Patents Assigned to Kyoto University
  • Patent number: 11518855
    Abstract: A low-density gel product of the present disclosure has a skeleton containing a polysiloxane chain and an organic polymer chain. In the skeleton, the polysiloxane chain and the organic polymer chain are bonded to each other by covalent bonds at a plurality of positions on both of the chains with silicon atoms of the polysiloxane chain as bonding points. The organic polymer chain may be an aliphatic hydrocarbon chain. The polysiloxane chain may be a polyorganosiloxane chain. The low-density gel product of the present disclosure is a novel low-density gel product with improved mechanical properties including bending flexibility.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: December 6, 2022
    Assignee: KYOTO UNIVERSITY
    Inventors: Kazuki Nakanishi, Kazuyoshi Kanamori, Guoqing Zu
  • Patent number: 11511262
    Abstract: This invention provides an anisotropic nanostructure represented by the formula: RuxM1-x, wherein 0.6?x?0.999, and M represents at least one member selected from the group consisting of Ir, Rh, Pt, Pd, and Au, and wherein Ru and M form a solid solution at the atomic level, and the anisotropic nanostructure has an anisotropic hexagonal close-packed structure (hcp).
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: November 29, 2022
    Assignee: KYOTO UNIVERSITY
    Inventors: Hiroshi Kitagawa, Dongshuang Wu, Kohei Kusada
  • Patent number: 11505785
    Abstract: Provided is a cell culture method comprising the step of culturing cells using a medium containing a laminin fragment having integrin binding activity, the method not comprising the step of coating a culture vessel with a laminin or a laminin fragment before seeding the cells in the culture vessel. The cell culture method of the present invention uses a smaller amount of a laminin fragment and still achieves a comparable culture efficiency as compared with the conventional cell culture method that uses a culture vessel precoated with a laminin or a laminin fragment.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: November 22, 2022
    Assignee: Kyoto University
    Inventors: Hirofumi Suemori, Takamichi Miyazaki
  • Publication number: 20220366221
    Abstract: An inference system includes: a learning unit that generates an inference model using a first dataset including a plurality of sample data whose ground truth is given and a second dataset including a plurality of sample data whose ground truth is not given; and an inference unit that determines an inference result. The inference model includes an encoder that calculates from sample data a first feature value independent of the first and second datasets and a second feature value dependent on the first or second dataset. The learning unit trains the encoder such that the same first feature value is calculated from any of first and second sample data for a pair of the first sample data among the first dataset and the second sample data which is among the second dataset and whose ground truth is to be identical to the ground truth of the first sample data.
    Type: Application
    Filed: November 9, 2020
    Publication date: November 17, 2022
    Applicants: OMRON CORPORATION, KYOTO UNIVERSITY
    Inventors: Atsushi HASHIMOTO, Masaaki IIYAMA, Ryuhei TAKAHASHI, Motoharu SONOGASHIRA
  • Patent number: 11500043
    Abstract: A magnetoencephalograph M1 includes: multiple pump-probe type optically pumped magnetometers 1A; a bias magnetic field forming coil 15 for applying a bias magnetic field in the same direction as a direction of pump light of each of the multiple pump-probe type optically pumped magnetometers 1A and in a direction approximately parallel to a scalp; a control device 5 that determines a current for the bias magnetic field forming coil and outputs a control signal corresponding to the determined current; and a coil power supply 6 that outputs a current to the bias magnetic field forming coil in response to the control signal output from the control device.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: November 15, 2022
    Assignees: HAMAMATSU PHOTONICS K.K., Kyoto University
