Abstract: Systems and methods for enabling gifting of a gift product on a merchant store front determine eligibility of an abstract product available for purchase on the merchant store front to be selected as a gift product, the abstract product representing a set of all available SKUs for a given product, a gift product representing a subset of all available SKUs for a given abstract product, and the subset including less than all available SKUs for the given abstract product and greater than one available SKU for the given abstract product; generate and place an embedded widget on the merchant store front to determine gift intent to initiate a gift transaction of the gift product; assign at least one representative SKU to represent the gift product; and mimic an orchestrated transaction between a user and the merchant store front prior to final selection of a specific SKU of the gift product.

Abstract: Neural activity in the brain arising from a stimulus is monitored. A stimulus is applied to a target structure of the brain and a neural measurement is obtained from at least one electrode implanted in contact with the target structure. The neural measurement is configured to capture a measure of any late response arising in the target structure, typically being a neural response arising after conclusion of an ECAP, such as in the period 1.5-10 ms after stimulus onset. The late response(s) can be a useful biomarker such as of therapeutic ranges of deep brain stimulation, disease progression, medication efficacy, and intra-operative changes.

Abstract: The disclosure provides processes for preparing 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile and for preparing sulindac, relating to the field of medicine. The former comprises mixing 6-fluoro-2-methyl-1-indanone, cyanoacetic acid, a first organic solvent and an acetic acid-based catalyst to proceed with a first condensation reaction to give a first condensation reaction solution, which contains 5-fluoro-2-methyl-3-indanacetonitrile; and mixing the first condensation reaction solution, per se, with a base, a second organic solvent and 4-(methylthio)benzaldehyde to proceed with a second condensation reaction to give 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile. The process is a one-pot process without separation of 5-fluoro-2-methyl-3-indanacetonitrile from the solvent, shortening the synthetic route, simplifying the preparation process and improving the 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile yield.

Abstract: An inhalant dispensing system is provided, comprising an inhalant delivery apparatus having a main body, a lower body coupled to the main body and comprising a mouthpiece, and an inhalant delivery mechanism disposed within the main body and configured to deliver an aerosolized solution to the mouthpiece for user inhalation; and a lock out system configured to selectively prevent delivery of the aerosolized solution to the mouthpiece. The inhalant delivery apparatus may be assembled by inserting a portion of the inhalant delivery mechanism into the main body. The lower body may be rotatably coupled to the main body and moveable between a dispensing position and a storage position. The system may be used to control and monitor dosages of a solution contained within a smart canister and administered from the canister via an inhaler, to prevent accidental or unwanted usage of the canister and/or over-dosing.

Abstract: Systems and methods of providing enhanced product visualization on a graphical display include generating a visual frame having a first set of frame dimensions and comprising an inner border and an outer border; receiving a selection of a graphical object to be displayed at least within the outer border of the visual frame on the graphical display; identifying a set of object dimensions of the graphical object; determining an appropriate proportion between the set of frame dimensions and the set of object dimensions such that the graphical object is displayable at least within the outer border of the visual frame on the graphical display; manipulating the set of frame dimensions and/or the set of object dimensions such that the graphical object is displayable within the outer border of the visual frame; and displaying the graphical object at least within the outer border of the visual frame.

Abstract: The disclosure provides processes for preparing 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile and for preparing sulindac, relating to the field of medicine. The former comprises mixing 6-fluoro-2-methyl-1-indanone, cyanoacetic acid, a first organic solvent and an acetic acid-based catalyst to proceed with a first condensation reaction to give a first condensation reaction solution, which contains 5-fluoro-2-methyl-3-indanacetonitrile; and mixing the first condensation reaction solution, per se, with a base, a second organic solvent and 4-(methylthio)benzaldehyde to proceed with a second condensation reaction to give 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile. The process is a one-pot process without separation of 5-fluoro-2-methyl-3-indanacetonitrile from the solvent, shortening the synthetic route, simplifying the preparation process and improving the 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile yield.

Abstract: Fitting a brain neurostimulator electrode array comprises positioning at least a first electrode in a desired target structure in a first cerebral hemisphere, and positioning at least a second electrode in a corresponding target structure in a contralateral cerebral hemisphere. Electrical stimuli are applied from the first electrode to the desired target structure. Neural responses observed at the second electrode in response to the electrical stimuli are recorded. The fitting of at least one of the first electrode and second electrode is assessed by reference to the recorded neural responses.

