Patents Assigned to Kyoto University
  • Method for producing CD4/CD8 double-positive T cells
    Patent number: 11578310
    Abstract: A method for producing CD4/CD8 double-positive T cells, comprising the steps of: (1) culturing pluripotent stem cells in a medium to induce hematopoietic progenitor cells; and (2) culturing the hematopoietic progenitor cells obtained in the step (1) in a medium containing a p38 inhibitor and/or SDF-1 to induce CD4/CD8 double-positive T cells.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: February 14, 2023
    Assignee: KYOTO UNIVERSITY
    Inventors: Shin Kaneko, Yutaka Yasui, Shoichi Iriguchi, Tatsuki Ueda
  • Compound, and method for producing regulatory T cells
    Patent number: 11578067
    Abstract: Provided are a novel compound having CDK8 and/or CDK19 inhibitory activity, and a production method for Tregs. The treatment of T cells with a CDK8 and/or CDK19 inhibitor induces Foxp3 in the T cells. Foxp3+ T cells can be induced by treating Foxp3? T cells with the CDK8 and/or CDK19 inhibitor in vitro. Thus, Tregs can be induced.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: February 14, 2023
    Assignees: KYOTO UNIVERSITY, ASTELLAS PHARMA INC.
    Inventors: Shimon Sakaguchi, Naganari Ohkura, Norihisa Mikami, Shuh Narumiya, Masahiko Akamatsu, Guliang Xia, Hironori Harada, Naoto Nakamura, Satoru Ujihara, Hisao Hamaguchi
  • Freeze-Dried Preparations Comprising Megakaryocytes and Platelets
    Publication number: 20230030814
    Abstract: The problem that differences among lots in components and amounts of growth factors and the like in platelet-rich plasmas derived from an autologous plasma and the freeze-dried preparations thereof are large, and the effects of the lots are not kept constant is solved. Specifically, a freeze-dried preparation comprising megakaryocytes and platelets induced to differentiate from stem cells, a pharmaceutical composition comprising the freeze-dried preparation, and the like are provided.
    Type: Application
    Filed: December 11, 2020
    Publication date: February 2, 2023
    Applicants: National University Corporation Chiba University, Kyoto University
    Inventors: Seiji Ohtori, Yasuhiro Shiga, Kentaro Kosaka, Koji Eto
  • Diagnostic agent and medicine comprising ADAMTS13 as main ingredient
    Patent number: 11567080
    Abstract: New use of ADAMTS13 in the clinical filed is provided. The use of ADAMTS13 as a biomarker for monitoring the onset of liver damage, hepatic ischemia/reperfusion injury or the liver function after liver transplantation: a method of testing liver damage, a method of testing hepatic ischemia/reperfusion injury, or a method of testing the liver function after liver transplantation, each of the methods comprising measuring or monitoring the ADAMTS13 activity in a sample from a mammal; an agent for treating diseases selected from the group consisting of liver damage, hepatic ischemia/reperfusion injury and hepatic dysfunction after liver transplantation, which comprises ADAMTS13 or a mutant of ADAMTS13 as an effective ingredient.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: January 31, 2023
    Assignees: KYOTO UNIVERSITY, KM BIOLOGICS CO., LTD.
    Inventors: Koichiro Hata, Shinji Uemoto, Hirofumi Hirao, Toyonari Kubota
  • Method for producing helper T cells from pluripotent stem cells
    Patent number: 11559548
    Abstract: A method of producing helper T cells, comprising: (i) culturing T cells, which have been induced from pluripotent stem cells and into which a CD4 gene or a gene product thereof has been introduced, in a medium containing IL-2 and IL-15; and (ii) isolating CD40L-highly expressing T cells from cells obtained in step (i).
