Abstract: A surface-emitting laser element includes a substrate, a first semiconductor layer, an active layer, a second semiconductor layer, an air-hole layer, and a reflection layer. A light emission surface is provided on a rear surface of the substrate. The air-hole layer has a diffraction surface that is a symmetrical center surface when light standing in the air-hole layer is diffracted with an electric field amplitude symmetrical in a direction orthogonal to the air-hole layer. A separation distance between the diffraction surface and the reflection surface is provided such that a light intensity of combined light of first diffracted light diffracted from the diffraction surface to a side of the light emission surface and second diffracted light diffracted from the diffraction surface to a side of the reflection layer and reflected on the reflection surface is larger than a light intensity of the first diffracted light.

Abstract: A surface-emitting laser element includes a translucent substrate, a back surface of which is light emission surface, an air-hole layer that is a photonic crystal layer, and a light reflection layer including a reflection surface. The air-hole layer has a diffraction surface which has a weakening region where a separation distance between the diffraction surface and the reflection surface is provided such that a light intensity of interference light generated by interference of first diffracted light and second diffracted light is lower than a light intensity of the first diffracted light is provided, and a strengthening region where a separation distance between the diffraction surface and the reflection surface is provided such that the light intensity of the interference light is higher than the light intensity of the first diffracted light is provided.

Abstract: A molded article including a plant material is produced by a production method including: mixing a plant material containing lignocellulose with an organic acid; dissolving the plant material in the organic acid to produce a lignocellulose solution; and removing a liquid component from the lignocellulose solution to produce a solid content. This plant material is an unused portion of an agricultural crop. The molded article including a plant material contains lignocellulose derived from the plant material as a main component. This lignocellulose has a higher-order structure similar to the plant material. A laminate includes the molded article including the plant material and a sheet laminated on the molded article. The peel strength between the molded article and the sheet is 0.005 MPa or higher.

Abstract: Peptides, salts thereof, peptide conjugates, and salts thereof having 5 to 15 amino acids and having an amino acid sequence comprising at least 5 consecutive amino acids from the amino acid sequence LSSTQAQQSX1 (SEQ ID) NO: 34).

Abstract: A brain activity determination device is equipped with a chaos index value calculation unit 201 for calculating a chaos index value, which is an index for determining the chaotic nature in chronologically ordered data; and a determination unit 205, which stores outputs obtained by inputting the RRI data obtained from a subject placed in a first state where the load on the brain is for obtaining reference value data, calculates an index value ratio that is a ratio of the reference value data and the chaos index value to be evaluated by inputting the RRI data obtained from a determination subject whose brain load is in a second state where evaluation target data is obtained to the chaos index value calculation unit 201 after obtaining the chaos index value to be evaluated, which is the data to be evaluated; and determines the brain activity state of the determination subject based on a comparison between the brain activity threshold and the index value ratio to determine the brain activity state.

Abstract: The present invention provides a method for producing, from pluripotent stem cells, neural crest cells specialized for differentiation into a mesenchymal lineage, wherein the method includes: 1) a step for culturing pluripotent stem cells under xeno-free and feeder-free conditions in culture broth containing an ALK inhibitor and a GSK-3? inhibitor to obtain neural crest cells; and 2) a step for culturing the neural crest cells under xeno-free and feeder-free conditions in culture broth that includes an ALK inhibitor, EGF, and FGF and is substantially free of GSK-3? inhibitor.

Abstract: The present disclosure provides siRNA that suppresses proliferation of new coronaviruses (SARS-CoV-2). The siRNA disclosed herein includes: a sense strand; and an antisense strand. The sense strand includes a target sequence comprising 19 to 23 bases in which a base at a 5? terminal is guanine (G) or cytosine (C), and an overhang comprising 2 to 4 bases added to a 3? terminal side of the target sequence. The antisense strand includes a sequence complementary to the target sequence, and an overhang comprising 2 to 4 bases added to a 3? terminal side of the complementary sequence. Here, at least a part of the target sequence contains at least a part of a base sequence encoding a signal peptide region of a spike protein (S protein) of SARS-CoV-2.

Abstract: A substrate has a moth-eye nano pattern on a surface of the substrate in which cone-shaped protrusions are periodically formed, a first semiconductor layer on the moth-eye nano pattern and having a photonic crystal layer, an active layer on the first semiconductor layer and having a light-emitting layer, and a second semiconductor layer on the active layer.

Abstract: A wavelength conversion device includes a wavelength converter having a plate shape and a plurality of antennas. The wavelength converter converts a wavelength of incident light and generates wavelength-converted light and emits the wavelength-converted light. The plurality of antennas are disposed on a light-emitting surface of the wavelength converter. The plurality of antennas form an antenna array in a first region of the light-emitting surface. The respective plurality of antennas are arranged with a predetermined period in the first region. The antenna array is absent in a second region outside the first region. An optical path length from a light-receiving surface of the wavelength converter to the light-emitting surface of the incident light that reaches a light-emitting surface of the first region is longer than an optical path length from the light-receiving surface to the light-emitting surface of the incident light that reaches a light-emitting surface of the second region.

Abstract: A factory is equipped with a manufacturing apparatus (300) installed therein for manufacturing a workpiece whose manufacturing quality changes depending on a temperature inside the factory and a humidity inside the factory.

