Patents Assigned to Kumamoto University
  • Patent number: 10478805
    Abstract: Provided are a supported catalyst including: a support body which is formed by a catalyst composition being supported by a carrier, in which the catalyst composition contains an oxide of copper, and the carrier contains ?Al2O3.?B2O3 (? and ? each represent a positive number); and a hydrogen production method for producing hydrogen from ammonia, including: an ammonia combustion step of reacting ammonia with oxygen in the presence of the supported catalyst; and an ammonia decomposition step of decomposing the ammonia into hydrogen and nitrogen by utilizing heat generated by the reaction between the ammonia and the oxygen.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: November 19, 2019
    Assignee: National University Corporation Kumamoto University
    Inventors: Satoshi Hinokuma, Masato Machida
  • Patent number: 10472372
    Abstract: Various embodiments relate to a compound of the formula (I): wherein X, X1, R1—R4 and R7 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I), or a pharmaceutical compositions comprising compounds of the formula (I), to a patient in need thereof.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: November 12, 2019
    Assignees: Purdue Research Foundation, National University Corporation Kumamoto University
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya
  • Publication number: 20190284546
    Abstract: A method for controlling the kinetics of a cultured cell includes: a culture step of culturing a cell adhered to the surface of a base material including titanium oxide having an anatase structure on the surface; an irradiation step of irradiating the surface with light in a wavelength range in which the titanium oxide exhibits photocatalytic activity during culture of the cell; and a control step of controlling the kinetics of the cell by controlling the irradiation amount of the light to the surface. The wavelength range may be 400 nm or less.
    Type: Application
    Filed: November 14, 2017
    Publication date: September 19, 2019
    Applicants: National University Corporation Kumamoto University, Ushio Denki Kabushiki Kaisha, Kyushu University, National University Corporation
    Inventors: Yuta NAKASHIMA, Kinichi MORITA, Kosuke TASHIRO
  • Publication number: 20190230967
    Abstract: The present invention provides a mucosal immunomodulator comprising, as an active ingredient, at least one selected from the group consisting of compounds represented by the following formula (1), compounds represented by the following formula (2) and compounds represented by the following formula (3), and salts thereof.
    Type: Application
    Filed: October 12, 2017
    Publication date: August 1, 2019
    Applicant: National Unversity Corporation Kumamoto University
    Inventors: Shogo MISUMI, Tomoki IKUTA, Tomoki TATEFUJI, Hiroko TANI, Hiroshi INOOKA
  • Patent number: 10358702
    Abstract: To provide a magnesium alloy having high incombustibility, high strength and high ductility together. A magnesium alloy including Ca in an amount of “a” atomic %, Al in an amount of “b” atomic % and a residue of Mg, including (Mg, Al)2Ca in an amount of “c” volume %, wherein “a”, “b” and “c” satisfy the following equations (1) to (4), and having the (Mg, Al)2Ca dispersed therein. 3?a?7??(1) 4.5?b?12??(2) 1.2?b/a?3.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: July 23, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Yoshihito Kawamura, Michiaki Yamasaki
  • Patent number: 10350367
    Abstract: Provided is a needle removal operation cover with which a user can safely perform an injection needle removal operation even when a needle tip is directly inserted into the needle removal operation cover, and with which the user can remove the injection needle without requiring a wrist twisting motion.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: July 16, 2019
    Assignees: THREE DYNE CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Koji Hagihira, Yoshitaka Nakanishi
  • Publication number: 20190165190
    Abstract: The nanoparticle assembly includes nanoparticles having an average primary particle size of 60 nm or less, and the nanoparticle assembly has a diameter of more than 500 nm and 5 ?m or less.
