Patents Assigned to Kyoto University
  • Publication number: 20240060051
    Abstract: Provided is a method for producing naive induced pluripotent stem cells from human somatic cells, comprising the following steps (1) to (3): (1) introducing one or more vectors containing a reprogramming factor into human somatic cells, (2) culturing said somatic cells in the presence of a naive medium, and (3) after step (2), culturing the resulting cells in the presence of the naive medium under the condition in which the amount of the vectors per the somatic cell is reduced to 30% or less of that at the start of step 3.
    Type: Application
    Filed: December 24, 2021
    Publication date: February 22, 2024
    Applicants: Kyoto University, ID PHARMA CO., LTD.
    Inventors: Akira Kunitomi, Tsugumine Shu, Jitsutaro Kawaguchi
  • Patent number: 11898163
    Abstract: A cell population comprising Corin- and/or Lrtm1-positive cells was produced by the following steps (1) and (2), from which Corin positive and/or Lrtm1 positive cells are collected using a substance that binds to Corin and/or a substance that binds to Lrtm1, and dopaminergic neuron progenitor cells are produced by performing suspension culture of the Corin positive and/or Lrtm1 positive cells in a culture solution containing one or more nutritional factors: (1) a step of performing adhesion culture of pluripotent stem cells in a medium for maintaining undifferentiated state containing a Sonic hedgehog (SHH) signal stimulant, and an undifferentiated state-maintaining factor in the absence of feeder cells but in the presence of an extracellular matrix, and (2) a step of culturing the cell population obtained in the step (1) in a culture solution containing one or more differentiation-inducing factors.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: February 13, 2024
    Assignees: KYOTO UNIVERSITY, SUMITOMO PHARMA CO., LTD.
    Inventors: Jun Takahashi, Daisuke Doi, Kenji Yoshida, Atsushi Kuwahara, Masayo Takahashi
  • Publication number: 20240043841
    Abstract: Provided is a medicinal composition to be topically administered for tooth regeneration therapy, said composition comprising an RNA molecule targeting USAG-1 or a nucleic acid molecule capable of yielding the RNA molecule and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: February 19, 2021
    Publication date: February 8, 2024
    Applicants: Kyoto University, University of Fukui, Aichi Prefecture
    Inventors: Katsu Takahashi, Kazuhisa Bessho, Yasuhiko Tabata, Manabu Sugai, Yoshihito Tokita
  • Publication number: 20240047944
    Abstract: A photonic-crystal surface emitting laser includes a first semiconductor layer, a photonic crystal layer having a refractive index higher than a refractive index of the first semiconductor layer and provided on the first semiconductor layer, and an active layer provided opposite to the first semiconductor layer with respect to the photonic crystal layer. The photonic crystal layer has a first region and a plurality of second regions each having a refractive index different from a refractive index of the first region and periodically disposed in the first region in a plane of the photonic crystal layer. The second regions extend from the photonic crystal layer to the first semiconductor layer.
    Type: Application
    Filed: October 29, 2021
    Publication date: February 8, 2024
    Applicants: Sumitomo Electric Industries, Ltd., Kyoto University
    Inventors: Naoya KONO, Yuki ITO, Naoki FUJIWARA, Susumu NODA, Takuya INOUE, Menaka De ZOYSA, Kenji ISHIZAKI
  • Publication number: 20240043628
    Abstract: An object of the present invention is to provide a method for isolating from plant biomass at least one member selected from the group consisting of lignin, hemicelluloses, lignin-polysaccharide complexes, cellulose, and hemicellulose-cellulose complexes. The object is achieved by a method for isolating from plant biomass at least one member selected from the group consisting of lignin, hemicelluloses, lignin-polysaccharide complexes, cellulose, and hemicellulose-cellulose complexes, the method comprising step (A) of bringing a solution containing an organic acid and a peracid into contact with plant biomass.
    Type: Application
    Filed: October 29, 2021
    Publication date: February 8, 2024
    Applicant: KYOTO UNIVERSITY
    Inventors: Hiroshi NISHIMURA, Takashi WATANABE, Misato YAMADA
  • Publication number: 20240044722
    Abstract: The present invention provides a temperature-sensitive probe containing a group 14 element-doped nanodiamond having an average particle size of 1 to 100 nm and including SiV centers.