Abstract: A molded article with improved mechanical strength properties and thermal properties, and a method for producing the molded article. A composite molded article (C) comprising a cellulosic nanomaterial (A) and a thermoplastic resin (B), an area under a stress-strain curve of the composite molded article (C) (AUC1) being at least two times an area under a stress-strain curve of a melt-molded article (D) having the same composition as that of the composite molded article (C) (AUC2), wherein the stress-strain curve is a curve drawn with strain (unit: %) on the horizontal axis and stress (unit: MPa) on the vertical axis and obtained by subjecting the composite molded article (C) or the melt-molded article (D) to a tensile test, and the area is an area up to the horizontal axis from under a curved portion of the curve that is from the origin (stress: 0) of the stress-strain curve to a fracture of the composite molded article (C) or the melt-molded article (D).

Abstract: Provided is a neutron shielding material having good light transparency and excellent shielding performance against thermal neutron rays, and a method for producing the same. A neutron shielding material according to the present invention includes a light transmitting material and a boron compound enriched in a boron isotope having a mass number of 10, the neutron shielding material being formed of a molded product having light transparency. Shielding performance against thermal neutron rays is improved by containing a boron compound enriched in a boron isotope having a mass number of 10. As a result, the neutron shielding material can be widely applied to members requiring visibility and neutron blocking properties.

Abstract: An electrode active material, an electrode, an electrochemical device, a module, and a method, each utilizing a fluoride ion reaction to improve the charge-discharge cycle performance, are provided. The electrode active material includes a carbon material. During discharge, a metal fluoride is generated. During charge, a fluoride ion is desorbed from the metal fluoride and reacts with the carbon material to form a C—F bond.

Abstract: The purpose of the present invention is to provide a screening method that enables efficient discovery of a novel senolytic drug and a senolytic drug obtained by the screening method. The present invention pertains to a senolytic drug that inhibits binding between PGAM and Chk1 and also selectively kills senescent cells. More particularly, the senolytic drug of the present invention contains, as an active ingredient, at least one selected from the group consisting of an mRSK1 kinase inhibitor, an Fak kinase inhibitor, an inhibitor of signaling pathways involving Fak kinase, a CDK inhibitor, a calcium antagonist agent, an inotropic glycoside, a DNA damaging agent, an antimicrobial agent, an Aurora kinase inhibitor, a flavonoid, a PI3K kinase inhibitor, an HDAC inhibitor, a therapeutic agent for age-related macular degeneration, a p38 MAPK inhibitor, an mTOR inhibitor, a tyrosine kinase inhibitor, a Bcl-2 inhibitor, statin, a serotonin receptor antagonist, other kinase inhibitors and Nutlin-3b.

Abstract: A composition containing a lignocellulose derivative contains at least one of the group consisting of a compound containing lignin and a compound containing hemicellulose. The composition may further contain a cellulose derivative in which some or all of hydroxyl groups in cellulose are etherified with an alkyl group having 2 or more carbons. A method for producing the composition includes subjecting a biomass as a raw material containing lignocellulose to an alkali treatment in a solvent; alkylating the lignocellulose by adding an alkylating agent to the alkali-treated biomass as a raw material; and fractionating the alkylated biomass as a raw material. The alkylating agent is an alkyl halide having 2 or more carbons.

Abstract: Provided are white lignin, a white lignin-polysaccharide complex, and methods for producing the same. A method for producing white lignin or a white lignin-polysaccharide complex, including: (a) a step of bringing a plant biomass into contact with an alkaline solution to obtain an alkali-treated material; (b) a step of washing the alkali-treated material with a liquid to obtain a washed material; and (c) a step of bringing a solution containing an organic acid into contact with the washed material.

Abstract: A two-dimensional photonic-crystal surface-emitting laser includes an active layer, a two-dimensional photonic crystal, and electrodes. The two-dimensional photonic crystal contains a plate-shaped base material arranged on one side of the active layer and different refractive index portions arranged at lattice points of a predetermined lattice in the base material and having a refractive index different from that of the base material, a band edge frequency for each position in an electric current supply region, which is at least a part of the two-dimensional photonic crystal, is monotonically increased in one direction parallel to the base material. Such a two-dimensional photonic crystal occurs when the different refractive index portion has a refractive index smaller than that of the base material, a filling factor, which is a ratio of a volume occupied by the different refractive index portion in a unit lattice constituting the lattice, is monotonically increased in the one direction.

Abstract: A motor main body of a switched reluctance motor includes a rotor-having a plurality of rotor salient poles, a stator having a plurality of stator salient poles, a drive winding of each phase wound around stator salient poles of the plurality of stator salient poles, of the phase, and a permanent magnet disposed in a stator yoke. A drive circuit outputs a drive current to the drive winding of each phase to rotate the rotor. A pulse current output circuit outputs a pulse current to be superimposed on the drive current during an application time shorter than an application time of the drive current to the drive winding of each phase.

Abstract: A surface emitting laser element includes a substrate and a hexagonal semiconductor structure layer formed on the substrate which emits a light from an upper surface side or a bottom surface side The semiconductor structure layer includes a first clad layer of a first conductivity type, a first guide layer of the first conductivity type having a photonic crystal layer and a first embedding layer, a second embedding layer, an active layer, second guide layer, and a second clad layer of a second conductivity type. The photonic crystal layer has a plurality of voids disposed having two-dimensional periodicity when viewed from above. The first embedding layer is formed on an upper side of the photonic crystal layer and closes openings of the voids. And an oxygen concentration of the second embedding layer is less than an oxygen concentration of the first embedding layer.

Abstract: Provided is a pharmaceutical composition that can improve tumor immunogenicity. The present disclosure relates to a pharmaceutical composition containing, as an active ingredient, a splicing controlling compound that modulates the activity of serine/arginine-rich splicing factors (SRSFs).