    Type: Application
    Filed: January 31, 2019
    Publication date: May 30, 2019
    Applicants: National University Corporation Kumamoto University, NIKON CORPORATION
    Inventors: Takao NAMIHIRA, Yasutaka NISHI, Makoto NAKAZUMI, Koichiro IWAHORI
  • Patent number: 10260130
    Abstract: Disclosed is a magnesium alloy material having excellent tensile strength and favorable ductility. Therefore, the magnesium alloy sheet material formed by rolling a magnesium alloy having a long period stacking order phase crystallized at the time of casting includes in a case where a sheet-thickness traverse section of an alloy structure is observed at a substantially right angle to the longitudinal direction by a scanning electron microscope, a structure mainly composed of the long period stacking order phase, in which, at least two or more ?Mg phases having thickness in the observed section of 0.5 ?m or less are laminated in a layered manner with the sheet-shape long period stacking order phase.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: April 16, 2019
    Assignees: National University Corporation Kumamoto University, Kumamoto Technology & Industry Foundation, Nissan Motor Co., Ltd
    Inventors: Yoshihito Kawamura, Masafumi Noda, Hiroshi Sakurai
  • Publication number: 20180354798
    Abstract: The present invention provides black particles having high electrical insulation properties, high blackness in a visible light region, and excellent dispersibility, and a method for producing the black particles. The present invention relates to black particles containing amorphous carbon, the amorphous carbon being derived from carbon contained in an oxazine resin, the black particles having a specific gravity of 1.8 g/cm3 or less, a zeta potential of ?70 to +80 mV, an average total light reflectance measured at a wavelength of 400 to 800 nm of 5% or less, and a peak intensity ratio between G band and D band as determined from a Raman spectrum of 1.2 or more.
    Type: Application
    Filed: February 17, 2017
    Publication date: December 13, 2018
    Applicants: SEKISUI CHEMICAL CO., LTD., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Ren-de SUN, Shoji NOZATO, Akira NAKASUGA, Hirotaka IHARA, Makoto TAKAFUJI, Yutaka KUWAHARA, Akiko MURAKAMI
  • Patent number: 10138535
    Abstract: A magnesium alloy having high strength and high ductility and in which at least one of corrosion resistance and flame resistance is enhanced, or a method of manufacturing the same. The magnesium alloy contains an atomic % of Ca and b atomic % of Al, totally contains k atomic % of at least one element selected from a group consisting of Mn, Zr, Ag, Y and Nd, has a composition in which a remaining part is formed of Mg and contains c volume % of (Mg, Al)2Ca, a, b, c and k satisfying formulae (1) to (4) and (21) below. The (Mg, Al)2Ca is dispersed and the at least one element is an element that enhances at least one of corrosion resistance and flame resistance: (1) 3?a?7, (2) 4.5?b?12, (3) 1.2?b/a?3.0, (4) 10?c?35, (21) 0<k?0.3.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: November 27, 2018
    Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Yoshihito Kawamura, Michiaki Yamasaki
  • Patent number: 10131777
    Abstract: A method produces a composite of a polymer and tungstic acid and/or molybdic acid; and the composite obtained by the method has high transparency and a desired refractive index. This composite contains tungstic acid and/or molybdic acid and a polymer that has a number average molecular weight of 1,000-10,000,000 and an ether bond and/or an ester bond. The content of tungstic acid and/or molybdic acid in the composite is 0.01-95% by weight.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: November 20, 2018
    Assignee: National University Corporation Kumamoto University
    Inventors: Hirotaka Ihara, Hirokuni Jintoku
  • Publication number: 20180264180
    Abstract: Provided is a biodegradable polymer coating stent effective in delaying the damage of physical properties (particularly radial force) of a core structure. The stent includes a core structure of a bioabsorbable material (e.g., Mg), a first coating layer of a first polymer with biodegradability, and a second coating layer of a second polymer with biodegradability, wherein the first coating layer covers the whole surface of the core structure; the second coating layer covers a part or the whole surface of the first coating layer; the first polymer has a glass transition point of lower than 37° C.; and the second polymer has a glass transition point of 47° C. or higher.
    Type: Application
    Filed: May 24, 2018
    Publication date: September 20, 2018
    Applicants: Japan Medical Device Technology Co., Ltd., National University Corporation Kumamoto University
    Inventors: Makoto SASAKI, Takuro NIIDOME, Zhen Yu JIN, Shuzo YAMASHITA
  • Patent number: 10072249
    Abstract: The purpose of the present invention is to provide a process or method that can be utilized when deriving a three-dimensional structure of a kidney from pluripotent stem cells such as ES cells or iPS cells. The differentiation inducing method is characterized by culturing pluripotent cells with the following three steps, in order: (a) a step of culturing an embryoid body induced from the pluripotent stem cells in medium containing Bmp4 and a high-concentration (concentration A) Wnt agonist; (b) a step of culturing the embryoid body in medium which contains activin, Bmp4, retinoic acid and a middle-concentration (concentration B) Wnt agonist; and (c) a step of culturing the embryoid body in medium containing Fgf9 and a low-concentration (concentration C) Wnt agonist (herein, the Wnt agonist concentrations is concentration A>concentration B>concentration C).
