Patents Assigned to Laboratorios del Dr. Esteve
  • PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS, THEIR PREPARATION AND USE AS SIGMA LIGANDS
    Publication number: 20140163010
    Abstract: New pyrazolo[3,4-d]pyrimidine compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for preparing these compounds, to compositions comprising them and to their use as medicaments.
    Type: Application
    Filed: July 13, 2012
    Publication date: June 12, 2014
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Maria Rosa Cuberes-Altisent, Jordi Corbera-Arjona, Jose Luis Diaz-Fernanadez, Carmen Almansa-Rosales
  • METHODS AND REAGENTS FOR EFFICIENT CONTROL OF HIV PROGRESSION
    Publication number: 20140148499
    Abstract: The invention relates to methods for the identification of HIV-1 infected subjects capable of controlling viral load based on the determination of the expression levels of several miRNAs. In addition, the invention also relates to methods for controlling HIV infection by using some of the differentially expressed miRNAs or polynucleotides encoding said miRNAs, as well as to compositions comprising a miRNA or a polynucleotide encoding said miRNA and an anti-HIV agent.
    Type: Application
    Filed: July 12, 2012
    Publication date: May 29, 2014
    Applicants: FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA, LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Mireia Arnedo Valero, Montserrat Plana Prades, Josep Maria Gatell Artigas
  • 5-methyl-1-(naphthalen-2-yl)-1H-pyrazole derivatives and their use in potentiating the effect of opioid analgesics
    Patent number: 8729073
    Abstract: The invention relates to pyrazole derivatives of formula I having pharmacological activity and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of pain.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: May 20, 2014
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Antoni Torrens Jover, María Rosa Cuberes-Altisent
  • USE OF SIGMA LIGANDS IN DIABETES TYPE-2 ASSOCIATED PAIN
    Publication number: 20140107111
    Abstract: The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and/or treat type-2 diabetes-associated pain and related symptoms.
    Type: Application
    Filed: May 18, 2012
    Publication date: April 17, 2014
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Jose Miguel Vela Hernandez, Maria Isabel Martin Fontelles
  • Pharmaceutical solid dosage form
    Patent number: 8685448
    Abstract: The present invention is directed to a solid dosage form comprising (i) a core comprising a benzimidazole; (ii) a separating layer comprising a water soluble polymer and glyceryl monostearate; and (iii) an enteric coating.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: April 1, 2014
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Angel Santanach-Delisau, Luis Soler Ranzani, Pierandrea Esposito
  • CO-CRYSTALS OF TRAMADOL AND COXIBS
    Publication number: 20140057879
    Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Application
    Filed: October 29, 2013
    Publication date: February 27, 2014
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Carlos Ramon PLATA SALAMAN, Nicolas TESSON
  • RAPID SELECTION METHOD FOR HIV GP-120 VARIANTS
    Publication number: 20140037667
    Abstract: The invention relates to a method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized HIV gp120 variants of a surface polypeptide displayed to said neutralizing antibodies. The invention relates as well to the use of the HIV gp120 immunogens isolated according to the RIS method of the invention in medicine for the treatment of diseases caused by a virus and in diagnosis for the identification of neutralizing antibodies in a patient.
    Type: Application
    Filed: February 24, 2012
    Publication date: February 6, 2014
    Applicants: FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA -CAIXA, LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: María Eloísa Yuste Herranz, Víctor Sánchez Merino, Carolina Ferreira
  • CO-CRYSTALS OF DULOXETINE AND COX-INHIBITORS FOR THE TREATMENT OF PAIN
    Publication number: 20140024697
    Abstract: The present invention relates to co-crystals of duloxetine and co-crystal formers selected from COX-INHIBITORS, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Application
    Filed: July 15, 2013
    Publication date: January 23, 2014
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Helmut Heinrich Buschmann, Lluis Sola Carandell, Jordi Benet Buchholz, Jordi Carles Ceron Bertran, Jesus Ramirez Artero
  • COMPOSITIONS COMPRISING TRAMADOL AND CELECOXIB IN THE TREATMENT OF PAIN
    Publication number: 20140024622
    Abstract: The present invention relates to pharmaceutical compositions comprising tramadol and celecoxib and their uses as medicaments or analgesics, more particularly for the treatment of severe to moderate pain with an inflammation component.