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: January 24, 2023
    Assignee: KYOTO UNIVERSITY
    Inventors: Shin Kaneko, Norihiro Ueda, Yasushi Uemura, Kyoko Fukuda
  • INFORMATION PROCESSING DEVICE AND MACHINE LEARNING METHOD
    Publication number: 20230013870
    Abstract: Accuracy of a model extracting a graph structure as an intermediate representation from input data is improved. An encoding unit (100) extracts a feature amount of each of a plurality of vertices included in a graph structure (Tr) from input data (10), and calculates a likelihood that an edge is connected to the vertex. A sampling unit (130) determines the graph structure (Tr) based on a conversion result of a Gumbel-Softmax function for the likelihood. A learning unit (150) optimizes a decoding unit (140) and the encoding unit (100) by back propagation using a loss function including an error (LP) between output data (20) generated from the graph structure (Tr) and correct data.
    Type: Application
    Filed: February 19, 2021
    Publication date: January 19, 2023
    Applicants: OMRON CORPORATION, KYOTO UNIVERSITY
    Inventors: Atsushi HASHIMOTO, Yoshitaka USHIKU, Shinsuke MORI, Taichi NISHIMURA
  • Metal oxide film formation method
    Patent number: 11555245
    Abstract: In a metal oxide film formation method of the present invention, the following steps are performed. In a solution vessel, a raw-material solution including aluminum as a metallic element is turned into a mist so that a raw-material solution mist is obtained. In a solution vessel provided independently of the solution vessel, a reaction aiding solution including a reaction aiding agent for formation of aluminum oxide is turned into a mist so that an aiding-agent mist is obtained. Then, the raw-material solution mist and the aiding-agent mist are fed to a nozzle provided in a reactor vessel via paths. Thereafter, the raw-material solution mist and the aiding-agent mist are mixed in the nozzle so that a mixed mist is obtained. Then, the mixed mist is fed onto a back surface of a heated P-type silicon substrate.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: January 17, 2023
    Assignees: Toshiba Mitsubishi-Electric Industrial Systems Corporation, Kyoto University, Kochi Prefectural Public University Corporation
    Inventors: Takahiro Hiramatsu, Hiroyuki Orita, Toshiyuki Kawaharamura, Shizuo Fujita, Takayuki Uchida
  • Agent for preventing and/or treating alzheimer's disease
    Patent number: 11554116
    Abstract: The present invention provides a prophylactic and/or therapeutic agent for Alzheimer's disease containing a compound represented by the formula (I) or the formula (II) or a salt thereof.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: January 17, 2023
    Assignee: KYOTO UNIVERSITY
    Inventors: Haruhisa Inoue, Takayuki Kondo
  • PEPTIDE
    Publication number: 20230011813
    Abstract: This invention provides a peptide consisting of (i) the amino acid sequence LSSTQAQQSY (SEQ ID NO: 1), (ii) the amino acid sequence LSSTQAQQSW (SEQ ID NO: 6), or (iii) the amino acid sequence LSSTQAQQSF (SEQ ID NO: 7).
    Type: Application
    Filed: April 12, 2022
    Publication date: January 12, 2023
    Applicants: Kyoto University, Kazusa DNA Research Institute
    Inventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
  • Benzisoxazole compound
    Patent number: 11548882
    Abstract: The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom; of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: January 10, 2023
    Assignees: Osaka University, Kyoto University, Inter-University Research Institute Corporation National Institutes of Natural Sciences
    Inventors: Ryu Nagata, Yasuo Mori, Masayuki Mori, Motohiro Nishida, Takuro Tomita
  • Composition for suppressing inflammation
    Patent number: 11549111
    Abstract: The disclosure provides a composition for suppressing inflammation comprising at least one substance that disrupts a stem-loop structure in the 3? untranslated region of a Regnase-1 mRNA, wherein the stem-loop structure is at least one stem-loop structure selected from a first stem-loop structure formed in a region corresponding to positions 231 to 245 of SEQ ID NO: 1 and a second stem-loop structure formed in a region corresponding to positions 424 to 442 of SEQ ID NO: 1.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: January 10, 2023
    Assignee: Kyoto University
    Inventor: Osamu Takeuchi
  • T-CELL MASTER CELL BANK
    Publication number: 20230000915
    Abstract: The present invention provides a system for providing a T cell product, including a T cell master cell bank and/or a T cell working cell bank.
