Patents Assigned to Korea Basic Science Institute
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Patent number: 8513596Abstract: An apparatus for electrospray ionization may include: a platform including an inlet port, a first channel connected to the inlet port, a second channel connected to the first channel, and an outlet port connected to the second channel; a nebulizer provided in the first channel and configured to spray inert gas to a sample sprayed into the first channel through the inlet port; and a focusing lens provided in the second channel and configured to focus ions produced from the sprayed sample toward the outlet port.Type: GrantFiled: December 23, 2010Date of Patent: August 20, 2013Assignee: Korea Basic Science InstituteInventors: Duk Jin Kang, Myoung Choul Choi, Jong Shin Yoo, Hyun Sik Kim
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Patent number: 8488236Abstract: Provided is an optical system for a thermal image microscope. The optical system includes an image forming unit and a relay unit. The image forming unit forms a focus. The relay unit elongates an optical path. Here, the image forming unit includes six lenses. The relay unit includes two lenses. Aspherical surfaces of the lenses are all convex surfaces.Type: GrantFiled: November 10, 2010Date of Patent: July 16, 2013Assignee: Korea Basic Science InstituteInventors: Geon Hee Kim, Sun Choel Yang, Ki Soo Chang, Hyo Sik Kim, Sang Hyeok Kim, Sang Yong Lee
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Patent number: 8461763Abstract: An apparatus of an electron cyclotron resonance ion source may include: a magnet unit containing a magnet for generating magnetic fields; an ionizing chamber housing unit for generating ions through electron cyclotron resonance from a plasma; a microwave generating unit for injecting microwaves to the ionizing chamber housing unit to generate ions; and a beam integrating and guiding unit for treating the generated ions. The magnet unit may include: a bobbin for winding the magnet; a variable spacer for dividing the bobbin into a plurality of sections; and the magnet which is wound into the form of a wire or a tape in the plurality of sections formed by the variable spacer.Type: GrantFiled: November 16, 2009Date of Patent: June 11, 2013Assignee: Korea Basic Science InstituteInventors: Mi-Sook Won, Byoung-Seob Lee, Jong-Pil Kim, Jang-Hee Yoon, Jong Seong Bae, Jeong Kyu Bang, Hyosang Lee, Jinyong Park
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Publication number: 20130130273Abstract: Disclosed is a novel method for detecting interactions of biomolecules. More particularly, the disclosed method includes (a) preparing a cell comprising (i) a first construct comprising a bait, a first labeling material and a translocation module; and (ii) a second construct comprising a prey and a second labeling material; (b) detecting the distribution of the first construct and the second construct in the cell. the present invention provides a method capable of detecting bindings and interactions occurring in a living cell in real time, and a method for screening a material that alters the binding and the interaction. The method of the present invention overcomes the disadvantages including inaccuracy and complexity of existing biomaterial interaction detection techniques. By labeling both constructs to promote accuracy, the present invention provides a novel real-time, antibody-free analysis.Type: ApplicationFiled: January 3, 2013Publication date: May 23, 2013Applicant: Korea Basic Science InstituteInventor: Korea Basic Science Institute
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Patent number: 8440966Abstract: A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) is provided. A preamplifier is installed as nearest to an ion cyclotron resonance (ICR) trap as possible at a detector part in the mass spectrometer, and thermal noise generated at the preamplifier is minimized by means of a cryo-cooling system to increase a signal-to-noise ratio of ion detection signals such that an ultra-low amount of specimen can be detected, which was impossible in the related art.Type: GrantFiled: December 29, 2008Date of Patent: May 14, 2013Assignee: Korea Basic Science InstituteInventors: Myoung Choul Choi, Yeon Suk Choi, Jeong Min Lee, Seung Yong Kim, Dong Lak Kim, Hyun Sik Kim, Jong Shin Yoo, Stefan Karl-Heinz Stahl
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Patent number: 8440982Abstract: The present invention relates to a cryo transfer holder for TEM including: a specimen support having a specimen rod with a specimen cradle provided on one side end thereof, while being airtightly inserted reciprocatingly on the other side end thereof into a cooling tube of a thermal insulating container, and a thermal insulating pipe configured to be fixed to the thermal insulating container on one side thereof and to surround the specimen rod except the specimen cradle at the time of observation. The thermal insulating container in which a cooling medium is contained has the cooling pipe penetrated thereinto. A specimen rod-reciprocating means is configured to be coupled to the side of the thermal insulating container to allow the specimen rod to be reciprocated relative to the thermal insulating container.Type: GrantFiled: December 19, 2011Date of Patent: May 14, 2013Assignee: Korea Basic Science InstituteInventors: Youn-Joong Kim, Jong-Man Jeung, Seok-Hoon Lee
