Patents Assigned to Laboratorios del Dr. Esteve
  • VECTORS AND SEQUENCES FOR THE TREATMENT OF DISEASES
    Publication number: 20130158104
    Abstract: The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses.
    Type: Application
    Filed: June 10, 2011
    Publication date: June 20, 2013
    Applicants: Laboratorios Del DR Esteve S.A, Universidad Autonoma De Barcelona
    Inventors: Fátima Bosch Tubert, Éduard Ayuso López, Albert Ruzo Matías
  • USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA
    Publication number: 20130158033
    Abstract: The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and/or treat opioid-induced hyperalgesia (OIH) associated to opioid therapy.
    Type: Application
    Filed: August 2, 2011
    Publication date: June 20, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: José Miguel Vela Hernández, Daniel Zamanillo-Castanedo, Margarita Puig Riera de Conias
  • 4-[-2-[[5-METHYL-1-(2-NAPHTALENYL)-1H-PYRAZOL-3-YL]OXY]ETHYL]MORPHOLINE HYDROCHLORIDE AMORPHOUS SOLID FORMS
    Publication number: 20130150575
    Abstract: The present invention relates to solid forms having a low degree of crystallinity or substantially amorphous of the hydrochloride salt of 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine (P027) and processes for their preparation.
    Type: Application
    Filed: August 8, 2011
    Publication date: June 13, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Jordi Benet Buchholz, Laura Puig Fernandez
  • SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY
    Publication number: 20130109692
    Abstract: The invention refers to the use of a sigma ligand, preferably a sigma ligand of formula (I), to prevent or treat emesis induced by a chemotherapeutic agent or radioactivity, especially emesis induced by taxanes, vinca alkaloids or platin chemotherapeutic drugs.
    Type: Application
    Filed: May 20, 2011
    Publication date: May 2, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: José Miguel Vela Hernández, Xavier Codony-Soler, Daniel Zamanillo-Castanedo
  • PHARMACEUTICAL COMPOSITIONS OF CO-CRYSTALS OF TRAMADOL AND COXIBS
    Publication number: 20130109659
    Abstract: The present invention relates to oral pharmaceutical compositions comprising co-crystals of tramadol and celecoxib and processes for the preparation of these oral pharmaceutical compositions. The present invention also relates to methods of using oral pharmaceutical compositions comprising co-crystals of tramadol and celecoxib as medicaments, more particularly for the treatment of pain.
    Type: Application
    Filed: June 3, 2011
    Publication date: May 2, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Luis Soler Ranzani, Albert Falivene Aldea
  • BICYCLIC TETRAHYDROPYRROLE COMPOUNDS
    Publication number: 20130072456
    Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Application
    Filed: October 26, 2012
    Publication date: March 21, 2013
    Applicant: Laboratorios del Dr. Esteve, S.A.
    Inventor: Laboratorios del Dr. Esteve, S.A.
  • COMPOSITIONS COMPRISING VENLAFAXINE AND CELECOXIB IN THE TREATMENT OF PAIN
    Publication number: 20130072534
    Abstract: The present invention relates to pharmaceutical compositions comprising venlafaxine and celecoxib and their uses as medicaments, more particularly for the treatment of pain, including chronic pain; or of depression in patients which suffer from pain or in patients with a chronic musculo-skeletal inflammatory illness, with the inflammatory illness preferably being selected from osteoarthritis or rheumatoid arthritis.
    Type: Application
    Filed: December 23, 2010
    Publication date: March 21, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Sebastia Videla Ces, Enrique Portillo Salido
  • Substituted pyrazole sigma receptor antagonists
    Patent number: 8394797
    Abstract: The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to pyrazole derivatives of formula I and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: March 12, 2013
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Jordi Corbera Arjona, Maria Rosa Cuberes-Altisent, Joerg Holenz, Daniel Martínez-Olmo, David Vaño-Domenech
  • Bicyclic tetrahydropyrrole compounds
    Patent number: 8372990
    Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: February 12, 2013
    Assignee: Laboratorios Del Dr. Esteve S.A.
    Inventors: Miguel Angel Pericas-Brondo, Antonio Torrens-Jover, Susana Yenes-Minguez, Félix Cuevas Cordobés, Carmen Garcia Granda
  • CO-CRYSTALS OF VENLAFAXINE AND CELECOXIB
    Publication number: 20130028937
    Abstract: The present invention relates to a co-crystal of celecoxib and venlafaxine, processes for preparation of the same and its use as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain, including chronic pain; or of depression in patients which suffer from chronic pain and/or chronic inflammation or in patients with a chronic musculo-skeletal inflammatory illness, with the inflammatory illness preferably being selected from osteoarthritis or rheumatoid arthritis.
