Abstract: Methods include generating a hypothetical formulation library of chemical formulations, including generating hypothetical formulations by one or more of: (a) directed combinatorics including: selecting starter formulations from historical data; performing substitution of one or more formulation components in at least one component class; and assigning concentration ratios within ranges established by the historical data; and (2) constrained randomization including: preparing template formulations including one or more component classes based on historical data; performing randomized substitution of formulation components in each of the component classes of the template formulations; randomly assign concentration ratios to the formulation components within ranges established by one or more constraints to produce hypothetical formulations; create descriptors for the hypothetical formulations; compare descriptor outputs from the hypothetical formulations with the range of descriptor outputs from the historical d

Abstract: Systems and methods for real-time patient record transcriptions and medical form population via mobile devices are described. A user (e.g., a medical professional) may speak into or near a mobile device operable to detect or record spoken language, and furthermore the mobile device may initiate real-time transcription of the spoken language to generate unstructured transcription text data corresponding to the spoken language. The unstructured transcription text data may be parsed for words or phrases indicative of medical information for generating structured data, where the structured data includes terms, phrases, and values identified via delineators and/or natural language processing techniques. Discrete data from the structured data may be directly inserted into corresponding locations (e.g., appropriate medical form text fields) in electronic medical records via APIs and service bus relays.

Abstract: A surgical implant device configured to adjust in planar orientation or angular orientation or both to correspond to the structure of the lamina to be spanned at the site of a cut of the laminoplasty surgery. The device includes a base having slots extending adjacent thereto, and an extension having a head configured to be adjustably positionable within the slots.

Abstract: A novel dosing regimen for erlotinib or a pharmaceutically acceptable salt thereof is described herein. The dosing regimen demonstrates impressive control of central nervous system disease, which is better than that reported with standard dose erlotinib. The use of the novel dosing regimen for treating patients in need thereof, including for controlling formation of metastatic brain, leptomeninges, or CNS lesions in a patient with non-small cell lung cancer (NSCLC) that harbors epidermal growth factor receptor (EGFR) mutation with or without pre-existing brain metastases, is also described herein.

Abstract: A system and method for scanning of coherent LIDAR. The system includes a motor, a laser source configured to generate an optical beam, and a deflector. A first facet of the plurality of facets has a facet normal direction. The deflector is coupled to the motor and is configured to rotate about a rotation axis to deflect the optical beam from the laser source. The laser source is configured to direct the optical beam such that the optical beam is incident on the deflector at a first incident angle in a first plane, wherein the first plane includes the rotation axis, wherein the first incident angle is spaced apart from the facet normal direction for the first facet. A second facet of the plurality of facets includes an optical element configured to deflect the optical beam at the first incident angle into a deflected angle.

Abstract: A content delivery network (CDN) includes a plurality of CDN components including at least one CDN rendezvous mechanism and at least one control core. The CDN components are controlled by control core data from the at least one control core. Some CDN components obtain CDN resources including control core data from at least some other CDN components. The CDN components use the CDN rendezvous mechanism to select one or more CDN components from which to obtain CDN resources.

Abstract: A bed rail having a guard frame that prevents a child from rolling off a bed and a pair of legs that extend between the mattress and box spring. The guard frame swings between up and down positions and is pivotally connected to the legs via a first junction. A second junction locks the guard frame to the legs. The second junction includes a rotatable seat that engages a pin extending from the guard frame. The bed rail further includes a strap that engages a proximal end of a leg, a distal end of the leg, and an anchor, which engages the side of the bed opposite of the bed rail.

Abstract: Apparatus and methods for variable-control fragrance dispensing. The disclosed device brings customization to the fragrance industry. Interchanging sub-containers and selecting the amounts of each sub-container allows a user to customize their scents. A mixing chamber contained to receive and mix a variable amount of each liquid from a plurality of sub-containers is described. The mixed liquid is sprayable out a spray head of the device. Selector knobs may be used to control valves which control the variable amount of each liquid dispensed.

Abstract: A technique for deploying an experimental version of a webpage includes using a mimic component to emulate functionality of a corresponding hidden UI component. The technique provides for receiving user input at the mimic component and, in response to the user input, executing a functional code block that bidirectionally communicates with an underlying platform code to update state data of the hidden UI component. The technique further provides for detecting, at the mimic component, an update to the state data of the hidden UI component, in response to the detection, updating state data of the mimic component based on the updated state data of the hidden UI component.

