Patents Assigned to Kyoto University
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Patent number: 11529281Abstract: A gait motion assisting apparatus of the present invention includes an actuator unit controlling driver so that assisting force calculated by applying gait motion timing based on detected thigh phase angle to output pattern saved data is imparted to lower leg, and a terminal device capable of wireless-communicating with control device of the actuator unit. The terminal device can receive assisting force setting value including assisting force imparting period during gait cycle and create, based on the assisting force setting value, output pattern setting data indicating a relationship between the gait motion timing and a size of assisting force to be imparted to the lower leg. The control device is configured to overwrite-save the output pattern setting data received from the terminal device as the output pattern saved data.Type: GrantFiled: November 5, 2018Date of Patent: December 20, 2022Assignees: Suncall Corporation, Kyoto University, National University Corporation Kyoto institute of TechnologyInventors: Rei Takahashi, Yukinobu Makihara, Tadao Tsuboyama, Koji Ohata, Yuichi Sawada, Yoshiyuki Higashi
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Publication number: 20220395585Abstract: Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.Type: ApplicationFiled: May 3, 2022Publication date: December 15, 2022Applicants: Massachusetts Institute of Technology, Kyoto UniversityInventors: Ron Weiss, Liliana Wroblewska, Velia Siciliano, Tasuku Kitada, Maria Hottelet Foley, Katie Bodner, Hirohide Saito, Kei Endo, Darrell J. Irvine, Tyler Wagner, Jacob Becraft
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Publication number: 20220386888Abstract: A brain measurement apparatus includes: a static magnetic field forming unit for forming a static magnetic field in a measurement area; a gradient magnetic field coil for forming a gradient magnetic field in the measurement area; a transmission coil for transmitting a transmission pulse toward a subject in the measurement area; a detection coil for detecting a nuclear magnetic resonance signal generated in the subject by transmission of the transmission pulse; and a generator for generating an MR image based on the nuclear magnetic resonance signal detected by the detection coil.Type: ApplicationFiled: June 1, 2022Publication date: December 8, 2022Applicants: HAMAMATSU PHOTONICS K.K., Kyoto UniversityInventors: Takahiro MORIYA, Takenori OIDA, Akinori SAITO, Motohiro SUYAMA, Tetsuo KOBAYASHI
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Publication number: 20220390533Abstract: An optically pumped magnetometer includes cells configured to form a first cell region and a second cell region on a measurement target, a pump laser, a probe laser, a first optical system configured to cause pump light to be incident on the first cell region, a second optical system configured to cause the pump light having passed through the first cell region to be incident on the second cell region, a third optical system configured to cause first probe light to be incident on the first cell region, a fourth optical system configured to cause second probe light to be incident on the second cell region, detection portions configured to detect the first probe light having passed through the first cell region and the second probe light having passed through the second cell region, and a deriving portion configured to derive an intensity of a magnetic field.Type: ApplicationFiled: June 1, 2022Publication date: December 8, 2022Applicants: HAMAMATSU PHOTONICS K.K., Kyoto UniversityInventors: Akinori SAITO, Takahiro MORIYA, Takenori OIDA, Motohiro SUYAMA, Tetsuo KOBAYASHI
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Publication number: 20220386873Abstract: A brain measurement apparatus configured to generate an MR image and a brain's magnetic field distribution of a subject includes: an MRI module having a transmission coil configured to transmit a transmission pulse toward the subject and a detection coil configured to detect a nuclear magnetic resonance signal generated in the subject by the transmission pulse; an optically pumped magnetometer configured to detect a brain's magnetic field of the subject; a generator configured to generate the MR image based on the nuclear magnetic resonance signal detected by the detection coil and generating the brain's magnetic field distribution based on the brain's magnetic field detected by the optically pumped magnetometer; a marker displayed on the MR image generated by the generator; and a helmet-type frame to which the detection coil, the optically pumped magnetometer, and the marker are attached and which is attached to a head of the subject.Type: ApplicationFiled: June 1, 2022Publication date: December 8, 2022Applicants: HAMAMATSU PHOTONICS K.K., Kyoto UniversityInventors: Takenori OIDA, Takahiro MORIYA, Akinori SAITO, Motohiro SUYAMA, Tetsuo KOBAYASHI