    Type: Application
    Filed: December 23, 2010
    Publication date: January 31, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Carlos Ramon Plata Salaman, Sebastia Videla Ces, Nicolas Tesson, Montserrat Trilla Castano
  • 1,2,4-triazole derivatives as sigma receptor inhibitors
    Patent number: 8349878
    Abstract: The invention relates to the use of compounds having pharmacological activity towards the sigma receptor, and more particularly to 1,2,4-triazole derivatives of formula I to processes of preparation of such compounds and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: January 8, 2013
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Nadine Jagerovic, Jose Maria Cumella-Montanchez, Maria Pilar Goya-Laza, Alberto Dordal Zueras, Maria Rosa Cuberes-Altisent
  • PHARMACEUTICAL COMPOSITION OF LANSOPRAZOLE
    Publication number: 20120321702
    Abstract: The invention refers to an oral solid pharmaceutical composition comprising a mixture of: (a) pellets comprising lansoprazole or a pharmaceutically acceptable salt thereof being free of alkaline-reacting compounds and (b) pellets comprising lansoprazole or a pharmaceutically acceptable salt thereof together with alkaline-reacting compounds.
    Type: Application
    Filed: June 27, 2011
    Publication date: December 20, 2012
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Gregorio José ENCINA GARCIA, Zhengguo XU
  • HETEROCYCYL-SUBSTITUTED-ALKYLAMINOPHENYL DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
    Publication number: 20120322842
    Abstract: The present invention relates to heterocyclyl-substituted alkylamino phenyl derivatives (I) to processes for the preparation thereof, to medicaments comprising them as well as to their use for the preparation of a medicament for the treatment of 5HT7 receptor mediated diseases or conditions. In the compounds (I) x-y-z together form —N—N?CR1— or ?C—NR2—N?.
    Type: Application
    Filed: September 22, 2010
    Publication date: December 20, 2012
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Monica Garcia-Lopez, Antoni Torrens-Jover, Monica Alonso-Xalma
  • 4-[-2-[[5-METHYL-1-(2-NAPHTALENYL)-1H-PYRAZOL-3-YL]OXY]ETHYL]MORPHOLINE HYDROCHLORIDE POLYMORPHS AND SOLVATES
    Publication number: 20120316336
    Abstract: The present invention relates to polymorphs and solvates of the hydrochloride salt of 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine (P027), processes for their preparation, and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: February 4, 2011
    Publication date: December 13, 2012
    Applicant: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Ramón Berenguer Maimó, Jorge Medrano Rupérez, Jordi Benet Buchholz, Laura Puig Fernandez, Lala Pellejà Puxeu
  • Process for the preparation of naphthalen-2-yl-pyrazol-3-one intermediates useful in the synthesis of sigma receptor inhibitors
    Patent number: 8329880
    Abstract: The invention relates to a process for preparing naphthalen-2-yl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: December 11, 2012
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Antoni Torrens Jover, Jordi Corbera Arjona, Maria Rosa Cuberes-Altisent
  • Sigma receptor inhibitors
    Patent number: 8314096
    Abstract: The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: November 20, 2012
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Christian Laggner, Maria Rosa Cuberes-Altisent, Joerg Holenz, Juana Maria Berrocal-Romero, Maria Montserrat Contijoch-Llobet
  • Bicyclic tetrahydropyrrole compounds
    Patent number: 8299113
    Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: October 30, 2012
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Miguel Angel Pericas-Brondo, Antonio Torrens-Jover, Susana Yenes-Minguez, Félix Cuevas Cordobes, Carmen Garcia Granda
  • INDANE-AMINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
    Publication number: 20120264799
    Abstract: The present invention relates to indane-amine derivatives, to processes for the preparation thereof, to medicaments comprising them as well as to their use for the preparation of a medicament for the treatment of 5HT7 receptor mediated diseases or conditions.
    Type: Application
    Filed: September 29, 2010
    Publication date: October 18, 2012
    Applicant: LABORATORIOS DEL DR. ESTEVE ,S.A.
    Inventors: Monica Garcia-Lopez, Anton Torrens-Jover, Monica Alonso-Xalma
  • 4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE DERIVATIVES AND THEIR USE AS SIGMA RECEPTOR LIGANDS
    Publication number: 20120238567
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.
    Type: Application
    Filed: May 30, 2012
    Publication date: September 20, 2012
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Jordi CORBERA-ARJONA, Daniel MARTINEZ-OLMO, David VANO-DOMENECH
  • PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS
    Publication number: 20120232093
    Abstract: The invention relates to compounds of formula I having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Application
    Filed: May 24, 2012
    Publication date: September 13, 2012
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Rosa CUBERES-ALTISENT, Joerg HOLENZ