Patents Assigned to Laboratorios del Dr. Esteve
  • Method of treating HIV-1 infection utilizing a multiepitope T cell immunogen comprising gag, pol, vif and nef epitopes
    Patent number: 11325946
    Abstract: The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: May 10, 2022
    Assignees: LABORATORIOS DEL DR. ESTEVE S.A., FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDE—CAIXA
    Inventors: Christian Brander, Beatriz Mothe Pujadas, Anuska Llano
  • Immunogens for HIV vaccination
    Patent number: 10815278
    Abstract: The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: October 27, 2020
    Assignees: Laboratorios del Dr. Esteve S.A., Fundació Privada Institut de Recerca de La Sida—Caixa
    Inventors: Christian Brander, Beatriz Mothe Pujadas, Anuska Llano
  • CO-CRYSTALS OF TRAMADOL AND COXIBS
    Publication number: 20190231800
    Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Application
    Filed: February 14, 2019
    Publication date: August 1, 2019
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Carlos Ramon PLATA SALAMAN, Nicolas TESSON
  • Amide derivatives having multimodal activity against pain
    Patent number: 10351549
    Abstract: The present invention relates to amide derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: July 16, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Monica Garcia-Lopez, Carmen Almansa-Rosales
  • Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Patent number: 10246465
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: April 2, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Monica Garcia Lopez
  • Co-crystals of tramadol and coxibs
    Patent number: 10245276
    Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: April 2, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Carlos Ramon Plata Salaman, Nicolas Tesson
  • Co-crystals of tramadol and coxibis
    Patent number: 10238668
    Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: March 26, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Carlos Ramon Plata Salaman, Nicolas Tesson
  • 1-methylpyrazole-piperazine compounds having multimodal activity against pain
    Patent number: 10189828
    Abstract: The present invention relates to 1-methylpyrazole-piperazine compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: January 29, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Carmen Almansa-Rosales, Monica Garcia-Lopez, Lourdes Garriga-Sanahuja, Ana Virginia Llorente-Fernandez
  • Oxa-azaspiro compounds having activity against pain
    Patent number: 10183918
    Abstract: The present invention relates to oxa-azaspiro compounds having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: January 22, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Carmen Almansa-Rosales, Carlos Alegret-Molina
  • 1-ARYL-3-AMINOALKOXY PYRAZOLES AS SIGMA LIGANDS ENHANCING ANALGESIC EFFECT OF OPIOIDS AND ATTENUATING THE DEPENDENCY THEREOF
    Publication number: 20190010128
    Abstract: The invention relates to the use of a group of sigma receptor ligands of formula (I) for the potentiation of the analgesic effect of opioids and opiates and at the same time for decreasing the dependency induced by them.
    Type: Application
    Filed: February 1, 2018
    Publication date: January 10, 2019
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Helmut Heinrich Buschmann, Jose Miguel Vela-Hernandez, Daniel Zamanillo-Castanedo
  • SUBSTITUTED MORPHOLINE DERIVATIVES HAVING ACTIVITY AGAINST PAIN
    Publication number: 20180305343
    Abstract: The present invention relates to substituted morpholine derivatives having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 25, 2018
    Applicant: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Marina VIRGILI-BERNADO, Carlos ALEGRET-MOLINA
  • 1-(4-(2-((1-(3,4-DIFLUOROPHENYL)-1H-PYRAZOL-3-YL)METHOXY)ETHYL)PIPERAZIN-1-YL)ETHANONE SALTS
    Publication number: 20180251430
    Abstract: The present invention relates to 1-(4-(2-((1-(3,4-difluorophenyl)-1 H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone salts, specifically to the hydrochloride and to the maleate, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of sigma receptor associated diseases.
    Type: Application
    Filed: September 1, 2016
    Publication date: September 6, 2018
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Antoni Torrens-Jover, Carmen Almansa Rosales
  • Piperidine derivatives having multimodal activity against pain
    Patent number: 9981942
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: May 29, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez
  • Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators
    Patent number: 9963453
    Abstract: The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 8, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Ramón Merce-Vidal, José-Luis Díaz-Fernández, Carmen Almansa-Rosales
  • Methods for identifying HIV neutralizing antibodies
    Patent number: 9952218
    Abstract: The present invention relates to an in vitro method for determining HIV neutralizing antibodies in a sample. It further relates to a fusion protein to be used in said method and a nucleic acid encoding said fusion protein.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: April 24, 2018
    Assignees: LABORATORIOS DEL DR. ESTEVE S.A., FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA
    Inventors: Julián Miguel Blanco Arbués, Jorge Carrillo Molina
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs) and Sigma receptor ligands combinations
    Patent number: 9931346
    Abstract: The invention refers to a synergistic combination comprising a Sigma ligand of general formula (I), and a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI), a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament, particularly for the prophylaxis and/or treatment of pain.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: April 3, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Daniel Zamanillo-Castanedo, Enrique Portillo-Salido
  • 1-aryl-3-aminoalkoxy pyrazoles as sigma ligands enhancing analgesic effect of opioids and attenuating the dependency thereof
    Patent number: 9914705
    Abstract: The invention relates to the use of a group of sigma receptor ligands of formula (I) for the potentiation of the analgesic effect of opioids and opiates and at the same time for decreasing the dependency induced by them.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: March 13, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Helmut Heinrich Buschmann, Jose Miguel Vela-Hernandez, Daniel Zamanillo-Castanedo
  • Piperidine compounds having multimodal activity against pain
    Patent number: 9902711
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: February 27, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez, Eva Maria Ayet Galcera, Maria Teresa Serafini Cabanes
  • Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments
    Patent number: 9879015
    Abstract: The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: January 30, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Ramón Merce-Vidal, José-Luis Díaz-Fernández
  • 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride polymorphs and solvates
    Patent number: RE47214
    Abstract: The present invention relates to polymorphs and solvates of the hydrochloride salt of 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine (P027), processes for their preparation, and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: January 29, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Ramón Berenguer Maimó, Jorge Medrano Rupérez, Jordi Benet Buchholz, Laura Puig Fernandez, Laia Pellejà Puxeu