Patents Assigned to Laboratorios del Dr. Esteve
  • 4-[-2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
    Patent number: 9428462
    Abstract: The present invention relates to solid forms having a low degree of crystallinity or substantially amorphous of the hydrochloride salt of 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine (P027) and processes for their preparation.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: August 30, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Jordi Benet Buchholz, Laura Puig Fernandez
  • Substituted pyrano and furanoquinolines, their preparation and use as medicaments
    Patent number: 9408842
    Abstract: The present invention relates to new substituted pyrano and furanoquinolines having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: August 9, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luis Diaz-Fernández, Ute Christmann
  • Sigma Ligands For the Prevention or Treatment of Pain Induced by Chemotherapy
    Publication number: 20160220575
    Abstract: The invention refers to the use of a sigma ligand of formula (I) to prevent or treat pain induced by a chemotherapeutic agent, especially pain induced by taxanes, vinca alkaloids or platinum-containing chemotherapeutic drugs.
    Type: Application
    Filed: April 7, 2016
    Publication date: August 4, 2016
    Applicant: Laboratorios del Dr. Esteve, S.A.
    Inventors: José Manuel Baeyens-Cabrera, Helmut Heinrich Buschmann, José Miguel Vela Hernández, Daniel Zamanillo-Castanedo, Francisco-Rafael Nieto-López
  • Sigma Ligands For the Prevention or Treatment of Pain Induced by Chemotherapy
    Publication number: 20160199380
    Abstract: The invention refers to the use of a sigma ligand of formula (I) to prevent or treat pain induced by a chemotherapeutic agent, especially pain induced by taxanes, vinca alkaloids or platinum-containing chemotherapeutic drugs.
    Type: Application
    Filed: March 17, 2016
    Publication date: July 14, 2016
    Applicant: Laboratorios del Dr. Esteve, S.A.
    Inventors: José Manuel Baeyens-Cabrera, Helmut Heinrich Buschmann, José Miguel Vela Hernández, Daniel Zamanillo-Castanedo, Francisco-Rafael Nieto-López
  • Vectors and sequences for the treatment of diseases
    Patent number: 9279132
    Abstract: The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: March 8, 2016
    Assignees: LABORATORIOS DEL DR. ESTEVE, S.A., UNIVERSIDAD AUTONOMA DE BARCELONA
    Inventors: Fátima Bosch Tubert, Éduard Ayuso López, Albert Ruzo Matías
  • Substituted pyrazolo[3,4-]pyrimidine compounds, their preparation and use as sigma receptors ligands
    Patent number: 9278974
    Abstract: The present invention relates to new substituted pyrazolo[3,4-d]pyrimidine compounds, having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: March 8, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José Luis Díaz Fernández, Carme Almansa, Jordi Corbera Arjona
  • Bicyclic tetrahydropyrrole compounds
    Patent number: 9271959
    Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: March 1, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Miguel Angel Pericas-Brondo, Antonio Torrens-Jover, Susana Yenes-Minguez, Felix Cuevas Cordobes, Carmen Garcia Granda
  • Substituted pyrano and furanoquinolines, their preparation and use as medicaments
    Patent number: 9193738
    Abstract: The present invention relates to new substituted pyrano and furanoquinolines having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: November 24, 2015
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luis Diaz-Fernández, Ute Christmann
  • Sigma receptor inhibitors
    Patent number: 9181195
    Abstract: The invention refers to compounds of general formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: November 10, 2015
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Mónica García López, Antoni Torrens Jover, José Luis Díaz Fernández, Ana María Caamaño Moure
  • Co-crystals of duloxetine and cox-inhibitors for the treatment of pain
    Patent number: 9084774
    Abstract: The present invention relates to co-crystals of duloxetine and co-crystal formers selected from COX-INHIBITORS, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: July 21, 2015
    Assignee: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Helmut Heinrich Buschmann, Lluis Sola Carandell, Jordi Benet Buchholz, Jordi Carles Ceron Bertran, Jesus Ramirez Artero
  • CO-CRYSTALS OF TRAMADOL AND COXIBS
    Publication number: 20150196503
    Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Application
    Filed: March 23, 2015
    Publication date: July 16, 2015
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Carlos Ramon PLATA SALAMAN, Nicolas TESSON
  • CO-CRYSTALS OF TRAMADOL AND COXIBS
    Publication number: 20150196504
    Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Application
    Filed: March 23, 2015
    Publication date: July 16, 2015
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Carlos Ramon PLATA SALAMAN, Nicolas TESSON
  • CONTROLLED RELEASE FORMULATION COMPRISING MESALAMINE
    Publication number: 20150164920
    Abstract: The present invention refers to a controlled release pharmaceutical formulation in solid form comprising Mesalamine. The invention also contemplates the preparation of the said formulation and its use for the treatment of patients suffering from inflammatory bowel disease (IBD).
