Abstract: The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a template nucleic acid, incorporating a pair of sequence identifiers into the template, and sequencing the template.

Abstract: Systems and methods describe providing alternate redemption options. One aspect involves receiving an order, analyzing consumer information using a redemption options algorithm to obtain redemption options including an alternate redemption option, providing an initial gift notification to a recipient device based on the gift order, the initial gift notification including the alternate redemption option, receiving an alternate redemption request, transmitting an alternate redemption information request, receiving alternate redemption information, adding alternate redemption information to the historical consumer information to obtain updated historical consumer information, training the redemption options algorithm using the updated historical consumer information to obtain an updated redemption options algorithm, and performing an alternate redemption action set using the alternate redemption information.

Abstract: A hybrid, optimized exchange is provided, the hybrid, optimized exchange operably connected to a demand-side platform (DSP), the hybrid, optimized exchange further operably connected to a supply-side platform (SSP), the hybrid, optimized exchange configured to receive an advertising request, the hybrid, optimized exchange further configured to conduct, using a bid floor, a hybrid, optimized DSP auction of the advertising request among a plurality of DSPs, thereby generating a winning DSP that makes a winning DSP bid in an automated advertising auction system after the SSP initiates an SSP auction of the advertising request, the hybrid, optimized exchange optimizing the bid floor provided to the plurality of DSPs in the hybrid, optimized DSP auction and simultaneously optimizing a shading factor used by the hybrid, optimized exchange to place a hybrid, optimized bid on behalf of the winning DSP in the SSP auction.

Abstract: The present disclosure relates to methods and systems suitable for use in identifying and providing personalised medicine to a patient. In some aspects, systems and method generate a co-therapy regimen for a patient suffering from a disease or condition. An identification of a co-therapy suitable to treat the disease or condition is received. A desired patient endpoint and a patient position are received, wherein the patient position is defined relative to the desired patient endpoint. A dataset relating to the patient is stored. The dataset comprises one or more patient data based on patient-related measurements. The dataset, the patient position and the desired patient endpoint are processed to generate a regimen for the co-therapy. The regimen is stored in a database.

Abstract: The invention relates to carrier screening and methods for describing a structural variant, such as a large rearrangement or chromosomal abnormality, in a person's genome using probes that are designed to determine the person's genetic sequence and reveal substitution mutations and small structural variants. Identifying a structural variant may include exposing a nucleic acid to a plurality of probes. Each probe has a linked pair of targeting arms designed to hybridize upstream and downstream of a target in a genome. The method includes hybridizing two of the probes to the nucleic acid and attaching the two probes together to create an inter-probe product as well as detecting the inter-probe product and reporting a structural variant of the genome in the nucleic acid.

Abstract: Systems and methods for generating dynamically definable gift objects are provided. A gift service may train a gift object algorithm and a gift selection algorithm using sample datasets. A gift request may be received and the gift service may generate a gift object with an undefined set of gift object using the gift object algorithm. A redemption request may be received and the gift service may generate a custom set of gift selection options using the gift selection algorithm in response to the redemption request. A selection from the custom set of gift selection options may be received and the gift object algorithm and the gift selection algorithm may be updated based on the redemption request, the custom set of gift selection options, and the selection.

Abstract: There is a dosage regimen for amlodipine for use in the treatment of hypertension.

Abstract: Disclosed techniques include video performance rendering modification based on device rotation metric. A media stream is received from a server. The media stream is targeted for display on a handheld media stream playback device. An orientation of the handheld device is determined during playback of the media stream on the handheld device. A change in the orientation of the handheld device is detected. The change occurs during playback of the media stream. Based on the detecting the change of orientation, a rotation angle of the handheld device is calculated. Based on the rotation angle, the playback speed of the media stream on the handheld device is changed. The changing the playback speed changes direction of playback rendering based on the rotation angle of the handheld device. The changing direction provides forward playback by rotating the handheld device in a clockwise direction from an initial orientation.

Abstract: A method of producing an intermediate program representation for an executable personalised medicine treatment program, comprising: providing a domain specific language environment comprising a personalised-medicine programming language syntax and a user interface; selecting a medical knowledge database for a medical condition; receiving user input to build, using the personalised-medicine programming language syntax and the medical knowledge database, a treatment package for implementing one or more treatment modalities for the medical condition, the treatment package including: treatment objectives defining terminating conditions of the one or more treatment modalities; safety guardrails for ensuring patient safety; and treatment titration definitions for modulating the one or more treatment modalities; and validating the treatment package to demonstrate that the treatment objectives, safety guardrails and treatment titration definitions will be satisfied during execution of the personalised medicine treatm

Abstract: Systems and methods for predictive gift subscriptions are provided. A gift subscription service may store a gift subscription and a profile associated with a gift recipient. The gift subscription service may then identify a time to send a gift to the gift recipient and associate a computational model with the gift recipient and the profile. When the gift subscription service determines a change in the profile, the gift subscription service may then update the computational model associated with the gift recipient in real-time by applying a machine learning algorithm to the change in the profile and use the updated computation model to formulate a prediction for the gift recipient that may then be used to identify a set of gifts to present to the gift recipient. The gift subscription service may then present the set of gifts to the gift recipient.

