Patents Assigned to Kumamoto University
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Patent number: 10765094Abstract: The present invention provides a method for detection of an inflammatory reaction, which comprises using a transformant or transgenic non-human animal transfected with a vector comprising a promoter for a gene encoding an inflammatory cytokine, a gene encoding a reporter protein, a gene encoding the inflammatory cytokine, and a gene encoding a proteolytic signal sequence to thereby detect an inflammatory reaction induced upon inflammatory stimulation in the transformant or in the transgenic non-human animal.Type: GrantFiled: July 31, 2014Date of Patent: September 8, 2020Assignees: TRANSGENIC INC., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITYInventors: Kenichi Yamamura, Takao Iwawaki, Daisuke Oikawa, Tomoo Ishikawa
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Publication number: 20200261584Abstract: To provide a protein preparation which enables reduction of aggregation and a stable long-time preservation, in a protein preparation having a high concentration or a protein preparation susceptible to aggregation. The protein preparation is a gel preparation which is thixotropic and in which an included protein is protected from a physical or chemical stress, is inhibited from aggregation, and thereby stably exists.Type: ApplicationFiled: May 6, 2020Publication date: August 20, 2020Applicants: TERUMO KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Hidetoshi ARIMA, Keiichi MOTOYAMA, Taishi HIGASHI, Anna TAJIMA, Naoko OHSHITA, Sawako KOYAMA, Ruriko IIBUCHI, Shuuhei MIEDA, Kenji HANDA
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Patent number: 10736941Abstract: The present invention addresses to provide a novel membrane permeability-improving agent which can be applied to high molecular drugs. More specifically, the present invention addresses to provide: a drug carrier which can improve the absorption efficiency of a high molecular drug in the small intestine; and a membrane permeation-improving agent containing the carrier. According to the present invention, a cell membrane-permeating peptide can be provided, which comprises an amino acid sequence selected from the group consisting of the following amino acid sequences: DNPGN (SEQ ID NO: 1); SRPAF (SEQ ID NO: 2); NDPRN (SEQ ID NO: 3); and MSVAN (SEQ ID NO: 4). According to the present invention, a cell membrane-permeable composition can also be provided, which comprises the peptide and a biologically active substance.Type: GrantFiled: May 18, 2016Date of Patent: August 11, 2020Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Shingo Ito, Sumio Ohtsuki
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Patent number: 10729723Abstract: An object of the present invention is to provide a pluripotent cell having high safety in application to regenerative medicine, and a method for production thereof. Another object of the present invention is to provide a pluripotent cell, particularly, having less concern for safety, such as a problem of cancerization of a cell, and the presence of bacteria in a cell, and a method for production thereof. According to the present invention, there is provided a method for producing a pluripotent cell from a somatic cell. The method comprises a step of inducing reprogramming of a somatic cell, by contacting the cell with a ribosome fraction derived from an organism. Further, according to the present invention, there is provided a composition for inducing reprogramming of a cell, comprising a ribosome fraction derived from an organism.Type: GrantFiled: May 11, 2015Date of Patent: August 4, 2020Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Kunimasa Ohta, Naofumi Ito
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Publication number: 20200208192Abstract: The present invention provides a method for highly sensitively and highly specifically detecting a kidney cancer. According to the present invention, there is provided, for example, a method for detecting a kidney cancer in a subject, comprising diluting a urine sample obtained from the subject at a predetermined ratio, and determining whether or not nematodes exhibit attraction behavior toward the diluted urine sample, wherein the predetermined ratio is 200 or more.Type: ApplicationFiled: August 20, 2018Publication date: July 2, 2020Applicants: HIROTSU BIO SCIENCE INC., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Takaaki HIROTSU, Hirofumi JONO
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Publication number: 20200129943Abstract: Provided is an explosive body X, i.e., an explosive body for nanodiamond synthesis, includes at least an explosive main body (10) that includes a frustum part (11) and a columnar part (12). The frustum part (11) includes an upper bottom surface (11a) including an open end of a hole (H), in which a triggering unit is received, and an angled side surface (11b) forming an imaginary apex angle ? on the upper bottom surface (11a) side. The columnar part (12) is formed contiguous with the frustum part (11) on an opposite side of the frustum part (11) to the upper bottom surface (11a) of the frustum part (11) and extends in a direction away from the upper bottom surface (11a). The explosive body for nanodiamond synthesis is suitable for improving the yield in nanodiamond synthesis by a detonation method.Type: ApplicationFiled: May 7, 2018Publication date: April 30, 2020Applicants: DAICEL CORPORATION, NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Tomoaki MAHIKO, Tomohide INA, Daisuke ISHIMOTO, Kazuyuki HOKAMOTO, Shigeru TANAKA