    Type: Application
    Filed: March 27, 2013
    Publication date: June 18, 2015
    Applicant: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Luis Soler Ranzani, Albert Falivene Aldea, Gemma Casadevall Pujals
  • COMPOSITIONS COMPRISING TRAMADOL AND CELECOXIB IN THE TREATMENT OF PAIN
    Publication number: 20150150889
    Abstract: The present invention relates to pharmaceutical compositions comprising tramadol and celecoxib and their uses as medicaments or analgesics, more particularly for the treatment of severe to moderate pain with an inflammation component.
    Type: Application
    Filed: February 4, 2015
    Publication date: June 4, 2015
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Enrique PORTILLO SALIDO, Sebastia VIDELA CES
  • Co-crystals of tramadol and coxibs
    Patent number: 9012440
    Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: April 21, 2015
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Carlos Ramon Plata Salaman, Nicolas Tesson
  • Vectors and sequences for the treatment of diseases
    Patent number: 8999948
    Abstract: The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: April 7, 2015
    Assignees: Laboratorios del Dr. Esteve, S.A., Universidad Autonoma de Barcelona
    Inventors: Fátima Bosch Tubert, Éduard Ayuso López, Albert Ruzo Matías
  • CO-CRYSTALS OF TRAMADOL AND NSAIDs
    Publication number: 20140350110
    Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Application
    Filed: July 7, 2014
    Publication date: November 27, 2014
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Helmut Heinrich BUSCHMANN, Lluis SOLA CARANDELL, Jordi BENET BUCHHOLZ, Jordi Carles CERON BERTRAN, Carlos Ramon PLATA SALAMAN, Nicolas TESSON
  • 1-aryl-3-aminoalkoxy pyrazoles as sigma ligands enhancing analgesic effect of opioids and attenuating the dependency thereof
    Patent number: 8877753
    Abstract: The invention relates to the use of a group of sigma receptor ligands of formula (I) for the potentiation of the analgesic effect of opioids and opiates and at the same time for decreasing the dependency induced by them.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: November 4, 2014
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Helmut Heinrich Buschmann, Jose Miguel Vela Hernandez, Daniel Zamanillo-Castanedo
  • Pharmaceutical compositions of co-crystals of tramadol and coxibs
    Patent number: 8846744
    Abstract: The present invention relates to oral pharmaceutical compositions comprising co-crystals of tramadol and celecoxib and processes for the preparation of these oral pharmaceutical compositions. The present invention also relates to methods of using oral pharmaceutical compositions comprising co-crystals of tramadol and celecoxib as medicaments, more particularly for the treatment of pain.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: September 30, 2014
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Luis Soler Ranzani, Albert Falivene Aldea
  • Domperidone at a low daily dose for use in the treatment or prevention of a disease associated with an alteration of the immune response
    Patent number: 8802691
    Abstract: The invention relates to the use of domperidone or a pharmaceutically acceptable salt thereof at low doses to prevent and/or treat a disease associated with an alteration of the immune response such as Leishmaniosis.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: August 12, 2014
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: David Sabate Elias, Josep M. Homedes Beguer, Pablo Gomez Ochoa