • Patent number: 9933376
    Abstract: The present invention provides a method for analyzing defects by using heat distribution measurement, comprising: a sample loading unit for loading a sample to check whether or not there is a defect through heat distribution characteristics; a light source for radiating visible light onto the sample; a power supply unit for generating a driving signal in order to periodically heat the sample; a detection unit for detecting reflected light from the surface of the sample; and a signal generator for synchronizing the detection unit with the driving signal of the power supply unit.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: April 3, 2018
    Assignee: Korea Basic Science Institute
    Inventors: Ki Soo Chang, Seon Young Ryu, Woo June Choi, Geon Hee Kim
  • Patent number: 9816868
    Abstract: The present invention pertains to a device for measuring a temperature distribution, which can measure a temperature distribution without contacting a minor sample having a three-dimensional structure. More particularly, the device for measuring the temperature distribution can measure a three-dimensional temperature distribution for a sample, wherein the temperature distribution in a depth direction (direction z) of the sample is measured by a thermo-reflectance technique using a chromatic dispersion lens, a diffraction spectrometer and an optical detection array; and the temperature distribution in parallel directions (direction x-y axes) of the sample is measured by the thermo-reflectance technique using a biaxial scanning mirror.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: November 14, 2017
    Assignee: Korea Basic Science Institute
    Inventors: Ki Soo Chang, Hae Young Choi, Seon Young Ryu, Geon Hee Kim, Sun Cheol Yang
  • Patent number: 9805830
    Abstract: The present invention provides a neutron generating device for generating a high neutron flux by forming plasma in the vicinity of a target and by accelerating electrons and charged particles in the plasma toward the target. Magnetic field is formed in the vicinity of the target and a microwave generator irradiates microwaves into the space where the magnetic field is generated to thereby generate plasma in the space. The accelerated electrons and charged particles collide with the target to generate neutron flux. Also, to prevent the target surface from being excessively heated, the plasma is generated in a pulsed mode and target voltage is applied in a pulsed mode. To secure a continuous process, the level of target bias voltage for the target is adjusted so that the target re-adsorbs elements when the elements adsorbed on the target are depleted.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: October 31, 2017
    Assignee: Korea Basic Science Institute
    Inventors: Suk Jae Yoo, Seong Bong Kim, Jung-sik Yoon
  • Patent number: 9718132
    Abstract: Provided is a manufacturing method of uniformly spherical gold nanoparticles using a synthesis method for controlling a size and a shape by repeating an etching and growing.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: August 1, 2017
    Assignees: Korea Basic Science Institute, Research & Business Foundation SUNGKYUNKWAN UNIVERSITY
    Inventors: Gaehang Lee, Gi-Ra Yi, You-Jin Lee, Dong Kwan Kim
  • Publication number: 20170200598
    Abstract: The present invention relates to an electron bean injection control of a mass spectrometer. A mass spectrometer of the present invention includes: a reference waveform generator configured to generate a reference waveform signal having one type of a square wave and a sine wave, a waveform generator configured to generate a sync signal synchronized with the reference waveform signal; an RF module configured to generate an RF voltage signal from the reference waveform signal and apply the RF voltage signal to an RF electrode in the ion trap, an electron beam generator configured to control an operation of an ultraviolet (UV) diode for generating an electron beam injected into the ion trap according to an input control signal, and a control circuit configured to generate the control signal by using the square wave signal.
    Type: Application
    Filed: December 9, 2015
    Publication date: July 13, 2017
    Applicant: Korea Basic Science Institute
    Inventors: Seung Yong KIM, Mo YANG, Hyun Sik KIM