Abstract: Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Abstract: Described are stabilized materials and methods and systems for providing said stabilized materials. The system includes a first unit for mixing a first combination that includes a quantity of drill cuttings and a drying agent. The system may include a second unit for mixing the first combination with at least a binder and/or a surface acting agent and providing a second combination. The second combination is formed when the first combination is caused to have a reduced moisture content, transitioning from a first state to a second state. The reduced moisture content in the second state is at least 20% less than the moisture content of the drill cuttings. The first combination in a second state is a stabilized material. The first combination in a second state may be a dried material. The binder and/or a surface acting agent with or without additional additives are not introduced until the first combination is in the second state.

Abstract: Methods and systems for optimizing fuel economy and maintaining particulate emissions below a threshold of an engine system in a vehicle. An engine system has port fuel injection, direct injection, variable compression ratio, and independent compression/expansion. A processor predicts settings for the four systems that optimize for a fuel economy that is maximized. A particulate rate of the engine system is computed based on the settings. A determination is made of whether the particulate rate is below a threshold. When the particulate rate is below the threshold, command signals are delivered to actuators of the systems to move to the settings. When the threshold is exceeded, the settings are revised to maintain the particulate below the threshold while optimizing for fuel economy.

Abstract: A fluid level and conductivity sensor having a sensing probe with four electrodes disposed therein particularly suited for high temperature applications. A distal end of the second and third electrodes are positioned a distance from the sensing end that is greater than distal ends of the first and fourth electrodes. The sensor includes an electronics system having a signal relay system for receiving signals from each of the electrodes and switching between different measurement modes by determining a resistance between selected pairs of electrodes based on instructions from the microcontroller. The measurement modes include a conductivity measurement mode in which a resistance between the first and fourth electrodes is determined, and a fluid level measurement mode in which a resistance between the first and third electrodes is determined and compared to a resistance between the second and third electrodes.

Abstract: In this disclosure, example quantum algorithms for approximate optimization based on a sudden quench of a Hamiltonian. While the algorithm is general, it is analyzed in this disclosure in the specific context of MAX-EK-LIN2, for both even and odd K. It is to be understood, however, that the algorithm can be generalized to other contexts. A duality can be found: roughly, either the algorithm provides some nontrivial improvement over random or there exist many solutions which are significantly worse than random. A classical approximation algorithm is then analyzed and a similar duality is found, though the quantum algorithm provides additional guarantees in certain cases.

Abstract: Various implementations relate to an operator monitoring system (OMS). Certain implementations include an OMS coupled to a rotatable portion of a steering wheel assembly of a vehicle. For example, the OMS may include an imaging unit, such as a camera, that is coupled to a central hub portion of the steering wheel assembly. The imaging unit has a field of view directed toward one or more occupants in the vehicle and is configured to capture an image signal corresponding to an imaging area in the field of view. The imaging area can be configured to encapsulate an expected position of one or more vehicle occupants. The OMS also includes one or more processing units in electrical communication with the imaging unit that receives and processes the image signal from the imaging unit to determine an occupant state and, in some implementations, provide feedback based on the determined occupant state.

Abstract: The present disclosure relates to processing operations configured to generate and present a chat bot diagnostic visualization that provides real-time visual insights into operation of a chat bot for debugging assistance. A chat bot diagnostic tool is programmed to launch a graphical user interface that displays a visual representation of diagnostic data for debugging a chat bot in real-time. To enable conversational specific data to be reviewed, the present disclosure is configured to implement a middleware adapter within in a run-time stack of a chat bot that is configured to trace data traffic between a chat bot and a channel of an application/service. This enables the chat bot diagnostic tool to observe data traffic and filter the data traffic to identify relevant data for debugging a chat bot. A debugging data visualization of a chat bot interaction is emulated through a graphical user interface of the chat bot diagnostic tool.

Abstract: A computer-implemented method of using video program viewer interaction data that has been loaded to a media measurement database as input to a measurement engine which then calculates Linear, DVR, and VOD asset viewing activity at three levels: (a) Video Program, (b) Video Program Airing, (c) Video Program Airing Segment, where each level provides summary metrics for groupings of Demographic, Geographic, and/or Device Characteristic, and also second-by-second viewing metrics, including counting advertising impressions, within the Demographic, Geographic, Device groupings. System also accounts for reduced value of ad viewing when viewer is using trick plays or when viewer delays viewing recorded content. Together these metrics provide detailed information on customer viewing behavior which can be used to drive business decisions for service providers, advertisers and content producers. Additionally, a viewing histogram analysis is produced.

Abstract: A computational photography system is described herein including a guidance system and a detail enhancement system. The guidance system uses a first neural network that maps an original image provided by an image sensor to a guidance image, which represents a color-corrected and lighting-corrected version of the original image. A combination unit combines the original image and the guidance image to produce a combined image. A detail-enhancement system then uses a second neural network to map the combined image to a predicted image. The predicted image supplements the guidance provided by the first neural network by sharpening details in the original image. A training system is also described herein for training the first and second neural networks. The training system alternates in the data it feeds the second neural network, first using a guidance image as input to the second neural network, and then using a corresponding ground-truth image.

Abstract: A control system of a self-driving tractor can access sensor data to determine a set of trailer configuration parameters of a cargo trailer coupled to the self-driving tractor. Based on the set of trailer configuration parameters, the control system can configure a motion planning model for autonomously controlling the acceleration, braking, and steering systems of the tractor.

Abstract: Described are embodiments for selecting a preamble for a random access procedure. In an embodiment, a wireless device receives one or more configuration parameters of physical random access channel (PRACH) occasions for the random access procedure. One or more PRACH occasions of the PRACH occasions correspond to a respective RS of a plurality of RSs. The wireless device determines a RS, from the plurality of RSs, based on a reference signal received power (RSRP) value of the RS, and a transmission power reduction value associated with the RS. The wireless device determines a PRACH occasion, associated with the RS, from the PRACH occasions. Then, the wireless device transmits, via the PRACH occasion, a preamble for the random access procedure.

