Patents Assigned to Lehigh University
  • Patent number: 6198005
    Abstract: A method wherein a methanol-containing waste gas stream, such as a pulp mill waste stream which contains methanol and other waste products, including methyl mercaptans, is passed in contact with a catalyst comprising a supported or unsupported bulk metal oxide catalyst in the presence of an oxidizing agent; preferably the gas stream is contacted with the catalyst, in the presence of the oxidizing agent, for a time sufficient to convert at least a portion of the methanol to formaldehyde (CH2O).
    Type: Grant
    Filed: April 20, 1999
    Date of Patent: March 6, 2001
    Assignee: Lehigh University
    Inventor: Israel E. Wachs
  • Patent number: 6147263
    Abstract: A process for the catalytic conversion of methanol to formaldehyde wherein a gas stream containing methanol and oxygen is contacted with a silver catalyst in a first conversion zone containing a silver catalyst to produce an effluent containing formaldehyde, unreacted methanol, and oxidation byproducts; and contacting the first zone effluent with a copper catalyst in a second conversion zone for further conversion of the unreacted methanol. No molecular oxygen is added to the first stage effluent or to the second conversion zone.
    Type: Grant
    Filed: April 19, 1999
    Date of Patent: November 14, 2000
    Assignee: Lehigh University
    Inventors: Israel E. Wachs, Chuan-Bao Wang
  • Patent number: 6084135
    Abstract: A method wherein a gas stream containing hydrogen, a carbon oxide and hydrogen sulfide is first passed in contact with a catalyst comprising a porous alumina supported sulfided metal selected from the group consisting of molybdenum (Mo), chromium (Cr), tungsten (W), manganese (Mn), nickel (Ni), iron (Fe), zinc (Zn), cobalt (Co), copper (Cu), tin (Sn), vanadium (Va) and mixtures thereof, optionally promoted by an alkali metal sulfide, to convert said hydrogen, carbon oxide and hydrogen sulfide to methyl mercaptans, (primarily methanethiol (CH.sub.3 SH)), and the gas stream containing the methyl mercaptans are passed in contact with a catalyst comprising a supported metal oxide or a bulk metal oxide in the presence of an oxidizing agent and for a time sufficient to convert at least a portion of the methyl mercaptan to formaldehyde (CH.sub.2 O), and sulfur dioxide (SO.sub.2).
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: July 4, 2000
    Assignee: Lehigh University
    Inventor: Israel E. Wachs
  • Patent number: 6074834
    Abstract: The present invention provides methods and reagents for assessing lipoprotein metabolism. The methods provided are applicable for use on multiple samples in a clinical laboratory, thus obviating the need for sophisticated instrumentation, such as flow cytometry. Selected cell types in a test sample are uniformly labelled with a detectable reporter substance, so that they may later be enumerated. Pre-determined lipoprotein receptors associated with the cells of interest are labelled with a receptor-selective marker, thereby to determine the number of lipoprotein receptors per cell in the test sample. Selected cells of interest are conveniently separated from the test sample by binding thereto a specific binding substance attached to a solid support. The specific binding substance binds specifically with a characteristic determinant of the cell subset of interest. The remainder of the test sample may be washed away or discarded.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: June 13, 2000
    Assignee: Lehigh University
    Inventors: Sue Ellen Slezak, John H. Abel, Barbara Obrepalska-Bielska, Eugene A. Nau, Kathy L. Gottlund
  • Patent number: 6037290
    Abstract: The method of the present invention involves in situ regeneration of metal-molybdate catalyst for methanol oxidation to formaldehyde comprising the step of regenerating spent metal-molybdate catalyst with an oxygen-free gas stream comprising methanol and an inert gas for a sufficient time and at an elevated temperature to regenerate the metal-molybdate catalyst.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: March 14, 2000
    Assignee: Lehigh University
    Inventors: Israel E. Wachs, Laura E. Briand
  • Patent number: 5969191
    Abstract: A method wherein a gas stream containing a methyl mercaptan is passed in contact with a catalyst comprising a supported metal oxide or a bulk metal oxide in the presence of an oxidizing agent and for a time sufficient to convert at least a portion of the methyl mercaptan to formaldehyde (CH.sub.2 O) and sulfur dioxide (SO.sub.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: October 19, 1999
    Assignee: Lehigh University
    Inventor: Israel E. Wachs
  • Patent number: 5907066
    Abstract: A method wherein a methanol-containing waste gas stream, such as a pulp mill waste stream which contains methanol and other waste products, including methyl mercaptans, is passed in contact with a catalyst comprising certain supported metal oxides in the presence of an oxidizing agent; preferably the gas stream is contacted with the catalyst, in the presence of the oxidizing agent, for a time sufficient to convert at least a portion of the methanol to formaldehyde (CH.sub.2 O).
