Patents Assigned to Kumamoto University
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Publication number: 20220266222Abstract: The present invention provides a column filler for liquid chromatography that has a great adsorption capacity, adjustable adsorption selectivity, and high shape retainability and therefore is usable for measurement of various substances and capable of achieving excellent separation performance and a high filling rate in a column when used as a column filler for liquid chromatography. Provided is a column filler for liquid chromatography including carbon-coated porous particles, the carbon-coated porous particles including porous particles each having a coating layer containing an amorphous carbon on a surface.Type: ApplicationFiled: May 13, 2022Publication date: August 25, 2022Applicants: SEKISUI CHEMICAL CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Ren-de SUN, Shoji NOZATO, Akira NAKASUGA, Hirotaka IHARA, Makoto TAKAFUJI, Yutaka KUWAHARA, Hiroki NOGUCHI, Tianhang LIU
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Publication number: 20220183690Abstract: An object of the present invention is to provide a means for fixing a pancreatic resection stump created during an operation for resecting a portion of the pancreas. The present invention provides a polymeric surgical clip characterized in that the clip comprises a first arm portion, a second arm portion, and a resilient hinge portion joining the first and second arm portions together, both the arm portions are joined to the resilient hinge portion at their bases, the first arm portion has a convex outer surface and a concave inner surface clamping the pancreas, the second arm portion has a convex or flat outer surface and a concave or flat inner surface clamping the pancreas, the first arm portion forms at its distal end a deflectable hook portion curved toward the second arm portion, and the clip is configured so that, in a closed position, a distal end of the second arm portion enters inside the curved hook portion and engages with the hook portion to lock the clip in the closed position.Type: ApplicationFiled: March 17, 2020Publication date: June 16, 2022Applicants: National University Corporation Kumamoto University, Kyushu University, National University CorporationInventors: Hideo Baba, Yoichi Yamashita, Ijima Hiroyuki
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Publication number: 20220112490Abstract: There is provided a method for suppressing protein expression, including using an oligomer for RNA having first, second, third, and fourth guanine repeat sequences (referred to as “first G sequence,” “second G sequence,” “third G sequence,” and “fourth G sequence,” respectively), the oligomer hybridizing with regions proximal to the guanine repeat sequences, so as to bring the guanine repeat sequences closer together, thereby forming a guanine-quadruplex structure.Type: ApplicationFiled: October 25, 2019Publication date: April 14, 2022Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, HIROSAKI UNIVERSITYInventors: Yosuke KATSUDA, Shinichi SATO, Masaki HAGIHARA, Toshihiro IHARA, Yusuke KITAMURA
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Publication number: 20220048857Abstract: An object of the present invention is to provide a novel plant growth inhibiting agent and a plant growth inhibiting method using the same. The plant growth inhibiting agent of the present invention comprises, as an active ingredient, a compound represented by the following formula (I?) and/or a salt thereof. In the formula (I?), R1a represents a substituted or unsubstituted C1 to C20 alkyl group, a substituted or unsubstituted C6 to C14 aryl group, a substituted or unsubstituted C3 to C13 heteroaryl group, or the like; R2 represents a substituted or unsubstituted C1 to C20 alkylene group, a substituted or unsubstituted C6 to C14 arylene group, or the like; R3a represents OH, a substituted or unsubstituted C1 to C6 alkoxy group, or the like; X represents an oxygen atom; Y represents a substituent; q represents any integer of 0 to 3; n represents 0 or 1; and m represents 0 or 1.Type: ApplicationFiled: September 10, 2021Publication date: February 17, 2022Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, Nippon Soda Co., Ltd.Inventors: Hayato ISHIKAWA, Tokio TANI, Shinichiro SAWA, Takashi ISHIDA, Yusuke FUKUSHIMA, Jun INAGAKI