Abstract: A system for handling sheets of flexible material. The system comprises a first roller (5.2) which comprises a plurality of first releasable connectors (3.2) and a second roller (5.3) which comprises a plurality of second releasable connectors. The system further comprises an array of third releasable connectors (2.1) which is displaceable between at least the first and second rollers (5.2, 5.3). The first, second and third releasable connectors releasably attach to a sheet of flexible material in use.

Abstract: A system architecture of a gift transaction system is disclosed. The gift transaction system can include a buyer interface module, a recipient interface module, a merchant backend interface module, a store front interface module, a curation module, a reminder module, an analytics module, or a media plug-in interface module. A method of operating the gift transaction system under the system architecture includes: providing an embedded widget on a website to determine gift intent to initiate a gift transaction by a buyer account for a recipient account; generating a gift buyer interface for a first client device to personalize a gift package including a gift item; generating a gift recipient interface for a second client device to customize the gift package; and communicating with a merchant backend system to complete the gift transaction to ship the gift package.

Abstract: A system architecture of a gift transaction system is disclosed. The gift transaction system can include a buyer interface module, a recipient interface module, a merchant backend interface module, a store front interface module, a curation module, a reminder module, an analytics module, or a media plug-in interface module. A method of operating the gift transaction system under the system architecture includes: providing an embedded widget on a website to determine gift intent to initiate a gift transaction by a buyer account for a recipient account; generating a gift buyer interface for a first client device to personalize a gift package including a gift item; generating a gift recipient interface for a second client device to customize the gift package; and communicating with a merchant backend system to complete the gift transaction to ship the gift package.

Abstract: Systems and methods for gift selection, attribution, and distribution are provided. The systems and methods may detect a gifting signal that is associated with an event corresponding to a recipient. The systems and methods can provide an option to generate a gift for the recipient. If the option is selected, the systems and methods can identify a set of product criteria associated with the event and the recipient. Based on the criteria, the systems and methods can obtain product selection options for the gift and provide these options to a gift sender. In response to a selection from the gift sender, the systems and methods can generate the gift, which includes a redemption option for the selection.

Abstract: A fuel cell anode flow field includes at least one flow channel with a cross-sectional area that varies along at least a portion of its length. In some embodiments, the channel width decreases along at least a portion of the channel length according to a natural exponential function. This type of anode flow field can improve performance, reduce fuel consumption and/or reduce detrimental effects such as carbon corrosion and catalyst degradation, thereby improving fuel cell longevity and durability. When operating the fuel cell on either a substantially pure or a dilute fuel stream, this type of anode flow field can provide more uniform current density. These flow channels can be incorporated into reactant flow field plates, fuel cells and fuel cell stacks.

Abstract: Techniques for video manipulation based on an immersive video experience including rotation are disclosed. Parameters pertaining to a video are determined. Second parameters pertaining to a video display are determined. A minimum scale value is calculated to inscribe a rectangle within an oval based on a height and a width of the video. A height and a width of the video display define the rectangle. A gravity sensor input is preprocessed using a low-pass filter before using it to determine the minimum scale value. The video is preprocessed using a video inset and a viewport inset. The video can be trimmed, and the rectangle can be scaled. A rectangular portion of the video is rendered on the video display wherein the rectangular portion is on or inside the boundaries of the oval.

Abstract: The present disclosure relates to methods and systems suitable for use in identifying and providing personalised medicine to a patient. In some aspects, systems and method generate a co-therapy regimen for a patient suffering from a disease or condition. An identification of a co-therapy suitable to treat the disease or condition is received. A desired patient endpoint and a patient position are received, wherein the patient position is defined relative to the desired patient endpoint. A dataset relating to the patient is stored. The dataset comprises one or more patient data based on patient-related measurements. The dataset, the patient position and the desired patient endpoint are processed to generate a regimen for the co-therapy. The regimen is stored in a database.

Abstract: Techniques for display based on inline frame-based video rendering within browser are disclosed. A plurality of short-form videos is obtained. Thumbnails of one or more short-form videos, from the plurality of short-form videos, are displayed. The displaying thumbnails occurs within a frame on a third-party webpage within a browser window. A user's selection of a video from the short-form videos is received. The video that was selected by a user is reduced. The reducing the video enables the video to be rendered in a portion of the browser window. The reducing the video to render the video in a portion of the browser window includes launching a reloaded version of the third-party webpage to render the video superimposed over the third-party webpage. The video that was reduced is rendered, along with a reloaded copy of the third-party webpage, in the browser window.