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Patent number: 11518855Abstract: A low-density gel product of the present disclosure has a skeleton containing a polysiloxane chain and an organic polymer chain. In the skeleton, the polysiloxane chain and the organic polymer chain are bonded to each other by covalent bonds at a plurality of positions on both of the chains with silicon atoms of the polysiloxane chain as bonding points. The organic polymer chain may be an aliphatic hydrocarbon chain. The polysiloxane chain may be a polyorganosiloxane chain. The low-density gel product of the present disclosure is a novel low-density gel product with improved mechanical properties including bending flexibility.Type: GrantFiled: August 23, 2018Date of Patent: December 6, 2022Assignee: KYOTO UNIVERSITYInventors: Kazuki Nakanishi, Kazuyoshi Kanamori, Guoqing Zu
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Patent number: 11511262Abstract: This invention provides an anisotropic nanostructure represented by the formula: RuxM1-x, wherein 0.6?x?0.999, and M represents at least one member selected from the group consisting of Ir, Rh, Pt, Pd, and Au, and wherein Ru and M form a solid solution at the atomic level, and the anisotropic nanostructure has an anisotropic hexagonal close-packed structure (hcp).Type: GrantFiled: December 26, 2018Date of Patent: November 29, 2022Assignee: KYOTO UNIVERSITYInventors: Hiroshi Kitagawa, Dongshuang Wu, Kohei Kusada
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Patent number: 11505785Abstract: Provided is a cell culture method comprising the step of culturing cells using a medium containing a laminin fragment having integrin binding activity, the method not comprising the step of coating a culture vessel with a laminin or a laminin fragment before seeding the cells in the culture vessel. The cell culture method of the present invention uses a smaller amount of a laminin fragment and still achieves a comparable culture efficiency as compared with the conventional cell culture method that uses a culture vessel precoated with a laminin or a laminin fragment.Type: GrantFiled: November 8, 2016Date of Patent: November 22, 2022Assignee: Kyoto UniversityInventors: Hirofumi Suemori, Takamichi Miyazaki
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Publication number: 20220366221Abstract: An inference system includes: a learning unit that generates an inference model using a first dataset including a plurality of sample data whose ground truth is given and a second dataset including a plurality of sample data whose ground truth is not given; and an inference unit that determines an inference result. The inference model includes an encoder that calculates from sample data a first feature value independent of the first and second datasets and a second feature value dependent on the first or second dataset. The learning unit trains the encoder such that the same first feature value is calculated from any of first and second sample data for a pair of the first sample data among the first dataset and the second sample data which is among the second dataset and whose ground truth is to be identical to the ground truth of the first sample data.Type: ApplicationFiled: November 9, 2020Publication date: November 17, 2022Applicants: OMRON CORPORATION, KYOTO UNIVERSITYInventors: Atsushi HASHIMOTO, Masaaki IIYAMA, Ryuhei TAKAHASHI, Motoharu SONOGASHIRA
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Patent number: 11500043Abstract: A magnetoencephalograph M1 includes: multiple pump-probe type optically pumped magnetometers 1A; a bias magnetic field forming coil 15 for applying a bias magnetic field in the same direction as a direction of pump light of each of the multiple pump-probe type optically pumped magnetometers 1A and in a direction approximately parallel to a scalp; a control device 5 that determines a current for the bias magnetic field forming coil and outputs a control signal corresponding to the determined current; and a coil power supply 6 that outputs a current to the bias magnetic field forming coil in response to the control signal output from the control device.Type: GrantFiled: June 14, 2021Date of Patent: November 15, 2022Assignees: HAMAMATSU PHOTONICS K.K., Kyoto UniversityInventors: Akinori Saito, Takahiro Moriya, Takenori Oida, Motohiro Suyama, Tetsuo Kobayashi