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Publication number: 20220031838Abstract: A mucosal adjuvant may have high mucosal immunogenicity and high safety and be useful in the preparation of mucosal vaccines, and a mucosal vaccine composition may include the same. Such mucosal adjuvant may include TGDK. A method for preparing the mucosal vaccine composition may include mixing TGDK with an immunogen.Type: ApplicationFiled: September 26, 2019Publication date: February 3, 2022Applicants: DENKA COMPANY LIMITED, NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Shogo MISUMI, Naoki KISHIMOTO, Ryotaro MITSUMATA, Nagisa NAKATA, Takuma GOTANDA
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Publication number: 20220031833Abstract: An inactivated whole-virus influenza vaccine may have its antibody-inducing ability is maintained or enhanced and may cause fewer side reactions. A method for preparing an inactivated whole-virus influenza vaccine may use an embryonated chicken egg method, including subjecting a virus solution including a whole influenza virus collected from embryonated chicken eggs to a hypotonic treatment.Type: ApplicationFiled: September 26, 2019Publication date: February 3, 2022Applicants: DENKA COMPANY LIMITED, NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Ryotaro MITSUMATA, Shogo MISUMI, Naoki KISHIMOTO, Takuma GOTANDA, Nagisa NAKATA
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Patent number: 11235073Abstract: A pharmaceutical composition can be provide for treating or preventing heart failure. Additionally, siRNA and a vector expressing said siRNA can be provided that can be used in the pharmaceutical composition for treating or preventing heart failure. For example, a pharmaceutical composition can be provided for treating or preventing heart failure that contains a DNA sequence encoding RNA containing a sense strand sequence of consecutive 18 to 29 nucleotides from angiopoietin-like protein 2 (ANGPTL2) mRNA or the alternative splicing type RNA thereof and an antisense strand sequence complementary to the sense strand sequence under control of a promoter, and a pharmaceutically acceptable carrier.Type: GrantFiled: March 23, 2020Date of Patent: February 1, 2022Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Yuichi Oike, Tian Zhe, Tsuyoshi Kadomatsu, Keishi Miyata, Haruki Horiguchi
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Patent number: 11219930Abstract: The present invention provides a new filter cleaning method that has cleaning performance superior to that of ultrasonic cleaning. The method for cleaning a filter of the present invention includes the steps of: generating a shock wave; and bringing the shock wave into contact with a filter to which a filler adhered, wherein in the shock wave contacting step, a pressure applied to the filter by the shock wave is 0.07 MPa or more.Type: GrantFiled: December 12, 2018Date of Patent: January 11, 2022Assignees: Nagase Filter Co, Ltd., National University Corporation Kumamoto UniversityInventors: Toshiki Eguchi, Masayoshi Shimo, Hideki Hayashi, Kazuyuki Hokamoto, Shigeru Tanaka
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Patent number: 11207448Abstract: Provided is a biodegradable polymer coating stent effective in delaying the damage of physical properties (particularly radial force) of a core structure. The stent includes a core structure of a bioabsorbable material (e.g., Mg), a first coating layer of a first polymer with biodegradability, and a second coating layer of a second polymer with biodegradability, wherein the first coating layer covers the whole surface of the core structure; the second coating layer covers a part or the whole surface of the first coating layer; the first polymer has a glass transition point of lower than 37° C.; and the second polymer has a glass transition point of 47° C. or higher.Type: GrantFiled: May 24, 2018Date of Patent: December 28, 2021Assignees: JAPAN MEDICAL DEVICE TECHNOLOGY CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Makoto Sasaki, Takuro Niidome, Zhen Yu Jin, Shuzo Yamashita
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Publication number: 20210355561Abstract: The present invention provides a novel heat exchange medium to replace lead. A carbon-steel wire 1A heated in a heating furnace 11 is passed through a bath 12A filled with a liquid-phase Mg—Al—Ca alloy 20 obtained by melting a Mg—Al—Ca alloy in which the main constituent elements are Mg (magnesium), Al (aluminum) and Ca (calcium). When it passes through the bath 12A, the carbon-steel wire 1A, which has been heated for example to about 950° C. in the heating furnace 11, is cooled to about 550° C. The Mg—Al—Ca alloy is non-toxic and has no environmental impact as well.Type: ApplicationFiled: July 27, 2021Publication date: November 18, 2021Applicants: TOKYO ROPE MANUFACTURING CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Kazuhiro ISHIMOTO, Yoshihito KAWAMURA