    Type: Application
    Filed: November 24, 2020
    Publication date: January 5, 2023
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Shin KANEKO, Suguru ARIMA, Maiko TAKIGUCHI, Yoshiaki KASSAI, Akira HAYASHI
  • Proton conductor, proton-conducting cell structure, water vapor electrolysis cell, and method for producing hydrogen electrode-solid electrolyte layer complex
    Patent number: 11545690
    Abstract: A proton conductor contains a metal oxide that has a perovskite structure and that is represented by formula (1): AxB1-yMyO3-?, where an element A is at least one element selected from the group consisting of Ba, Ca, and Sr, an element B is at least one element selected from the group consisting of Ce and Zr, an element M is at least one element selected from the group consisting of Y, Yb, Er, Ho, Tm, Gd, In, and Sc, ? indicates an oxygen deficiency amount, and 0.95?x?1 and 0<y?0.5 are satisfied.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: January 3, 2023
    Assignees: KYOTO UNIVERSITY, SUMITOMO ELECTRIC INDUSTRIES, LTD.
    Inventors: Takahiro Higashino, Yohei Noda, Chihiro Hiraiwa, Naho Mizuhara, Mitsuyasu Ogawa, Hiromasa Tawarayama, Masatoshi Majima, Tetsuya Uda, Donglin Han, Takayuki Onishi
  • METHOD FOR PRODUCING T CELLS
    Publication number: 20220411752
    Abstract: Provided is an excellent method for producing an IL-4 non-secreting and IFN-? secreting (Th1-type) or IFN-? non-secreting and IL-4 secreting (Th2-type) CD4 single-positive T cell (CD4SP T cell). The method for producing the Th1-type or Th2-type CD4SP T cell of the present invention comprises a step of inducing a CD4 single-positive T cell from a hematopoietic stem cell (HSC) and/or a hematopoietic progenitor cell (HPC) substantially defective in a factor involved in IL-4 secretion or a factor involved in IFN-? secretion.
    Type: Application
    Filed: October 30, 2020
    Publication date: December 29, 2022
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Shin KANEKO, Hisashi YANO, Tokuyuki SHINOHARA
  • BRONCHIAL EMBOLIZATION MATERIAL
    Publication number: 20220409779
    Abstract: A material for endobronchial occlusion capable of repairing or replacing tissue is disclosed. The material contains a protein (A), wherein the protein (A) contains at least one of a polypeptide chain (Y) or a polypeptide chain (Y?), a total number of the polypeptide chain (Y) and the polypeptide chain (Y?) in the protein (A) is 1 to 100, the polypeptide chain (Y) is a polypeptide chain consisting of 2 to 200 tandem repeats of at least one amino acid sequence (X) among an amino acid sequence VPGVG, an amino acid sequence GVGVP 4, GPP, GAP, and an amino acid sequence GAHGPAGPK, the polypeptide chain (Y?) is a polypeptide chain in which each of a total of 5% or less of amino acids in the polypeptide chain (Y) is replaced by at least one of a lysine residue or an arginine residue, with a total number of the lysine and arginine residues being 1 to 100.
    Type: Application
    Filed: November 27, 2020
    Publication date: December 29, 2022
    Applicants: Kyoto University, SANYO CHEMICAL INDUSTRIES, LTD.
    Inventors: Toshihiko SATO, Yuichiro UEDA, Shingo KAWABATA, Satoshi SOMAMOTO
  • Surface emitting laser element and manufacturing method of the same
    Patent number: 11539187
    Abstract: A surface emission laser formed of a group III nitride semiconductor includes a first conductivity type first clad layer; a first conductivity type first guide layer on the first clad layer; a light-emitting layer on the first guide layer; a second guide layer on the light-emitting layer; and a second conductivity type second clad layer on the second guide layer. The first or second guide layer internally includes voids periodically arranged at square lattice positions with two axes perpendicular to one another as arrangement directions in a surface parallel to the guide layer. The voids have a polygonal prism structure or an oval columnar structure with a long axis and a short axis perpendicular to the long axis in the parallel surface, and the long axis is inclined with respect to one axis among the arrangement directions of the voids.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: December 27, 2022
    Assignees: KYOTO UNIVERSITY, STANLEY ELECTRIC CO., LTD.