Abstract: Systems and methods for gift selection, attribution, and distribution are provided. The systems and methods may detect a gifting signal that is associated with an event corresponding to a recipient. The systems and methods can provide an option to generate a gift for the recipient. If the option is selected, the systems and methods can identify a set of product criteria associated with the event and the recipient. Based on the criteria, the systems and methods can obtain product selection options for the gift and provide these options to a gift sender. In response to a selection from the gift sender, the systems and methods can generate the gift, which includes a redemption option for the selection.

Abstract: Provided are systems, methods, and computer-program products for a proxy network that can determine, for a set of objects, an initial differential, where the initial differential is determined using a rules data store of a host network. The proxy network can further determine a supplemental differential for the set of objects. The proxy network can further determine a final differential that is the sum of the initial differential and the supplemental differential. The proxy network can further determine a final sum for the set of objects that is the object value less the final differential. The proxy network can further generate an outbound data packet that includes values corresponding to the set of objects and the final sum. When the host network receives the outbound data packet, the host network can modify an object data store using the values corresponding to the set of objects and the final sum.

Abstract: An electrolyzer or unitized regenerative fuel cell has a flow field with at least one channel, wherein the cross-sectional area of the channel varies along at least a portion of the channel length. In some embodiments the channel width decreases along at least a portion of the length of the channel according to a natural exponential function. The use of this type of improved flow field channel can improve performance and efficiency of operation of the electrolyzer device.

Abstract: Systems and methods for automatically generating a graphical interface include determining a counter value associated with a counter object and automatically determining one or more corresponding objects using the counter value. A subset of the one or more corresponding objects is determined and a graphical interface including the subset is generated. An updated counter value associated with the counter object is determined according to a modification and one or more updated corresponding objects are automatically determined using the updated counter value. An updated subset of the one or more updated corresponding objects is determined an updated graphical interface including the updated subset is generated and is transmitted, wherein when the updated graphical interface is received, the updated graphical interface facilitates a selection of an updated corresponding object from the updated subset.

Abstract: The invention generally relates to method for assessing a genomic region of a subject. In certain embodiments, methods of the invention involve obtaining a sample including nucleic acid from a subject. The nucleic acid includes a target sequence from a target genomic region and a paralogous sequence from a non-target genomic region. The target sequence and the paralogous sequence are isolated from the sample. The target sequence and the paralogous sequence are sequenced to obtain sequence reads that include target sequence reads and paralogous sequence reads. The paralogous sequence reads are excluded, and the genomic region of the subject are assessed based on the target sequence reads.

Abstract: The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a template nucleic acid, incorporating a pair of sequence identifiers into the template, and sequencing the template.

Abstract: The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a template nucleic acid, incorporating a pair of sequence identifiers into the template, and sequencing the template.

Abstract: A composite safety toothbrush is disclosed. The toothbrush apparatus detailed herein employs a composite head made from a rigid inner polymer material and a softer thermoplastic material surrounding the inner material. The softer material provides safety for prison toothbrush applications as well as elderly and patient care where care givers may brush the teeth of a patient. Innovative pin connectors in the inner toothbrush head assist in the composite formation. The toothbrush solution herein further importantly provides for a toothbrush having a flexible handle.

Abstract: A motor response of a muscle to neural stimulation is assessed. Electrical stimuli are applied from a first electrode to a selected neural pathway to evoke an efferent neural response. A slow neural response upon the neural pathway evoked by the electrical stimuli is observed. Based on the slow neural response, a motor response of at least one muscle to the stimuli is assessed.

Abstract: Provided are systems, methods, and computer-program products for a proxy network that can determine, for a set of objects, an initial differential, where the initial differential is determined using a rules data store of a host network. The proxy network can further determine a supplemental differential for the set of objects. The proxy network can further determine a final differential that is the sum of the initial differential and the supplemental differential. The proxy network can further determine a final sum for the set of objects that is the object value less the final differential. The proxy network can further generate an outbound data packet that includes values corresponding to the set of objects and the final sum. When the host network receives the outbound data packet, the host network can modify an object data store using the values corresponding to the set of objects and the final sum.