Abstract: A configurable container includes a first divider and a container body. The divider has a divider body and a first projection extending from the divider body, wherein the first projection has a length having a first dimension and a width having a second dimension different than the first dimension. The container body includes a first wall that includes a first groove facing inward toward the internal cavity, wherein the first groove has a width configured to receive the width of the first projection of the first divider in a first orientation. At least one of the first wall and a second wall includes a second groove also facing inward toward the internal cavity, wherein the second groove has a width configured to receive the length of the first projection in a second orientation, wherein the width of the second groove is different than the width of the first groove.

Abstract: An attachment system incorporating a platform having an outwardly facing side, an opposite back side, the platform comprising laminated layers including at least one fabric layer comprising a polyethylene or para-aramid fabric, the platform having a plurality of slits therethrough defined and bound by edges of the layers fused together to have increased stiffness, wear and abrasion resistance. The slits are arranged in a predetermined pattern of aligned and spaced apart rows, the slits being configured to receive straps therethrough between the outwardly facing side and the back side to attach at least one holder to the outwardly facing side, and the platform being supported by and comprising an element of a carrier to be carried on a user's body.

Abstract: A bone graft loading system includes a loading funnel, syringe, cannula, plunger, and loading tool. The loading funnel includes an interior passageway to receive the cannula and a syringe docking portion. The syringe may be coupled to the syringe docking portion so that it extends along a longitudinal axis that is transverse to the longitudinal axes of the cannula and the loading funnel. A user may advance bone graft from the syringe to a holding area of the loading funnel. The user may then move the loading tool through the holding area and into the interior space of the cannula to load the cannula with bone graft. This process may be repeated until the cannula is fully loaded with bone graft. The cannula and the plunger inside the cannula may then be removed from the loading funnel and coupled to an injector assembly for use in surgery.

Abstract: Example methods, apparatus, systems and articles of manufacture to implement under-addressable advertisement measurement are disclosed. Example apparatus disclosed herein determine a tuned under-addressable advertisement duration and a total tuned advertisement duration for a first television broadcast at a first monitored site, the tuned under-addressable advertisement duration and the total tuned advertisement duration determined based on (i) return-path tuning data associated with the first monitored site, (ii) linear advertisement log data associated with a broadcast area including the first monitored site, and (iii) addressable advertisement log data associated with the first monitored site.

Abstract: A method for producing a poultry litter-based fertilizer by a) supplying poultry litter to a rotating rotary drum, b) adding acid or a source of acid to the rotating rotary drum, wherein acid reacts with the poultry litter to form an acidified mixture, c) adding ammonia or a source of ammonia to the rotating rotary drum, d) drying and cooling the ammoniated product by evaporation of water to form a dried, cooled product in a free-flowing semi-solid or solid form, repeating the steps b) through d) until a desired nitrogen content is reached in the poultry litter-based fertilizer.

Abstract: In a see-through waveguide-based HMD device configured to display holographic virtual images within a field of view (FOV) of the device user, a single pixel or group of pixels are lit to supply illumination at known locations on the display that is reflected from the user's eyes and captured by one or more sensors in an eye tracker. The eye tracker may apply real-time image analysis to the captured reflected light, called “glints,” to extract features of the user's eyes to determine where the HMD device user is looking—the gaze point—and calculate eye movement, location, and orientation. A negative lens functionality utilized in the HMD device to provide a fixed focal depth for the virtual images enables the lit pixels to function as virtual glint sources for the eye tracker sensor that are located at the fixed focal depth and from multiple illumination positions within the user's FOV.

Abstract: Systems and methods for identifying a status of components of hydraulic fracturing units including a prime mover and a hydraulic fracturing pump to pump fracturing fluid into a wellhead via a manifold may include a diagnostic control assembly. The diagnostic control assembly may include sensors associated with the hydraulic fracturing units or the manifold, and a supervisory control unit to determine whether the sensors are generating signals outside a calibration range, determine whether a fluid parameter associated with an auxiliary system of the hydraulic fracturing units is indicative of a fluid-related problem, determine whether lubrication associated with the prime mover, the hydraulic fracturing pump, or a transmission of the hydraulic fracturing units has a lubrication fluid temperature greater than a maximum lubrication temperature, or determine an extent to which a heat exchanger assembly associated with the hydraulic fracturing units is cooling fluid passing through the heat exchanger assembly.

Abstract: In one embodiment, a semiconductor package may be formed having a first side and a second side that is substantially opposite to the first side. An embodiment may include forming an attachment clip extending substantially laterally between the first and second sides wherein the attachment clip is positioned near a distal end of the first and second sides. An embodiment may also include forming the attachment clip to have a flexible main portion that can bend away from a plane of the main portion toward a bottom side of the semiconductor package.

Abstract: Techniques described herein are directed to arbitrating between multiple potentially-responsive, automated-assistant capable electronic devices to determine which should respond to the user's utterance, and/or which should defer to other electronic device(s). In various implementations, a spoken utterance of a user may be detected at a microphone of a first electronic device, a spoken utterance provided by a user. Sound(s) emitted by additional electronic device(s) may also be detected at the microphone. Each of the sound(s) may encode a timestamp corresponding to detection of the spoken utterance at a respective electronic device. Timestamp(s) may be extracted from the sound(s) and compared to a local timestamp corresponding to detection of the spoken utterance at the first electronic device. Based on the comparison, the first electronic device may either invoke an automated assistant locally or defer to one of the additional electronic devices.