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Publication number: 20130112864Abstract: Provided are a controller and a control method for improving signal performance of an ion cyclotron resonance mass spectrometer. The controller and control method apply electric signals for causing ions injected into an ion trap of the ion cyclotron resonance mass spectrometer to be injected to the center of the trap as close as possible to trap electrodes, and adjust biased ion motion by appropriately adjusting signals of trap electrodes for causing the injected ions to make ion motion, thereby improving the fidelity of ion signals. The control method for improving signal performance of an ion cyclotron resonance mass spectrometer includes an ion position adjustment process and an ion signal detection process.Type: ApplicationFiled: October 31, 2011Publication date: May 9, 2013Applicant: Korea Basic Science InstituteInventors: Seung Yong Kim, Hyun Sik Kim, Myoung Choul Choi, Jong Shin Yoo
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Patent number: 8420046Abstract: Disclosed is a method of preparing high crystalline nanoporous titanium dioxide photocatalyst, capable of preparing the high crystalline nanoporous titanium dioxide photocatalyst in mass production through a simply synthesis method using an ultrasonification. The method includes the steps of (a) mixing a titanium precursor and a surfactant in a first solvent and performing a sol-gel reaction; (b) maturing a reactant obtained through the sol-gel reaction for 15 hours to 25 hours; (c) filtering the matured reactant and washing the matured reactant; (d) primarily drying the washed reactant at a temperature of 20° C. to 50° C. to obtain titanium sediments; (e) mixing the titanium sediments in a second solvent and performing an ultrasonification with respect to the mixed solution for 10 minutes to 120 minutes; and (f) secondarily drying the mixed solution, which has been subject to the ultrasonification, at a temperature of 15° C. to 45° C. to obtain titanium dioxide photocatalytic particles.Type: GrantFiled: February 29, 2012Date of Patent: April 16, 2013Assignee: Korea Basic Science InstituteInventors: Hae-Jin Kim, Jou-Hahn Lee, Soon-Chang Lee, Hyun-Uk Lee, Won-Ki Hong, Hye-Ran Kim, Jung-Hye Seo
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Patent number: 8357348Abstract: The present invention relates to a method for preparing anatase-type titanium dioxide (TiO2) nanoparticles, the method comprising the steps of: uniformly mixing titanium n-butoxide and cetyltrimethyl ammonium salt (CTAS) in water; subjecting the mixture to hydrothermal treatment at a temperature of 60˜120° C.; and collecting anatase-type titanium dioxide nanoparticles produced by the hydrothermal treatment and drying the collected nanoparticles. According to the present invention, anatase-type titanium dioxide nanoparticles having excellent crystallinity can be easily prepared in large amounts by a simple process without needing heat treatment.Type: GrantFiled: February 18, 2011Date of Patent: January 22, 2013Assignee: Korea Basic Science InstituteInventors: Hae Jin Kim, Soon Chang Lee, Jin Bae Lee
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Patent number: 8296300Abstract: The present invention relates to a method for reconstructing protein database for identifying a protein and a method for screening a protein using the same, more precisely a method for reconstructing protein database, and a method for identifying a protein using the same. The method for reconstructing protein database and the method for identifying the protein of the invention are very useful for the investigation of endogenous proteins and their functions and interactions, and are further effectively used for the development of diagnostic and therapeutic agents for various diseases.Type: GrantFiled: August 18, 2006Date of Patent: October 23, 2012Assignee: Korea Basic Science InstituteInventors: Kyung-Hoon Kwon, Jong Shin Yoo
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Patent number: 8206566Abstract: Disclosed herein is an electrochemical measurement system for analyzing heavy metals in organic compound-containing samples, comprising: a lower plate; a flow channel plate; an upper plate; an organic compound-decomposing electrode and a heavy metal analysis electrode; and a flow changeover portion. The disclosed system can continuously perform a pretreatment process for organic compound decomposition and a process for heavy metal analysis, thus making it possible to achieve the selective analysis and separation of heavy metals in wastewater. Also, it can substitute for expensive spectrophotometric analysis equipment and makes it possible to monitor trace heavy metals on-line in situ. In addition, it may include a small-sized battery as a power source, such that it is easy to carry and use.Type: GrantFiled: July 20, 2010Date of Patent: June 26, 2012Assignee: Korea Basic Science InstituteInventors: Jang-Hee Yoon, Mi-Sook Won