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Patent number: 11177399Abstract: The nanoparticle assembly includes nanoparticles having an average primary particle size of 60 nm or less, and the nanoparticle assembly has a diameter of more than 500 nm and 5 ?m or less.Type: GrantFiled: January 31, 2019Date of Patent: November 16, 2021Assignees: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, NIKON CORPORATIONInventors: Takao Namihira, Yasutaka Nishi, Makoto Nakazumi, Koichiro Iwahori
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Patent number: 11142497Abstract: An object of the present invention is to provide a novel plant growth inhibiting agent and a plant growth inhibiting method using the same. The plant growth inhibiting agent of the present invention comprises, as an active ingredient, a compound represented by the following formula (I?) and/or a salt thereof. In the formula (I?), R1a represents a substituted or unsubstituted C1 to C20 alkyl group, a substituted or unsubstituted C6 to C14 aryl group, a substituted or unsubstituted C3 to C13 heteroaryl group, or the like; R2 represents a substituted or unsubstituted C1 to C20 alkylene group, a substituted or unsubstituted C6 to C14 arylene group, or the like; R3a represents OH, a substituted or unsubstituted C1 to C6 alkoxy group, or the like; X represents an oxygen atom; Y represents a substituent; q represents any integer of 0 to 3; n represents 0 or 1; and m represents 0 or 1.Type: GrantFiled: February 6, 2018Date of Patent: October 12, 2021Assignees: National University Corporation Kumamoto University, Nippon Soda Co., Ltd.Inventors: Hayato Ishikawa, Tokio Tani, Shinichiro Sawa, Takashi Ishida, Yusuke Fukushima, Jun Inagaki
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Patent number: 11135425Abstract: Provided is a new means for suppressing inflammation or suppressing inflammatory cytokine production. Provided is a device in which a weak pulse current is passed through a living body or living tissue to suppress inflammation in the living body or the living tissue. This device is provided with a power supply means, and a current control means for receiving a supply of power to intermittently apply a direct current at prescribed intervals, and is configured such that the current control means includes a pulse width modulation control means, and the pulse width modulation control means generates a pulse wave that is a rectangular wave, and in which the time indicating a peak value for rising in one cycle of the pulse wave (“pulse duration”) is at least 0.1 millisecond, the peak value is 1.0-20 V, inclusive, and the duty ratio of the pulse wave is at least 5.5%.Type: GrantFiled: October 13, 2016Date of Patent: October 5, 2021Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Hirofumi Kai, Tsuyoshi Shuto, Ann Soten Mary Suico, Eiichi Araki, Tatsuya Kondo
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Publication number: 20210283576Abstract: The present invention provides a column filler for liquid chromatography that has a great adsorption capacity, adjustable adsorption selectivity, and high shape retainability and therefore is usable for measurement of various substances and capable of achieving excellent separation performance and a high filling rate in a column when used as a column filler for liquid chromatography. Provided is a column filler for liquid chromatography including carbon-coated porous particles, the carbon-coated porous particles including porous particles each having a coating layer containing an amorphous carbon on a surface.Type: ApplicationFiled: November 11, 2017Publication date: September 16, 2021Applicants: SEKISUI CHEMICAL CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Ren-de SUN, Shoji NOZATO, Akira NAKASUGA, Hirotaka IHARA, Makoto TAKAFUJI, Yutaka KUWAHARA, Hiroki NOGUCHI, Tianhang LIU
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Publication number: 20210276950Abstract: An object of the present invention is to provide a novel plant growth inhibiting agent and a plant growth inhibiting method using the same. The plant growth inhibiting agent of the present invention comprises, as an active ingredient, a compound represented by the following formula (I?) and/or a salt thereof. In the formula (I?), R1a represents a substituted or unsubstituted C1 to C20 alkyl group, a substituted or unsubstituted C6 to C14 aryl group, a substituted or unsubstituted C3 to C13 heteroaryl group, or the like; R2 represents a substituted or unsubstituted C1 to C20 alkylene group, a substituted or unsubstituted C6 to C14 arylene group, or the like; R3a represents OH, a substituted or unsubstituted C1 to C6 alkoxy group, or the like; X represents an oxygen atom; Y represents a substituent; q represents any integer of 0 to 3; n represents 0 or 1; and m represents 0 or 1.Type: ApplicationFiled: February 6, 2018Publication date: September 9, 2021Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, Nippon Soda Co., Ltd.Inventors: Hayato ISHIKAWA, Tokio TANI, Shinichiro SAWA, Takashi ISHIDA, Yusuke FUKUSHIMA, Jun INAGAKI