    Type: Application
    Filed: December 23, 2021
    Publication date: February 8, 2024
    Applicants: DAICEL CORPORATION, Kyoto University
    Inventors: Masahiro NISHIKAWA, Ming LIU, Norikazu MIZUOCHI, Izuru OHKI, Masanori FUJIWARA
  • Publication number: 20240033332
    Abstract: Developing an agent for activating a neuron which activates a brain neuron. The agent is suitable for promoting cell transplantation for a neural disease, survival of a transplanted cell, differentiation of the transplanted cell into a neuronal cell, and/or maturation of the neuron.
    Type: Application
    Filed: December 16, 2021
    Publication date: February 1, 2024
    Applicant: KYOTO UNIVERSITY
    Inventors: Jun TAKAHASHI, Bumpei SAMATA
  • Publication number: 20240026017
    Abstract: A monoclonal antibody is provided which binds to a human CC chemokine receptor 1 (CCR1) and inhibits activation of the human CCR1, or an antibody fragment thereof. The monoclonal antibody binds to an extracellular region of a human CCR1 and inhibits activation of the human CCR1 by a human CC chemokine ligand 15 (CCL15). An antibody fragment thereof, a hybridoma producing the antibody, a nucleic acid having a nucleotide sequence encoding the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment using the hybridoma or the transformant cell; a therapeutic agent and a diagnostic agent containing the antibody or the antibody fragment, and a method for treating and diagnosing a CCR1-related disease using the antibody or the antibody fragment are also provided.
    Type: Application
    Filed: September 1, 2023
    Publication date: January 25, 2024
    Applicants: Kyowa Kirin Co., Ltd., Kyoto University
    Inventors: Masayuki Kai, Shinya Ogawa, Makoto Taketo, Kenji Kawada, Hideyo Hirai, Yoshiharu Sakai, Taira Maekawa
  • Publication number: 20240019372
    Abstract: The present invention relates to an improved technology for a device that identifies and diagnoses an environmental stress state of plants. An environmental stress diagnosis device comprises a measurement light source 12, an induction light source 14, and a transmitted light detector 18. The measurement light source 12 radiates a first measurement light ML1 and a second measurement light ML2 to a plant sample S, the induction light source 14 radiates a first photosynthesis inducing light FR and a second photosynthesis inducing light AL to the plant sample S, and the transmitted light detector 18 detects a first transmitted light TL1 and a second transmitted light TL2. The control unit 20 has an analysis circuit 20a and a control circuit 20b.
    Type: Application
    Filed: November 12, 2021
    Publication date: January 18, 2024
    Applicants: KYOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, BUNKOUKEIKI CO., LTD.
    Inventors: Kentaro IFUKU, Yufen CHE, Shoko TSUJI, Chikahiro MIYAKE, Takayuki SOHTOME
  • Patent number: 11874348
    Abstract: Provided is a brain measurement system including: a geomagnetic correction coil; a geomagnetic gradient correction coil; a transmission coil; a receiving coil; a plurality of resonance adjustment circuits; a plurality of OPM modules provided corresponding to each of the plurality of resonance adjustment circuits for detecting a signal having a resonance frequency output from the resonance adjustment circuit; and a control device for generating an MR image based on the signal detected by the OPM module, wherein, when a direction parallel to a central axis of a head portion of a subject is defined as a Z-axis direction, the resonance frequency related to each of the plurality of resonance adjustment circuits is set according to a magnetic field gradient in the Z-axis direction generated by control of a position of the corresponding receiving coil in the Z-axis direction and a tilted magnetic field.