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Patent number: 11491117Abstract: The disclosure pertains to a compound of formula (I), one of its pharmaceutically acceptable salts, or a composition comprising thereof, for use in the prevention or treatment of glucose intolerance related conditions, insulin deficit related conditions, nonalcoholic fatty liver disease and/or obesity.Type: GrantFiled: October 4, 2018Date of Patent: November 8, 2022Assignees: SORBONNE UNIVERSITÉ, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS, KYOTO UNIVERSITYInventors: Dominique Gauguier, Fumihiko Matsuda, François Brial
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Publication number: 20220348966Abstract: A method for producing metabolites that are heavy alcohols, and particularly branched-chain alcohols is provided, involving contacting a suitable substrate with recombinant microorganisms. The microorganisms contain at least one deletion, disruptions, or mutations from the GLN gene family, VPS gene family, GNP gene family, AVT gene family, GCN gene family, or YDR391C, and combinations thereof, and overproduce the heavy alcohol as compared to a wild-type yeast strain.Type: ApplicationFiled: September 25, 2020Publication date: November 3, 2022Applicants: The Trustees of Princeton University, Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Kyoto UniversityInventors: José L. AVALOS, Sarah K. HAMMER, Kouichi KURODA, Gerald R. FINK, Gregory STEPHANOPOULOS
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Publication number: 20220348737Abstract: The present invention provides: nanoparticles including a compound that includes porous silica and at least one high-atom selected from the group consisting of gadolinium atoms, iodine atoms, gold atoms, silver atoms, and platinum atoms; and a pharmaceutical composition for radiation treatment, useful for treatment of solid tumors, etc., and including these nanoparticles and a pharmaceutically acceptable carrier.Type: ApplicationFiled: September 25, 2020Publication date: November 3, 2022Applicants: KYOTO UNIVERSITY, NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECHNOLOGY, THE REGENTS OF THE UNIV. OF CALIFORNIAInventors: Fuyuhiko TAMANOI, Kotaro MATSUMOTO, Hiroyuki SAITOH, Ayumi SENOUCHI, Toshiki TAJIMA
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Patent number: 11480635Abstract: A tension measuring method installs a reel having a cylindrical coil forming part on a cable to be measured, forms a coil by winding a conductor around the coil forming part, measures a magnetic hysteresis loop of the cable by supplying a current to the coil to generate a magnetic field, and computes a tension of the cable using a parameter determined from the hysteresis loop. A magnetic field sensor and a magnetic flux sensor are provided inside a through hole in the coil forming part, and the cable is positioned inside the through hole. The magnetic field is varied so that the hysteresis loop includes a near-saturation magnetization region, to measure the hysteresis loop using the sensors. The parameter is selected from a magnetic flux or a magnetic flux density, a remanent magnetization, a coercivity, a magnetic permeability, and a hysteresis loss in the near-saturation magnetization region.Type: GrantFiled: September 1, 2021Date of Patent: October 25, 2022Assignees: KYOTO UNIVERSITY, TOKYO ROPE MFG. CO., LTD., SUMITOMO ELECTRIC INDUSTRIES, LTD.Inventors: Kazuhiko Tsukada, Toshiyuki Moriya, Hiroaki Itoi, Sadanori Shiiki, Masashi Oikawa, Shinji Nakaue
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Patent number: 11473058Abstract: The present invention provides a method for producing dopaminergic neuron progenitor cells from pluripotent stem cells, which method comprises the steps of: (i) performing adherent culture of pluripotent stem cells on an extracellular matrix in a medium containing a reagent(s) selected from the group consisting of BMP inhibitor, TGF? inhibitor, SHH signal-stimulating agent, FGF8, and GSK3? inhibitor; (ii) collecting Corin- and/or Lrtm1-positive cells from the cells obtained in Step (i) using a substance which binds to Corin and/or a substance which binds to Lrtm1; and (iii) performing suspension culture of the cells obtained in Step (ii) in a medium containing a neurotrophic factor.Type: GrantFiled: September 4, 2014Date of Patent: October 18, 2022Assignees: Kyoto University, Osaka University, Eisai R&D Management Co., Ltd.Inventors: Jun Takahashi, Daisuke Doi, Bumpei Samata, Kiyotoshi Sekiguchi, Yuichi Ono