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Publication number: 20120137707Abstract: An apparatus for transferring cryogenic refrigeration includes a cryocooler interface, a housing, a working fluid, a heat exchanger, a flexible thermal link, and a remote cartridge cold head. The cryocooler interface is thermally connected to a cryocooler providing a source of refrigeration. The refrigeration is passed from the crycooler into the heat exchanger via the cryocooler interface. The remote cartridge cold head is attached to a remote location. Heat is drawn from the remote location through the remote cartridge cold head and into the heat exchanger via the working fluid within the flexible thermal link and housing. Within the heat exchanger, heat is transferred from the working fluid to the refrigeration source, such as a cryocooler; accordingly, the remote location is cooled.Type: ApplicationFiled: December 12, 2011Publication date: June 7, 2012Applicants: Korea Basic Science Institute, The Florida State University Research Foundation, Inc.Inventors: Thomas Andrew Painter, Yeon Suk Choi, Dong Lak Kim, Hongyu Bai
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Publication number: 20120109533Abstract: The present invention relates to a method of analyzing a protein or proteins comprising the steps of: (A) pre-treating a mixture containing at least one protein to obtain peptides; (B) obtaining information about retention times and mass values of the obtained peptides by performing data-independent analysis; (C) searching a first database on the basis of the information obtained in step (B) to quantify and qualify a target protein or proteins; (D) extracting information about the quantified and qualified target protein or proteins; (E) obtaining information about retention times and mass values by performing data-dependent analysis from the extracted information of step (D); (F) searching a second database on the basis of the information obtained in step (E) to further quantify and qualify the target protein or proteins; and (G) comparing the search results of step (C) and (F) to verify the quantification and qualification.Type: ApplicationFiled: December 1, 2011Publication date: May 3, 2012Applicant: Korea Basic Science InstituteInventors: Joseph KWON, Chiyoul PARK, Gookpil ROH, Taehoon LEE, Jongsoon CHOI
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Patent number: 8167682Abstract: Disclosed is an automatic constant pressure polishing apparatus. The automatic constant pressure polishing apparatus comprises a housing having a hollow section therein, a rubber pad installed in the housing and having superior expansion and contraction characteristics, a pressure fixture having a male screw section, which is formed on an outer peripheral surface thereof in order to press and fix the rubber pad, and a central hole formed at a central portion thereof, a slider screw-coupled into the housing to adjust pressure in the housing according to a rotational degree of the rotating shaft, and a polishing pad installed at a front end portion of the housing.Type: GrantFiled: November 14, 2007Date of Patent: May 1, 2012Assignee: Korea Basic Science InstituteInventors: Geonhee Kim, Sunchoel Yang, Myengsang Kim, Kisoo Chang, Hyosik Kim
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Publication number: 20110150753Abstract: The present invention relates to a method for preparing anatase-type titanium dioxide (TiO2) nanoparticles, the method comprising the steps of: uniformly mixing titanium n-butoxide and cetyltrimethyl ammonium salt (CTAS) in water; subjecting the mixture to hydrothermal treatment at a temperature of 60˜120° C.; and collecting anatase-type titanium dioxide nanoparticles produced by the hydrothermal treatment and drying the collected nanoparticles. According to the present invention, anatase-type titanium dioxide nanoparticles having excellent crystallinity can be easily prepared in large amounts by a simple process without needing heat treatment.Type: ApplicationFiled: February 18, 2011Publication date: June 23, 2011Applicant: Korea Basic Science InstituteInventors: Hae jin Kim, Soon Chang Lee, Jin Bae Lee