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Publication number: 20200124522Abstract: A purpose of the present invention is to provide an optical measurement system or the like suitable for optical measurement of nucleic acids, proteins, etc. In a first aspect of the present invention, an optical measurement system that provides optical sample measurement comprises: an optical cell having a sample-holding hollow portion; and a light source unit that emits broadband light containing first and second light to the optical cell. The optical cell includes: a first light guide where light passes through a first transparent portion that transmits the first light more readily than the second light and the hollow portion without passing through a second transparent portion that transmits the second light more readily than the first light; and a second light guide that differs from the first light guide, in which light passes through the second transparent portion and the hollow portion without passing through the first transparent portion.Type: ApplicationFiled: January 19, 2018Publication date: April 23, 2020Applicants: National University Corporation Kumamoto University, Ushio Denki Kabushiki KaishaInventors: Yuta NAKASHIMA, Kinichi MORITA
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Patent number: 10604562Abstract: A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.Type: GrantFiled: January 23, 2015Date of Patent: March 31, 2020Assignees: KM BIOLOGICS CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Akihiko Hosoi, Masaharu Torikai, Tomoyo Takeo, Masayo Ueno, Hirofumi Higuchi, Kenji Soejima, Toshihiro Nakashima, Yukio Ando, Hirofumi Jono, Yu Su
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Patent number: 10588921Abstract: Provided is a pharmaceutical composition for the treatment of disorders such as Niemann-Pick disease and GM1 gangliosidosis which are caused by the storage of cholesterol, such as lysosomal storage disease. Also provided is a method for screening for said pharmaceutical compositions that uses iPS cell strains that phenocopy phentotypes of these disorders. Provided is a pharmaceutical composition for the treatment and/or prevention of lysosomal storage disease, characterized by containing hydroxypropyl-?-cyclodextrin as an active ingredient. Also provided are an iPS cell strain derived from patients suffering from intractable disorders and prepared using a new temperature-sensitive Sendai virus vector, and a screening method for pharmaceuticals using said iPS cell strain.Type: GrantFiled: December 3, 2014Date of Patent: March 17, 2020Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Takumi Era, Tetsumi Irie
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Patent number: 10526654Abstract: An object of the present invention is to provide a method for detecting a modification present in RNA using a small amount of RNA sample. Another object of the present invention is to provide a method for detecting a modification present in tRNA, for example, thiomethylation. Still another object of the present invention is to provide a method for detecting the thiomethylation of tRNA, thereby diagnosing human type 2 diabetes or the risk thereof. The present invention is characterized in that, with respect to a modification present in RNA in an RNA sample, cDNA is produced by reverse transcription of RNA using a first primer, and the resulting amount of cDNA is compared with the amount of cDNA produced by reverse transcription of RNA using a second primer, thereby detecting a modification (e.g., thiomethylation) present in RNA.Type: GrantFiled: March 6, 2014Date of Patent: January 7, 2020Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Kazuhito Tomizawa, Fanyan Wei, Takeo Suzuki, Tsutomu Suzuki
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Patent number: 10500275Abstract: An object of the present invention is to provide a novel method that is excellent in superovulation induction efficiency. Specifically, it is an object to provide a method giving superior superovulation induction efficiency as compared with conventional methods using equine chorionic gonadotropin (eCG) and human chorionic gonadotropin (hCG). The present invention provides a superovulation inducing method, comprising simultaneously administering anti-inhibin antibody and equine chorionic gonadotropin (eCG), then, administering human chorionic gonadotropin (hCG), to a female mouse.Type: GrantFiled: February 19, 2016Date of Patent: December 10, 2019Assignee: National University Corporation Kumamoto UniversityInventors: Naomi Nakagata, Toru Takeo
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Patent number: 10478805Abstract: Provided are a supported catalyst including: a support body which is formed by a catalyst composition being supported by a carrier, in which the catalyst composition contains an oxide of copper, and the carrier contains ?Al2O3.?B2O3 (? and ? each represent a positive number); and a hydrogen production method for producing hydrogen from ammonia, including: an ammonia combustion step of reacting ammonia with oxygen in the presence of the supported catalyst; and an ammonia decomposition step of decomposing the ammonia into hydrogen and nitrogen by utilizing heat generated by the reaction between the ammonia and the oxygen.Type: GrantFiled: August 4, 2016Date of Patent: November 19, 2019Assignee: National University Corporation Kumamoto UniversityInventors: Satoshi Hinokuma, Masato Machida