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: May 25, 1999
    Assignee: Lehigh University
    Inventor: Israel E. Wachs
  • Patent number: 5834453
    Abstract: A method of forming a pharmaceutical composition of antimicrobial sterol conjugates having the following formulae: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Y are as defined in the specification. Also disclosed is a method of inducing an antimicrobial effect by administrating these pharmaceutical compositions.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: November 10, 1998
    Assignee: Lehigh University
    Inventor: Steven L. Regen
  • Patent number: 5830927
    Abstract: Aqueous based printing ink compositions adapted for use in gravure and flexographic printing on hydrophobic substrates are prepared by combining a low-viscosity resin emulsion having an average particle diameter of less than about 0.5 microns and comprised of hydrophobic, moisture resistant, adherent resin forming components with a pigment paste containing a water-soluble polymer. The printing inks are substantially devoid of volatile organic solvent.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: November 3, 1998
    Assignee: Lehigh University
    Inventors: John W. Vanderhoff, Philippe Huwart
  • Patent number: 5614077
    Abstract: An electrokinetic system and method are provided for removing charged species from a sample in which said charged species is commingled with at least one radionuclide. The apparatus comprises an anode compartment comprising an anode, a cathode compartment comprising a cathode, and a treatment zone in fluid communication with the anode and cathode compartments for containing the sample. The anode compartment, cathode compartment, and treatment zone are arranged so that a voltage gradient applied between the anode and the cathode induces an electrical current flow through the sample in the treatment zone. The current causes migration of the positively charged species in the sample toward the cathode and the negatively charges species toward the anode. A pH controller is provided for monitoring and adjusting acidity and basicity to facilitate the removal of salts while maintaining contaminants within the sample.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: March 25, 1997
    Assignees: Electro-Petroleum, Inc., Lehigh University
    Inventors: J. Kenneth Wittle, Sibel Pamukcu
  • Patent number: 5583239
    Abstract: The invention discloses steroid conjugates having the following structure: ##STR1## where Y is NHCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2, NH(CH.sub.2).sub.3 NH(CH.sub.2).sub.4 NH(CH.sub.2).sub.3 NH.sub.2, or NHCH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.2 NH.sub.2, and each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is individually H, OH and OSO.sub.3 H. These conjugates posses antimicrobial properties and are, therefore, useful as antibiotics.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: December 10, 1996
    Assignee: Lehigh University
    Inventor: Steven L. Regen
  • Patent number: 5473083
    Abstract: The invention features phototherapeutic compositions comprising Type 1, Type 2, or Type 3 psoralens and methods of using such compounds for treatment of proliferative diseases of skin, blood and bone marrow.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: December 5, 1995
    Assignees: Lehigh University, University of Medicine and Dentistry of New Jersey
    Inventors: Ned D. Heindel, Jeffrey D. Laskin
  • Patent number: 5356929
    Abstract: The invention features phototherapeutic compositions comprising Type 1, Type 2, or Type 3 psoralens and methods of using such compounds for treatment of proliferative diseases of skin, blood and bone marrow.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: October 18, 1994
    Assignee: Lehigh University
    Inventors: Ned D. Heindel, Jeffrey D. Laskin
  • Patent number: 5304309
    Abstract: An improved, continuous, cyclic process for selective coagulant recovery from clarifier sludge in water treatment plants. The improvement comprises several steps. First, the pH of the clarifier sludge is adjusted to about 3.5. Next, a composite membrane is provided having a chelating exchanger enmeshed in porous polymeric thin sheets. That composite membrane is placed in contact with the acidified sludge for selectively sorbing metal ion from the acidified sludge onto the composite membrane. The composite membrane, now carrying the metal ion, is withdrawn from contact with the acidified sludge and introduced into a stirred regeneration tank containing acid. In that tank, the chelating exchanger of the composite membrane is regenerated by desorbing the metal ion, thereby recovering the coagulant substantially devoid of organic material and undesirable metals.