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: September 11, 2018
    Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Ryuichi Nishinakamura, Atsuhiro Taguchi
  • Publication number: 20180244688
    Abstract: Various embodiments relate to a compound of the formula (I): wherein X, X1, R1-R4 and R7 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I), or a pharmaceutical compositions comprising compounds of the formula (I), to a patient in need thereof.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 30, 2018
    Applicants: Purdue Research Foundation, National University Corporation Kumamoto University
    Inventors: Arun K. Ghosh, Hiroaki Mitsuya
  • Patent number: 10034900
    Abstract: An object of the present invention is to provide a method of producing a myeloid blood cell possessing a proliferative capability. According to the present invention, provided is a method of producing a myeloid blood cell possessing a proliferative capability, including forcedly expressing (A) a cMYC gene, and (B) at least one gene selected from the group consisting of a BMI1 gene, an EZH2 gene, an MDM2 gene, an MDM4 gene, and an HIF1A gene in a myeloid blood cell.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: July 31, 2018
    Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventor: Satoru Senju
  • Patent number: 10036095
    Abstract: An electrolytic treatment method in which a predetermined treatment is performed using treatment subject ions contained in a treatment liquid, the method including: an electrode positioning step for positioning a direct electrode and a counter electrode so as to sandwich the treatment liquid, and positioning an indirect electrode for forming an electric field in the treatment liquid; a treatment subject ion migration step for applying a voltage to the indirect electrode and thereby moving the treatment subject ions in the treatment liquid to the counter electrode side; and a treatment subject ion redox step for applying a voltage between the direct electrode and the counter electrode and thereby oxidizing or reducing the treatment subject ions which have migrated to the counter electrode side.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: July 31, 2018
    Assignees: TOKYO ELECTRON LIMITED, NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Haruo Iwatsu, Hidenori Akiyama
  • Patent number: 10010059
    Abstract: A method for producing a model animal which has a desired lifetime, and in which a predetermined biological reaction can be induced, and a model animal are provided. The present invention produces a first individual in which a gene of interest is heterozygously deficient using a first ES cell from a non-human mammalian animal. Meanwhile, a fragment containing a homologous gene that has homology to the gene of interest is made, a second ES cell constituted so that a predetermined region on X chromosome of the animal can be substituted is used, and the fragment is introduced into the second ES cell to generate a substituted ES cell in which the predetermined region has been substituted with the fragment. A second individual is produced using the substituted ES cell. The first individual and the second individual are mated with each other to produce a model animal.
    Type: Grant
    Filed: June 19, 2012
    Date of Patent: July 3, 2018
    Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Masaki Ohmuraya, Kimi Araki
  • Patent number: 10000739
    Abstract: The purpose of the present invention is to provide a method and a culture medium which are capable of efficiently inducing the differentiation of pluripotent stem cells such as ES cells and iPS cells into desired cells by a simple means. The differentiation of pluripotent stem cells can be induced by culturing mammal-derived pluripotent stem cells in a differentiation culture medium that does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine. Also provided is a differentiation-inducing culture medium which does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: June 19, 2018
    Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Shoen Kume, Fumio Endo, Nobuaki Shiraki, Yasuko Shiraki, Kazuhiko Kume
  • Patent number: 9994868
    Abstract: Provided are a method for preparing a mammalian ovum or embryo in which zona pellucida has been thinned or eliminated, and a method for fertilization using the mammalian ovum prepared by the aforementioned method. The resulting mammalian ovum or embryo is capable of realizing an improved fertilization rate and development rate when used for in vitro fertilization, transplantation of a fertilized ovum, or for preparation of an embryo in the early stages of development used in the production of a genetically modified animal.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: June 12, 2018
    Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Naomi Nakagata, Toru Takeo
  • Publication number: 20180066361
    Abstract: An object of the invention is to provide a thin film manufacturing device which further reduces a load on a substrate. Provided is a thin film manufacturing device for forming a thin film on a substrate by supplying a mist of a solution including a thin-film forming material to the substrate, characterized in that the device includes: a plasma generation unit including a first electrode and a second electrode disposed closer to one surface of the substrate, which generates plasma between the first electrode and the second electrode; and a mist supply unit which passes the mist between the first electrode and the second electrode and supplies the mist to the substrate.
    Type: Application
    Filed: August 18, 2017
    Publication date: March 8, 2018
    Applicants: NIKON CORPORATION, NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Kei NARA, Makoto NAKAZUMI, Yasutaka NISHI, Yusui NAKAMURA, Takao NAMIHIRA, Norimitsu TAKAMURA