Patents Assigned to Kumamoto University
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Patent number: 10131777Abstract: A method produces a composite of a polymer and tungstic acid and/or molybdic acid; and the composite obtained by the method has high transparency and a desired refractive index. This composite contains tungstic acid and/or molybdic acid and a polymer that has a number average molecular weight of 1,000-10,000,000 and an ether bond and/or an ester bond. The content of tungstic acid and/or molybdic acid in the composite is 0.01-95% by weight.Type: GrantFiled: June 17, 2013Date of Patent: November 20, 2018Assignee: National University Corporation Kumamoto UniversityInventors: Hirotaka Ihara, Hirokuni Jintoku
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Publication number: 20180264180Abstract: Provided is a biodegradable polymer coating stent effective in delaying the damage of physical properties (particularly radial force) of a core structure. The stent includes a core structure of a bioabsorbable material (e.g., Mg), a first coating layer of a first polymer with biodegradability, and a second coating layer of a second polymer with biodegradability, wherein the first coating layer covers the whole surface of the core structure; the second coating layer covers a part or the whole surface of the first coating layer; the first polymer has a glass transition point of lower than 37° C.; and the second polymer has a glass transition point of 47° C. or higher.Type: ApplicationFiled: May 24, 2018Publication date: September 20, 2018Applicants: Japan Medical Device Technology Co., Ltd., National University Corporation Kumamoto UniversityInventors: Makoto SASAKI, Takuro NIIDOME, Zhen Yu JIN, Shuzo YAMASHITA
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Publication number: 20180244688Abstract: Various embodiments relate to a compound of the formula (I): wherein X, X1, R1-R4 and R7 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I), or a pharmaceutical compositions comprising compounds of the formula (I), to a patient in need thereof.Type: ApplicationFiled: August 17, 2016Publication date: August 30, 2018Applicants: Purdue Research Foundation, National University Corporation Kumamoto UniversityInventors: Arun K. Ghosh, Hiroaki Mitsuya
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Publication number: 20170360833Abstract: An object of the present invention is to provide a pluripotent cell having high safety in application to regenerative medicine, and a method for production thereof. Another object of the present invention is to provide a pluripotent cell, particularly, having less concern for safety, such as a problem of cancerization of a cell, and the presence of bacteria in a cell, and a method for production thereof. According to the present invention, there is provided a method for producing a pluripotent cell from a somatic cell. The method comprises a step of inducing reprogramming of a somatic cell, by contacting the cell with a ribosome fraction derived from an organism. Further, according to the present invention, there is provided a composition for inducing reprogramming of a cell, comprising a ribosome fraction derived from an organism.Type: ApplicationFiled: May 11, 2015Publication date: December 21, 2017Applicant: National University Corporation Kumamoto UniversityInventors: Kunimasa OHTA, Naofumi ITO
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Patent number: 9670225Abstract: Various embodiments of the present invention are directed to compounds of the formula (I) or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein X1, X2, X3, R1, R2, R11, and n are defined herein. These compounds are useful as inhibitors of HIV-1 protease and, as a result, are useful in the treatment of HIV infection.Type: GrantFiled: May 15, 2015Date of Patent: June 6, 2017Assignees: Purdue Research Foundation, National University Corporation Kumamoto UniversityInventors: Arun K. Ghosh, Venkateswara Rao Kalapala, Hiroaki Mitsuya
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Patent number: 9664287Abstract: Provided is a shaft seal device provided with a seal member which possesses excellent liquid tightness, small friction resistance and high wear resistance. In a shaft seal device which is arranged around the periphery of a shaft which is supported in a rotatable manner or in a reciprocating manner, and is provided with a seal member for securing liquid tightness around the shaft, the seal member is formed of a porous body formed by using a hydrophilic polymer resin in which chains are cross-linked. The shaft seal device is also characterized in that: the shaft is a shaft which extends between a liquid phase region and a gas phase region; the seal member is a seal member which suppresses a leakage of a liquid to the gas phase region from the liquid phase region; and an aqueous lubricant which is prepared by adding a water soluble thickening agent is impregnated into the seal member.Type: GrantFiled: November 27, 2013Date of Patent: May 30, 2017Assignee: National University Corporation Kumamoto UniversityInventor: Yoshitaka Nakanishi
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Patent number: 9592213Abstract: Disclosed is a prophylactic and/or therapeutic agent for dysmenorrhea and/or associated symptoms thereof. Specifically disclosed is a prophylactic and/or therapeutic agent for dysmenorrhea and/or associated symptoms thereof, which comprises tranilast as an active ingredient thereof.Type: GrantFiled: June 17, 2010Date of Patent: March 14, 2017Assignees: National University Corporation Kumamoto University, Keio University, Link Genomis, Inc.Inventors: Hidetaka Katabuchi, Ritsuo Honda, Hideyuki Saya, Yoshimi Arima, Shinichiro Niwa, Yasutaka Makino