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Publication number: 20220313733Abstract: A method for producing renal stromal cells, comprising a step (3) of culturing renal stromal precursors in a medium comprising a platelet derived growth factor receptor agonist to obtain renal stromal cells is provided as a technique for supplying renal stromal cells. This production method can further comprise a step (2) of inducing renal stromal precursors from neural crest cells, and a step (1) of culturing pluripotent stem cells in a medium comprising a GSK3? inhibitor, a TGF? inhibitor, and retinoic acid and/or a derivative thereof to induce neural crest cells.Type: ApplicationFiled: June 10, 2020Publication date: October 6, 2022Applicants: Kyoto University, Takeda Pharmaceutical Company LimitedInventors: Makoto IKEYA, Daisuke KAMIYA
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Publication number: 20220306985Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the likeType: ApplicationFiled: May 23, 2022Publication date: September 29, 2022Applicants: Nissan Chemical Industries, Ltd., Kyoto UniversityInventors: Taito NISHINO, Tatsuro KANAKI, Ayako OTANI, Koichiro SARUHASHI, Misayo Tomura, Takehisa IWAMA, Masato HORIKAWA, Norio NAKATSUJI, Tomomi OTSUJI
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Publication number: 20220302443Abstract: A main object of the present disclosure is to provide a new active material that can be used in a fluoride ion battery. The present disclosure achieves the object by providing an active material to be used in a fluoride ion battery, the active material comprising: a crystal phase including an infinite layer structure, and represented by ApBqOr, provided that A is at least one of an alkali earth metal element and a rare earth element, B is a transition metal element, p satisfies 0.8?p?1, q satisfies 0.8?q?1, and r satisfies 1.5?r?2.5.Type: ApplicationFiled: March 8, 2022Publication date: September 22, 2022Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, KYOTO UNIVERSITYInventors: Hidenori MIKI, Yoshiharu UCHIMOTO, Kentaro YAMAMOTO
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Patent number: 11440799Abstract: A carbon material has at least either a peak related to diamond bonds, or a peak related to diamond-like bonds, appearing in a range of 1250 to 1400 cm?1 in a spectrum measured by Raman scattering spectrometry, and a full width at half maximum of a maximum peak, or each of full widths at half maximum of the maximum peak and a second largest peak, among peaks appearing in the range of 1250 to 1400 cm?1, has a signal less than 100 cm?1.Type: GrantFiled: November 21, 2017Date of Patent: September 13, 2022Assignees: SUMITOMO ELECTRIC INDUSTRIES, LTD., KYOTO UNIVERSITYInventors: Tomoyuki Awazu, Masatoshi Majima, Yoshiki Nishibayashi, Toshiyuki Nohira, Kouji Yasuda, Kouji Hidaka
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Cell evaluation method, cell evaluation device, and recording medium storing cell evaluation program
Patent number: 11436719Abstract: A cell evaluation method evaluates the quality of a cell population including a plurality of cells. The cell evaluation method comprises: an index calculation step of calculating an index, based on a captured image of the cell population, the index including at least any one of an average distance representing a packing degree of the cells, a spring constant representing a degree of consistency in distances between the cells, and a hexagonal order parameter representing a degree to which an arrangement of the cells resembles a regular hexagon; and an evaluation step of evaluating the cell population, based on the index calculated in the index calculation step.Type: GrantFiled: February 15, 2018Date of Patent: September 6, 2022Assignees: Kyoto University, Kyoto Prefectural Public University CorporationInventors: Motomu Tanaka, Akihisa Yamamoto, Morio Ueno, Junji Hamuro, Shigeru Kinoshita, Hiroshi Tanaka, Munetoyo Toda, Chie Sotozono