    Type: Grant
    Filed: August 19, 2022
    Date of Patent: January 16, 2024
    Assignees: HAMAMATSU PHOTONICS K.K., Kyoto University
    Inventors: Takenori Oida, Takahiro Moriya, Akinori Saito, Motohiro Suyama, Tetsuo Kobayashi
  • Patent number: 11863164
    Abstract: The quantum circuit learning device includes a signal input unit that provides a quantum circuit including plural quantum bits with an input signal, a signal acquisition unit that observes states of quantum bits that the quantum circuit includes and acquires an output signal based on the observed states, and an adjustment unit that adjusts a circuit parameter that defines a circuit configuration of the quantum circuit, using an output signal that the signal acquisition unit acquires and a cost function that is set based on a teacher signal corresponding to the output signal.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: January 2, 2024
    Assignees: KYOTO UNIVERSITY, OSAKA UNIVERSITY
    Inventors: Keisuke Fujii, Makoto Negoro, Kosuke Mitarai, Masahiro Kitagawa
  • Patent number: 11859209
    Abstract: The present invention provides a method for inducing osteogenic differentiation, the method comprising the following steps of: (1) culturing pluripotent stem cells under feeder-free conditions, (2) culturing the cells in a mixed culture medium of an osteogenic induction medium and a pluripotent stem cell medium, the mixed culture medium containing a ROCK inhibitor and a retinoic acid receptor ? or ? agonist, and (3) culturing the cells in an osteogenic induction medium containing the retinoic acid receptor ? or ? agonist. The method for inducing osteogenic differentiation according to the present invention is a simple, short-term, highly efficient and highly reproducible one-procedure method for inducing osteogenic differentiation, wherein the method is suitable for bone regeneration therapies, the development of bone metabolic drugs and the development of novel therapies for bone diseases.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: January 2, 2024
    Assignee: KYOTO UNIVERSITY
    Inventors: Junya Toguchida, Shunsuke Kawai, Hiroyuki Yoshitomi, Cantas Alev
  • Publication number: 20230421083
    Abstract: A superconducting rotating machine, including: a stator that has a tubular stator iron core and stator windings wound around the stator iron core and generates a rotating magnetic field; a superconducting rotor having: a superconducting squirrel-cage winding that is held rotatably with the rotating magnetic field of the stator on an inner peripheral side and has one or more rotor bars and end rings each made of a superconducting material; and a rotor iron core that has a plurality of slots to accommodate the rotor bars; a pulse voltage output unit that outputs a pulse voltage to shift the superconducting squirrel-cage winding to a magnetic flux flow state; a drive voltage output unit that applies a drive voltage to the stator windings to rotationally drive the superconducting rotor, wherein the pulse voltage output from the pulse voltage output unit is superimposed on the drive voltage.
    Type: Application
    Filed: November 22, 2021
    Publication date: December 28, 2023
    Applicant: KYOTO UNIVERSITY
    Inventors: Taketsune NAKAMURA, Alexandre COLLE, Kenjiro MATSUKI
  • Publication number: 20230402881
    Abstract: A power transmission apparatus according to an aspect of the present disclosure includes a control unit that controls a power transmitting unit that performs wireless power transmission. The control unit causes the power transmitting unit to radiate a power transmission beam for supplying electrical power to a target power reception apparatus in accordance with a control parameter related to a radiation direction and a beam shape of the beam. The control unit refers to a position of an edge in an image obtained by photographing a periphery of the target power reception apparatus and monitoring entry of a biological body or an object with respect to a no-entry region that is created in a periphery of a path of the beam. The control unit stops radiation of the beam when entry of a biological body or an object with respect to the no-entry region is detected.
    Type: Application
    Filed: August 21, 2023
    Publication date: December 14, 2023
    Applicant: Kyoto University Katsura Venture Plaza
    Inventors: Nobuyuki Takabayashi, Minoru Furukawa
  • Publication number: 20230395221
    Abstract: A health improvement path search device including: a first model generating unit configured to generate a first model predicting a value of a health index; a second model generating unit configured to generate a second model deriving a presence probability; and a path searching unit configured to derive the value of the health index and the presence probability corresponding to each measurement target value specify a plurality of paths transitioning to each of the measurement target values from the current values as start points, specify paths in which the value of the health index at an end point is improved from the current value of the health index among the plurality of paths as candidate paths, and specify a path for which a product of the presence probabilities of the measurement target values included in the candidate path is a maximum as a health improvement path.