    Inventors: Akinori Saito, Takahiro Moriya, Takenori Oida, Motohiro Suyama, Tetsuo Kobayashi
  • Patent number: 11491117
    Abstract: The disclosure pertains to a compound of formula (I), one of its pharmaceutically acceptable salts, or a composition comprising thereof, for use in the prevention or treatment of glucose intolerance related conditions, insulin deficit related conditions, nonalcoholic fatty liver disease and/or obesity.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: November 8, 2022
    Assignees: SORBONNE UNIVERSITÉ, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS, KYOTO UNIVERSITY
    Inventors: Dominique Gauguier, Fumihiko Matsuda, François Brial
  • Publication number: 20220348737
    Abstract: The present invention provides: nanoparticles including a compound that includes porous silica and at least one high-atom selected from the group consisting of gadolinium atoms, iodine atoms, gold atoms, silver atoms, and platinum atoms; and a pharmaceutical composition for radiation treatment, useful for treatment of solid tumors, etc., and including these nanoparticles and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: September 25, 2020
    Publication date: November 3, 2022
    Applicants: KYOTO UNIVERSITY, NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECHNOLOGY, THE REGENTS OF THE UNIV. OF CALIFORNIA
    Inventors: Fuyuhiko TAMANOI, Kotaro MATSUMOTO, Hiroyuki SAITOH, Ayumi SENOUCHI, Toshiki TAJIMA
  • Patent number: 11480635
    Abstract: A tension measuring method installs a reel having a cylindrical coil forming part on a cable to be measured, forms a coil by winding a conductor around the coil forming part, measures a magnetic hysteresis loop of the cable by supplying a current to the coil to generate a magnetic field, and computes a tension of the cable using a parameter determined from the hysteresis loop. A magnetic field sensor and a magnetic flux sensor are provided inside a through hole in the coil forming part, and the cable is positioned inside the through hole. The magnetic field is varied so that the hysteresis loop includes a near-saturation magnetization region, to measure the hysteresis loop using the sensors. The parameter is selected from a magnetic flux or a magnetic flux density, a remanent magnetization, a coercivity, a magnetic permeability, and a hysteresis loss in the near-saturation magnetization region.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: October 25, 2022
    Assignees: KYOTO UNIVERSITY, TOKYO ROPE MFG. CO., LTD., SUMITOMO ELECTRIC INDUSTRIES, LTD.
    Inventors: Kazuhiko Tsukada, Toshiyuki Moriya, Hiroaki Itoi, Sadanori Shiiki, Masashi Oikawa, Shinji Nakaue
  • Patent number: 11473058
    Abstract: The present invention provides a method for producing dopaminergic neuron progenitor cells from pluripotent stem cells, which method comprises the steps of: (i) performing adherent culture of pluripotent stem cells on an extracellular matrix in a medium containing a reagent(s) selected from the group consisting of BMP inhibitor, TGF? inhibitor, SHH signal-stimulating agent, FGF8, and GSK3? inhibitor; (ii) collecting Corin- and/or Lrtm1-positive cells from the cells obtained in Step (i) using a substance which binds to Corin and/or a substance which binds to Lrtm1; and (iii) performing suspension culture of the cells obtained in Step (ii) in a medium containing a neurotrophic factor.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: October 18, 2022
    Assignees: Kyoto University, Osaka University, Eisai R&D Management Co., Ltd.
    Inventors: Jun Takahashi, Daisuke Doi, Bumpei Samata, Kiyotoshi Sekiguchi, Yuichi Ono
  • Publication number: 20220313733
    Abstract: A method for producing renal stromal cells, comprising a step (3) of culturing renal stromal precursors in a medium comprising a platelet derived growth factor receptor agonist to obtain renal stromal cells is provided as a technique for supplying renal stromal cells. This production method can further comprise a step (2) of inducing renal stromal precursors from neural crest cells, and a step (1) of culturing pluripotent stem cells in a medium comprising a GSK3? inhibitor, a TGF? inhibitor, and retinoic acid and/or a derivative thereof to induce neural crest cells.