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Patent number: 10472372Abstract: Various embodiments relate to a compound of the formula (I): wherein X, X1, R1—R4 and R7 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I), or a pharmaceutical compositions comprising compounds of the formula (I), to a patient in need thereof.Type: GrantFiled: August 17, 2016Date of Patent: November 12, 2019Assignees: Purdue Research Foundation, National University Corporation Kumamoto UniversityInventors: Arun K. Ghosh, Hiroaki Mitsuya
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Publication number: 20190284546Abstract: A method for controlling the kinetics of a cultured cell includes: a culture step of culturing a cell adhered to the surface of a base material including titanium oxide having an anatase structure on the surface; an irradiation step of irradiating the surface with light in a wavelength range in which the titanium oxide exhibits photocatalytic activity during culture of the cell; and a control step of controlling the kinetics of the cell by controlling the irradiation amount of the light to the surface. The wavelength range may be 400 nm or less.Type: ApplicationFiled: November 14, 2017Publication date: September 19, 2019Applicants: National University Corporation Kumamoto University, Ushio Denki Kabushiki Kaisha, Kyushu University, National University CorporationInventors: Yuta NAKASHIMA, Kinichi MORITA, Kosuke TASHIRO
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Publication number: 20190230967Abstract: The present invention provides a mucosal immunomodulator comprising, as an active ingredient, at least one selected from the group consisting of compounds represented by the following formula (1), compounds represented by the following formula (2) and compounds represented by the following formula (3), and salts thereof.Type: ApplicationFiled: October 12, 2017Publication date: August 1, 2019Applicant: National Unversity Corporation Kumamoto UniversityInventors: Shogo MISUMI, Tomoki IKUTA, Tomoki TATEFUJI, Hiroko TANI, Hiroshi INOOKA
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Patent number: 10358702Abstract: To provide a magnesium alloy having high incombustibility, high strength and high ductility together. A magnesium alloy including Ca in an amount of “a” atomic %, Al in an amount of “b” atomic % and a residue of Mg, including (Mg, Al)2Ca in an amount of “c” volume %, wherein “a”, “b” and “c” satisfy the following equations (1) to (4), and having the (Mg, Al)2Ca dispersed therein. 3?a?7??(1) 4.5?b?12??(2) 1.2?b/a?3.Type: GrantFiled: April 16, 2013Date of Patent: July 23, 2019Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Yoshihito Kawamura, Michiaki Yamasaki
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Patent number: 10350367Abstract: Provided is a needle removal operation cover with which a user can safely perform an injection needle removal operation even when a needle tip is directly inserted into the needle removal operation cover, and with which the user can remove the injection needle without requiring a wrist twisting motion.Type: GrantFiled: September 10, 2015Date of Patent: July 16, 2019Assignees: THREE DYNE CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Koji Hagihira, Yoshitaka Nakanishi
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Publication number: 20190165190Abstract: The nanoparticle assembly includes nanoparticles having an average primary particle size of 60 nm or less, and the nanoparticle assembly has a diameter of more than 500 nm and 5 ?m or less.Type: ApplicationFiled: January 31, 2019Publication date: May 30, 2019Applicants: National University Corporation Kumamoto University, NIKON CORPORATIONInventors: Takao NAMIHIRA, Yasutaka NISHI, Makoto NAKAZUMI, Koichiro IWAHORI
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Patent number: 10260130Abstract: Disclosed is a magnesium alloy material having excellent tensile strength and favorable ductility. Therefore, the magnesium alloy sheet material formed by rolling a magnesium alloy having a long period stacking order phase crystallized at the time of casting includes in a case where a sheet-thickness traverse section of an alloy structure is observed at a substantially right angle to the longitudinal direction by a scanning electron microscope, a structure mainly composed of the long period stacking order phase, in which, at least two or more ?Mg phases having thickness in the observed section of 0.5 ?m or less are laminated in a layered manner with the sheet-shape long period stacking order phase.Type: GrantFiled: March 13, 2015Date of Patent: April 16, 2019Assignees: National University Corporation Kumamoto University, Kumamoto Technology & Industry Foundation, Nissan Motor Co., LtdInventors: Yoshihito Kawamura, Masafumi Noda, Hiroshi Sakurai
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Publication number: 20180354798Abstract: The present invention provides black particles having high electrical insulation properties, high blackness in a visible light region, and excellent dispersibility, and a method for producing the black particles. The present invention relates to black particles containing amorphous carbon, the amorphous carbon being derived from carbon contained in an oxazine resin, the black particles having a specific gravity of 1.8 g/cm3 or less, a zeta potential of ?70 to +80 mV, an average total light reflectance measured at a wavelength of 400 to 800 nm of 5% or less, and a peak intensity ratio between G band and D band as determined from a Raman spectrum of 1.2 or more.Type: ApplicationFiled: February 17, 2017Publication date: December 13, 2018Applicants: SEKISUI CHEMICAL CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITYInventors: Ren-de SUN, Shoji NOZATO, Akira NAKASUGA, Hirotaka IHARA, Makoto TAKAFUJI, Yutaka KUWAHARA, Akiko MURAKAMI