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Patent number: 7939799Abstract: A tandem Fourier transform ion cyclotron resonance mass spectrometer is provided. In the mass spectrometer, the ions selected by a FT-ICR mass analyzer, which can perform an ion selection process and a mass measurement process with a time interval between the processes, are transmitted through an ion guide to a collision cell, which is located a predetermined distance from the FT-ICR mass analyzer, to split into fragment ions. The fragment ions are transmitted to the FT-ICR mass analyzer that measures the mass of the fragment ions. The fragment ions are generated in the collision cell 60 established separately from the FT-ICR mass analyzer 40 according to the mass spectrometer. Accordingly, It can solve various problems (e.g., the radius reduction of cyclotron motion of colliding ions, or the removal of periphery gas after generating the fragment ions) occurred in a tandem mass spectrometer using a conventional tandem-in-time mass analysis method.Type: GrantFiled: September 12, 2006Date of Patent: May 10, 2011Assignee: Korea Basic Science InstituteInventors: Hyun Sik Kim, Myoung Choul Choi, Jong Shin Yoo
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Patent number: 7889034Abstract: Disclosed is a method for designing a superconducting magnet for generating high magnetic fields with high uniformity for controlling a stray field to be within an allowable range and acquiring structural and magnetic stability by optimizing the arrangement of positions and shapes of coils configuring the superconducting magnet. Volumes of a main coil and a shielding coil are set to be variables, and the critical value of a wires related on the current and magnetic field, the heat transfer depth, and the quench strain are defined to be restriction conditions so that linear programming is applied to determine an initial shape of the shielding coil and division of the main coil based on the sum of total volumes, that is, an objective function. The initial shapes of the main coil and the shielding coil determined through the linear programming are revised and the shape of a shimming coil is determined by using non-linear programming based on the objective function.Type: GrantFiled: November 29, 2005Date of Patent: February 15, 2011Assignee: Korea Basic Science InstituteInventors: Byoung-Seob Lee, Dong-Lak Kim, Hyun-Sik Kim, Jong-Shin Yoo
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Publication number: 20100301957Abstract: Disclosed herein is a relaxation oscillator using a spintronic device. The relaxation oscillator includes a power source unit, a spintronic device, and a capacitor. The power source unit applies power. The spintronic device is driven by the power applied by the power source unit, and has a variable voltage value depending on the intensity of a magnetic field. The capacitor is connected in parallel with the spintronic device, and is discharged when it assumes a minimum-voltage value in the threshold voltage range of the spintronic device and charged when it assumes a maximum voltage value in the threshold voltage range.Type: ApplicationFiled: July 20, 2009Publication date: December 2, 2010Applicant: Korea Basic Science InstituteInventors: Seung Young Park, Younghun Jo
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Publication number: 20100282606Abstract: Disclosed herein is an electrochemical measurement system for analyzing heavy metals in organic compound-containing samples, comprising: a lower plate; a flow channel plate; an upper plate; an organic compound-decomposing electrode and a heavy metal analysis electrode; and a flow changeover portion. The disclosed system can continuously perform a pretreatment process for organic compound decomposition and a process for heavy metal analysis, thus making it possible to achieve the selective analysis and separation of heavy metals in wastewater. Also, it can substitute for expensive spectrophotometric analysis equipment and makes it possible to monitor trace heavy metals on-line in situ. In addition, it may include a small-sized battery as a power source, such that it is easy to carry and use.Type: ApplicationFiled: July 20, 2010Publication date: November 11, 2010Applicant: Korea Basic Science InstituteInventors: Jang-Hee Yoon, Mi-Sook Won
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Patent number: 7820982Abstract: Disclosed is a moon grid for transmission electron microscopy tomography, including a mesh sheet for protecting an upper objects and a support film formed on the mesh sheet and having nanoparticles dispersed throughout, in which the nanoparticles dispersed throughout the support film are used as reference points in the reconstruction of two-dimensional transmission electron microscopy images into a three-dimensional image, thus omitting a process of attaching markers in the course of preparation of a sample and easily forming reference points even on a sample to which it is impossible to attach markers. A method of fabricating such a moon grid is also provided.Type: GrantFiled: July 10, 2008Date of Patent: October 26, 2010Assignee: Korea Basic Science InstituteInventors: Won Jin Moon, Byung Kyu Park, Youn Joong Kim, Jee Young Lee, Sang Hee Lee, Dong Sik Bae