Abstract: Systems, methods, and devices for providing an adjusted yardage recommendation (AYR) to a golfer prior to a golf shot. AYRs are determined based on predicted golf ball trajectories that are modeled from a golfer's golf ball launch data, using non-classical mathematical approximation methods. Each of the modeled trajectories are unique, and result in personalized AYR values that are personalized to each individual golfer, even where two golfers hit a ball with the same club the same distance while having two different ball flights. Devices that can perform the methods of the present invention include rangefinder devices and/or portable computing devices, such as a smartphone. Systems can include a rangefinder device and a portable computing device, in which the rangefinder device determines the line-of-sight distance and angle of elevation to a target and communicates the same to the portable computing device, which calculates the AYR.

Abstract: Systems and methods for monitoring operation of a sump pump are provided. A method includes connecting a power adapter to the sump pump and a float-switch. The power adapter includes a controller positioned within a housing, prongs in communication with components coupled to the controller, a first receptacle and a second receptacle. The controller is configured to establish a wireless connection to a first wireless network, and transmit a message to a remote server over the first wireless network. The controller is further configured to determine a power status of a float switch and control the pump based on power status of the float switch.

Abstract: Methods and techniques for using an augmented reality device for determining an orientation of an instrument for inserting a medical device are provided. One such method includes simulating an insertion point and an orientation of a simulated surgical hardware installation on a diagnostic representation of a bone, and using an augmented reality based electronic device to align an instrument for inserting a surgical hardware installation at a desired orientation through an insertion point of the bone by displaying visual indicia indicating the insertion point and the orientation of the simulated surgical hardware installation. Disclosed herein is also a system and method having a concentric shape alignment system for medical device placement in the body, such as in a bone.

Abstract: A system for ordered food preferences accompanying symptomatic inputs, the system including a computing device, the computing device designed and configured to retrieve a food profile pertaining to a user; select a first food element as a function of the food profile; select a second food element as a function of the first food element; create a food preference menu wherein the food preference menu contains the first food element and the second food element; and modify the food preference menu as a function of an entry contained within a symptomatic database.

Abstract: A spacer panel for a rear side of a seat backrest of a vehicle includes a support structure having a first end and a second end with a tapered section extending from a first portion of the support structure to the first end of the support structure. The support structure is configured to be attached to the rear side of the backrest of the seat. The spacer panel has a honeycomb plastic structure with a thickness varying along a length of the support structure from the first end to the second end of the support structure. A gap hider is associated with the seat such that when the seat is folded, an outer surface of the spacer panel and an upper surface of the loading floor of the vehicle remains in line and oriented at the same angle forming an extended load floor and also providing support to the gap hider.

Abstract: A dynamic data extraction, distillation, and enhancement system is disclosed that includes a dynamic extraction, distillation, and enhancement framework. The framework includes an allocator, extractor, and deconstructor stored in a non-transitory memory that, when executed by a processor, receive files in different formats from data sources, determine a native format of each file, identify and extract an embedded object from a file, deconstruct the file into components, assign each file to one of a plurality of streams based on the native format of the file, assign the embedded object to a stream based on a format of the embedded object, and assign a deconstructed component to a stream based on a format of the deconstructed component. The native format includes one of text, video, image, or audio. Each stream corresponds to one native format. The streams include a text stream, an audio stream, a video stream, and an image stream.

Abstract: This disclosure describes methods and compositions for protein and peptide sequencing.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for using comfort scales to assess the performance of autonomous vehicles. One of the methods includes receiving data representing a traffic encounter between a vehicle and a pedestrian. A plurality of comfort scale ratings of the encounter assigned by a rater belonging to a first rater pool are received. An input element is generated for a rating transformation model configured to predict how comfort scale ratings assigned by a particular rater pool would have been assigned by a representative rater belonging to a reference rater pool. An inference pass is performed over the rating transformation model using the input element to obtain a plurality of transformed comfort scale ratings for the reference rater pool.

Abstract: Provided are approaches for providing multiple user accounts in a same transaction card assembly. The transaction card assembly may include a first card including a first card first side opposite a first card second side, the first card first side including a first pair of magnetic stripes and the first card second side including a first pair of identification chips. The transaction card assembly may further include a second card coupled to the first card, the second card including a second card first side opposite a second card second side, the second card first side including a second pair of magnetic stripes, and the second card second side including a second pair of identification chips. The first and second cards are slidable relative to one another between multiple positions to selectively expose and cover each identification chip of the first and second pairs of identification chips.

Abstract: Systems and methods provide real-time communication between website operators and website visitors including monitoring, gathering, managing and sharing of information.