    Type: Grant
    Filed: June 24, 1992
    Date of Patent: April 19, 1994
    Assignee: Lehigh University
    Inventor: Arup K. Sengupta
  • Patent number: 5284823
    Abstract: A process for superplastically forming and shaping a solid object including 123 superconductor, including preparing a solid object having grains of 123 superconductor that have an average grain size of less than 10 microns, and superplastically deforming the prepared solid object by heating the solid object to between 500.degree. and 1015.degree. C. while simultaneously applying to said solid object stress which is less than the fracture strength of the solid object, thereby producing a strain rate in the solid object. The solid object may be a composite including silver or gold.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: February 8, 1994
    Assignee: Lehigh University
    Inventors: Ye T. Chou, Martin P. Harmer, Jondo Yun
  • Patent number: 5244300
    Abstract: A structural connector used to interconnect at least a first and a second member which includes a cone-shaped male part having an approximately elliptical cross-section attached to the first member and a female part forming a correspondingly elliptical cone-shaped cavity attached to the second member and adapted to receive the male part, whereby upon receipt of the male part within the cavity of the female part the first and second members are interconnected.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: September 14, 1993
    Assignee: Lehigh University
    Inventors: Noel D. Perreira, B. Vincent Viscomi, Robert B. Fleischman
  • Patent number: 5223237
    Abstract: A process for removing the sulfur oxides from a gas stream by sorbing the sulfur oxide gases in a zeolite and subsequently purging the previously-sorbed sulfur oxide gases by exposing the zeolite to water or water vapor, which is preferentially sorbed on the zeolite. The zeolite is then regenerated by desorbing the water or water vapor from the zeolite. A gas stream having a reduced volume and an increased sulfur oxide gas concentration is isolated and directed to sulfur oxide removal and processing apparatuses.
    Type: Grant
    Filed: January 3, 1992
    Date of Patent: June 29, 1993
    Assignee: Lehigh University
    Inventors: Dale R. Simpson, Harvey G. Stenger
  • Patent number: 5216176
    Abstract: A photochemotherapeutic compound of the formula ##STR1## wherein (i) n is zero, W is a (C.sub.1-16) alkyl, alkenyl, or alkynyl linear or branched chain hydrocarbon, having no more than four O, N, or S atoms in or attached to the chain; or(ii) n is 1, W is CR or CR.sub.2, and R, R', and R" are independently H or CH.sub.3 ; or(iii) N is 2, W is CR or CR.sub.2, and R, R', and R" are independently H or CH.sub.3 ; andA, B, C, and D are independently selected from hydrogen, alkyl, aryl, halogen, amino, aminoalkyl, nitro, alkoxy, aryloxy, hydroxy, carboxy, haloalkyl, or haloalkoxy, particularly compounds of the foregoing structure in which W is a charged substiuent and n=0 or 1.
    Type: Grant
    Filed: December 21, 1990
    Date of Patent: June 1, 1993
    Assignee: Lehigh University
    Inventors: Ned D. Heindel, Michele C. Jetter nee Siller, Jeffrey D. Laskin, Michael A. Gallo
  • Patent number: 5182021
    Abstract: A method is disclosed for attaining concurrent biological nitrification and dentrification in an aerobic zone of an activated sludge treatment plant. The method comprises aerating a mixed liquor in an aerobic stage of a secondary treatment zone to attain nitrification of ammonia values to NO.sub.x, transferring the mixed liquor to a settling zone where activated sludge is allowed to settle from the mixed liquor, transferring at least a portion of the sludge to an anaerobic sludge holding zone where it is held for a prolonged period, and returning the aged sludge from the sludge holding zone to the secondary treatment zone for mixing with influent wastewater. By holding the sludge in the sludge holding zone for a prolonged period, a culture of organisms is developed which exhibits an oxygen respiration block in the presence of NO.sub.x. When returned to the aerobic zone where nitrification is achieved, these organisms utilize the NO.sub.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: January 26, 1993
    Assignee: Lehigh University
    Inventor: Marshall L. Spector
  • Patent number: 5175093
    Abstract: Bioactive cells are immobilized by suspending bioactive cells in an aqueous solution of a salt-free osmolarity adjuster, alginate and polyethylene glycol, dividing the suspension into bead-sized globules, contacting the globules with a solution of divalent cations to gel the alginate to form beads containing polyethylene glycol-filled areas and removing the polyethylene glycol to form voids in the beads entrapping the bioactive cells. By perfusing the beads with a nutrient medium, the cells can proliferate in the voids to produce high cell densities and produce a product which can be separated from the medium.
    Type: Grant
    Filed: November 7, 1989
    Date of Patent: December 29, 1992
    Assignee: Lehigh University
    Inventor: Douglas B. Seifert