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Patent number: 11089805Abstract: The present invention provides a mucosal immunomodulator comprising, as an active ingredient, at least one selected from the group consisting of compounds represented by the following formula (1), compounds represented by the following formula (2) and compounds represented by the following formula (3), and salts thereof.Type: GrantFiled: October 12, 2017Date of Patent: August 17, 2021Assignees: Yamada Bee Company, Inc., National University Corporation Kumamoto UniversityInventors: Shogo Misumi, Tomoki Ikuta, Tomoki Tatefuji, Hiroko Tani, Hiroshi Inooka
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Publication number: 20210162137Abstract: The injection needle removal device has: a cylindrical outer cylinder on an upper opening of an injection needle case; a helical track on an inner peripheral surface of the outer cylinder in a helical shape from an upper locking point to a lower locking point; a syringe holding cylinder helically advances in the outer cylinder along the helical track; an injection needle tightening ring on a lower end portion of the syringe holding cylinder, the injection needle tightening ring holds an injection needle base portion of a syringe in the syringe holding cylinder to clamp the injection needle base portion; and a locking mechanism that stops the syringe holding cylinder where the injection needle tightening ring is exposed from a lower side of the outer cylinder at the lower locking point.Type: ApplicationFiled: December 7, 2018Publication date: June 3, 2021Applicants: THREE DYNE CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: KOJI HAGIHIRA, YOSHITAKA NAKANISHI, KAZUMA SHIBATA
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Publication number: 20210155890Abstract: A purpose of the present invention is to provide an incubator device and the like capable of performing measurements in a manner such as to minimize changes in the state of a medium. The incubator device is designed to control the cell culture environment and includes an airtight housing, a light source for irradiating a medium containing seeded cells with light, a light measurement unit for measuring the intensity of light from the medium, and a light guide member for guiding the light from the medium to the light measurement unit. The light source unit, the light measurement unit and the light guide member are placed within the housing.Type: ApplicationFiled: April 8, 2019Publication date: May 27, 2021Applicants: National University Corporation Kumamoto University, Ushio Denki Kabushiki KaishaInventors: Yuta NAKASHIMA, Kinichi MORITA
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Patent number: 10987651Abstract: Means for removing endotoxin is provided. Endotoxin is removed by contacting an endotoxin adsorbent including a cellulose nanofiber having an amino group with a liquid containing endotoxin.Type: GrantFiled: July 29, 2016Date of Patent: April 27, 2021Assignees: National University Corporation Kumamoto University, Nagase ChemteX CorporationInventors: Masayo Sakata, Towako Sakamoto, Daisuke Nakamura, Yuki Maeda
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Patent number: 10813765Abstract: [Problem] The present invention provides a voice disorder treatment tool in which a clamping section thereof does not break easily. [Solution] The present invention includes a plurality of clamping sections 1, 1 that are provided with a front surface piece 1b disposed on a front surface 11a of incised thyroid cartilage 11 and a rear surface piece 1c disposed on a rear surface of the thyroid cartilage 11, and fit to cut ends 12 of the incised thyroid cartilage 11 that are facing each other, and a bridging section 2 that connects the plurality of clamping sections 1, 1. The front surface piece 1b includes a bending region 15 deformable about a virtual line K extending in a width direction of this front surface piece 1b, and the bending region 15 has a reinforcing structure S.Type: GrantFiled: August 9, 2016Date of Patent: October 27, 2020Assignees: NOBELPHARMA CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, WAKAYOSHI SEISAKUSHO CO., LTD.Inventors: Tetsuji Sanuki, Shuji Wakayoshi, Tsukasa Harada, Seiichi Masuda, Hiroyuki Nishihata, Kazuhiro Kinoshita, Takako Aburada