Abstract: Novel molecules and novel fragrance molecules are disclosed, with the series of related molecules all containing a cyclic acetal or dioxepane sub-structure in combination with a carbonyl sub-structure and a cyclic structure which may be a phenyl or non-phenyl substituent. The molecules may contain further substitutions or modifications. The molecules compose or modify the sensory qualities of a fragrance, flavor, or a scented or flavored product. Further information is given on the predicted olfactory receptor activity of the invention and a method for composing novel molecular structures with regard to particular receptors of interest in order to improve the pleasantness, multidimensionality, and utility of olfactory molecules.

Abstract: A method includes receiving a content feed that includes audio data corresponding to speech utterances and processing the content feed to generate a semantically-rich, structured document. The structured document includes a transcription of the speech utterances and includes a plurality of words each aligned with a corresponding audio segment of the audio data that indicates a time when the word was recognized in the audio data. During playback of the content feed, the method also includes receiving a query from a user requesting information contained in the content feed and processing, by a large language model, the query and the structured document to generate a response to the query. The response conveys the requested information contained in the content feed. The method also includes providing, for output from a user device associated with the user, the response to the query.

Abstract: Provided herein are methods for preventing biomineralization in brain tissue or neuronal tissue in vivo or in vitro by inhibiting the deposition of hydroxyapatite therein. Also provided are methods for delaying the progression or onset of Alzheimer's disease in a subject and for preventing the development of Alzheimer's disease in a post-traumatic brain injury subject. Contacting the brain tissue or neuronal tissue with or administering to a subject the drugs Levamisole and/or Foscarnet and/or a bisphosphonate inhibits or decreases levels of alkaline phosphatase and calcium and counteracts alpha-glycerophosphate therein to inhibit the activation of spontaneous biomineralization within a brain tissue to decrease or prevent ectopic biomineralization.

Abstract: A modeling platform for a finite state machine (FSM)-modeled system. The platform may include a design phase module configured for receiving FSM data associated with a design of the FSM-modeled system from a user device, wherein the FSM data describes static properties, dynamic properties, structural properties, states, state transitions, events, and outputs of the FSM-modeled system, wherein the design phase module is configured for generating design data based at least in part on the FSM data. The platform may further include a verification and testing phase module configured for providing a plurality of tools operable for utilizing the FSM and design data to facilitate aiding in design and implementation of the FSM-modeled system according to an identification of undesirable properties and usability deficiencies within the static properties, dynamic properties, structural properties, states, state transitions, events, and outputs of the design.

Abstract: The mouthpiece includes an enhanced mouthpiece, a data sensor, and a personal data device. The data sensor collects data regarding the bite force, the number of bites and the duration of each bite. The data sensor wirelessly transfers the collected data to a personal data device.

Abstract: A board for thermally regulating the temperature of a patient disposed on the board is provided. The board includes a board body formed by at least two laminate layers and a temperature regulating apparatus embedded between the first laminate layer and the second laminate layer of the board body. The temperature regulating apparatus may include a heating element that selectively emits thermal radiation to at least one of the first laminate layer and the second laminate layer. Alternatively, the temperature regulating apparatus may include a fluid tube for receiving a flow of a temperature regulating fluid therethrough. The board may further include a fluid pump and a fluid tank that holds the temperature regulating fluid therein. The fluid pump generates the flow of the temperature regulating fluid though the fluid tube. The fluid tank, fluid pump, and fluid tube form a recirculating flow circuit for the temperature regulating fluid.

Abstract: An apparatus, system, and method may be used to replace a natural or artificial articular surface of a joint, and to repair a bone that is associated with the joint. In some embodiments, the apparatus, system, and method may include a joint replacement prosthesis with a prosthetic articular surface, a support structure securable to the bone, and a first attachment interface. The system may also include a bone plate with a bone engagement surface securable to the bone on either side of a fracture formed in the bone, or a damaged area of the bone. The bone plate may include a second attachment interface that is attachable to the first attachment interface of the joint replacement prosthesis in order to couple the bone plate to the joint replacement prosthesis.

Abstract: Aspects of the present disclosure involve systems, methods, computer program products, and the like, for determining an estimated capacity for providing data from a telecommunications network to a plurality of end users. In one implementation, the estimated capacity for delivering the data to the end users is per transmission path or per access network connected to the telecommunications network. This information may be aggregated into a traffic flow table that illustrates the traffic flow and available capacity to one or more end user networks. Through analysis of the traffic flow table, the system determines an estimated available capacity to provide the data to the end users. The traffic flow table thus provides a more accurate estimate of the capacity of the telecommunications network to provide the data to the end users over previous capacity estimates.

Abstract: A climbing simulation exercise machine having a stationary support frame, arc-shaped wheel tracks, pedal assemblies, a rocker lever mounted on the stationary support frame, linkages connection hubs mounted on the stationary support frame, handle levers mounted on the stationary support frame, handles mounted on the handle levers, first and second linkage bars connected to the pedal carriages and to the linkages connection hubs, third linkage bars connected to the linkages connection hubs and the rocker lever, fourth linkage bars connected to the handle levers and the linkages connection hubs, in which the rocker lever synchronizes and controls the motions of the handle levers and the pedal assemblies such that a left side handle lever and a left side pedal assembly move in opposite directions from each other and a right side handle lever and a right side pedal assembly move in opposite directions from each other during operation.

Abstract: A device comprises a sensor and processing circuitry coupled to the sensor. The sensor is configured to obtain authentication information from an identification label of a cartridge of an electronic vaping device. The processing circuitry is configured to perform authentication of the cartridge based on the authentication information; and determine whether to unlock a battery section of the electronic vaping device to power the cartridge based on a result of the authentication of the cartridge.