    Type: Application
    Filed: September 25, 2013
    Publication date: January 23, 2014
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Enrique PORTILLO SALIDO, Sebastia VIDELA CES
  • USE OF SIGMA LIGANDS IN BONE CANCER PAIN
    Publication number: 20130324535
    Abstract: The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and/or treat pain associated to bone cancer.
    Type: Application
    Filed: December 2, 2011
    Publication date: December 5, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Daniel Zamanillo-Castanedo, José Miguel Vela-Hernández, Carlos Plata-Salaman
  • Co-crystals of tramadol and coxibs
    Patent number: 8598152
    Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses in pharmaceutical formulations for the treatment of pain.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: December 3, 2013
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Carlos Ramon Plata Salaman, Nicolas Tesson
  • HIGHLY IMMUNOGENIC HIV P24 SEQUENCES
    Publication number: 20130302364
    Abstract: The invention relates to peptides comprising part or all of a conserved element within a Center-of-Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.
    Type: Application
    Filed: November 10, 2011
    Publication date: November 14, 2013
    Applicants: LABORATORIOS DEL DR. ESTEVE, S.A., UNIVERSITY OF WASHINGTON, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA - CAIXA
    Inventors: Beatriz Mothe Pujadas, Christian Brander, James I. Mullins
  • 5-METHYL-1-(NAPHTHALEN-2-YL)-1H-PYRAZOLE DERIVATIVES AND THEIR USE IN POTENTIATING THE EFFECT OF OPIOID ANALGESICS
    Publication number: 20130303540
    Abstract: The invention relates to pyrazole derivatives of formula I having pharmacological activity and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of pain.
    Type: Application
    Filed: December 2, 2011
    Publication date: November 14, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Antoni Torrens Jover, María Rosa Cuberes-Altisen
  • Compositions comprising tramadol and celecoxib in the treatment of pain
    Patent number: 8569271
    Abstract: The present invention relates to pharmaceutical compositions comprising tramadol and celecoxib and their uses as medicaments or analgesics, more particularly for the treatment of severe to moderate pain with an inflammation component.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: October 29, 2013
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Enrique Portillo Salido, Sebastia Videla Ces
  • COMPRESSED SOLID DOSAGE FORMS
    Publication number: 20130280325
    Abstract: This invention relates to compressed solid oral dosage form able to contain a high load of active pharmaceutical ingredient, showing a controlled release profile, and consisting of individual particles wherein each individual particle comprises an active pharmaceutical ingredient and wherein each individual particle is coated with a layer comprising at least one plasticizer.
    Type: Application
    Filed: December 22, 2011
    Publication date: October 24, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Luis Soler Ranzani, Albert Falivene Aldea, Ángel Santanach Delisau, Gemma Casadevall Pujals
  • Co-crystals of duloxetine and COX-INHIBITORs for the treatment of pain
    Patent number: 8501802
    Abstract: The present invention relates to co-crystals of duloxetine and co-crystal formers selected from COX-INHIBITORs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: August 6, 2013
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Helmut Heinrich Buschmann, Lluis Solá Carandell, Jordi Benet Buchholz, Jordi Carles Ceròn Bertran, Jesüs Ramirez Artero
  • 4,5,6,7-tetrahydrobenzo[B]thiophene derivatives and their use as sigma receptor ligands
    Patent number: 8492563
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: July 23, 2013
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Jordi Corbera-Arjona, Daniel Martinez-Olmo, David Vano-Domenech
  • Sigma receptor compounds
    Patent number: 8481567
    Abstract: The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: July 9, 2013
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Jordi Corbera-Arjona, David Vano-Domenech, Joerg Holenz
  • Sigma receptor inhibitors
    Patent number: 8470867
    Abstract: The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: June 25, 2013
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Christian Laggner, María Rosa Cuberes-Altisent, Joerg Holenz, Juana María Berrocal-Romero, Maria Montserrat Contijoch-Llobet
  • SIGMA RECEPTOR INHIBITORS
    Publication number: 20130158029
    Abstract: The invention refers to compounds of general formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Application
    Filed: May 26, 2011
    Publication date: June 20, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Monica Garcia López, Antoni Torrens Jover, José Luis Diaz Fernández, Ana Maria Caamaño Moure