    Type: Application
    Filed: June 10, 2020
    Publication date: October 6, 2022
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Makoto IKEYA, Daisuke KAMIYA
  • Publication number: 20220306985
    Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like
    Type: Application
    Filed: May 23, 2022
    Publication date: September 29, 2022
    Applicants: Nissan Chemical Industries, Ltd., Kyoto University
    Inventors: Taito NISHINO, Tatsuro KANAKI, Ayako OTANI, Koichiro SARUHASHI, Misayo Tomura, Takehisa IWAMA, Masato HORIKAWA, Norio NAKATSUJI, Tomomi OTSUJI
  • Publication number: 20220302443
    Abstract: A main object of the present disclosure is to provide a new active material that can be used in a fluoride ion battery. The present disclosure achieves the object by providing an active material to be used in a fluoride ion battery, the active material comprising: a crystal phase including an infinite layer structure, and represented by ApBqOr, provided that A is at least one of an alkali earth metal element and a rare earth element, B is a transition metal element, p satisfies 0.8?p?1, q satisfies 0.8?q?1, and r satisfies 1.5?r?2.5.
    Type: Application
    Filed: March 8, 2022
    Publication date: September 22, 2022
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, KYOTO UNIVERSITY
    Inventors: Hidenori MIKI, Yoshiharu UCHIMOTO, Kentaro YAMAMOTO
  • Patent number: 11440799
    Abstract: A carbon material has at least either a peak related to diamond bonds, or a peak related to diamond-like bonds, appearing in a range of 1250 to 1400 cm?1 in a spectrum measured by Raman scattering spectrometry, and a full width at half maximum of a maximum peak, or each of full widths at half maximum of the maximum peak and a second largest peak, among peaks appearing in the range of 1250 to 1400 cm?1, has a signal less than 100 cm?1.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: September 13, 2022
    Assignees: SUMITOMO ELECTRIC INDUSTRIES, LTD., KYOTO UNIVERSITY
    Inventors: Tomoyuki Awazu, Masatoshi Majima, Yoshiki Nishibayashi, Toshiyuki Nohira, Kouji Yasuda, Kouji Hidaka
  • Patent number: 11436719
    Abstract: A cell evaluation method evaluates the quality of a cell population including a plurality of cells. The cell evaluation method comprises: an index calculation step of calculating an index, based on a captured image of the cell population, the index including at least any one of an average distance representing a packing degree of the cells, a spring constant representing a degree of consistency in distances between the cells, and a hexagonal order parameter representing a degree to which an arrangement of the cells resembles a regular hexagon; and an evaluation step of evaluating the cell population, based on the index calculated in the index calculation step.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: September 6, 2022
    Assignees: Kyoto University, Kyoto Prefectural Public University Corporation
    Inventors: Motomu Tanaka, Akihisa Yamamoto, Morio Ueno, Junji Hamuro, Shigeru Kinoshita, Hiroshi Tanaka, Munetoyo Toda, Chie Sotozono
  • Patent number: 11427538
    Abstract: An organic tellurium compound is disclosed having a versatility that, when used as a living radical polymerization initiator, it is applicable to polymerization of a vinyl monomer in an aqueous vehicle without using any surfactant or dispersant. The organic tellurium compound is represented by a general formula (1), where R1 and R2 each independently represent a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, A represents an alkali metal atom or an alkaline earth metal atom, x=1 when A is monovalent, x=½ when A is divalent, and R3 is represented by a general formula (2), where in the general formula (2) R4 represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, R5 and R6 each independently represent an alkylene group having 2 to 8 carbon atoms, and a represents an integer from 0 to 10.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: August 30, 2022
    Assignees: KYOTO UNIVERSITY, OTSUKA CHEMICAL CO., LTD.
    Inventors: Shigeru Yamago, Osamu Ito
  • Patent number: 11427806
    Abstract: The present invention provides a method for producing dopaminergic neuron progenitor cells from pluripotent stem cells, which method comprises the steps of: (i) performing adherent culture of pluripotent stem cells on an extracellular matrix in a medium containing a reagent(s) selected from the group consisting of BMP inhibitor, TGF? inhibitor, SHH signal-stimulating agent, FGF8, and GSK3? inhibitor; (ii) collecting Corin- and/or Lrtm1-positive cells from the cells obtained in Step (i) using a substance which binds to Corin and/or a substance which binds to Lrtm1; and (iii) performing suspension culture of the cells obtained in Step (ii) in a medium containing a neurotrophic factor.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: August 30, 2022
    Assignees: Kyoto University, Osaka University, Eisai R&D Management Co., Ltd.