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Publication number: 20160369378Abstract: A magnesium alloy having high strength and high ductility and in which at least one of corrosion resistance and flame resistance is enhanced, or a method of manufacturing the same. The magnesium alloy contains an atomic % of Ca and b atomic % of Al, totally contains k atomic % of at least one element selected from a group consisting of Mn, Zr, Ag, Y and Nd, has a composition in which a remaining part is formed of Mg and contains c volume % of (Mg, Al)2Ca, a, b, c and k satisfying formulae (1) to (4) and (21) below. The (Mg, Al)2Ca is dispersed and the at least one element is an element that enhances at least one of corrosion resistance and flame resistance: (1) 3?a?7, (2) 4.5?b?12, (3) 1.2?b/a?3.0, (4) 10?c?35, (21) 0<k?0.3.Type: ApplicationFiled: October 22, 2014Publication date: December 22, 2016Applicant: National University Corporation Kumamoto UniversityInventors: Yoshihito KAWAMURA, Michiaki YAMASAKI
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Patent number: 9487541Abstract: Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with HIV are also described.Type: GrantFiled: October 8, 2013Date of Patent: November 8, 2016Assignees: Purdue Research Foundation, National University Corporation Kumamoto UniversityInventors: Arun K. Ghosh, Chun-Xiao Xu, Hiroaki Mitsuya, Garth Parham
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Patent number: 9376665Abstract: An object of the present invention is to provide a method of producing intestinal cells by use of pluripotent stem cells as a starting material. According to the present invention, provided is a method of producing intestinal cells, comprising the steps of: (A) inducing differentiation of pluripotent stem cells into definitive endoderm cells; and (B) culturing the definitive endoderm cells in the presence of (2?Z,3?E)-6-bromoindirubin-3?-oxime (BIO) and N-[(3,5-difluorophenyl)acetyl]-L-Ala-2-phenyl-L-Gly-tert-butyl-OH (DAPT) to thereby induce differentiation of the definitive endoderm cells into intestinal cells.Type: GrantFiled: October 31, 2011Date of Patent: June 28, 2016Assignees: National University Corporation Kumamoto University, LSIP, LLCInventors: Shoen Kume, Soichiro Ogaki, Nobuaki Shiraki, Kazuhiko Kume
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Publication number: 20160168666Abstract: A method of manufacturing a flame-retardant magnesium alloy having mechanical properties of a long period stacking ordered magnesium alloy and having an ignition temperature of 800° C. or more is provided. In the method of manufacturing a flame-retardant magnesium alloy, a flame-retardant magnesium alloy which contains a atomic % of Zn, b atomic % of at least one element selected from a group consisting of Gd, Tb, Tm and Lu, and x atomic % of Ca and in which a remaining part is formed of Mg and a, b and x satisfy Formulae 1 to 4 below is melted. 0.2?a?5.0??(Formula 1) 0.5?b?5.0??(Formula 2) 0.5a?0.5?b??(Formula 3) 0<x?0.Type: ApplicationFiled: April 14, 2014Publication date: June 16, 2016Applicant: National University Corporation Kumamoto UniversityInventors: Yoshihito KAWAMURA, Jonghyun KIM
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Publication number: 20160083856Abstract: An electrolytic treatment method in which a predetermined treatment is performed using treatment subject ions contained in a treatment liquid, the method including: an electrode positioning step for positioning a direct electrode and a counter electrode so as to sandwich the treatment liquid, and positioning an indirect electrode for forming an electric field in the treatment liquid; a treatment subject ion migration step for applying a voltage to the indirect electrode and thereby moving the treatment subject ions in the treatment liquid to the counter electrode side; and a treatment subject ion redox step for applying a voltage between the direct electrode and the counter electrode and thereby oxidizing or reducing the treatment subject ions which have migrated to the counter electrode side.Type: ApplicationFiled: May 12, 2014Publication date: March 24, 2016Applicants: TOKYO ELECTRON LIMITED, National University Corporation Kumamoto UniversityInventors: Haruo IWATSU, Hidenori AKIYAMA
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Publication number: 20160068933Abstract: A method of manufacturing a flame-retardant magnesium alloy having mechanical properties of a long period stacking ordered magnesium alloy and having an ignition temperature of 800° C. or more is provided. The method of manufacturing a flame-retardant magnesium alloy comprises a step of melting a flame-retardant magnesium alloy which contains a atomic % of Zn, b atomic % of Y, x atomic % of Ca and a residue of Mg, and a, b and x satisfy formulae 1 to 4 below. 0.5?a<5.0??(Formula 1) 0.5<b<5.0??(Formula 2) ?a???b??(Formula 3) 0<x?0.Type: ApplicationFiled: April 14, 2014Publication date: March 10, 2016Applicant: National University Corporation Kumamoto UniversityInventors: Yoshihito KAWAMURA, Jonghyun KIM
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Patent number: 9167805Abstract: A method of producing a chimera animal, characterized by transplanting, into a host animal, an aggregate of a first pluripotent stem cell that is of interest to strain establishment, a second pluripotent stem cell in which the ability to form germ cells is absent or decreased, and embryo.Type: GrantFiled: August 30, 2011Date of Patent: October 27, 2015Assignee: National University Corporation Kumamoto UniversityInventors: Masatake Araki, Kimi Araki