    Type: Application
    Filed: October 22, 2021
    Publication date: December 7, 2023
    Applicants: KYOWA HAKKO BIO CO., LTD., Kyoto University, HIROSAKI UNIVERSITY
    Inventors: Kazuki NAKAMURA, Yasushi OKUNO, Ryosuke KOJIMA, Eiichiro UCHINO, Koichi MURASHITA, Ken ITOH, Shigeyuki NAKAJI
  • Patent number: 11837850
    Abstract: A method for manufacturing a GaN-based surface-emitting laser by an MOVPE includes: (a) growing a first cladding layer with a {0001} growth plane; (b) growing a guide layer on the first cladding layer; (c) forming holes in a surface of the guide layer by etching, the holes being two-dimensionally periodically arranged within a plane parallel to the guide layer; (d) etching the guide layer by using an etchant having selectivity to the {0001} plane and a {10?10} plane of the guide layer; (e) supplying a gas containing a nitrogen source to cause mass transport without supplying a group-III material gas, and then supplying the group-III material gas for growth, whereby a first embedding layer closing openings of the holes is formed to form a photonic crystal layer; and (f) growing an active layer and a second cladding layer in this order on the first embedding layer.
    Type: Grant
    Filed: December 16, 2020
    Date of Patent: December 5, 2023
    Assignees: KYOTO UNIVERSITY, STANLEY ELECTRIC CO., LTD.
    Inventors: Susumu Noda, Tomoaki Koizumi, Kei Emoto
  • Patent number: 11835603
    Abstract: An optically pumped magnetometer includes cells configured to form a first cell region and a second cell region on a measurement target, a pump laser, a probe laser, a first optical system configured to cause pump light to be incident on the first cell region, a second optical system configured to cause the pump light having passed through the first cell region to be incident on the second cell region, a third optical system configured to cause first probe light to be incident on the first cell region, a fourth optical system configured to cause second probe light to be incident on the second cell region, detection portions configured to detect the first probe light having passed through the first cell region and the second probe light having passed through the second cell region, and a deriving portion configured to derive an intensity of a magnetic field.
    Type: Grant
    Filed: June 1, 2022
    Date of Patent: December 5, 2023
    Assignees: HAMAMATSU PHOTONICS K.K., Kyoto University
    Inventors: Akinori Saito, Takahiro Moriya, Takenori Oida, Motohiro Suyama, Tetsuo Kobayashi
  • Publication number: 20230387659
    Abstract: A method of manufacturing a surface-emitting laser, includes (a) forming a first semiconductor layer including a photonic-crystal (PC) layer, (b) growing, on the first semiconductor layer, an active layer and a second semiconductor layer, (c) performing spectrometry in which a thickness from a surface of the second semiconductor layer to a position where the spectrometry light is reflected by the PC layer is measured, (d) forming a translucent electrode having a thickness calculated based on an optical path length corresponding to the thickness obtained by the spectrometry on the second semiconductor layer, and (e) forming a reflection layer on the translucent electrode, in which the layer thickness of the translucent electrode is determined such that a light intensity of interference light of (i) direct diffracted light radiated from the PC layer and (ii) reflected diffracted light radiated from the PC layer and reflected by the reflection layer is larger than a light intensity of the direct diffracted light
    Type: Application
    Filed: May 12, 2023
    Publication date: November 30, 2023
    Applicants: KYOTO UNIVERSITY, STANLEY ELECTRIC CO., LTD.
    Inventors: Susumu NODA, Kei EMOTO, Tomoaki KOIZUMI, Hiroshi KOTANI
  • Publication number: 20230372309
    Abstract: Provided in one aspect is a pharmaceutical composition for analgesia. The present disclosure relates to a pharmaceutical composition for analgesia that contains an a2 adrenergic receptor antagonist as an active ingredient. In one or more embodiments, the pharmaceutical composition according to the present disclosure is a composition for analgesia through inhibition of an a2 adrenergic receptor, or a composition for analgesia through inhibition of an a2B adrenergic receptor.
    Type: Application
    Filed: September 22, 2021
    Publication date: November 23, 2023
    Applicant: Kyoto University
    Inventors: Masatoshi Hagiwara, Masayasu Toyomoto
  • Patent number: 11824241
    Abstract: A proton conductor is in contact with a catalyst containing platinum. The proton conductor includes a cationic organic molecule, a metal ion, and an oxoacid anion. A protic ionic liquid containing the cationic organic molecule and the oxoacid anion is coordinated to the metal ion to form a coordination polymer.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: November 21, 2023
    Assignees: DENSO CORPORATION, Kyoto University, KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Kazuki Takahashi, Nobuyoshi Sakakibara, Kenichiro Kami, Satoshi Horike, Tomofumi Tada