Abstract: An active-substance-containing transdermal therapeutic system for the controlled release of estradiol or its pharmaceutically acceptable able derivatives alone or combined with gestagens consisting of a layer, an active-substance-containing reservoir which is bonded thereto and produced by using pressure sensitive adhesives, and a removable protective layer is characterized by the fact that the pressure sensitive adhesive comprises esters of colophony.
Abstract: A pharmaceutical product for the release of medicinal agents to the skin having absorption-increasing auxiliary agents is characterized in that the auxiliary material forms subcooled melts.
Abstract: The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.
Type:
Grant
Filed:
December 21, 2000
Date of Patent:
January 1, 2002
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Thomas Hille, Hans-Rainer Hoffmann, Mirko Kreh, Rudolf Matusch
Abstract: Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methyl-phenyl-carbamate in free base or acid addition salt form and an anti-oxidant. Said pharmaceutical compositions may be delivered to a patient using a transdermal delivery device.
Type:
Grant
Filed:
April 14, 1999
Date of Patent:
January 1, 2002
Assignees:
Novartis AG, LTS Lohmann Therapie-Systeme GmbH Co. KG
Inventors:
Bodo Asmussen, Michael Horstmann, Kai Köpke, Henricus L. G. M. Tiemessen, Steven Minh Dinh, Paul M. Gargiulo
Abstract: In a solid medicament form for the peroral application of active agents containing a uniform distribution of active agent in a polymer material, the polymer material is in the form of flat fragments.
Type:
Grant
Filed:
July 10, 1997
Date of Patent:
December 25, 2001
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Bodo Asmussen, Walter Müller, Karsten Cremer
Abstract: A process for continuously manufacturing transdermal therapeutic patches having a backing layer, a pressure-sensitive adhesive drug reservoir layer, and a removable protective layer, whereby loss of active substances during fabrication of the patches is minimized, said process being characterized in that, in a tape-like laminate having a pressure-sensitive adhesive backing layer (1) and a removable protective layer (3), single quadrangular pressure-sensitive adhesive drug reservoir sections (2) are inserted one after the other in the longitudinal direction between the layers (2,3); the clearance between said drug reservoir sections remains constant in the longitudinal direction; their width is calculated such that the backing layer (1) and the removable protective layer (3) project beyond both sides of said sections; the pressure-sensitive adhesive backing layer (1) is first cut by punching in such a way that the punching line (1a) surrounds the individual drug reservoir sections (2) at an evident distance fr
Type:
Grant
Filed:
September 22, 1995
Date of Patent:
November 13, 2001
Assignee:
LTS Lohmann Therapie-Systeme GmbH & Co. KG
Inventors:
Dieter Anhauser, Lothar Deurer, Thomas Hille, Peter Steinborn
Abstract: Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methyl-phenyl-carbamate in free base or acid addition salt form and an antioxidant. Said pharmaceutical compositions may be delivered to a patient using a transdermal delivery device.
Abstract: A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
Type:
Grant
Filed:
August 2, 2000
Date of Patent:
September 4, 2001
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Horst Georg Zerbe, Jian-Hwa Guo, Anthony Serino
Abstract: A pharmaceutical product for the release of medicinal agents to the skin having absorption-increasing auxiliary agents is characterized in that the auxiliary material forms subcooled melts.
Abstract: The invention concerns a transdermal application system for antithrombotic therapy and for the prophylaxis against cancer, respectively, containing as active substance acetylsalicylic acid and/or pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
August 4, 1994
Date of Patent:
July 24, 2001
Assignee:
LTS Lohmann Therapie-Systeme GmbH & Co. KG
Abstract: A dry-coated tablet for controlled release of active substance, having an erodible core tablet (1) containing at least one active substance, and a substantially erosion-resistant shell consisting of a dry-coated layer (5), is characterized in that the dry-coated layer (5) has at least one opening (6), and one end of the core tablet (1) extends as far as the opening (6).
Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).
Type:
Grant
Filed:
October 28, 1999
Date of Patent:
July 24, 2001
Assignee:
LTS Lohmann Therapie-Systeme GmbH & Co. KG
Abstract: An oral preparation, comprising at least one pharmaceutical active compound in a matrix which is swellable in aqueous medium, which is released from the matrix into the aqueous medium in a delayed manner on swelling thereof, while the matrix is largely resistant to disintegration during the release process, it is characterized in that it is a layered tablet with layers adhering to one another, of which at least one layer is the swellable matrix layer and at least another layer is an auxiliary and/or excipient layer, and in that the swellable matrix layer contains an amount of crosslinked amylose.
Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).
Type:
Grant
Filed:
March 9, 1998
Date of Patent:
May 1, 2001
Assignee:
LTS Lohmann Therapie-Systeme GmbH & Co. KG
Abstract: The invention relates to reservoirs with a delivery surface for the controlled delivery of active substances decreasing over the time of use to solid, liquid or gaseous acceptors and whereby at least at one point of the reservoir a cross-sectional surface of the reservoir is parallel to the delivery surface and smaller in area than the delivery surface. The invention also relates to an apparatus for the controlled delivery of active substances decreasing over the time of use, which has at least one reservoir. At least one active substance to be delivered is active in the technical, human and veterinary medical, cosmetic and pest control sectors.
Type:
Grant
Filed:
August 31, 1995
Date of Patent:
March 27, 2001
Assignee:
LTS Lohmann Therapie-Systeme GmbH & Co. KG
Abstract: The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.
Type:
Grant
Filed:
August 7, 1998
Date of Patent:
February 27, 2001
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Thomas Hille, Hans-Rainer Hoffmann, Mirko Kreh, Rudolf Matusch
Abstract: A device for the release of substances from pressure sensitive hot-melt adhesives with a uniform or non-uniform distribution of said substances is characterized by the fact that the pressure sensitive hot-melt adhesive is hydrophilic and comprises at least one water-soluble, or at least water-swellable, polymer, at least one water-soluble, meltable adhesive resin, as well as substance to be released.
Abstract: The present invention relates to a process and a device for the production of a flat administration form comprising a preparation that contains pharmaceutical active substances. The flowable preparation is conveyed to an applicator unit (12) by means of a metering pump, and flows through a distribution chamber (2) having a distribution plate (3) provided with passages (4). This application device (12) transfers the preparation onto a layer of the flat administration form (6,11) which is therefor contacted with the distribution plate (3) for a short time.
Type:
Grant
Filed:
August 22, 1996
Date of Patent:
February 13, 2001
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Thomas Hille, Ludwig Grader, Klaus Schumann
Abstract: A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
Type:
Grant
Filed:
April 6, 1999
Date of Patent:
January 23, 2001
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Horst Georg Zerbe, Jian-Hwa Guo, Anthony Serino
Abstract: A transdermal therapeutic system for the release of active substances to a substrate is characterized by the structure of the system comprising a substrate (1) provided with a separating layer (2), a film layer (3) comprising the active substance, and a protective layer (4) provided with a nonstick finish, the separating layer (2) consisting of a material whose bond to the film layer (3) may be abolished. By means of printing methods, such systems having small application thickness and high flexibility can be manufactured, it being possible to provide a substrate that has been rendered adhesive as an alternative to the substrate/separating layer-complex. A printing method limiting the active substance-containing region to the application site reduces disposal problems.
Type:
Grant
Filed:
April 26, 1999
Date of Patent:
December 26, 2000
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Reinhard v. Kleinsorgen, Britta v. Kleinsorgen