    Inventors: Jun Takahashi, Daisuke Doi, Bumpei Samata, Kiyotoshi Sekiguchi, Yuichi Ono
  • Publication number: 20220271503
    Abstract: A two-dimensional photonic-crystal surface-emitting laser includes an active layer, a two-dimensional photonic crystal, and electrodes. The two-dimensional photonic crystal contains a plate-shaped base material arranged on one side of the active layer and different refractive index portions arranged at lattice points of a predetermined lattice in the base material and having a refractive index different from that of the base material, a band edge frequency for each position in an electric current supply region, which is at least a part of the two-dimensional photonic crystal, is monotonically increased in one direction parallel to the base material. Such a two-dimensional photonic crystal occurs when the different refractive index portion has a refractive index smaller than that of the base material, a filling factor, which is a ratio of a volume occupied by the different refractive index portion in a unit lattice constituting the lattice, is monotonically increased in the one direction.
    Type: Application
    Filed: August 4, 2020
    Publication date: August 25, 2022
    Applicant: KYOTO UNIVERSITY
    Inventors: Susumu NODA, Takuya INOUE, Masahiro YOSHIDA, Menaka DE ZOYSA
  • Publication number: 20220265714
    Abstract: The present disclosure includes a method of producing a cell population containing Chimeric Antigen Receptor (CAR)-expressing immune cells, comprising co-culturing CAR-expressing immune cells and cells expressing a target antigen of the CAR, wherein the CAR-expressing immune cells are cells into which a CAR gene has been introduced and the target antigen-expressing cells are normal blood cells that have been engineered to express the target antigen.
    Type: Application
    Filed: July 30, 2020
    Publication date: August 25, 2022
    Applicants: SHINSHU UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, BrightPath Biotherapeutics Co., Ltd.
    Inventors: Yozo Nakazawa, Shigeki YAGYU, Miyuki TANAKA, Kayoko NAKAMURA, Masahiro OKADA, Makoto KONDO, Tomokuni SHIGEURA, Shogo HIROTA
  • Patent number: 11424320
    Abstract: A new and useful p-type oxide semiconductor with a wide band gap and an enhanced electrical conductivity and the method of manufacturing the p-type oxide semiconductor are provided. A method of manufacturing a p-type oxide semiconductor including: generating atomized droplets by atomizing a raw material solution containing at least a d-block metal in the periodic table and a metal of Group 13 of the periodic table; carrying the atomized droplets onto a surface of a base by using a carrier gas; causing a thermal reaction of the atomized droplets adjacent to the surface of the base under an atmosphere of oxygen to form the p-type oxide semiconductor on the base.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: August 23, 2022
    Assignees: FLOSFIA INC., KYOTO UNIVERSITY
    Inventors: Shizuo Fujita, Kentaro Kaneko, Toshimi Hitora, Tomochika Tanikawa
  • Patent number: 11421247
    Abstract: Disclosed is a viral vector comprising (a) a cDNA of a recombinant viral RNA having a sequence of a Borna disease viral genome comprising a disrupted G gene of the Borna disease viral genome and an inserted G gene of an avian bornaviral genome, wherein the cDNA of the recombinant viral RNA has at least an N gene, an X gene, a P gene and an L gene of the Borna disease viral genome in the same order as in the Borna disease viral genome and has an inserted foreign gene; (b) DNAs encoding ribozymes; and (c) a promoter sequence, wherein (b) the DNAs encoding ribozymes are located upstream and downstream of (a) the cDNA of the recombinant viral RNA, and (a) the cDNA of the recombinant viral RNA and (b) the DNAs encoding ribozymes are located downstream of (c) the promoter sequence.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: August 23, 2022
    Assignee: Kyoto University
    Inventors: Keizo Tomonaga, Akiko Makino