    Inventors: Susumu Noda, Yoshinori Tanaka, Menaka De Zoysa, Tomoaki Koizumi, Kei Emoto
  • Co-culture device for anaerobic bacterium and epithelial cells
    Patent number: 11535821
    Abstract: A culture system for co-culturing a first cell group consisting of one or more kinds of cells and a cell layer or tissue formed of a second cell group consisting of one or more kinds of cells different from the former cells comprising: a first culture tank for co-culturing under anaerobic conditions the first cell group consisting of one or more kinds of cells and the cell layer or tissue formed of the second cell group consisting of one or more kinds of cells; a second culture tank for pooling a liquid culture medium of aerobic conditions; one or more substance-exchange structures that are disposed so as to connect the first culture tank to the second culture tank; and the aforesaid cell layer or tissue that is disposed so as to cover the surface on the first culture tank side of the substance-exchange structure(s).
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: December 27, 2022
    Assignee: Kyoto University
    Inventors: Takane Katayama, Taiho Kambe
  • Actuator-equipped knee ankle foot orthosis
    Patent number: 11534359
    Abstract: The present invention provides an actuator-equipped knee ankle foot orthosis in which a control device calculates a thigh phase angle based on an angle-related signal detected by a thigh orientation detecting means at one sampling point, applies the thigh phase angle at that sampling point to an assisting force control data, which is stored in the control device in advance and indicates the relationship between the thigh phase angle and a size of the assisting force to be imparted to a lower leg-side brace, to obtain the size of the assisting force to be imparted to the lower leg-side brace at that sampling point, and executes operational control for an actuator unit such that the assisting force having the size is output.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: December 27, 2022
    Assignees: Suncall Corporation, National University Corporation Kyoto Institute of Technology, Kyoto University
    Inventors: Rei Takahashi, Yuichi Sawada, Yoshiyuki Higashi, Tadao Tsuboyama, Noriaki Ichihashi, Koji Ohata, Toshikazu Kawaguchi
  • Combination Therapy Based on PD-1 Signaling Inhibitors
    Publication number: 20220401385
    Abstract: The present invention provides a novel therapeutic strategy for anti-PD-1 antibody therapy. The present invention relates to a pharmaceutical composition which increases the function of oxidative phosphorylation in T cells; and a pharmaceutical composition which has an action for increasing the function of oxidative phosphorylation in T cells and is administered before, after or simultaneously with the administration of a PD-1 signaling inhibitor.
    Type: Application
    Filed: November 4, 2020
    Publication date: December 22, 2022
    Applicant: Kyoto University
    Inventors: Tasuku Honjo, Kenji Chamoto, Sidonia Fagarasan
  • Pharmaceutical Composition for Protecting Cartilage
    Publication number: 20220401461
    Abstract: The inventors have found that compounds of formula (I) have an effect to protect cartilage. Accordingly the disclosure provides a pharmaceutical composition for protecting cartilage comprising a compound of formula (I) or an ester, oxide, pharmaceutically acceptable salt, or solvate thereof. The pharmaceutical composition can be used for treating and/or preventing a disease associated with cartilage degeneration such as osteoarthritis.
    Type: Application
    Filed: October 23, 2020
    Publication date: December 22, 2022
    Applicants: Kyoto University, Kyoto Drug Discovery & Development Co., Ltd.
    Inventors: Kohei Nishitani, Akira Kakizuka, Hanako Ikeda, Shuichi Matsuda, Sachiko Iwai, Motoo Saito, Kunihiro Musashi