Abstract: A cartridge includes an air flow passageway defining a first airflow direction, a heating element having a longitudinal axis, the longitudinal axis perpendicular to the first airflow direction, and a jacket at least partially surrounding the heating element along the longitudinal axis of the heating element and defining a second airflow direction perpendicular to the first airflow direction.

Abstract: A cupsole for footwear, said cupsole comprising at least a sidewall, a bottom surface and a central portion and wherein said sidewall circumscribes the central portion, said central portion having openings, preferably in the form of at least one honeycomb structure and wherein at least the sidewall and the bottom surface of the cupsole have a solid structure with no openings and wherein the complete cupsole is customized on the base of specific and measured data obtained directly from the user and printed in 1 single 3D printing step thereby using a thermoplastic polymer.

Abstract: A nicotine pod assembly for a nicotine e-vaping device may include a pod body and a connector module. The pod body has an upstream end and a downstream end and is configured to hold a nicotine pre-vapor formulation. The upstream end of the pod body defines a cavity. The connector module is configured to be seated within the cavity of the pod body. The connector module may include an external face and a side face. The external face of the connector module includes at least one electrical contact and defines a pod inlet. The side face of the connector module defines at least one module inlet. The side face of the connector module faces a sidewall of the cavity in the pod body when the connector module is seated within the cavity.

Abstract: The present hook-based vehicle restraining system is capable of reducing the effects of RIG wedge or forced hook rotation in the disengaging direction. A cam located within a hook pocket inside of the hook allows the hook to move translationally in cases of RIG wedge, thereby dislodging the hook. At least one transition stop contacts the hook to prevent the hook from rotating beyond the transition stop, thereby preventing the hook from being forced downwards.

Abstract: This disclosure is related to improved security authentication frameworks for crowdsourced gaming systems that facilitate collaboration among multiple virtual participants over a network. In certain embodiments, an electronic gaming platform includes a geolocation authentication system that authenticates, verifies, and authorizes virtual user participants prior to accepting submissions in virtual multi-participant contests hosted by the electronic gaming platform. The geolocation authentication system can transition collaborative gaming applications operated by virtual user participants between a restricted functionality state that locks one or more functionalities pertaining to the virtual multi-participant contests hosted by the electronic platform and an unrestricted functionality state that unlocks one or more functionalities pertaining to the virtual multi-participant contests.

Abstract: Apparatus for classroom scheduling and method of use are disclosed. The apparatus includes at least a processor and a memory communicatively connected to the at least a processor. The memory includes instructions configuring the at least a processor to receive user data, wherein the user data includes a class preference, obtain class data, wherein the class data includes class information and a class constraint, classify the user data into one or more user data groups, wherein the one or more user data groups includes a class preference group, classify the class data into one or more fitness class groups, wherein the one or more fitness class groups includes a class constraint group, generate a user preferred class as a function of the class preference group, generate a classroom timetable for a fitness classroom as a function of the user preferred class and the class constraint group.

Abstract: A shifter assembly for an electric vehicle includes a base, a shifter handle, and a plurality of actuators. The base defines an opening. The shifter handle extends through the opening of the base and is pivotably coupled to the base. Each actuator of the plurality of actuators are pivotably coupled to the base at a first end and pivotably coupled to the shifter handle at a second end that is opposite the first end. The plurality of actuators are configured to permit movement of the shifter handle relative to the base in a predetermined virtual pathway and inhibit movement of the shifter handle relative to the base outside the predetermined virtual path.

Abstract: The present document describes a camera module with electrostatic discharge (ESD) protection. In particular, the camera module includes a lightning rod structure, which guides an ESD current to a safe location (e.g., system ground) when a lens retainer of the camera module is hit by an ESD spark. Due to the impact on camera focus tuning and the risk of audio rub and buzz, the lightning rod structure does not physically touch the lens retainer. As such, a gap separates the lightning rod structure from the lens retainer. When the lens retainer is stressed by an ESD spark, the gap is broken down and a conductive path is established to guide the ESD current to the safe location through the lightning rod structure. In this way, the ESD current flows along a controlled path instead of jumping to arbitrary locations, which protects nearby susceptible circuitry.

Abstract: Disclosed herein are methods for training and deploying a predictive model for generating a prediction, e.g., patient eligibility for a CAR-T therapy. Datasets, such as open healthcare claims datasets, may be missing data. Missing data may hamper the ability to generate sufficient information needed for training a predictive model. Methods include leveraging comprehensive datasets, such as closed claims datasets, to create training examples for input into a machine learning algorithm. In various embodiments, the comprehensive dataset is modified to simulate the data missingness in the target dataset; then, the modified dataset is paired with the ground truth label derived from the comprehensive dataset to create training examples. In various embodiments, a comprehensive dataset is paired with a target dataset to create training examples. After training a predictive model on such examples, the model can be deployed to make predictions in the target dataset even in light of missing data.

Abstract: A dosing pen includes a barrel housing a reservoir of fluid and coupled to a piston plunger longitudinally movable within the reservoir. A needle assembly fits to a distal end of the barrel providing a channel for the fluid to exit an orifice of a needle in the assembly. A dosage knob calibrates a volume of the fluid to be forced through the needle upon the actuation of the plunger. As well, an injection button, upon depression, motivates the plunger towards the assembly. A feedback element fixed to the dosing pen has dual states of an operable state initiated in response to the depression of the button and for a period of time measured by a countdown timer triggered by the depression, and an inoperable state otherwise. Finally, a finger placement sensor at a top surface of the button electrically actuates the feedback element when latched in the operable state.