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Patent number: 9051733Abstract: A vibration damping device for suppressing vibrations of a structure includes: a slide body mechanism having a concave slide body and a convex slide body which are fixed to the structure and are arranged so as to be slidable relative to each other in a reciprocating manner; and a biasing means which pushes the slide bodies to each other. Each slide body has: a first slide surface having a shape which increases a height of the slide body mechanism 2 along with the increase of a displacement amount of the slide body in one sliding direction from a neutral position relative to the counterpart slide body; and a second slide surface having a shape by which the height of the slide body mechanism is increased along with the increase of the displacement of the slide body in the other sliding direction from the neutral position.Type: GrantFiled: June 14, 2011Date of Patent: June 9, 2015Assignees: National University Corporation Kumamoto University, Kimigafuchi GakuenInventors: Toshitaka Yamao, Takuro Katayama, Koji Azuma
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Publication number: 20150052625Abstract: The present invention provides embryonic stem cells obtainable from an embryo of an immunodeficient mouse which is deficient in both Rag2 and Jak3 genes by culture in the presence of a GSK3 inhibitor and an MEK inhibitor, as well as a transgenic mouse, which is created with the use of these embryonic stem cells.Type: ApplicationFiled: March 27, 2012Publication date: February 19, 2015Applicants: Trans Genic Inc., National University Corporation Kumamoto UniversityInventors: Ken-ichi Yamamura, Kimi Araki, Seiji Okada, Akihiko Shimono
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Patent number: 8944307Abstract: A welding method of applying energy to an interface where a metal glass and a crystalline metal make contact with each other or to the metal glass near the interface, heating and melting the metal glass to form a molten layer, and joining the metal glass and the crystalline metal. The metal glass has a glass formation ability in which a nose time of a TTT curve when a solid of the metal glass is reheated is 0.2 seconds or more. The metal glass and the crystalline metal are formed with a material that satisfies a temperature range of a temperature of the metal glass at which a spread factor of the crystalline metal that has not been melted and the molten metal glass is 25% or more and a melting point of the crystalline metal to be 100 K or more.Type: GrantFiled: March 18, 2010Date of Patent: February 3, 2015Assignees: National University Corporation Kumamoto University, Kuroki Kogosyo Co., Ltd.Inventors: Yoshihito Kawamura, Jonghyun Kim, Hironori Kuroki, Yuji Yanagida, Naohisa Sawai, Masafumi Miyajima
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Patent number: 8940270Abstract: To provide a sulfur trioxide decomposition catalyst, particularly, a sulfur trioxide decomposition catalyst capable of lowering the temperature required when producing hydrogen by an S—I cycle process. A sulfur trioxide decomposition catalyst comprising a composite oxide of vanadium and at least one metal selected from the group consisting of transition metal and rare earth elements is provided. Also, a sulfur dioxide production process comprising decomposing sulfur trioxide into sulfur dioxide and oxygen by using the sulfur trioxide decomposition catalyst above, is provided. Furthermore, a hydrogen production process, wherein the reaction of decomposing sulfur trioxide into sulfur dioxide and oxygen by an S—I cycle process is performed by the above-described sulfur dioxide production process, is provided.Type: GrantFiled: December 27, 2011Date of Patent: January 27, 2015Assignees: Toyota Jidosha Kabushiki Kaisha, National University Corporation Kumamoto UniversityInventors: Shinichi Takeshima, Masato Machida
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Patent number: 8932555Abstract: A sulfur trioxide decomposition catalyst, in particular, a sulfur trioxide decomposition catalyst capable of lowering the temperature required when producing hydrogen by an S—I cycle process is disclosed. A sulfur trioxide decomposition catalyst that includes a composite oxide of tungsten, vanadium and at least one metal selected from the group consisting of transition metal and rare earth elements is provided. Also, a sulfur dioxide production process that includes decomposing sulfur trioxide into sulfur dioxide and oxygen by using the sulfur trioxide decomposition catalyst above is provided. Furthermore, a hydrogen production process, wherein the reaction of decomposing sulfur trioxide into sulfur dioxide and oxygen by an S—I cycle process is performed by the above-described sulfur dioxide production process is provided.Type: GrantFiled: May 18, 2012Date of Patent: January 13, 2015Assignees: Toyota Jidosha Kabushiki Kaisha, National University Corporation Kumamoto UniversityInventors: Shinichi Takeshima, Masato Machida
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Patent number: 8877082Abstract: Disclosed is a processing method which can achieve a high processing rate, and is capable of making a surface smooth. In order to achieve this an SiC substrate is arranged in a potassium hydroxide solution containing hydrogen peroxide, and ultraviolent radiation is irradiated on the surface of the SiC substrate. An SiO2 layer is formed on the surface of the SiC substrate due to the irradiation of ultraviolet radiation, and this SiO2 layer is chemically removed by means of the potassium hydroxide solution, and also removed by a synthetic quartz surface plate.Type: GrantFiled: March 18, 2011Date of Patent: November 4, 2014Assignee: National University Corporation Kumamoto UniversityInventors: Akihisa Kubota, Mutsumi Touge